{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T03:00:54Z","timestamp":1768273254349,"version":"3.49.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1006055","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T00:00:00Z","timestamp":1523577600000}}],"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T00:00:00Z","timestamp":1522713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Edmond J. Safra Center for Bioinformatics at Tel Aviv University"},{"name":"the Ela Kodesz institute for medical physics and engineering."},{"DOI":"10.13039\/100006221","name":"United States - Israel Binational Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006221","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1006055","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T18:28:35Z","timestamp":1522780115000},"page":"e1006055","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Computational analysis of the oscillatory behavior at the translation level induced by mRNA levels oscillations due to finite intracellular resources"],"prefix":"10.1371","volume":"14","author":[{"given":"Yoram","family":"Zarai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4194-7068","authenticated-orcid":true,"given":"Tamir","family":"Tuller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,4,3]]},"reference":[{"key":"ref1","article-title":"Molecular Biology of the Cell","author":"B Alberts","year":"2008"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1752-0509-2-87","article-title":"A quantitative estimation of the global translational activity in logarithmically growing yeast cells","volume":"2","author":"T von der Haar","year":"2008","journal-title":"BMC Syst Biol"},{"issue":"50","key":"ref3","doi-asserted-by":"crossref","first-page":"47150","DOI":"10.1074\/jbc.M109581200","article-title":"Quantitation of the RNA polymerase II transcription machinery in yeast","volume":"276","author":"T Borggrefe","year":"2001","journal-title":"J Biol Chem"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nmeth.3339","article-title":"Quantifying cellular capacity identifies gene expression designs with reduced burden","volume":"12","author":"F Ceroni","year":"2015","journal-title":"Nature methods"},{"key":"ref5","article-title":"Isocost lines describe the cellular economy of genetic circuits","author":"A Gyorgy","year":"2015","journal-title":"Biophysical J"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1089\/cmb.2011.0275","article-title":"Efficient manipulations of synonymous mutations for controlling translation rate: an analytical approach","volume":"19","author":"A Dana","year":"2012","journal-title":"Journal of Computational Biology"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1021\/sb4001245","article-title":"Using synthetic biological parts and microbioreactors to explore the protein expression characteristics of Escherichia coli","volume":"3","author":"TE Gorochowski","year":"2014","journal-title":"ACS Synth Biol"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1002\/biot.201200085","article-title":"Contextualizing context for synthetic biology\u2013identifying causes of failure of synthetic biological systems","volume":"7","author":"S Cardinale","year":"2012","journal-title":"Biotechnol J"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1016\/j.bpj.2013.04.049","article-title":"Translational cross talk in gene networks","volume":"104","author":"WH Mather","year":"2013","journal-title":"Biophysical J"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2010.03.031","article-title":"An evolutionarily conserved mechanism for controlling the efficiency of protein translation","volume":"141","author":"T Tuller","year":"2010","journal-title":"Cell"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1128\/JB.150.2.572-581.1982","article-title":"Transcription in bacteria at different DNA concentrations","volume":"150","author":"G Churchward","year":"1982","journal-title":"Journal of bacteriology"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1006\/jmbi.1993.1319","article-title":"Synthesis of proteins in Escherichia coli is limited by the concentration of free ribosomes: expression from reporter genes does not always reflect functional mRNA levels","volume":"231","author":"J Vind","year":"1993","journal-title":"Journal of molecular biology"},{"issue":"1544","key":"ref13","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1098\/rstb.2009.0305","article-title":"Forces that influence the evolution of codon bias","volume":"365","author":"PM Sharp","year":"2010","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/nar\/gku1313","article-title":"Multiple roles of the coding sequence 5\u2019 end in gene expression regulation","volume":"43","author":"T Tuller","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0092-8674(81)90372-X","article-title":"Differential capacity for translation and lack of competition between mRNAs that segregate to free and membrane-bound polysomes","volume":"27","author":"JD Richter","year":"1981","journal-title":"Cell"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nrg3853","article-title":"Competition between target sites of regulators shapes post-transcriptional gene regulation","volume":"16","author":"M Jens","year":"2015","journal-title":"Nature Reviews Genetics"},{"issue":"12","key":"ref17","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1091\/mbc.9.12.3273","article-title":"Comprehensive identification of cell cycle\u2013regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization","volume":"9","author":"PT Spellman","year":"1998","journal-title":"Molecular Biology of the Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/msb.2012.3","article-title":"Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels","volume":"8","author":"M Frenkel-Morgenstern","year":"2012","journal-title":"Mol Syst Biol"},{"issue":"23","key":"ref19","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.1091\/mbc.E13-05-0264","article-title":"Identification of cell cycle\u2013regulated genes periodically expressed in U2OS cells and their regulation by FOXM1 and E2F transcription factors","volume":"24","author":"GD Grant","year":"2013","journal-title":"Molecular biology of the cell"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1747-1028-5-10","article-title":"Expression of human eukaryotic initiation factor 3f oscillates with cell cycle in A549 cells and is essential for cell viability","volume":"5","author":"AE Higareda-Mendoza","year":"2010","journal-title":"Cell Division"},{"issue":"27","key":"ref21","doi-asserted-by":"crossref","first-page":"11292","DOI":"10.1073\/pnas.0701837104","article-title":"Ultradian oscillations of Stat, Smad, and Hes1 expression in response to serum","volume":"104","author":"S Yoshiura","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S1534-5807(03)00119-9","article-title":"Two redundant oscillatory mechanisms in the yeast cell cycle","volume":"4","author":"FR Cross","year":"2003","journal-title":"Developmental cell"},{"issue":"5997","key":"ref23","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.1191937","article-title":"Oscillating gene expression determines competence for periodic Arabidopsis root branching","volume":"329","author":"MA Moreno-Risueno","year":"2010","journal-title":"Science"},{"issue":"6258","key":"ref24","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/343536a0","article-title":"Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels","volume":"343","author":"PE Hardin","year":"1990","journal-title":"Nature"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1016\/j.bpj.2012.04.023","article-title":"Transcription factor oscillations induce differential gene expressions","volume":"102","author":"KB Wee","year":"2012","journal-title":"Biophysical journal"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.molcel.2013.12.013","article-title":"Extensive oscillatory gene expression during C. elegans larval development","volume":"53","author":"GJ Hendriks","year":"2014","journal-title":"Molecular cell"},{"issue":"19","key":"ref27","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1242\/dev.104497","article-title":"Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions","volume":"141","author":"A Isomura","year":"2014","journal-title":"Development"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/nar\/gkn893","article-title":"Mouse period 2 mRNA circadian oscillation is modulated by PTBmediated rhythmic mRNA degradation","volume":"37","author":"KC Woo","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"8350","DOI":"10.1038\/ncomms9350","article-title":"Oscillation of p38 activity controls efficient pro-inflammatory gene expression","volume":"6","author":"T Tomida","year":"2015","journal-title":"Nat Commun"},{"issue":"7186","key":"ref30","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/nature06685","article-title":"Haematopoietic stem cell release is regulated by circadian oscillations","volume":"452","author":"S Mendez-Ferrer","year":"2008","journal-title":"Nature"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0169-328X(98)00092-8","article-title":"BDNF and trkB mRNAs oscillate in rat brain during the light-dark cycle","volume":"57","author":"R Bova","year":"1998","journal-title":"Mol Brain Res"},{"issue":"16","key":"ref32","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/S0960-9822(03)00494-9","article-title":"Oscillatory expression of Hes1, p53, and NF-kappaB driven by transcriptional time delays","volume":"13","author":"NA Monk","year":"2003","journal-title":"Curr Biol"},{"issue":"5594","key":"ref33","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1126\/science.1074560","article-title":"Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loop","volume":"298","author":"H Hirata","year":"2002","journal-title":"Science"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1042\/bst0190533","article-title":"Circadian oscillations in protein and mRNA levels of the period gene of Drosophila melanogaster","volume":"19","author":"LJ Zwiebel","year":"1991","journal-title":"Biochem Soc Trans"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrg2775","article-title":"Synthetic biology: applications come of age","volume":"11","author":"AS Khalil","year":"2010","journal-title":"Nat Rev Genet"},{"issue":"7038","key":"ref36","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature03508","article-title":"A synthetic gene\u2013metabolic oscillator","volume":"435","author":"E Fung","year":"2005","journal-title":"Nature"},{"issue":"7221","key":"ref37","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nature07389","article-title":"A fast, robust and tunable synthetic gene oscillator","volume":"456","author":"J Stricker","year":"2008","journal-title":"Nature"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cels.2017.09.016","article-title":"Design of tunable oscillatory dynamics in a synthetic NF-<italic>\u03ba<\/italic>B signaling circuit","volume":"5","author":"ZB Zhang","year":"2017","journal-title":"Cell systems"},{"issue":"6251","key":"ref39","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1126\/science.aaa3794","article-title":"Emergent genetic oscillations in a synthetic microbial consortium","volume":"349","author":"Y Chen","year":"2015","journal-title":"Science"},{"issue":"7626","key":"ref40","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature19841","article-title":"Synchronous long-term oscillations in a synthetic gene circuit","volume":"538","author":"L Potvin-Trottier","year":"2016","journal-title":"Nature"},{"issue":"6767","key":"ref41","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/35002125","article-title":"A synthetic oscillatory network of transcriptional regulators","volume":"403","author":"MB Elowitz","year":"2000","journal-title":"Nature"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/0006-291X(66)90276-2","article-title":"Continuous oscillations in a cell-free extract of S. carlsbergensis","volume":"23","author":"B Hess","year":"1966","journal-title":"Biochem Biophys Res Commun"},{"issue":"116","key":"ref43","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2015.1062","article-title":"A model for competition for ribosomes in the cell","volume":"13","author":"A Raveh","year":"2016","journal-title":"J Royal Society Interface"},{"issue":"19","key":"ref44","first-page":"9031","article-title":"Predictive biophysical modeling and understanding of the dynamics of mRNA translation and its evolution","volume":"44","author":"H Zur","year":"2016","journal-title":"Nucleic Acids Research"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"e1002127","DOI":"10.1371\/journal.pcbi.1002127","article-title":"Genome-scale analysis of translation elongation with a ribosome flow model","volume":"7","author":"S Reuveni","year":"2011","journal-title":"PLOS Computational Biology"},{"issue":"12","key":"ref46","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/nsmb.1514","article-title":"Single-RNA counting reveals alternative modes of gene expression in yeast","volume":"15","author":"D Zenklusen","year":"2008","journal-title":"Nature structural and molecular biology"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/embj.201385651","article-title":"Translation elongation can control translation initiation on eukaryotic mRNAs","volume":"33","author":"D Chu","year":"2014","journal-title":"EMBO J"},{"issue":"30","key":"ref48","first-page":"274","article-title":"RNA:protein ratio of the unicellular organism as a characteristic of phosphorous and nitrogen stoichiometry and of the cellular requirement of ribosomes for protein synthesis","volume":"4","author":"TV Karpinets","year":"2006","journal-title":"BMC Biol"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0378-1119(93)90511-Z","article-title":"High-level heterologous gene expression in Saccharomyces cerevisiae from a stable 2<italic>\u03bc<\/italic>m plasmid system","volume":"132","author":"DL Ludwig","year":"1993","journal-title":"Gene"},{"key":"ref50","first-page":"1121","article-title":"Expression systems for production of heterologous proteins","author":"M Rai","year":"2001","journal-title":"Current Science"},{"issue":"7626","key":"ref51","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/nature19841","article-title":"Synchronous long-term oscillations in a synthetic gene circuit","volume":"538","author":"L Potvin-Trottier","year":"2016","journal-title":"Nature"},{"issue":"6767","key":"ref52","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/35002125","article-title":"A synthetic oscillatory network of transcriptional regulators","volume":"403","author":"MB Elowitz","year":"2000","journal-title":"Nature"},{"issue":"5720","key":"ref53","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1126\/science.1108451","article-title":"Reconstitution of circadian oscillation of cyanobacterial KaiC phosphorylation in vitro","volume":"308","author":"M Nakajima","year":"2005","journal-title":"Science"},{"issue":"5931","key":"ref54","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1126\/science.1172005","article-title":"Synthetic gene networks that count","volume":"324","author":"AE Friedland","year":"2009","journal-title":"science"},{"issue":"7227","key":"ref55","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/nature07616","article-title":"A tunable synthetic mammalian oscillator","volume":"457","author":"M Tigges","year":"2009","journal-title":"Nature"},{"issue":"7279","key":"ref56","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/nature08753","article-title":"A synchronized quorum of genetic clocks","volume":"463","author":"T Danino","year":"2010","journal-title":"Nature"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"e09771","DOI":"10.7554\/eLife.09771","article-title":"Rapid cell-free forward engineering of novel genetic ring oscillators","volume":"4","author":"H Niederholtmeyer","year":"2015","journal-title":"Elife"},{"issue":"7156","key":"ref58","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/nature06072","article-title":"The effects of molecular noise and size control on variability in the budding yeast cell cycle","volume":"448","author":"SD Talia","year":"2007","journal-title":"Nature"},{"key":"ref59","article-title":"The cell cycle, principles of control","author":"DO Morgan","year":"2007"},{"issue":"4","key":"ref60","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.jtbi.2005.08.007","article-title":"A model of protein translation including codon bias, nonsense errors, and ribosome recycling","volume":"239","author":"MA Gilchrist","year":"2006","journal-title":"J Theoretical Biology"},{"issue":"4","key":"ref61","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/j.cell.2011.10.002","article-title":"Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes","volume":"147","author":"NT Ingolia","year":"2011","journal-title":"Cell"},{"issue":"11","key":"ref62","doi-asserted-by":"crossref","first-page":"R110","DOI":"10.1186\/gb-2011-12-11-r110","article-title":"Composite effects of gene determinants on the translation speed and density of ribosomes","volume":"12","author":"T Tuller","year":"2011","journal-title":"Genome Biol"},{"issue":"7","key":"ref63","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1261\/rna.059188.116","article-title":"Computational analysis of nascent peptides that induce ribosome stalling and their proteomic distribution in Saccharomyces cerevisiae","volume":"23","author":"R Sabi","year":"2017","journal-title":"RNA"},{"issue":"5991","key":"ref64","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1126\/science.1188308","article-title":"coli proteome and transcriptome with single-molecule sensitivity in single cells","volume":"329","author":"Y Taniguchi","year":"2010","journal-title":"science"},{"issue":"3","key":"ref65","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.bpj.2012.06.025","article-title":"Delayed protein synthesis reduces the correlation between mRNA and protein fluctuations","volume":"103","author":"T Gedeon","year":"2012","journal-title":"Biophysical journal"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"20130267","DOI":"10.1098\/rsif.2013.0267","article-title":"Ribosome flow model with positive feedback","volume":"10","author":"M Margaliot","year":"2013","journal-title":"J Royal Society Interface"},{"key":"ref67","article-title":"Stochastic Transport in Complex Systems: From Molecules to Vehicles","author":"A Schadschneider","year":"2011"},{"issue":"46","key":"ref68","doi-asserted-by":"crossref","first-page":"R333","DOI":"10.1088\/1751-8113\/40\/46\/R01","article-title":"Nonequilibrium steady states of matrix-product form: a solver\u2019s guide","volume":"40","author":"RA Blythe","year":"2007","journal-title":"J Phys A: Math Gen"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1109\/TCBB.2012.88","article-title":"Stability analysis of the ribosome flow model","volume":"9","author":"M Margaliot","year":"2012","journal-title":"IEEE\/ACM Trans Computational Biology and Bioinformatics"},{"key":"ref70","article-title":"vol. 41 of Mathematical Surveys and Monographs","author":"HL Smith","year":"1995"},{"issue":"5","key":"ref71","doi-asserted-by":"crossref","first-page":"e96039","DOI":"10.1371\/journal.pone.0096039","article-title":"Entrainment to periodic initiation and transition rates in a computational model for gene translation","volume":"9","author":"M Margaliot","year":"2014","journal-title":"PLoS ONE"},{"key":"ref72","article-title":"Tracking the evolution of mRNA translation via multi-organism whole cell simulations","author":"Z Zur","year":"2018","journal-title":"Under review"},{"key":"ref73","article-title":"Mean of the typical decoding rates: a new translation efficiency index based on ribosome analysis data","author":"A Dana","year":"2014","journal-title":"G3: Genes, Genomes, Genetics"},{"issue":"3","key":"ref74","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1101\/gr.164996.113","article-title":"Ribosome profiling reveals post-transcriptional buffering of divergent gene expression in yeast","volume":"24","author":"CJ McManus","year":"2014","journal-title":"Genome Research"},{"issue":"11","key":"ref75","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0968-0004(99)01460-7","article-title":"The economics of ribosome biosynthesis in yeast","volume":"24","author":"JR Warner","year":"1999","journal-title":"Trends in biochemical sciences"},{"issue":"1","key":"ref76","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s13062-016-0127-4","article-title":"Estimation of ribosome profiling performance and reproducibility at various levels of resolution","volume":"11","author":"A Diament","year":"2016","journal-title":"Biology direct"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1109\/TCBB.2012.120","article-title":"On the steady-state distribution in the homogeneous ribosome flow model","volume":"9","author":"M Margaliot","year":"2012","journal-title":"IEEE\/ACM Trans Computational Biology and Bioinformatics"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1006055","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T00:00:00Z","timestamp":1523577600000}},{"DOI":"10.1371\/journal.pcbi.1007192","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,7,2]],"date-time":"2019-07-02T00:00:00Z","timestamp":1562025600000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T23:28:41Z","timestamp":1604100521000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006055"}},"subtitle":[],"editor":[{"given":"Alexandre V.","family":"Morozov","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,4,3]]},"references-count":77,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1006055","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1006055","asserted-by":"object"}],"correction":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1007192","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,3]]}}}