{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:05:02Z","timestamp":1772172302309,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1006075","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000}}],"reference-count":85,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T00:00:00Z","timestamp":1523232000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB740"],"award-info":[{"award-number":["SFB740"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Federal Ministry of Science, Research and Economy of Austria","award":["SPA 05\/172"],"award-info":[{"award-number":["SPA 05\/172"]}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1006075","type":"journal-article","created":{"date-parts":[[2018,4,9]],"date-time":"2018-04-09T13:25:49Z","timestamp":1523280349000},"page":"e1006075","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Spatial modeling of the membrane-cytosolic interface in protein kinase signal transduction"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0872-0929","authenticated-orcid":true,"given":"Wolfgang","family":"Giese","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3495-0787","authenticated-orcid":true,"given":"Gregor","family":"Milicic","sequence":"additional","affiliation":[]},{"given":"Andreas","family":"Schr\u00f6der","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0567-7075","authenticated-orcid":true,"given":"Edda","family":"Klipp","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2018,4,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1146\/annurev.biochem.75.103004.142710","article-title":"Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits","volume":"75","author":"RP Bhattacharyya","year":"2006","journal-title":"Annu Rev Biochem"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0968-0004(00)89042-8","article-title":"The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions","volume":"20","author":"S McLaughlin","year":"1995","journal-title":"Trends in biochemical sciences"},{"issue":"5716","key":"ref3","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1126\/science.1105654","article-title":"An acylation cycle regulates localization and activity of palmitoylated Ras isoforms","volume":"307","author":"O Rocks","year":"2005","journal-title":"Science"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nchembio818","article-title":"Therapeutic intervention based on protein prenylation and associated modifications","volume":"2","author":"MH Gelb","year":"2006","journal-title":"Nature chemical biology"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"494","DOI":"10.2183\/pjab.86.494","article-title":"N-myristoylated proteins, key components in intracellular signal transduction systems enabling rapid and flexible cell responses","volume":"86","author":"N Hayashi","year":"2010","journal-title":"Proceedings of the Japan Academy, Series B"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrm.2015.11","article-title":"Protein prenylation: unique fats make their mark on biology","volume":"17","author":"M Wang","year":"2016","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.sbi.2016.06.012","article-title":"Modular engineering of cellular signaling proteins and networks","volume":"39","author":"RM Gordley","year":"2016","journal-title":"Current opinion in structural biology"},{"key":"ref8","unstructured":"Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P. Molecular Biology of the Cell, 5th edn, Garland Science, New York. ISBN. 2007;1174808063:1392."},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S1097-2765(02)00528-2","article-title":"Mathematical models of protein kinase signal transduction","volume":"9","author":"R Heinrich","year":"2002","journal-title":"Molecular cell"},{"issue":"10","key":"ref10","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/yea.1122","article-title":"Modelling the dynamics of the yeast pheromone pathway","volume":"21","author":"B Kofahl","year":"2004","journal-title":"Yeast"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1186\/1471-2202-7-S1-S10","article-title":"Mathematical modeling of intracellular signaling pathways","volume":"7","author":"E Klipp","year":"2006","journal-title":"BMC neuroscience"},{"issue":"121","key":"ref12","doi-asserted-by":"crossref","first-page":"20160409","DOI":"10.1098\/rsif.2016.0409","article-title":"Linear models of activation cascades: analytical solutions and coarse-graining of delayed signal transduction","volume":"13","author":"M Beguerisse-D\u00edaz","year":"2016","journal-title":"Journal of The Royal Society Interface"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/nrm2901","article-title":"Signalling ballet in space and time","volume":"11","author":"B Kholodenko","year":"2010","journal-title":"Nature reviews Molecular cell biology"},{"issue":"11","key":"ref14","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/ncb1652","article-title":"Spatial regulation of Fus3 MAP kinase activity through a reaction-diffusion mechanism in yeast pheromone signalling","volume":"9","author":"CI Maeder","year":"2007","journal-title":"Nat Cell Biol"},{"issue":"19","key":"ref15","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1101\/gad.286922.116","article-title":"Spatial focalization of pheromone\/MAPK signaling triggers commitment to cell\u2013cell fusion","volume":"30","author":"O Dudin","year":"2016","journal-title":"Genes & development"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.cell.2008.04.025","article-title":"Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks","volume":"133","author":"SR Neves","year":"2008","journal-title":"Cell"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"e1004735","DOI":"10.1371\/journal.pcbi.1004735","article-title":"Control of <italic>\u03b2<\/italic>AR-and N-methyl-D-aspartate (NMDA) receptor-dependent cAMP dynamics in hippocampal neurons","volume":"12","author":"A Chay","year":"2016","journal-title":"PLoS Comput Biol"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"e1003396","DOI":"10.1371\/journal.pcbi.1003396","article-title":"GDI-mediated cell polarization in yeast provides precise spatial and temporal control of Cdc42 signaling","volume":"9","author":"B Kl\u00fcnder","year":"2013","journal-title":"PLoS Comput Biol"},{"key":"ref19","first-page":"drs022","article-title":"Finite element analysis for a coupled bulk\u2013surface partial differential equation","author":"CM Elliott","year":"2012","journal-title":"IMA Journal of Numerical Analysis"},{"key":"ref20","first-page":"drw080","article-title":"A posteriori error control for stationary coupled bulk-surface equations","author":"M Eigel","year":"2017","journal-title":"IMA Journal of Numerical Analysis"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"061912","DOI":"10.1103\/PhysRevE.72.061912","article-title":"Membrane-bound Turing patterns","volume":"72","author":"H Levine","year":"2005","journal-title":"Physical Review E"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s00285-011-0495-4","article-title":"Turing instabilities in a mathematical model for signaling networks","volume":"65","author":"A R\u00e4tz","year":"2012","journal-title":"Journal of mathematical biology"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"066014","DOI":"10.1088\/1478-3975\/12\/6\/066014","article-title":"Influence of cell shape, inhomogeneities and diffusion barriers in cell polarization models","volume":"12","author":"W Giese","year":"2015","journal-title":"Physical biology"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1073\/pnas.1515191113","article-title":"Geometry-induced protein pattern formation","volume":"113","author":"D Thalmeier","year":"2016","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"8","key":"ref25","doi-asserted-by":"crossref","first-page":"L59","DOI":"10.1016\/j.bpj.2010.07.045","article-title":"How long does it take to establish a morphogen gradient?","volume":"99","author":"AM Berezhkovskii","year":"2010","journal-title":"Biophysical journal"},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nbt1114","article-title":"Integrative model of the response of yeast to osmotic shock","volume":"23","author":"E Klipp","year":"2005","journal-title":"Nature biotechnology"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.cell.2009.04.047","article-title":"A systems-level analysis of perfect adaptation in yeast osmoregulation","volume":"138","author":"D Muzzey","year":"2009","journal-title":"Cell"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1478-811X-8-32","article-title":"Phosphorylation meets nuclear import: a review","volume":"8","author":"JD Nardozzi","year":"2010","journal-title":"Cell Communication and Signaling"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.cell.2007.02.043","article-title":"Endocytosis optimizes the dynamic localization of membrane proteins that regulate cortical polarity","volume":"129","author":"E Marco","year":"2007","journal-title":"Cell"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"e3103","DOI":"10.1371\/journal.pone.0003103","article-title":"Modeling robustness tradeoffs in yeast cell polarization induced by spatial gradients","volume":"3","author":"CS Chou","year":"2008","journal-title":"PloS one"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.devcel.2013.06.015","article-title":"Daughter cell identity emerges from the interplay of Cdc42, septins, and exocytosis","volume":"26","author":"S Okada","year":"2013","journal-title":"Developmental cell"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0014-5793(99)01058-3","article-title":"Spatial gradients of cellular phospho-proteins","volume":"457","author":"GC Brown","year":"1999","journal-title":"FEBS letters"},{"issue":"17","key":"ref33","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.cub.2006.07.056","article-title":"Potential for control of signaling pathways via cell size and shape","volume":"16","author":"J Meyers","year":"2006","journal-title":"Current biology"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1128\/JB.181.1.197-203.1999","article-title":"Protein Mobility in the Cytoplasm ofEscherichia coli","volume":"181","author":"MB Elowitz","year":"1999","journal-title":"Journal of bacteriology"},{"issue":"5828","key":"ref35","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1126\/science.1141967","article-title":"Probing transcription factor dynamics at the single-molecule level in a living cell","volume":"316","author":"J Elf","year":"2007","journal-title":"Science"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1073\/pnas.0906885107","article-title":"Spatio-temporal correlations can drastically change the response of a MAPK pathway","volume":"107","author":"K Takahashi","year":"2010","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref37","article-title":"Handbook of mathematical functions: with formulas, graphs, and mathematical tables","volume":"vol. 55","author":"M Abramowitz","year":"1964"},{"issue":"1","key":"ref38","first-page":"28","article-title":"Four-dimensional dynamics of MAPK information-processing systems","volume":"1","author":"BN Kholodenko","year":"2009","journal-title":"Wiley Interdisciplinary Reviews: Systems Biology and Medicine"},{"issue":"21","key":"ref39","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.cub.2008.09.027","article-title":"Oscillatory phosphorylation of yeast Fus3 MAP kinase controls periodic gene expression and morphogenesis","volume":"18","author":"Z Hilioti","year":"2008","journal-title":"Curr Biol"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003690","article-title":"Yeast Mating and Image-Based Quantification of Spatial Pattern Formation","volume":"10","author":"C Diener","year":"2014","journal-title":"PLoS Computational Biology"},{"issue":"1-2","key":"ref41","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00285-008-0162-6","article-title":"Signaling cascades as cellular devices for spatial computations","volume":"58","author":"J Stelling","year":"2009","journal-title":"Journal of mathematical biology"},{"issue":"3","key":"ref42","doi-asserted-by":"crossref","first-page":"e1000330","DOI":"10.1371\/journal.pcbi.1000330","article-title":"Positional information generated by spatially distributed signaling cascades","volume":"5","author":"J Mu\u00f1oz-Garc\u00eda","year":"2009","journal-title":"PLoS Comput Biol"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/cyto.990060202","article-title":"A comparison of different focus functions for use in autofocus algorithms","volume":"6","author":"FC Groen","year":"1985","journal-title":"Cytometry Part A"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1002\/jemt.20118","article-title":"Autofocusing in computer microscopy: selecting the optimal focus algorithm","volume":"65","author":"Y Sun","year":"2004","journal-title":"Microscopy research and technique"},{"issue":"10","key":"ref45","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/0262-8856(93)90059-P","article-title":"Autofocusing for tissue microscopy","volume":"11","author":"T Yeo","year":"1993","journal-title":"Image and vision computing"},{"key":"ref46","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-61798-0","article-title":"Elliptic partial differential equations of second order","author":"D Gilbarg","year":"2001"},{"issue":"15","key":"ref47","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.1111\/j.1742-4658.2009.07117.x","article-title":"Toggle switches, pulses and oscillations are intrinsic properties of the Src activation\/deactivation cycle","volume":"276","author":"NP Kaimachnikov","year":"2009","journal-title":"The FEBS journal"},{"issue":"5","key":"ref48","doi-asserted-by":"crossref","first-page":"051906","DOI":"10.1103\/PhysRevE.83.051906","article-title":"Formation of morphogen gradients: Local accumulation time","volume":"83","author":"AM Berezhkovskii","year":"2011","journal-title":"Physical Review E"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"054102","DOI":"10.1103\/PhysRevE.88.054102","article-title":"Simplified approach for calculating moments of action for linear reaction-diffusion equations","volume":"88","author":"AJ Ellery","year":"2013","journal-title":"Physical Review E"},{"issue":"03","key":"ref50","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1017\/S1446181113000059","article-title":"Critical timescales and time intervals for coupled linear processes","volume":"54","author":"MJ Simpson","year":"2013","journal-title":"The ANZIAM Journal"},{"issue":"12","key":"ref51","doi-asserted-by":"crossref","first-page":"e3865","DOI":"10.1371\/journal.pone.0003865","article-title":"Robust spatial sensing of mating pheromone gradients by yeast cells","volume":"3","author":"TI Moore","year":"2008","journal-title":"PloS one"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0022-5193(03)00289-3","article-title":"Control of spatially heterogeneous and time-varying cellular reaction networks: a new summation law","volume":"225","author":"MA Peletier","year":"2003","journal-title":"Journal of Theoretical biology"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"130008","DOI":"10.1098\/rsob.130008","article-title":"Mate and fuse: how yeast cells do it","volume":"3","author":"L Merlini","year":"2013","journal-title":"Open biology"},{"issue":"4","key":"ref54","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1137\/120880173","article-title":"Geometrical structure of Laplacian eigenfunctions","volume":"55","author":"DS Grebenkov","year":"2013","journal-title":"SIAM Review"},{"issue":"50","key":"ref55","doi-asserted-by":"crossref","first-page":"20265","DOI":"10.1073\/pnas.1004042108","article-title":"Scaffold number in yeast signaling system sets tradeoff between system output and dynamic range","volume":"108","author":"TM Thomson","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"37","key":"ref56","doi-asserted-by":"crossref","first-page":"E3860","DOI":"10.1073\/pnas.1322761111","article-title":"Utilization of extracellular information before ligand-receptor binding reaches equilibrium expands and shifts the input dynamic range","volume":"111","author":"AC Ventura","year":"2014","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"9","key":"ref57","doi-asserted-by":"crossref","first-page":"e0184706","DOI":"10.1371\/journal.pone.0184706","article-title":"A microtubule-based minimal model for spontaneous and persistent spherical cell polarity","volume":"12","author":"P Foteinopoulos","year":"2017","journal-title":"PloS one"},{"issue":"63","key":"ref58","doi-asserted-by":"crossref","first-page":"ra13","DOI":"10.1126\/scisignal.2000056","article-title":"Dynamic signaling in the Hog1 MAPK pathway relies on high basal signal transduction","volume":"2","author":"J Macia","year":"2009","journal-title":"Sci Signal"},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/msb.2011.27","article-title":"Strong negative feedback from Erk to Raf confers robustness to MAPK signalling","volume":"7","author":"R Fritsche-Guenther","year":"2011","journal-title":"Molecular systems biology"},{"issue":"1","key":"ref60","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/msb.2012.53","article-title":"Modelling reveals novel roles of two parallel signalling pathways and homeostatic feedbacks in yeast","volume":"8","author":"J Schaber","year":"2012","journal-title":"Molecular systems biology"},{"issue":"12","key":"ref61","doi-asserted-by":"crossref","first-page":"e1005298","DOI":"10.1371\/journal.pcbi.1005298","article-title":"Feedback, mass conservation and reaction kinetics impact the robustness of cellular oscillations","volume":"12","author":"K Baum","year":"2016","journal-title":"PLoS computational biology"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/0065-2571(65)90067-1","article-title":"Oscillatory behavior in enzymatic control processes","volume":"3","author":"BC Goodwin","year":"1965","journal-title":"Advances in Enzyme Regulation"},{"issue":"8","key":"ref63","doi-asserted-by":"crossref","first-page":"e104761","DOI":"10.1371\/journal.pone.0104761","article-title":"Positive feedback promotes oscillations in negative feedback loops","volume":"9","author":"B Ananthasubramaniam","year":"2014","journal-title":"PLoS One"},{"key":"ref64","first-page":"230","article-title":"Computational cell biology: An Introductory Text on Computer Modeling in Molecular and Cell Biology","author":"JJ Tyson","year":"2002"},{"issue":"1","key":"ref65","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/msb.2008.29","article-title":"Recurrent design patterns in the feedback regulation of the mammalian signalling network","volume":"4","author":"S Legewie","year":"2008","journal-title":"Molecular systems biology"},{"issue":"6","key":"ref66","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1007\/s11538-007-9200-6","article-title":"Mathematical model for spatial segregation of the Rho-family GTPases based on inhibitory crosstalk","volume":"69","author":"A Jilkine","year":"2007","journal-title":"Bulletin of mathematical biology"},{"issue":"5365","key":"ref67","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1126\/science.280.5365.895","article-title":"The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes","volume":"280","author":"JE Ferrell","year":"1998","journal-title":"Science"},{"key":"ref68","first-page":"201610081","article-title":"Single-cell dynamics and variability of MAPK activity in a yeast differentiation pathway","author":"P Conlon","year":"2016","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"ref69","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12590","article-title":"Sensory input attenuation allows predictive sexual response in yeast","volume":"7","author":"A Banderas","year":"2016","journal-title":"Nature Communications"},{"issue":"3","key":"ref70","doi-asserted-by":"crossref","first-page":"a001255","DOI":"10.1101\/cshperspect.a001255","article-title":"Morphogen gradient formation","volume":"1","author":"O Wartlick","year":"2009","journal-title":"Cold Spring Harbor perspectives in biology"},{"issue":"6","key":"ref71","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1046\/j.1432-1327.2000.01197.x","article-title":"Negative feedback and ultrasensitivity can bring about oscillations in the mitogen-activated protein kinase cascades","volume":"267","author":"BN Kholodenko","year":"2000","journal-title":"European Journal of Biochemistry"},{"issue":"15","key":"ref72","doi-asserted-by":"crossref","first-page":"6157","DOI":"10.1073\/pnas.1019245108","article-title":"Local kinetics of morphogen gradients","volume":"108","author":"PV Gordon","year":"2011","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"6","key":"ref73","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.celrep.2012.04.005","article-title":"Highly canalized MinD transfer and MinE sequestration explain the origin of robust MinCDE-protein dynamics","volume":"1","author":"J Halatek","year":"2012","journal-title":"Cell Reports"},{"issue":"6","key":"ref74","doi-asserted-by":"crossref","first-page":"873","DOI":"10.15252\/msb.20156724","article-title":"Multistability and dynamic transitions of intracellular Min protein patterns","volume":"12","author":"F Wu","year":"2016","journal-title":"Molecular systems biology"},{"issue":"39","key":"ref75","doi-asserted-by":"crossref","first-page":"9311","DOI":"10.1039\/c3sm50650a","article-title":"Domain formation on curved membranes: phase separation or Turing patterns?","volume":"9","author":"E Orlandini","year":"2013","journal-title":"Soft Matter"},{"issue":"7","key":"ref76","doi-asserted-by":"crossref","first-page":"e1004988","DOI":"10.1371\/journal.pcbi.1004988","article-title":"Modelling of Yeast Mating Reveals Robustness Strategies for Cell-Cell Interactions","volume":"12","author":"W Chen","year":"2016","journal-title":"PLoS computational biology"},{"key":"ref77","unstructured":"Giese W. The choreography of yeast mating. Humboldt-Universit\u00e4t zu Berlin, Lebenswissenschaftliche Fakult\u00e4t; 2016."},{"issue":"4","key":"ref78","doi-asserted-by":"crossref","first-page":"045006","DOI":"10.1088\/1478-3975\/9\/4\/045006","article-title":"Weakly nonlinear analysis of symmetry breaking in cell polarity models","volume":"9","author":"B Rubinstein","year":"2012","journal-title":"Physical biology"},{"issue":"1629","key":"ref79","doi-asserted-by":"crossref","first-page":"20130003","DOI":"10.1098\/rstb.2013.0003","article-title":"From simple to detailed models for cell polarization","volume":"368","author":"L Edelstein-Keshet","year":"2013","journal-title":"Philosophical Transactions of the Royal Society of London B: Biological Sciences"},{"issue":"8","key":"ref80","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1088\/0951-7715\/27\/8\/1805","article-title":"Symmetry breaking in a bulk\u2013surface reaction\u2013diffusion model for signalling networks","volume":"27","author":"A R\u00e4tz","year":"2014","journal-title":"Nonlinearity"},{"issue":"06","key":"ref81","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1142\/S0218202516500275","article-title":"A coupled surface-Cahn\u2013Hilliard bulk-diffusion system modeling lipid raft formation in cell membranes","volume":"26","author":"H Garcke","year":"2016","journal-title":"Mathematical Models and Methods in Applied Sciences"},{"issue":"4","key":"ref82","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.3934\/dcds.2016.36.2133","article-title":"Stability analysis of reaction-diffusion models on evolving domains: the effects of cross-diffusion","volume":"36","author":"A Madzvamuse","year":"2016","journal-title":"Discrete and Continuous Dynamical Systems-Series A"},{"issue":"100","key":"ref83","article-title":"The FEniCS Project Version 1.5","volume":"3","author":"MS Aln\u00e6s","year":"2015","journal-title":"Archive of Numerical Software"},{"key":"ref84","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-23099-8","article-title":"Automated Solution of Differential Equations by the Finite Element Method","author":"A Logg","year":"2012"},{"key":"ref85","article-title":"CGAL User and Reference Manual","year":"2017"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1006075","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T06:48:55Z","timestamp":1604126935000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006075"}},"subtitle":[],"editor":[{"given":"Jens","family":"Nielsen","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2018,4,9]]},"references-count":85,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1006075","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/191940","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,9]]}}}