{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T15:56:03Z","timestamp":1781452563768,"version":"3.54.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1006273","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000}}],"reference-count":81,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T00:00:00Z","timestamp":1552003200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["PhysCancer"],"award-info":[{"award-number":["PhysCancer"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ITMO"},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["NOTOX"],"award-info":[{"award-number":["NOTOX"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["LiSym"],"award-info":[{"award-number":["LiSym"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013501","name":"INCA","doi-asserted-by":"crossref","award":["2012-1-PL BIO-09-IO"],"award-info":[{"award-number":["2012-1-PL BIO-09-IO"]}],"id":[{"id":"10.13039\/100013501","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["BLANC SVSE5 Invaders"],"award-info":[{"award-number":["BLANC SVSE5 Invaders"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["iLite"],"award-info":[{"award-number":["iLite"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["Virtual Liver Network"],"award-info":[{"award-number":["Virtual Liver Network"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["LEBERSIMULATOR"],"award-info":[{"award-number":["LEBERSIMULATOR"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1006273","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T18:34:45Z","timestamp":1552070085000},"page":"e1006273","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":66,"title":["Quantitative cell-based model predicts mechanical stress response of growing tumor spheroids over various growth conditions and cell lines"],"prefix":"10.1371","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9314-6281","authenticated-orcid":true,"given":"Paul","family":"Van Liedekerke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Neitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Johann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Alessandri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4615-9431","authenticated-orcid":true,"given":"Pierre","family":"Nassoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9995-5987","authenticated-orcid":true,"given":"Dirk","family":"Drasdo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,3,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2006.06.044","article-title":"Matrix Elasticity Directs Stem Cell Lineage Specification","volume":"126","author":"AJ Engler","year":"2006","journal-title":"Cell"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrc2544","article-title":"A tense situation: forcing tumour progression","volume":"9","author":"DT Butcher","year":"2009","journal-title":"Nature reviews Cancer"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2976\/1.3086732","article-title":"Homeostatic competition drives tumor growth and metastasis nucleation","volume":"3","author":"M Basan","year":"2009","journal-title":"HFSP Journal"},{"issue":"4849","key":"ref4","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1126\/science.2451290","article-title":"Cell and environment interactions in tumor microregions: the multicell spheroid model","volume":"240","author":"RM Sutherland","year":"1988","journal-title":"Science (New York, NY)"},{"issue":"7","key":"ref5","first-page":"3504","article-title":"Regulation of growth saturation and development of necrosis in EMT6\/Ro multicellular spheroids by the glucose and oxygen supply","volume":"46","author":"JP Freyer","year":"1986","journal-title":"Cancer research"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1088\/1478-3975\/2\/3\/001","article-title":"A single-cell-based model of tumor growth in vitro: monolayers and spheroids","volume":"2","author":"D Drasdo","year":"2005","journal-title":"Physical Biology"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"51910","DOI":"10.1103\/PhysRevE.71.051910","article-title":"Multicellular tumor spheroid in an off-lattice Voronoi-Delaunay cell model","volume":"71","author":"G Schaller","year":"2005","journal-title":"Phys Rev E"},{"issue":"8","key":"ref8","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nbt0897-778","article-title":"Solid stress inhibits the growth of multicellular tumor spheroids","volume":"15","author":"G Helmlinger","year":"1997","journal-title":"Nature biotechnology"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"e4632","DOI":"10.1371\/journal.pone.0004632","article-title":"Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells","volume":"4","author":"G Cheng","year":"2009","journal-title":"PloS one"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103245","article-title":"Elastic free energy drives the shape of prevascular solid tumors","volume":"9","author":"KL Mills","year":"2014","journal-title":"PLoS ONE"},{"issue":"18","key":"ref11","doi-asserted-by":"crossref","first-page":"188102","DOI":"10.1103\/PhysRevLett.107.188102","article-title":"Stress Clamp Experiments on Multicellular Tumor Spheroids","volume":"107","author":"F Montel","year":"2011","journal-title":"Phys Rev Lett"},{"issue":"8","key":"ref12","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.bpj.2014.08.031","article-title":"Compressive Stress Inhibits Proliferation in Tumor Spheroids through a Volume Limitation","volume":"107","author":"M Delarue","year":"2014","journal-title":"Biophysical Journal"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.jtbi.2010.02.036","article-title":"Three-dimensional multispecies nonlinear tumor growth-II: Tumor invasion and angiogenesis","volume":"264","author":"HB Frieboes","year":"2010","journal-title":"Journal of theoretical biology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s002850100091","article-title":"The influence of growth-induced stress from the surrounding medium on the development of multicell spheroids","volume":"43","author":"CY Chen","year":"2001","journal-title":"Journal of Mathematical Biology"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s00285-003-0238-2","article-title":"The role of stress in the growth of a multicell spheroid","volume":"48","author":"D Ambrosi","year":"2004","journal-title":"Journal of Mathematical Biology"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/imammb\/dql009","article-title":"Mathematical modelling of the loss of tissue compression responsiveness and its role in solid tumour development","volume":"23","author":"MAJ Chaplain","journal-title":"Mathematical Medicine and Biology"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","DOI":"10.1007\/s10237-015-0755-0","article-title":"Predicting the growth of glioblastoma multiforme spheroids using a multiphase porous media model","volume":"15","author":"P Mascheroni","year":"2016","journal-title":"Biomechanics and modeling in mechanobiology"},{"issue":"7","key":"ref18","article-title":"A cell based modelling framework for skeletal tissue engineering applications","volume":"43","author":"L Geris","year":"2010","journal-title":"Journal of biomechanics"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"55025","DOI":"10.1088\/1367-2630\/14\/5\/055025","article-title":"Modeling the impact of granular embedding media, and pulling versus pushing cells on growing cell clones","volume":"14","author":"D Drasdo","year":"2012","journal-title":"New Journal of Physics"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"055008","DOI":"10.1088\/1367-2630\/14\/5\/055008","article-title":"Isotropic stress reduces cell proliferation in tumor spheroids","volume":"14","author":"F Montel","year":"2012","journal-title":"New Journal of Physics"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s40571-015-0082-3","article-title":"Simulating tissue mechanics with agent-based models: concepts, perspectives and some novel results","volume":"2","author":"P Van Liedekerke","year":"2015","journal-title":"Computational Particle Mechanics"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","DOI":"10.1039\/c0sm01261k","article-title":"Mechanisms of soft cellular tissue bruising. A particle based simulation approach","volume":"7","author":"P Van Liedekerke","year":"2011","journal-title":"Soft Matter"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","DOI":"10.1088\/1478-3975\/7\/2\/026006","article-title":"A particle-based model to simulate the micromechanics of single-plant parenchyma cells and aggregates","volume":"7","author":"P Van Liedekerke","year":"2010","journal-title":"Physical biology"},{"key":"ref24","article-title":"Modeling contact interactions between triangulated rounded bodies for the discrete element method","volume":"227","author":"B Smeets","year":"2014","journal-title":"Computer Methods in Applied Mechanics and Engineering"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","DOI":"10.1088\/1478-3975\/6\/1\/016009","article-title":"Multi-scale simulation of plant tissue deformation using a model for individual cell mechanics","volume":"6","author":"P Ghysels","year":"2009","journal-title":"Physical Biology"},{"issue":"37","key":"ref26","doi-asserted-by":"crossref","first-page":"14843","DOI":"10.1073\/pnas.1309482110","article-title":"Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro","volume":"110","author":"K Alessandri","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.jhep.2014.06.013","article-title":"How predictive quantitative modelling of tissue organisation can inform liver disease pathogenesis","volume":"61","author":"D Drasdo","year":"2014","journal-title":"Journal of hepatology"},{"issue":"23","key":"ref28","doi-asserted-by":"crossref","first-page":"10371","DOI":"10.1073\/pnas.0909374107","article-title":"Prediction and validation of cell alignment along microvessels as order principle to restore tissue architecture in liver regeneration","volume":"107","author":"S Hoehme","year":"2010","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"e1004412","DOI":"10.1371\/journal.pcbi.1004412","article-title":"Inferring Growth Control Mechanisms in Growing Multi-cellular Spheroids of NSCLC Cells from Spatial-Temporal Image Data","volume":"12","author":"N Jagiella","year":"2016","journal-title":"PLoS computational biology"},{"issue":"7","key":"ref30","doi-asserted-by":"crossref","first-page":"e67590","DOI":"10.1371\/journal.pone.0067590","article-title":"Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells","volume":"8","author":"F Feij\u00f3 Delgado","year":"2013","journal-title":"PloS one"},{"key":"ref31","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511781452","article-title":"Multiscale Modeling of Cancer: An Integrated Experimental and Mathematical Modeling Approach","author":"V Cristini","year":"2010"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.cell.2010.12.031","article-title":"Cells respond to mechanical stress by rapid disassembly of caveolae","volume":"144","author":"B Sinha","year":"2011","journal-title":"Cell"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.cell.2013.07.042","article-title":"A mechanical checkpoint controls multicellular growth through YAP\/TAZ regulation by actin-processing factors","volume":"154","author":"M Aragona","year":"2013","journal-title":"Cell"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S0955-0674(98)80122-1","article-title":"Connections between growth and the cell cycle","volume":"10","author":"TP Neufeld","year":"1998","journal-title":"Current Opinion in Cell Biology"},{"issue":"5937","key":"ref35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1126\/science.1174294","article-title":"Cell Growth and Size Homeostasis in Proliferating Animal Cells","volume":"325","author":"A Tzur","year":"2009","journal-title":"Science"},{"key":"ref36","article-title":"Optical measurement of cycle-dependent cell growth","author":"M Mir","year":"2011","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"7438","key":"ref37","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nature11897","article-title":"Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle","volume":"494","author":"R Kafri","year":"2013","journal-title":"Nature"},{"issue":"9","key":"ref38","doi-asserted-by":"crossref","first-page":"3318","DOI":"10.1073\/pnas.0404782102","article-title":"Mechanical feedback as a possible regulator of tissue growth","volume":"102","author":"BI Shraiman","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1073\/pnas.1007809109","article-title":"Collective and single cell behavior in epithelial contact inhibition","volume":"109","author":"A Puliafito","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref40","article-title":"The Cell Cycle: Principles of Control","author":"DO Morgan","year":"2007"},{"key":"ref41","article-title":"Principles of development","author":"L Wolpert","year":"2015"},{"issue":"44","key":"ref42","doi-asserted-by":"crossref","first-page":"18581","DOI":"10.1073\/pnas.0903353106","article-title":"Role of cortical tension in bleb growth","volume":"106","author":"JY Tinevez","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"20140033","DOI":"10.1098\/rsfs.2014.0033","article-title":"Stress distributions and cell flows in a growing cell aggregate","volume":"4","author":"M Delarue","year":"2014","journal-title":"Interface focus"},{"issue":"23","key":"ref44","first-page":"233901","article-title":"Cell compressibility studies utilizing noncontact hydrostatic pressure measurements on single living cells in a microchamber","volume":"92","author":"L Lin","year":"2008","journal-title":"Applied Physics"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1529\/biophysj.104.041459","article-title":"Modeling the effect of deregulated proliferation and apoptosis on the growth dynamics of epithelial cell populations in vitro","volume":"88","author":"J Galle","year":"2005","journal-title":"Biophysical journal"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"e1001045","DOI":"10.1371\/journal.pcbi.1001045","article-title":"A Comprehensive Model of the Spatio-Temporal Stem Cell and Tissue Organisation in the Intestinal Crypt","volume":"7","author":"P Buske","year":"2011","journal-title":"PLoS Comput Biol"},{"issue":"41","key":"ref47","doi-asserted-by":"crossref","first-page":"17271","DOI":"10.1073\/pnas.0902085106","article-title":"The role of fluctuations and stress on the effective viscosity of cell aggregates","volume":"106","author":"P Marmottant","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref48","unstructured":"The Cellular Capsules technology And its applications to investigate model tumor. UPMC; 2013."},{"issue":"166-187","key":"ref49","first-page":"37","article-title":"Mathematical Population Studies: An International Journal of Mathematical Biomechanical and Nutrient Controls in the Growth of Mammalian Cell Populations","volume":"17","author":"S Hoehme","year":"2010","journal-title":"Mathematical Population Studies: An International Journal of Mathematical Biomechanical and Nutrient Controls in the Growth of Mammalian Cell Populations"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"28102","DOI":"10.1103\/PhysRevLett.94.028102","article-title":"Johnson-Kendall-Roberts Theory Applied to Living Cells","volume":"94","author":"YS Chu","year":"2005","journal-title":"Physical Review Letters"},{"issue":"02n03","key":"ref51","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1142\/S0219525905000440","article-title":"Coarse Graining in simulated cell populations","volume":"08","author":"D DRASDO","year":"2005","journal-title":"Advances in Complex Systems"},{"key":"ref52","unstructured":"von Mikroorganismen und Zellkulturen DS. Deutsche Sammlung von Mikroorganismen und Zellkulturen; 2000. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.dsmz.de\/catalogues\/catalogue-human-and-animal-cell-lines.html\" xlink:type=\"simple\">https:\/\/www.dsmz.de\/catalogues\/catalogue-human-and-animal-cell-lines.html<\/ext-link>."},{"key":"ref53","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s10955-007-9289-x","article-title":"On the Role of Physics in the Growth and Pattern Formation of Multi-Cellular Systems: What can we Learn from Individual-Cell Based Models","volume":"128","author":"D Drasdo","year":"2007","journal-title":"Journal of Statistical Physics"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/0012-1606(81)90276-1","article-title":"The mechanical basis of morphogenesis. I. Epithelial folding and invagination","volume":"85","author":"GM Odell","year":"1981","journal-title":"Developmental biology"},{"issue":"5111","key":"ref55","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1126\/science.7684161","article-title":"Mechanotransduction across the cell surface and through the cytoskeleton","volume":"260","author":"N Wang","year":"1993","journal-title":"Science"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1152\/jappl.2000.89.5.2085","article-title":"Engineering approaches to cytoskeletal mechanics","volume":"89","author":"D Stamenovic","year":"2000","journal-title":"J Appl Physiol"},{"issue":"46","key":"ref57","doi-asserted-by":"crossref","first-page":"35886","DOI":"10.1074\/jbc.M002377200","article-title":"Strain Hardening of actin filament networks regulation by the dynamic cross-linking protein \u03b1-actinin","volume":"275","author":"J Xu","year":"2000","journal-title":"Journal of Biological Chemistry"},{"key":"ref58","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9781139022217","article-title":"Mechanics of the Cell","author":"D Boal","year":"2012"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"98103","DOI":"10.1103\/PhysRevLett.94.098103","article-title":"Optical Rheology of Biological Cells","volume":"94","author":"F Wottawah","year":"2005","journal-title":"Physical Review Letters"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"45007","DOI":"10.1088\/1478-3975\/8\/4\/045007","article-title":"Emergent cell and tissue dynamics from subcellular modeling of active biomechanical processes","volume":"8","author":"SA Sandersius","year":"2011","journal-title":"Physical Biology"},{"key":"ref61","article-title":"LBIBCell: a cell-based simulation environment for morphogenetic problems","author":"S Tanaka","year":"2015","journal-title":"Bioinformatics"},{"issue":"3","key":"ref62","doi-asserted-by":"crossref","first-page":"36001","DOI":"10.1088\/1478-3975\/6\/3\/036001","article-title":"A computational study of discrete mechanical tissue models","volume":"6","author":"P Pathmanathan","year":"2009","journal-title":"Physical Biology"},{"issue":"2","key":"ref63","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.jtbi.2006.03.021","article-title":"Quantifying the contribution of actin networks to the elastic strength of fibroblasts","volume":"242","author":"R Ananthakrishnan","year":"2006","journal-title":"Journal of Theoretical Biology"},{"key":"ref64","article-title":"Theoretical Physics","volume":"Volume 7","author":"LD Landau","year":"1986"},{"issue":"3","key":"ref65","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1104\/pp.107.101964","article-title":"Loss of Stability: A New Look at the Physics of Cell Wall Behavior during Plant Cell Growth","volume":"145","author":"C Wei","journal-title":"Plant Physiology"},{"issue":"13","key":"ref66","doi-asserted-by":"crossref","first-page":"138103","DOI":"10.1103\/PhysRevLett.110.138103","article-title":"Mechanical Control of Cell flow in Multicellular Spheroids","volume":"110","author":"M Delarue","year":"2013","journal-title":"Phys Rev Lett"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"9467","DOI":"10.1073\/pnas.97.17.9467","article-title":"Cell sorting is analogous to phase ordering in fluids","volume":"97","author":"DA Beysens","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.cpc.2013.02.013","article-title":"Solving microscopic flow problems using Stokes equations in SPH","volume":"184","author":"P Van Liedekerke","year":"2013","journal-title":"Computer Physics Communications"},{"issue":"29\u201332","key":"ref69","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1016\/j.cma.2010.02.001","article-title":"Systematic coarse-graining of spectrin-level red blood cell models","volume":"199","author":"DA Fedosov","year":"2010","journal-title":"Computer Methods in Applied Mechanics and Engineering"},{"issue":"10","key":"ref70","doi-asserted-by":"crossref","first-page":"e1003267","DOI":"10.1371\/journal.pcbi.1003267","article-title":"Analysis of Initial Cell Spreading Using Mechanistic Contact Formulations for a Deformable Cell Model","volume":"9","author":"T Odenthal","year":"2013","journal-title":"PLoS Computational Biology"},{"issue":"6, Part 1","key":"ref71","doi-asserted-by":"crossref","first-page":"61906","DOI":"10.1103\/PhysRevE.81.061906","article-title":"Particle-based model to simulate the micromechanics of biological cells","volume":"81","author":"P Van Liedekerke","year":"2010","journal-title":"Physical Review E"},{"issue":"5","key":"ref72","doi-asserted-by":"crossref","first-page":"051924","DOI":"10.1103\/PhysRevE.78.051924","article-title":"Elastic properties and mechanical stability of chiral and filled viral capsids","volume":"78","author":"M Buenemann","year":"2008","journal-title":"Physical Review E"},{"issue":"2","key":"ref73","doi-asserted-by":"crossref","first-page":"26014","DOI":"10.1088\/1478-3975\/8\/2\/026014","article-title":"Dissipative particle dynamics simulations for biological tissues: rheology and competition","volume":"8","author":"M Basan","year":"2011","journal-title":"Physical biology"},{"key":"ref74","article-title":"A phenomenological model for cell and nucleus deformation during cancer metastasis","author":"J Chen","year":"2018","journal-title":"Biomechanics and Modeling in Mechanobiology"},{"issue":"1","key":"ref75","article-title":"A semi-stochastic cell-based formalism to model the dynamics of migration of cells in colonies","volume":"11","author":"F J Vermolen","year":"2012","journal-title":"Biomechanics and Modeling in Mechanobiology"},{"issue":"3","key":"ref76","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2005.08.010","article-title":"Tensional homeostasis and the malignant phenotype","volume":"8","author":"MJ Paszek","year":"2005","journal-title":"Cancer Cell"},{"issue":"138","key":"ref77","doi-asserted-by":"crossref","DOI":"10.1098\/rsif.2017.0703","article-title":"Towards personalized computational oncology: from spatial models of tumour spheroids, to organoids, to tissues","volume":"15","author":"A Karolak","year":"2018","journal-title":"Journal of The Royal Society Interface"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ymeth.2015.07.009","article-title":"Effect of an osmotic stress on multicellular aggregates","volume":"94","author":"Sylvain Monnier","year":"2016","journal-title":"Methods"},{"issue":"12","key":"ref79","doi-asserted-by":"crossref","first-page":"e1005108","DOI":"10.1371\/journal.pcbi.1005108","article-title":"Immersed Boundary Models for Quantifying Flow-Induced Mechanical Stimuli on Stem Cells Seeded on 3D Scaffolds in Perfusion Bioreactors","volume":"9","author":"Y Guyot","year":"2016","journal-title":"PLoS computational biology"},{"issue":"4","key":"ref80","doi-asserted-by":"crossref","DOI":"10.1007\/s10237-017-0881-y","article-title":"Biomedical implications from a morphoelastic continuum model for the simulation of contracture formation in skin grafts that cover excised burns","volume":"16","author":"DC Koppenol","year":"2017","journal-title":"Biomechanics and modeling in mechanobiology"},{"issue":"2","key":"ref81","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bpj.2017.11.3739","article-title":"Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces","volume":"114","author":"E Ban","year":"2018","journal-title":"Biophysical Journal"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1006273","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T13:26:12Z","timestamp":1589030772000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006273"}},"subtitle":[],"editor":[{"given":"Natalia L.","family":"Komarova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,3,8]]},"references-count":81,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1006273","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1006273","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,8]]}}}