{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T08:58:05Z","timestamp":1778057885712,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1006130","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000}}],"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T00:00:00Z","timestamp":1525046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1006130","type":"journal-article","created":{"date-parts":[[2018,4,30]],"date-time":"2018-04-30T17:34:18Z","timestamp":1525109658000},"page":"e1006130","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Quantitative analysis reveals crosstalk mechanisms of heat shock-induced attenuation of NF-\u03baB signaling at the single cell level"],"prefix":"10.1371","volume":"14","author":[{"given":"Ma\u0142gorzata","family":"Kardy\u0144ska","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Paszek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6120-4424","authenticated-orcid":true,"given":"Jaros\u0142aw","family":"\u015amieja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Spiller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wies\u0142awa","family":"Wid\u0142ak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R. H.","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0363-0716","authenticated-orcid":true,"given":"Pawel","family":"Paszek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marek","family":"Kimmel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,4,30]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"214074","DOI":"10.1155\/2010\/214074","article-title":"Cellular stress responses: cell survival and cell death","volume":"2010","author":"S Fulda","year":"2010","journal-title":"Int J Cell Biol"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1189\/jlb.0313153","article-title":"Cellular stress response and innate immune signaling: integrating pathways in host defense and inflammation","volume":"94","author":"S Muralidharan","year":"2013","journal-title":"Journal of leukocyte biology"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cell.2008.01.020","article-title":"Shared principles in NF-kappaB signaling","volume":"132","author":"MS Hayden","year":"2008","journal-title":"Cell"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1146\/annurev.immunol.021908.132641","article-title":"Regulation and function of NF-kappaB transcription factors in the immune system","volume":"27","author":"S Vallabhapurapu","year":"2009","journal-title":"Annu Rev Immunol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.tcb.2003.12.004","article-title":"NF-\u03baB: tumor promoter or suppressor?","volume":"14","author":"ND Perkins","year":"2004","journal-title":"Trends Cell Biol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1210\/rp.58.1.95","article-title":"Identification of a nuclear factor kappa B-dependent gene network","volume":"58","author":"B Tian","year":"2003","journal-title":"Recent Prog Horm Res"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm2083","article-title":"Integrating cell-signalling pathways with NF-kappaB and IKK function","volume":"8","author":"ND Perkins","year":"2007","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.tibs.2003.12.003","article-title":"IkappaB kinases: key regulators of the NF-kappaB pathway","volume":"29","author":"Y Yamamoto","year":"2004","journal-title":"Trends Biochem Sci"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/0092-8674(86)90346-6","article-title":"Multiple nuclear factors interact with the immunoglobulin enhancer sequences","volume":"46","author":"R Sen","year":"1986","journal-title":"Cell"},{"issue":"5488","key":"ref10","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1126\/science.289.5488.2350","article-title":"Failure to regulate TNF-induced NF-kappa B and cell death responses in A20-deficient mice","volume":"289","author":"EG Lee","year":"2000","journal-title":"Science"},{"issue":"5296","key":"ref11","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1126\/science.1099962","article-title":"Oscillations in NF-kappa B signaling control the dynamics of gene expression","volume":"306","author":"DE Nelson","year":"2004","journal-title":"Science"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.cell.2015.01.013","article-title":"Noise Facilitates Transcriptional Control under Dynamic Inputs","volume":"160","author":"RA Kellogg","year":"2015","journal-title":"Cell"},{"issue":"6163","key":"ref13","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1126\/science.1239999","article-title":"Functional roles of pulsing in genetic circuits","volume":"342","author":"JH Levine","year":"2013","journal-title":"Science"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.cels.2016.04.016","article-title":"Distinct NF-kappaB and MAPK Activation Thresholds Uncouple Steady-State Microbe Sensing from Anti-pathogen Inflammatory Responses","volume":"2","author":"RA Gottschalk","year":"2016","journal-title":"Cell Syst"},{"key":"ref15","first-page":"5","article-title":"Dynamic NF-kappaB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation","author":"JM Ankers","year":"2016","journal-title":"Elife"},{"issue":"7303","key":"ref16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/nature09145","article-title":"Single-cell NF-kappaB dynamics reveal digital activation and analogue information processing","volume":"466","author":"S Tay","year":"2010","journal-title":"Nature"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1186\/1471-2105-8-376","article-title":"Single TNFalpha trimers mediating NF-kappaB activation: stochastic robustness of NF-kappaB signaling","volume":"8","author":"T Lipniacki","year":"2007","journal-title":"BMC bioinformatics"},{"issue":"Pt 16","key":"ref18","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1242\/jcs.069641","article-title":"Physiological levels of TNFalpha stimulation induce stochastic dynamics of NF-kappaB responses in single living cells","volume":"123","author":"DA Turner","year":"2010","journal-title":"J Cell Sci"},{"issue":"5596","key":"ref19","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1126\/science.1071914","article-title":"The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation","volume":"298","author":"A Hoffmann","year":"2002","journal-title":"Science"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1084\/jem.177.1.231","article-title":"Heat-shock proteins protect cells from monocyte cytotoxicity: possible mechanism of self-protection","volume":"177","author":"M Jaattela","year":"1993","journal-title":"J Exp Med"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.cardiores.2005.10.009","article-title":"NFkappaB, heat shock proteins, HSF-1, and inflammation","volume":"69","author":"AA Knowlton","year":"2006","journal-title":"Cardiovasc Res"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.imlet.2007.12.017","article-title":"Innate immunity meets with cellular stress at the IKK complex: regulation of the IKK complex by HSP70 and HSP90","volume":"117","author":"A Salminen","year":"2008","journal-title":"Immunol Lett"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.4049\/jimmunol.161.5.2594","article-title":"The heat shock response inhibits RANTES gene expression in cultured human lung epithelium","volume":"161","author":"O Ayad","year":"1998","journal-title":"J Immunol"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1006\/niox.1997.0117","article-title":"Suppression of glial nitric oxide synthase induction by heat shock: effects on proteolytic degradation of IkappaB-alpha","volume":"1","author":"DL Feinstein","year":"1997","journal-title":"Nitric Oxide"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1111\/j.1365-2443.2011.01560.x","article-title":"NF-kappaB signaling pathway is inhibited by heat shock independently of active transcription factor HSF1 and increased levels of inducible heat shock proteins","volume":"16","author":"P Janus","year":"2011","journal-title":"Genes to cells: devoted to molecular & cellular mechanisms"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1172\/JCI119425","article-title":"Stress response decreases NF-kappaB nuclear translocation and increases I-kappaBalpha expression in A549 cells","volume":"99","author":"HR Wong","year":"1997","journal-title":"J Clin Invest"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1006\/bbrc.1997.6076","article-title":"The heat shock response inhibits inducible nitric oxide synthase gene expression by blocking I kappa-B degradation and NF-kappa B nuclear translocation","volume":"231","author":"HR Wong","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.yexcr.2004.05.013","article-title":"The heat-shock-induced suppression of the IkappaB\/NF-kappaB cascade is due to inactivation of upstream regulators of IkappaBalpha through insolubilization","volume":"299","author":"KH Lee","year":"2004","journal-title":"Exp Cell Res"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"384","DOI":"10.4049\/jimmunol.174.1.384","article-title":"Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein 90","volume":"174","author":"JF Pittet","year":"2005","journal-title":"J Immunol"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S1097-2765(02)00450-1","article-title":"TNF-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90","volume":"9","author":"G Chen","year":"2002","journal-title":"Mol Cell"},{"issue":"12","key":"ref31","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1101\/gad.1188204","article-title":"Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling","volume":"18","author":"R Ran","year":"2004","journal-title":"Genes Dev"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1003471","article-title":"Overexpression of Heat Shock Protein 72 Attenuates NF-kappa B Activation Using a Combination of Regulatory Mechanisms in Microglia","volume":"10","author":"PW Sheppard","year":"2014","journal-title":"PLoS computational biology"},{"issue":"37","key":"ref33","doi-asserted-by":"crossref","first-page":"35272","DOI":"10.1074\/jbc.M305095200","article-title":"Heat shock protein 27 association with the I kappa B kinase complex regulates tumor necrosis factor alpha-induced NF-kappa B activation","volume":"278","author":"KJ Park","year":"2003","journal-title":"J Biol Chem"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.yexcr.2005.03.014","article-title":"Heat shock protein 70 negatively regulates the heat-shock-induced suppression of the IkappaB\/NF-kappaB cascade by facilitating IkappaB kinase renaturation and blocking its further denaturation","volume":"307","author":"KH Lee","year":"2005","journal-title":"Exp Cell Res"},{"issue":"8","key":"ref35","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1091\/mbc.e10-10-0860","article-title":"Heat shock protein 90-mediated inactivation of nuclear factor-kappaB switches autophagy to apoptosis through becn1 transcriptional inhibition in selenite-induced NB4 cells","volume":"22","author":"Q Jiang","year":"2011","journal-title":"Mol Biol Cell"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cardiores.2005.07.004","article-title":"Small interfering RNA knocks down heat shock factor-1 (HSF-1) and exacerbates pro-inflammatory activation of NF-kappaB and AP-1 in vascular smooth muscle cells","volume":"69","author":"Y Chen","year":"2006","journal-title":"Cardiovasc Res"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1111\/j.1582-4934.2009.00716.x","article-title":"HSP70 interacts with TRAF2 and differentially regulates TNFalpha signalling in human colon cancer cells","volume":"14","author":"S Dai","year":"2010","journal-title":"J Cell Mol Med"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/sj.jcbfm.9600502","article-title":"Anti-inflammatory effects of the 70 kDa heat shock protein in experimental stroke","volume":"28","author":"Z Zheng","year":"2008","journal-title":"J Cereb Blood Flow Metab"},{"issue":"9","key":"ref39","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1097\/01.CCM.0000278915.78030.74","article-title":"Enhanced heat shock protein 70 expression alters proteasomal degradation of IkappaB kinase in experimental acute respiratory distress syndrome","volume":"35","author":"YG Weiss","year":"2007","journal-title":"Crit Care Med"},{"issue":"5","key":"ref40","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1356-9597.2004.00734.x","article-title":"Heat-shock induced nuclear retention and recycling inhibition of importin alpha","volume":"9","author":"M Furuta","year":"2004","journal-title":"Genes Cells"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"C171","DOI":"10.1152\/ajpcell.00346.2009","article-title":"Febrile-range temperature modifies cytokine gene expression in LPS-stimulated macrophages by differentially modifying NF-{kappa}B recruitment to cytokine gene promoters","volume":"298","author":"ZA Cooper","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1007\/s00438-015-1055-1","article-title":"Cross talk between cytokine and hyperthermia-induced pathways: identification of different subsets of NF-\u03baB-dependent genes regulated by TNF\u03b1 and heat shock","volume":"290","author":"P Janus","year":"2015","journal-title":"Molecular Genetics and Genomics"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"e1004326","DOI":"10.1371\/journal.pcbi.1004326","article-title":"Spatio-temporal Dynamics and Mechanisms of Stress Granule Assembly","volume":"11","author":"D Ohshima","year":"2015","journal-title":"PLoS Comput Biol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/msb.2008.30","article-title":"Understanding NF-kappaB signaling via mathematical modeling","volume":"4","author":"R Cheong","year":"2008","journal-title":"Mol Syst Biol"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.jtbi.2004.01.001","article-title":"Mathematical model of NF-kappaB regulatory module","volume":"228","author":"T Lipniacki","year":"2004","journal-title":"Journal of theoretical biology"},{"issue":"5924","key":"ref46","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1126\/science.1164860","article-title":"Pulsatile stimulation determines timing and specificity of NF-kappaB-dependent transcription","volume":"324","author":"L Ashall","year":"2009","journal-title":"Science"},{"issue":"25","key":"ref47","doi-asserted-by":"crossref","first-page":"11644","DOI":"10.1073\/pnas.0913798107","article-title":"Population robustness arising from cellular heterogeneity","volume":"107","author":"P Paszek","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1752-0509-5-23","article-title":"Interactions among oscillatory pathways in NF-kappa B signaling","volume":"5","author":"Y Wang","year":"2011","journal-title":"BMC Syst Biol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jtbi.2011.12.014","article-title":"A systematic survey of the response of a model NF-kappaB signalling pathway to TNFalpha stimulation","volume":"297","author":"Y Wang","year":"2012","journal-title":"Journal of theoretical biology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jtbi.2014.01.015","article-title":"A simple model of NF-kappaB dynamics reproduces experimental observations","volume":"347","author":"S Zambrano","year":"2014","journal-title":"J Theor Biol"},{"issue":"29","key":"ref51","doi-asserted-by":"crossref","first-page":"10840","DOI":"10.1073\/pnas.0604085103","article-title":"Minimal model of spiky oscillations in NF-kappaB signaling","volume":"103","author":"S Krishna","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1007\/s00285-014-0775-x","article-title":"A method of &apos;speed coefficients&apos; for biochemical model reduction applied to the NF-kappaB system","volume":"70","author":"S West","year":"2015","journal-title":"J Math Biol"},{"key":"ref53","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12057","article-title":"Signal transduction controls heterogeneous NF-[kappa]B dynamics and target gene expression through cytokine-specific refractory states","volume":"7","author":"A Adamson","year":"2016","journal-title":"Nat Commun"},{"issue":"3","key":"ref54","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1529\/biophysj.104.056754","article-title":"Stochastic regulation in early immune response","volume":"90","author":"T Lipniacki","year":"2006","journal-title":"Biophysical journal"},{"issue":"3","key":"ref55","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1529\/biophysj.104.055301","article-title":"Mathematical modeling of the eukaryotic heat-shock response: dynamics of the hsp70 promoter","volume":"88","author":"TR Rieger","year":"2005","journal-title":"Biophys J"},{"issue":"88","key":"ref56","doi-asserted-by":"crossref","first-page":"20130527","DOI":"10.1098\/rsif.2013.0527","article-title":"Modelling the efficacy of hyperthermia treatment","volume":"10","author":"M Rybinski","year":"2013","journal-title":"J R Soc Interface"},{"issue":"3","key":"ref57","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.jtbi.2009.03.021","article-title":"Mathematical modeling of heat shock protein synthesis in response to temperature change","volume":"259","author":"Z Szymanska","year":"2009","journal-title":"J Theor Biol"},{"key":"ref58","article-title":"Local hyperthermia in head and neck cancer: mechanism, application and advance","author":"S Gao","year":"2016","journal-title":"Oncotarget"},{"issue":"13","key":"ref59","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1016\/j.febslet.2006.04.066","article-title":"Hsp70 inhibits lipopolysaccharide-induced NF-kappaB activation by interacting with TRAF6 and inhibiting its ubiquitination","volume":"580","author":"H Chen","year":"2006","journal-title":"FEBS Lett"},{"issue":"6","key":"ref60","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.molcel.2014.01.026","article-title":"Fold change of nuclear NF-kappaB determines TNF-induced transcription in single cells","volume":"53","author":"RE Lee","year":"2014","journal-title":"Mol Cell"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrc3204","article-title":"The diverse and complex roles of NF-kappaB subunits in cancer","volume":"12","author":"ND Perkins","year":"2012","journal-title":"Nature reviews Cancer"},{"issue":"11","key":"ref62","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1098\/rsif.2006.0137","article-title":"Automated tracking of gene expression in individual cells and cell compartments","volume":"3","author":"H Shen","year":"2006","journal-title":"J R Soc Interface"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1006130","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,5,10]],"date-time":"2018-05-10T00:00:00Z","timestamp":1525910400000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T11:41:52Z","timestamp":1720266112000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006130"}},"subtitle":[],"editor":[{"given":"Jeffrey J.","family":"Saucerman","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,4,30]]},"references-count":62,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1006130","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1006130","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,30]]}}}