{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T01:44:41Z","timestamp":1769219081289,"version":"3.49.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1006060","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000}}],"reference-count":87,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T00:00:00Z","timestamp":1523836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1006060","type":"journal-article","created":{"date-parts":[[2018,4,16]],"date-time":"2018-04-16T17:33:06Z","timestamp":1523899986000},"page":"e1006060","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Whole-body iron transport and metabolism: Mechanistic, multi-scale model to improve treatment of anemia in chronic kidney disease"],"prefix":"10.1371","volume":"14","author":[{"given":"Joydeep","family":"Sarkar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1877-0172","authenticated-orcid":true,"given":"Alka A.","family":"Potdar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2159-2343","authenticated-orcid":true,"given":"Gerald M.","family":"Saidel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"ref1","author":"JH Brock","year":"1994"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S1367-5931(99)80033-7","article-title":"Iron metabolism","volume":"3","author":"P Aisen","year":"1999","journal-title":"Curr Opin Chem Biol"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/713609210","article-title":"Iron metabolism in the reticuloendothelial system","volume":"38","author":"M Knutson","year":"2003","journal-title":"Crit Rev Biochem Mol Biol"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/10409239991209318","article-title":"Biochemistry of iron uptake","volume":"34","author":"M Wessling-Resnick","year":"1999","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev.bi.49.070180.002041","article-title":"Iron transport and storage proteins","volume":"49","author":"P Aisen","year":"1980","journal-title":"Annu Rev Biochem"},{"key":"ref6","unstructured":"Marshall A. Lichtman EB, Thomas J. Kipps, Uri Seligsohn, Kenneth Kaushansky, Josef T. Prchal Williams Hematology. 2006. Epub 7th edition."},{"key":"ref7","unstructured":"Greer JP. Wintrobe&apos;s Clinical Hematology. 11th edition ed2003. 2800 p."},{"issue":"26","key":"ref8","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1056\/NEJM199912233412607","article-title":"Disorders of iron metabolism","volume":"341","author":"NC Andrews","year":"1999","journal-title":"N Engl J Med"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0022-2143(99)90166-X","article-title":"Role of ceruloplasmin and ascorbate in cellular iron release","volume":"134","author":"DR Richardson","year":"1999","journal-title":"J Lab Clin Med"},{"issue":"5351","key":"ref10","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1126\/science.279.5351.714","article-title":"Role of ceruloplasmin in cellular iron uptake","volume":"279","author":"CK Mukhopadhyay","year":"1998","journal-title":"Science"},{"issue":"45","key":"ref11","doi-asserted-by":"crossref","first-page":"44018","DOI":"10.1074\/jbc.M304926200","article-title":"Role of ceruloplasmin in macrophage iron efflux during hypoxia","volume":"278","author":"J Sarkar","year":"2003","journal-title":"J Biol Chem"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.cmet.2005.10.003","article-title":"Unexpected role of ceruloplasmin in intestinal iron absorption","volume":"2","author":"S Cherukuri","year":"2005","journal-title":"Cell Metab"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1182\/blood-2004-12-4844","article-title":"Hepcidin in iron overload disorders","volume":"105","author":"G Papanikolaou","year":"2005","journal-title":"Blood"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1182\/blood-2004-08-3042","article-title":"Hepcidin is decreased in TFR2 hemochromatosis","volume":"105","author":"E Nemeth","year":"2005","journal-title":"Blood"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1182\/blood-2003-03-0672","article-title":"Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation","volume":"102","author":"T Ganz","year":"2003","journal-title":"Blood"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.beha.2004.08.020","article-title":"Hepcidin\u2014a regulator of intestinal iron absorption and iron recycling by macrophages","volume":"18","author":"T Ganz","year":"2005","journal-title":"Best Pract Res Clin Haematol"},{"issue":"5704","key":"ref17","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"E Nemeth","year":"2004","journal-title":"Science"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00275072","article-title":"A mathematical model of iron metabolism","volume":"15","author":"PC Franzone","year":"1982","journal-title":"J Math Biol"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/1752-0509-4-147","article-title":"Mathematical modeling of the dynamic storage of iron in ferritin","volume":"4","author":"JC Salgado","year":"2010","journal-title":"BMC Syst Biol"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"e1003299","DOI":"10.1371\/journal.pcbi.1003299","article-title":"A computational model of liver iron metabolism","volume":"9","author":"S Mitchell","year":"2013","journal-title":"PLoS Comput Biol"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"e1005322","DOI":"10.1371\/journal.pcbi.1005322","article-title":"Modelling Systemic Iron Regulation during Dietary Iron Overload and Acute Inflammation: Role of Hepcidin-Independent Mechanisms","volume":"13","author":"M Enculescu","year":"2017","journal-title":"PLoS Comput Biol"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"e1003701","DOI":"10.1371\/journal.pcbi.1003701","article-title":"Computational modeling and analysis of iron release from macrophages","volume":"10","author":"AA Potdar","year":"2014","journal-title":"PLoS Comput Biol"},{"issue":"21","key":"ref23","doi-asserted-by":"crossref","first-page":"5053","DOI":"10.1016\/S0021-9258(18)99669-9","article-title":"Kinetic studies of ferrous ion oxidation with crystalline human ferroxidase (ceruloplasmin)","volume":"241","author":"S Osaki","year":"1966","journal-title":"J Biol Chem"},{"issue":"20","key":"ref24","doi-asserted-by":"crossref","first-page":"5757","DOI":"10.1016\/S0021-9258(18)63623-3","article-title":"Mobilization of liver iron by ferroxidase (ceruloplasmin)","volume":"244","author":"S Osaki","year":"1969","journal-title":"J Biol Chem"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1006\/jtbi.1997.0537","article-title":"Hematopoietic model with moving boundary condition and state dependent delay: applications in erythropoiesis","volume":"190","author":"JM Mahaffy","year":"1998","journal-title":"J Theor Biol"},{"issue":"80","key":"ref26","doi-asserted-by":"crossref","first-page":"20120817","DOI":"10.1098\/rsif.2012.0817","article-title":"Dynamical modelling of haematopoiesis: an integrated view over the system in homeostasis and under perturbation","volume":"10","author":"E Manesso","year":"2013","journal-title":"J R Soc Interface"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1053\/j.ajkd.2007.10.003","article-title":"Model predictive control of erythropoietin administration in the anemia of ESRD","volume":"51","author":"AE Gaweda","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1109\/IEMBS.2006.260685","article-title":"Model predictive control with reinforcement learning for drug delivery in renal anemia management","volume":"1","author":"AE Gaweda","year":"2006","journal-title":"Conf Proc IEEE Eng Med Biol Soc"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.2215\/CJN.03540410","article-title":"Determining optimum hemoglobin sampling for anemia management from every-treatment data","volume":"5","author":"AE Gaweda","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.semnephrol.2006.05.005","article-title":"Anemia and the heart in chronic kidney disease","volume":"26","author":"N Zalunardo","year":"2006","journal-title":"Semin Nephrol"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1525-139X.2006.00171.x","article-title":"Anemia management in chronic kidney disease: what have we learned after 17 years?","volume":"19","author":"DM Spiegel","year":"2006","journal-title":"Semin Dial"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0889-8588(18)30536-7","article-title":"Erythropoietin: biology and clinical use","volume":"3","author":"SE Graber","year":"1989","journal-title":"Hematol Oncol Clin North Am"},{"issue":"3\u20134","key":"ref33","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3121\/cmr.2008.811","article-title":"Safety issues with intravenous iron products in the management of anemia in chronic kidney disease","volume":"6","author":"A Hayat","year":"2008","journal-title":"Clin Med Res"},{"key":"ref34","first-page":"195","article-title":"Erythropoietin stimulating agents in the management of anemia of chronic kidney disease","volume":"2","author":"A Hayat","year":"2008","journal-title":"Patient Prefer Adherence"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"576","DOI":"10.2215\/CJN.04710709","article-title":"Iron, inflammation, dialysis adequacy, nutritional status, and hyperparathyroidism modify erythropoietic response","volume":"5","author":"AE Gaweda","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"issue":"9","key":"ref36","doi-asserted-by":"crossref","first-page":"2029","DOI":"10.1681\/ASN.V1092029","article-title":"An indistinct balance: the safety and efficacy of parenteral iron therapy","volume":"10","author":"A Besarab","year":"1999","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"ref37","first-page":"833","article-title":"Molecular bases of cellular iron toxicity","volume":"32","author":"JW Eaton","year":"2002","journal-title":"Free Radic Biol Med"},{"issue":"1\u20132","key":"ref38","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0025-5564(94)00078-E","article-title":"Age-structured and two-delay models for erythropoiesis","volume":"128","author":"J Belair","year":"1995","journal-title":"Math Biosci"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"e65630","DOI":"10.1371\/journal.pone.0065630","article-title":"A biomathematical model of human erythropoiesis under erythropoietin and chemotherapy administration","volume":"8","author":"S Schirm","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1073\/pnas.78.1.621","article-title":"Interaction of human diferric transferrin with reticulocytes","volume":"78","author":"H Huebers","year":"1981","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"ref41","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1182\/blood-2003-04-1250","article-title":"Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages","volume":"102","author":"MD Knutson","year":"2003","journal-title":"Blood"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/S0168-8278(03)00408-2","article-title":"The role of the iron responsive element in the control of ferroportin1\/IREG1\/MTP1 gene expression","volume":"39","author":"A Lymboussaki","year":"2003","journal-title":"J Hepatol"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2110-5820-1-3","article-title":"Erythropoietin (EPO) in acute kidney injury","volume":"1","author":"E Moore","year":"2011","journal-title":"Ann Intensive Care"},{"key":"ref44","article-title":"Guyton and Hall Textbook of Medical Physiology","author":"JE Hall","year":"2010"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1152\/jappl.1989.66.4.1785","article-title":"Rate of erythropoietin formation in humans in response to acute hypobaric hypoxia","volume":"66","author":"KU Eckardt","year":"1989","journal-title":"J Appl Physiol (1985)"},{"issue":"Pt 6","key":"ref46","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1113\/jphysiol.2010.195057","article-title":"Regulation of erythropoietin production","volume":"589","author":"W Jelkmann","year":"2011","journal-title":"J Physiol"},{"issue":"10","key":"ref47","doi-asserted-by":"crossref","first-page":"4142","DOI":"10.1182\/blood-2005-08-3364","article-title":"Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease","volume":"107","author":"I Theurl","year":"2006","journal-title":"Blood"},{"issue":"12","key":"ref48","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.3324\/haematol.2011.048926","article-title":"Pathways for the regulation of hepcidin expression in anemia of chronic disease and iron deficiency anemia in vivo","volume":"96","author":"I Theurl","year":"2011","journal-title":"Haematologica"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"L417","DOI":"10.1152\/ajplung.00484.2005","article-title":"Hepcidin expression and iron transport in alveolar macrophages","volume":"291","author":"NB Nguyen","year":"2006","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3324\/haematol.2010.033449","article-title":"A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis","volume":"96","author":"D Girelli","year":"2011","journal-title":"Haematologica"},{"issue":"10","key":"ref51","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1182\/blood-2014-01-548594","article-title":"New signaling pathways for hepcidin regulation","volume":"123","author":"P Arosio","year":"2014","journal-title":"Blood"},{"key":"ref52","article-title":"An Age-Structured Model for Erythropoiesis following a Phlebotomy","author":"M J.M.","year":"1999"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev.nutr.20.1.129","article-title":"Iron transport","volume":"20","author":"M Wessling-Resnick","year":"2000","journal-title":"Annu Rev Nutr"},{"issue":"6","key":"ref54","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1182\/blood.V49.6.957.957","article-title":"Role of transferrin in determining internal iron distribution","volume":"49","author":"P Pootrakul","year":"1977","journal-title":"Blood"},{"issue":"21","key":"ref55","first-page":"4907","article-title":"Human transferrin. Molecular weight and sedimentation properties","volume":"241","author":"R Roberts","year":"1966","journal-title":"J Biol Chem"},{"key":"ref56","unstructured":"Pubchem. Iron(II) Sulfate 2017. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/24393\" xlink:type=\"simple\">https:\/\/pubchem.ncbi.nlm.nih.gov\/compound\/24393<\/ext-link>."},{"key":"ref57","first-page":"1675","article-title":"Physical and chemical studies on ceruloplasmin. I. The relation between blue color and the valence states of copper","volume":"238","author":"WE Blumberg","year":"1963","journal-title":"J Biol Chem"},{"issue":"40","key":"ref58","doi-asserted-by":"crossref","first-page":"37597","DOI":"10.1074\/jbc.M205305200","article-title":"The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis","volume":"277","author":"HN Hunter","year":"2002","journal-title":"J Biol Chem"},{"key":"ref59","first-page":"1549","article-title":"The structure of human hemoglobin. I. The separation of the alpha and beta chains and their amino acid composition","volume":"237","author":"RJ Hill","year":"1962","journal-title":"J Biol Chem"},{"issue":"3","key":"ref60","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1042\/BJ20101825","article-title":"Regulation of cellular iron metabolism","volume":"434","author":"J Wang","year":"2011","journal-title":"Biochem J"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1370\/afm.25","article-title":"Elevated serum transferrin saturation and mortality","volume":"2","author":"AG 3rd Mainous","year":"2004","journal-title":"Ann Fam Med"},{"issue":"3","key":"ref62","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.cmet.2007.11.016","article-title":"The transferrin receptor modulates Hfe-dependent regulation of hepcidin expression","volume":"7","author":"PJ Schmidt","year":"2008","journal-title":"Cell Metab"},{"key":"ref63","first-page":"131","article-title":"Structure and function of the transferrin receptor","volume":"13","author":"PA Seligman","year":"1983","journal-title":"Prog Hematol"},{"issue":"16","key":"ref64","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.4155\/bio.11.180","article-title":"Analysis of total and transferrin-bound iron in human serum for pharmacokinetic studies of iron-sucrose formulations","volume":"3","author":"MM Goggin","year":"2011","journal-title":"Bioanalysis"},{"issue":"4","key":"ref65","doi-asserted-by":"crossref","first-page":"2572","DOI":"10.1073\/pnas.78.4.2572","article-title":"Uptake and release of iron from human transferrin","volume":"78","author":"H Huebers","year":"1981","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref66","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1073\/pnas.80.1.300","article-title":"Competitive advantage of diferric transferrin in delivering iron to reticulocytes","volume":"80","author":"HA Huebers","year":"1983","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"Pt 1","key":"ref67","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1042\/bj2900109","article-title":"The hepatic acute-phase proteins alpha 1-antitrypsin and alpha 2-macroglobulin inhibit binding of transferrin to its receptor","volume":"290","author":"I Graziadei","year":"1993","journal-title":"Biochem J"},{"key":"ref68","article-title":"Differential evolution: a practical approach to global optimization","volume":"xix","author":"KV Price","year":"2005"},{"key":"ref69","author":"WE Schiesser","year":"1997"},{"key":"ref70","first-page":"55","article-title":"ODEPACK, a systematized collection of ode solvers","author":"AC Hindmarsh","year":"1983","journal-title":"Scientific Computing"},{"issue":"6","key":"ref71","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1182\/blood-2005-04-1766","article-title":"Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs","volume":"106","author":"S Rivera","year":"2005","journal-title":"Blood"},{"issue":"4","key":"ref72","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.2215\/CJN.05671207","article-title":"Pharmacokinetic and pharmacodynamic profiles of extended dosing of epoetin alfa in anemic patients who have chronic kidney disease and are not on dialysis","volume":"3","author":"T McGowan","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"issue":"4","key":"ref73","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2215\/CJN.05681207","article-title":"A randomized study of extended dosing regimens for initiation of epoetin alfa treatment for anemia of chronic kidney disease","volume":"3","author":"B Spinowitz","year":"2008","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"ref74","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1185\/03007990903512461","article-title":"Iron supplementation in the non-dialysis chronic kidney disease (ND-CKD) patient: oral or intravenous?","volume":"26","author":"IC Macdougall","year":"2010","journal-title":"Curr Med Res Opin"},{"issue":"11","key":"ref75","doi-asserted-by":"crossref","first-page":"e504","DOI":"10.1016\/S2352-3026(16)30152-1","article-title":"Definition of functional iron deficiency and intravenous iron supplementation","volume":"3","author":"MF Eisenga","year":"2016","journal-title":"Lancet Haematol"},{"issue":"5","key":"ref76","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1053\/j.ajkd.2008.05.033","article-title":"Intravenous versus oral iron supplementation for the treatment of anemia in CKD: systematic review and meta-analysis","volume":"52","author":"B Rozen-Zvi","year":"2008","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"ref77","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1053\/j.ajkd.2016.04.018","article-title":"Intravenous Versus Oral Iron Supplementation for the Treatment of Anemia in CKD: An Updated Systematic Review and Meta-analysis","volume":"68","author":"D Shepshelovich","year":"2016","journal-title":"Am J Kidney Dis"},{"issue":"4","key":"ref78","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1007\/s00467-006-0405-y","article-title":"Iron therapy for renal anemia: how much needed, how much harmful?","volume":"22","author":"WH Horl","year":"2007","journal-title":"Pediatr Nephrol"},{"issue":"4","key":"ref79","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.jtbi.2006.06.033","article-title":"A compartmental model of iron regulation in the mouse","volume":"243","author":"BJ Lao","year":"2006","journal-title":"J Theor Biol"},{"issue":"10","key":"ref80","doi-asserted-by":"crossref","first-page":"e1002750","DOI":"10.1371\/journal.pcbi.1002750","article-title":"Integrating Cellular Metabolism into a Multiscale Whole-Body Model","volume":"8","author":"M Krauss","year":"2012","journal-title":"PLoS Comput Biol"},{"key":"ref81","article-title":"The role of erythroferrone in iron metabolism: From experimental results to pathogenesis","author":"N Vallet","year":"2017","journal-title":"Rev Med Interne"},{"issue":"4","key":"ref82","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S0272-6386(82)80059-0","article-title":"Gastrointestinal blood loss in patients with chronic renal failure","volume":"1","author":"SG Rosenblatt","year":"1982","journal-title":"Am J Kidney Dis"},{"issue":"3","key":"ref83","first-page":"209","article-title":"Comparison of life span of erythrocytes in some inbred strains of mouse using 14C-labelled glycine","volume":"27","author":"J Horky","year":"1978","journal-title":"Physiol Bohemoslov"},{"issue":"1","key":"ref84","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4103\/0971-4065.179301","article-title":"Study of anemia in nondialysis dependent chronic kidney disease with special reference to serum hepcidin","volume":"27","author":"H Goyal","year":"2017","journal-title":"Indian J Nephrol"},{"issue":"3","key":"ref85","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/1744-9987.12102","article-title":"Serum hepcidin levels are associated with serum triglycerides and interleukin-6 concentrations in patients with end-stage renal disease","volume":"18","author":"E Samouilidou","year":"2014","journal-title":"Ther Apher Dial"},{"issue":"4","key":"ref86","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1182\/blood-2004-08-3375","article-title":"Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia","volume":"105","author":"S Rivera","year":"2005","journal-title":"Blood"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1172\/JCI104310","article-title":"The quantitative determination of iron kinetics and hemoglobin synthesis in human subjects","volume":"40","author":"M Pollycove","year":"1961","journal-title":"J Clin Invest"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1006060","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006060","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T02:05:49Z","timestamp":1720231549000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006060"}},"subtitle":[],"editor":[{"given":"Daniel A.","family":"Beard","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,4,16]]},"references-count":87,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1006060","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1006060","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,16]]}}}