{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T19:39:34Z","timestamp":1774035574807,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1006293","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000}}],"reference-count":131,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology","doi-asserted-by":"publisher","award":["BT\/PR12973\/MED\/122\/47\/2016"],"award-info":[{"award-number":["BT\/PR12973\/MED\/122\/47\/2016"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1006293","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T17:25:46Z","timestamp":1531934746000},"page":"e1006293","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["A biophysically detailed computational model of urinary bladder small DRG neuron soma"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7104-4604","authenticated-orcid":true,"given":"Darshan","family":"Mandge","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7383-3482","authenticated-orcid":true,"given":"Rohit","family":"Manchanda","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2018,7,18]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1442-2042.1997.tb00156.x","article-title":"Neural control of the lower urinary tract","volume":"4","author":"N Yoshimura","year":"1997","journal-title":"International journal of urology"},{"issue":"6A Suppl","key":"ref2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0090-4295(97)00587-6","article-title":"A neurologic basis for the overactive bladder","volume":"50","author":"WC de Groat","year":"1997","journal-title":"Urology"},{"key":"ref3","first-page":"91","article-title":"Sensory Nerves","author":"WC de Groat","year":"2009"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.expneurol.2011.05.003","article-title":"Plasticity in reflex pathways to the lower urinary tract following spinal cord injury","volume":"235","author":"WC de Groat","year":"2012","journal-title":"Experimental neurology"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"F796","DOI":"10.1152\/ajprenal.00097.2017","article-title":"The role of capsaicin-sensitive C-fiber afferent pathways in the control of micturition in spinal-intact and spinal cord-injured mice","volume":"313","author":"K Kadekawa","year":"2017","journal-title":"American Journal of Physiology-Renal Physiology"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s11884-017-0402-y","article-title":"Pathophysiology of Overactive Bladder: Current Understanding","volume":"12","author":"CJ Palmer","year":"2017","journal-title":"Current Bladder Dysfunction Reports"},{"issue":"Pt 1","key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1996.sp021471","article-title":"Different types of Na+ and A-type K+ currents in dorsal root ganglion neurones innervating the rat urinary bladder","volume":"494","author":"N Yoshimura","year":"1996","journal-title":"The Journal of physiology"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.brainres.2006.04.085","article-title":"Characterization of hyperpolarization-activated current (<italic>I<\/italic><sub><italic>h<\/italic><\/sub>) in dorsal root ganglion neurons innervating rat urinary bladder","volume":"1096","author":"N Masuda","year":"2006","journal-title":"Brain research"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1469-7793.1997.269bh.x","article-title":"Plasticity of Na+ channels in afferent neurones innervating rat urinary bladder following spinal cord injury","volume":"503","author":"N Yoshimura","year":"1997","journal-title":"The Journal of Physiology"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"4644","DOI":"10.1523\/JNEUROSCI.19-11-04644.1999","article-title":"Increased excitability of afferent neurons innervating rat urinary bladder after chronic bladder inflammation","volume":"19","author":"N Yoshimura","year":"1999","journal-title":"The Journal of neuroscience"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1113\/jphysiol.2012.242750","article-title":"Failure of action potential propagation in sensory neurons: mechanisms and loss of afferent filtering in C-type units after painful nerve injury","volume":"591","author":"G Gemes","year":"2013","journal-title":"The Journal of physiology"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1016\/j.pain.2014.08.025","article-title":"Control of somatic membrane potential in nociceptive neurons and its implications for peripheral nociceptive transmission","volume":"155","author":"X Du","year":"2014","journal-title":"PAIN"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1152\/jn.00226.2015","article-title":"Spike propagation through the dorsal root ganglia in an unmyelinated sensory neuron: a modeling study","volume":"114","author":"D Sundt","year":"2015","journal-title":"Journal of neurophysiology"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0304-3959(83)90164-1","article-title":"Sensory afferent impulses originate from dorsal root ganglia as well as from the periphery in normal and nerve injured rats","volume":"17","author":"P Wall","year":"1983","journal-title":"Pain"},{"key":"ref15","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2015.00412","article-title":"Role of satellite glial cells in gastrointestinal pain","volume":"9","author":"M Hanani","year":"2015","journal-title":"Frontiers in cellular neuroscience"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/ner.12028","article-title":"Effect of electrical field stimulation on dorsal root ganglion neuronal function","volume":"16","author":"AS Koopmeiners","year":"2013","journal-title":"Neuromodulation: Technology at the Neural Interface"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"G517","DOI":"10.1152\/ajpgi.00228.2013","article-title":"A detailed, conductance-based computer model of intrinsic sensory neurons of the gastrointestinal tract","volume":"307","author":"JD Chambers","year":"2014","journal-title":"American Journal of Physiology-Gastrointestinal and Liver Physiology"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1152\/jn.1994.72.2.622","article-title":"Action potential propagation through embryonic dorsal root ganglion cells in culture. I. Influence of the cell morphology on propagation properties","volume":"72","author":"C Luscher","year":"1994","journal-title":"Journal of neurophysiology"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/S0006-3495(03)75024-3","article-title":"Electrical excitability of the soma of sensory neurons is required for spike invasion of the soma, but not for through-conduction","volume":"84","author":"R Amir","year":"2003","journal-title":"Biophysical journal"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1113\/jphysiol.2005.089771","article-title":"Protein kinase C mediates up-regulation of tetrodotoxin-resistant, persistent Na<sup>+<\/sup> current in rat and mouse sensory neurones","volume":"567","author":"MD Baker","year":"2005","journal-title":"The Journal of physiology"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1113\/jphysiol.2006.127027","article-title":"A Nav1. 7 channel mutation associated with hereditary erythromelalgia contributes to neuronal hyperexcitability and displays reduced lidocaine sensitivity","volume":"581","author":"PL Sheets","year":"2007","journal-title":"The Journal of physiology"},{"issue":"10","key":"ref22","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1016\/j.pain.2011.07.006","article-title":"The transcription factor Smad-interacting protein 1 controls pain sensitivity via modulation of DRG neuron excitability","volume":"152","author":"M Jeub","year":"2011","journal-title":"PAIN"},{"issue":"9","key":"ref23","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1152\/jn.00777.2012","article-title":"Modeling activity-dependent changes of axonal spike conduction in primary afferent C-nociceptors","volume":"111","author":"J Tigerholm","year":"2014","journal-title":"Journal of neurophysiology"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"2207","DOI":"10.1016\/S0006-3495(01)76193-0","article-title":"Inwardly rectifying current-voltage relationship of small-conductance Ca 2+-activated K+ channels rendered by intracellular divalent cation blockade","volume":"80","author":"H Soh","year":"2001","journal-title":"Biophysical Journal"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1016\/S0006-3495(02)75264-8","article-title":"Localization of divalent cation-binding site in the pore of a small conductance Ca 2+-activated K+ channel and its role in determining current-voltage relationship","volume":"83","author":"H Soh","year":"2002","journal-title":"Biophysical journal"},{"issue":"15","key":"ref26","doi-asserted-by":"crossref","first-page":"5946","DOI":"10.1073\/pnas.1103090108","article-title":"Electrostatic influences of charged inner pore residues on the conductance and gating of small conductance Ca2+ activated K+ channels","volume":"108","author":"W Li","year":"2011","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbamem.2004.07.006","article-title":"Activation of human IK and SK Ca 2+-activated K+ channels by NS309 (6, 7-dichloro-1H-indole-2, 3-dione 3-oxime)","volume":"1665","author":"D Str\u00f8b\u00e6k","year":"2004","journal-title":"Biochimica et Biophysica Acta (BBA)-Biomembranes"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"697","DOI":"10.2174\/092986712798992039","article-title":"Targeting SKCa channels in cancer: potential new therapeutic approaches","volume":"19","author":"A Girault","year":"2012","journal-title":"Current medicinal chemistry"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s10827-009-0161-7","article-title":"Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents","volume":"27","author":"JE Steephen","year":"2009","journal-title":"Journal of computational neuroscience"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1124\/jpet.108.143123","article-title":"A positive modulator of KCa2 and KCa3 channels, 4, 5-dichloro-1, 3-diethyl-1, 3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo","volume":"328","author":"C Hougaard","year":"2009","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"ref31","first-page":"563","article-title":"Sensory Nerves","author":"T Gover","year":"2009"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0301-0082(02)00004-7","article-title":"Channels underlying neuronal calcium-activated potassium currents","volume":"66","author":"P Sah","year":"2002","journal-title":"Progress in neurobiology"},{"issue":"42","key":"ref33","doi-asserted-by":"crossref","first-page":"10847","DOI":"10.1523\/JNEUROSCI.3023-06.2006","article-title":"Bladder overactivity and hyperexcitability of bladder afferent neurons after intrathecal delivery of nerve growth factor in rats","volume":"26","author":"N Yoshimura","year":"2006","journal-title":"The Journal of neuroscience"},{"issue":"6","key":"ref34","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1016\/j.juro.2013.07.058","article-title":"Hyperexcitability of bladder afferent neurons associated with reduction of Kv1. 4 <italic>\u03b1<\/italic>-subunit in rats with spinal cord injury","volume":"190","author":"R Takahashi","year":"2013","journal-title":"The Journal of urology"},{"issue":"10","key":"ref35","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1152\/jn.00054.2014","article-title":"Differential contribution of Kv4-containing channels to A-type, voltage-gated potassium currents in somatic and visceral dorsal root ganglion neurons","volume":"112","author":"T Yunoki","year":"2014","journal-title":"Journal of neurophysiology"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"R1661","DOI":"10.1152\/ajpregu.91054.2008","article-title":"Bladder hyperactivity and increased excitability of bladder afferent neurons associated with reduced expression of Kv1. 4 <italic>\u03b1<\/italic>-subunit in rats with cystitis","volume":"296","author":"Y Hayashi","year":"2009","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"},{"key":"ref37","doi-asserted-by":"crossref","unstructured":"Mandge D, Manchanda R. Computational studies on bladder small dorsal root ganglion neurons: Modelling BK channels. In: Engineering in Medicine and Biology Society (EMBC), 2015 37th Annual International Conference of the IEEE. IEEE; 2015. p. 5376\u20135379.","DOI":"10.1109\/EMBC.2015.7319606"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Mandge D, Bhatnagar A, Manchanda R. Computational model for intercellular communication between DRG neurons via satellite glial cells using ATP. In: Neural Engineering (NER), 2017 8th International IEEE\/EMBS Conference on. IEEE; 2017. p. 648\u2013651.","DOI":"10.1109\/NER.2017.8008434"},{"key":"ref39","doi-asserted-by":"crossref","unstructured":"Aruljothi S, Mandge D, Manchanda R. A biophysical model of heat sensitivity in nociceptive C-fiber neurons. In: Neural Engineering (NER), 2017 8th International IEEE\/EMBS Conference on. IEEE; 2017. p. 596\u2013599.","DOI":"10.1109\/NER.2017.8008422"},{"issue":"6","key":"ref40","article-title":"The NEURON simulation environment","volume":"9","author":"ML Hines","year":"2006","journal-title":"NEURON"},{"issue":"10","key":"ref41","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/j.1365-2982.2006.00807.x","article-title":"Hyperexcitability of convergent colon and bladder dorsal root ganglion neurons after colonic inflammation: mechanism for pelvic organ cross-talk","volume":"18","author":"A Malykhina","year":"2006","journal-title":"Neurogastroenterology & Motility"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.brainres.2016.06.042","article-title":"Electrophysiological properties of lumbosacral primary afferent neurons innervating urothelial and non-urothelial layers of mouse urinary bladder","volume":"1648","author":"H Kanda","year":"2016","journal-title":"Brain Research"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1152\/jn.00100.2011","article-title":"Physiological interactions between Nav 1.7 and Nav 1.8 sodium channels: a computer simulation study","volume":"106","author":"JS Choi","year":"2011","journal-title":"Journal of neurophysiology"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1113\/jphysiol.1992.sp019316","article-title":"Ca2+ efflux mechanisms following depolarization evoked calcium transients in cultured rat sensory neurones","volume":"455","author":"C Benham","year":"1992","journal-title":"The Journal of physiology"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1113\/jphysiol.1990.sp018094","article-title":"Regulation of the intracellular free calcium concentration in single rat dorsal root ganglion neurones in vitro","volume":"425","author":"SA Thayer","year":"1990","journal-title":"The Journal of Physiology"},{"issue":"1","key":"ref46","first-page":"55","article-title":"Anoctamin-1 Cl- channels in nociception: activation by an N-aroylaminothiazole and capsaicin and inhibition by T16A [inh]-A01","volume":"11","author":"F Deba","year":"2015","journal-title":"Molecular pain"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuroscience.2011.04.049","article-title":"Differences in the expression of transient receptor potential channel V1, transient receptor potential channel A1 and mechanosensitive two pore-domain K+ channels between the lumbar splanchnic and pelvic nerve innervations of mouse urinary bladder and colon","volume":"186","author":"JH La","year":"2011","journal-title":"Neuroscience"},{"key":"ref48","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511541612","article-title":"The NEURON book","author":"NT Carnevale","year":"2006"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/S0301-0082(98)00070-7","article-title":"Bladder afferent pathway and spinal cord injury: possible mechanisms inducing hyperreflexia of the urinary bladder","volume":"57","author":"N Yoshimura","year":"1999","journal-title":"Progress in neurobiology"},{"issue":"9","key":"ref50","doi-asserted-by":"crossref","first-page":"3172","DOI":"10.1152\/jn.00113.2015","article-title":"Human Na V 1.8: enhanced persistent and ramp currents contribute to distinct firing properties of human DRG neurons","volume":"113","author":"C Han","year":"2015","journal-title":"Journal of neurophysiology"},{"issue":"1","key":"ref51","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0006-8993(02)03957-4","article-title":"Tetrodotoxin-resistant sodium channels Nav1.8\/SNS and Nav1.9\/NaN in afferent neurons innervating urinary bladder in control and spinal cord injured rats","volume":"963","author":"JA Black","year":"2003","journal-title":"Brain research"},{"issue":"6","key":"ref52","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/sj.bjp.0707278","article-title":"A-272651, a nonpeptidic blocker of large-conductance Ca2+-activated K+ channels, modulates bladder smooth muscle contractility and neuronal action potentials","volume":"151","author":"CC Shieh","year":"2007","journal-title":"British journal of pharmacology"},{"issue":"1","key":"ref53","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1469-7793.1998.055by.x","article-title":"Properties and functions of calcium-activated K+ channels in small neurones of rat dorsal root ganglion studied in a thin slice preparation","volume":"513","author":"A Scholz","year":"1998","journal-title":"The Journal of Physiology"},{"issue":"3","key":"ref54","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/j.1460-9568.2009.07060.x","article-title":"BK<sub>Ca<\/sub> currents are enriched in a subpopulation of adult rat cutaneous nociceptive dorsal root ganglion neurons","volume":"31","author":"XL Zhang","year":"2010","journal-title":"European Journal of Neuroscience"},{"issue":"5","key":"ref55","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1124\/mol.106.027110","article-title":"Inhibitory gating modulation of small conductance Ca2+-activated K+ channels by the synthetic compound (R)-N-(benzimidazol-2-yl)-1, 2, 3, 4-tetrahydro-1-naphtylamine (NS8593) reduces afterhyperpolarizing current in hippocampal CA1 neurons","volume":"70","author":"D Str\u00f8b\u00e6k","year":"2006","journal-title":"Molecular pharmacology"},{"issue":"18","key":"ref56","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1523\/JNEUROSCI.23-18-07227.2003","article-title":"KCNQ\/M currents in sensory neurons: significance for pain therapy","volume":"23","author":"GM Passmore","year":"2003","journal-title":"Journal of Neuroscience"},{"issue":"3","key":"ref57","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.vascn.2004.08.007","article-title":"Dorsal root ganglion neurones in culture: A model system for identifying novel analgesic targets?","volume":"51","author":"GM Passmore","year":"2005","journal-title":"Journal of pharmacological and toxicological methods"},{"issue":"3","key":"ref58","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1085\/jgp.200709935","article-title":"Inflammatory mediators increase Nav1. 9 current and excitability in nociceptors through a coincident detection mechanism","volume":"131","author":"F Maingret","year":"2008","journal-title":"The Journal of general physiology"},{"issue":"3","key":"ref59","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1469-7793.1998.743bj.x","article-title":"Na+-activated K+ channels in small dorsal root ganglion neurones of rat","volume":"510","author":"U Bischoff","year":"1998","journal-title":"The Journal of physiology"},{"issue":"1","key":"ref60","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1113\/jphysiol.1987.sp016864","article-title":"Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones","volume":"394","author":"A Fox","year":"1987","journal-title":"The Journal of Physiology"},{"issue":"4","key":"ref61","doi-asserted-by":"crossref","first-page":"e18685","DOI":"10.1371\/journal.pone.0018685","article-title":"A computational model of the ionic currents, Ca2+ dynamics and action potentials underlying contraction of isolated uterine smooth muscle","volume":"6","author":"WC Tong","year":"2011","journal-title":"PloS one"},{"issue":"1","key":"ref62","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1113\/jphysiol.1987.sp016865","article-title":"Single-channel recordings of three types of calcium channels in chick sensory neurones","volume":"394","author":"A Fox","year":"1987","journal-title":"The Journal of physiology"},{"issue":"2","key":"ref63","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/BF00580957","article-title":"Characterization of two kinds of high-voltage-activated Ca-channel currents in chick sensory neurons","volume":"414","author":"T Aosaki","year":"1989","journal-title":"Pfl\u00fcgers Archiv"},{"issue":"3","key":"ref64","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neures.2012.04.006","article-title":"Ca 2+ channel currents in dorsal root ganglion neurons of P\/Q-type voltage-gated Ca<sup>2+<\/sup> channel mutant mouse, rolling mouse Nagoya","volume":"73","author":"N Fukumoto","year":"2012","journal-title":"Neuroscience research"},{"issue":"1","key":"ref65","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0306-4522(97)00101-2","article-title":"Toxin-resistant calcium currents in embryonic mouse sensory neurons","volume":"80","author":"C Hilaire","year":"1997","journal-title":"Neuroscience"},{"issue":"2","key":"ref66","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/0306-4522(95)00267-M","article-title":"Diversity of voltage-gated calcium currents in large diameter embryonic mouse sensory neurons","volume":"69","author":"S Diochot","year":"1995","journal-title":"Neuroscience"},{"issue":"49","key":"ref67","doi-asserted-by":"crossref","first-page":"13420","DOI":"10.1523\/JNEUROSCI.1709-07.2007","article-title":"Differential gating and recruitment of P\/Q-, N-, and R-type Ca<sup>2+<\/sup> channels in hippocampal mossy fiber boutons","volume":"27","author":"L Li","year":"2007","journal-title":"Journal of Neuroscience"},{"issue":"1","key":"ref68","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.brainres.2006.08.052","article-title":"Expression of hyperpolarization-activated cyclic nucleotide-gated cation channels in rat dorsal root ganglion neurons innervating urinary bladder","volume":"1119","author":"H Matsuyoshi","year":"2006","journal-title":"Brain research"},{"issue":"4","key":"ref69","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.neuroscience.2008.03.032","article-title":"Hyperpolarization-activated cyclic nucleotide-gated channel mRNA and protein expression in large versus small diameter dorsal root ganglion neurons: correlation with hyperpolarization-activated current gating","volume":"153","author":"E Kouranova","year":"2008","journal-title":"Neuroscience"},{"issue":"1","key":"ref70","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1469-7793.1999.0115o.x","article-title":"Ca<sup>2+<\/sup> influx in resting rat sensory neurones that regulates and is regulated by ryanodine-sensitive Ca<sup>2+<\/sup> stores","volume":"519","author":"YM Usachev","year":"1999","journal-title":"The Journal of Physiology"},{"issue":"7203","key":"ref71","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nature07065","article-title":"Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation","volume":"454","author":"RM Luik","year":"2008","journal-title":"Nature"},{"issue":"290","key":"ref72","doi-asserted-by":"crossref","first-page":"ra73","DOI":"10.1126\/scisignal.2004184","article-title":"Activation of the Cl<sup>\u2212<\/sup> channel ANO1 by localized calcium signals in nociceptive sensory neurons requires coupling with the IP3 receptor","volume":"6","author":"X Jin","year":"2013","journal-title":"Science signaling"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.neuropharm.2016.08.006","article-title":"Control of sensory neuron excitability by serotonin involves 5HT2C receptors and Ca<sup>2+<\/sup>-activated chloride channels","volume":"110","author":"I Salzer","year":"2016","journal-title":"Neuropharmacology"},{"issue":"21","key":"ref74","doi-asserted-by":"crossref","first-page":"8891","DOI":"10.1073\/pnas.1102147108","article-title":"Voltage-and calcium-dependent gating of TMEM16A\/Ano1 chloride channels are physically coupled by the first intracellular loop","volume":"108","author":"Q Xiao","year":"2011","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"3","key":"ref75","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neures.2009.07.005","article-title":"Expression of the TRPM8-immunoreactivity in dorsal root ganglion neurons innervating the rat urinary bladder","volume":"65","author":"T Hayashi","year":"2009","journal-title":"Neuroscience research"},{"issue":"10","key":"ref76","doi-asserted-by":"crossref","first-page":"e0139314","DOI":"10.1371\/journal.pone.0139314","article-title":"TRPM8-dependent dynamic response in a mathematical model of cold thermoreceptor","volume":"10","author":"E Olivares","year":"2015","journal-title":"PloS one"},{"issue":"8","key":"ref77","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1038\/sj.bjp.0705170","article-title":"Properties of the Na<sup>+<\/sup>\/K<sup>+<\/sup> pump current in small neurons from adult rat dorsal root ganglia","volume":"138","author":"K Hamada","year":"2003","journal-title":"British journal of pharmacology"},{"issue":"22","key":"ref78","doi-asserted-by":"crossref","first-page":"4969","DOI":"10.1113\/jphysiol.2014.278036","article-title":"The properties, distribution and function of Na<sup>+<\/sup>\u2013Ca<sup>2+<\/sup> exchanger isoforms in rat cutaneous sensory neurons","volume":"592","author":"N Scheff","year":"2014","journal-title":"The Journal of physiology"},{"issue":"1","key":"ref79","doi-asserted-by":"crossref","first-page":"H301","DOI":"10.1152\/ajpheart.1998.275.1.H301","article-title":"Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model","volume":"275","author":"M Courtemanche","year":"1998","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"issue":"1","key":"ref80","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2210-10-6","article-title":"An evaluation of R 2 as an inadequate measure for nonlinear models in pharmacological and biochemical research: a Monte Carlo approach","volume":"10","author":"AN Spiess","year":"2010","journal-title":"BMC pharmacology"},{"key":"ref81","unstructured":"Frost J. Why Is There No R-Squared for Nonlinear Regression?; 2014. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/blog.minitab.com\/blog\/adventures-in-statistics-2\/why-is-there-no-r-squared-for-nonlinear-regression\" xlink:type=\"simple\">http:\/\/blog.minitab.com\/blog\/adventures-in-statistics-2\/why-is-there-no-r-squared-for-nonlinear-regression<\/ext-link>."},{"issue":"4","key":"ref82","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1124\/pr.57.4.4","article-title":"International Union of Pharmacology. XLVII. Nomenclature and Structure-Function Relationships of Voltage-Gated Sodium Channels","volume":"57","author":"WA Catterall","year":"2005","journal-title":"Pharmacological Reviews"},{"issue":"2","key":"ref83","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1023\/A:1008880518515","article-title":"An improved parameter estimation method for Hodgkin-Huxley models","volume":"6","author":"AR Willms","year":"1999","journal-title":"Journal of computational neuroscience"},{"issue":"9","key":"ref84","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1046\/j.1440-1681.2000.03317.x","article-title":"Calcium-activated potassium currents in mammalian neurons","volume":"27","author":"P Sah","year":"2000","journal-title":"Clinical and Experimental Pharmacology and Physiology"},{"issue":"2","key":"ref85","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/0006-8993(87)90106-5","article-title":"Distribution of capsaicin-sensitive urinary bladder afferents in the rat spinal cord","volume":"418","author":"G Jancs\u00f3","year":"1987","journal-title":"Brain research"},{"issue":"4","key":"ref86","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/cne.903190411","article-title":"Segmental distribution and peptide content of primary afferent neurons innervating the urogenital organs and colon of male rats","volume":"319","author":"J Keast","year":"1992","journal-title":"Journal of Comparative Neurology"},{"issue":"14","key":"ref87","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1523\/JNEUROSCI.0597-05.2005","article-title":"A functional role for small-conductance calcium-activated potassium channels in sensory pathways including nociceptive processes","volume":"25","author":"PK Bahia","year":"2005","journal-title":"Journal of Neuroscience"},{"issue":"5","key":"ref88","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/sj.bjp.0707281","article-title":"Selective positive modulation of the SK3 and SK2 subtypes of small conductance Ca2+-activated K+ channels","volume":"151","author":"C Hougaard","year":"2007","journal-title":"British journal of pharmacology"},{"issue":"1","key":"ref89","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1152\/jn.2001.86.1.304","article-title":"Nitric oxide modulates Ca<sup>2+<\/sup> channels in dorsal root ganglion neurons innervating rat urinary bladder","volume":"86","author":"N Yoshimura","year":"2001","journal-title":"Journal of neurophysiology"},{"issue":"10","key":"ref90","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.1523\/JNEUROSCI.23-10-04355.2003","article-title":"Histological and electrical properties of rat dorsal root ganglion neurons innervating the lower urinary tract","volume":"23","author":"N Yoshimura","year":"2003","journal-title":"Journal of Neuroscience"},{"issue":"4","key":"ref91","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF00590950","article-title":"Effect of internal calcium concentration on calcium currents in rat sensory neurones","volume":"406","author":"JL Dupont","year":"1986","journal-title":"Pfl\u00fcgers Archiv European Journal of Physiology"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ceca.2017.01.005","article-title":"Paclitaxel-induced increase in mitochondrial volume mediates dysregulation of intracellular Ca 2+ in putative nociceptive glabrous skin neurons from the rat","volume":"62","author":"E Yilmaz","year":"2017","journal-title":"Cell calcium"},{"issue":"2","key":"ref93","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0014-2999(02)01838-1","article-title":"The endoplasmic reticulum as an integrating signalling organelle: from neuronal signalling to neuronal death","volume":"447","author":"A Verkhratsky","year":"2002","journal-title":"European journal of pharmacology"},{"key":"ref94","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9780511975899","article-title":"Principles of computational modelling in neuroscience","author":"D Sterratt","year":"2011"},{"issue":"5","key":"ref95","doi-asserted-by":"crossref","first-page":"2834","DOI":"10.1152\/jn.1996.76.5.2834","article-title":"Ca2+ permeability of the sustained proton-induced cation current in adult rat dorsal root ganglion neurons","volume":"76","author":"H Zeilhofer","year":"1996","journal-title":"Journal of neurophysiology"},{"key":"ref96","first-page":"93","article-title":"Computational Modeling Methods for Neuroscientists","author":"E De Schutter","year":"2009"},{"issue":"2","key":"ref97","doi-asserted-by":"crossref","first-page":"C342","DOI":"10.1152\/ajpcell.00270.2003","article-title":"An Excel-based model of Ca2+ diffusion and fura 2 measurements in a spherical cell","volume":"286","author":"J McHugh","year":"2004","journal-title":"American Journal of Physiology-Cell Physiology"},{"issue":"1","key":"ref98","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0006-3495(00)76281-3","article-title":"An image-based model of calcium waves in differentiated neuroblastoma cells","volume":"79","author":"CC Fink","year":"2000","journal-title":"Biophysical Journal"},{"issue":"1","key":"ref99","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1529\/biophysj.107.122507","article-title":"A biophysically based mathematical model of unitary potential activity in interstitial cells of Cajal","volume":"95","author":"R Faville","year":"2008","journal-title":"Biophysical journal"},{"key":"ref100","article-title":"Ion channels of excitable membranes","volume":"vol. 507","author":"B Hille","year":"2001"},{"issue":"1","key":"ref101","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1113\/jphysiol.2006.116418","article-title":"Intracellular calcium regulation among subpopulations of rat dorsal root ganglion neurons","volume":"577","author":"SG Lu","year":"2006","journal-title":"The Journal of physiology"},{"issue":"1","key":"ref102","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ceca.2013.04.002","article-title":"Contribution of endoplasmic reticulum Ca 2+ regulatory mechanisms to the inflammation-induced increase in the evoked Ca 2+ transient in rat cutaneous dorsal root ganglion neurons","volume":"54","author":"NN Scheff","year":"2013","journal-title":"Cell calcium"},{"issue":"1-3","key":"ref103","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0014-5793(01)03312-9","article-title":"Functional properties of ryanodine receptors from rat dorsal root ganglia","volume":"511","author":"AJ Lokuta","year":"2002","journal-title":"FEBS letters"},{"issue":"4","key":"ref104","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1006\/jtbi.1994.1041","article-title":"Equations for InsP 3 receptor-mediated [Ca 2+] i oscillations derived from a detailed kinetic model: a Hodgkin-Huxley like formalism","volume":"166","author":"YX Li","year":"1994","journal-title":"Journal of theoretical Biology"},{"key":"ref105","article-title":"Calcium dynamics in large neuronal models","volume":"2","author":"E De Schutter","year":"1998","journal-title":"Methods in neuronal modeling: From ions to networks"},{"issue":"10","key":"ref106","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1113\/jphysiol.2012.249219","article-title":"Mitochondria and plasma membrane Ca2+-ATPase control presynaptic Ca2+ clearance in capsaicin-sensitive rat sensory neurons","volume":"591","author":"LP Shutov","year":"2013","journal-title":"The Journal of physiology"},{"issue":"18","key":"ref107","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1097\/00001756-199712220-00017","article-title":"Mitochondria buffer Ca2+ entry but not intracellular Ca2+ release in mouse DRG neurones","volume":"8","author":"N Svichar","year":"1997","journal-title":"Neuroreport"},{"key":"ref108","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.yjmcc.2013.03.012","article-title":"NCLX: the mitochondrial sodium calcium exchanger","volume":"59","author":"L Boyman","year":"2013","journal-title":"Journal of molecular and cellular cardiology"},{"issue":"1","key":"ref109","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0006-3495(94)80500-4","article-title":"Effects of rapid buffers on Ca2+ diffusion and Ca2+ oscillations","volume":"67","author":"J Wagner","year":"1994","journal-title":"Biophysical Journal"},{"issue":"2","key":"ref110","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0006-3495(96)79653-4","article-title":"Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons","volume":"70","author":"F Helmchen","year":"1996","journal-title":"Biophysical Journal"},{"issue":"2","key":"ref111","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.juro.2013.01.048","article-title":"Co-cultures provide a new tool to probe communication between adult sensory neurons and urothelium","volume":"190","author":"LM O\u2019mullane","year":"2013","journal-title":"The Journal of urology"},{"issue":"6","key":"ref112","doi-asserted-by":"crossref","first-page":"3440","DOI":"10.1016\/S0021-9258(19)83641-4","article-title":"A new generation of Ca2+ indicators with greatly improved fluorescence properties","volume":"260","author":"G Grynkiewicz","year":"1985","journal-title":"Journal of Biological Chemistry"},{"issue":"6","key":"ref113","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/S0006-3495(90)82494-2","article-title":"Intracellular diffusion, binding, and compartmentalization of the fluorescent calcium indicators indo-1 and fura-2","volume":"58","author":"L Blatter","year":"1990","journal-title":"Biophysical journal"},{"issue":"6","key":"ref114","doi-asserted-by":"crossref","first-page":"3197","DOI":"10.1073\/pnas.051636098","article-title":"Circularly permuted green fluorescent proteins engineered to sense Ca2+","volume":"98","author":"T Nagai","year":"2001","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"ref115","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0896-6273(01)00557-8","article-title":"Bradykinin and ATP accelerate Ca<sup>2+<\/sup> efflux from rat sensory neurons via protein kinase C and the plasma membrane Ca 2+ pump isoform 4","volume":"33","author":"YM Usachev","year":"2002","journal-title":"Neuron"},{"issue":"20","key":"ref116","doi-asserted-by":"crossref","first-page":"5295","DOI":"10.1523\/JNEUROSCI.4810-07.2008","article-title":"Mechanisms of prolonged presynaptic Ca2+ signaling and glutamate release induced by TRPV1 activation in rat sensory neurons","volume":"28","author":"YV Medvedeva","year":"2008","journal-title":"Journal of Neuroscience"},{"issue":"3","key":"ref117","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1113\/jphysiol.1995.sp021078","article-title":"Calcium-induced calcium release in rat sensory neurons","volume":"489","author":"A Shmigol","year":"1995","journal-title":"The Journal of physiology"},{"issue":"1","key":"ref118","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.neuroscience.2008.02.006","article-title":"Inflammation-induced increase in evoked calcium transients in subpopulations of rat dorsal root ganglion neurons","volume":"153","author":"SG Lu","year":"2008","journal-title":"Neuroscience"},{"issue":"17","key":"ref119","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1097\/00001756-200412030-00008","article-title":"Colonic inflammation increases Na+ currents in bladder sensory neurons","volume":"15","author":"AP Malykhina","year":"2004","journal-title":"Neuroreport"},{"issue":"14","key":"ref120","doi-asserted-by":"crossref","first-page":"7650","DOI":"10.1073\/pnas.96.14.7650","article-title":"Calcium regulation of a slow post-spike hyperpolarization in vagal afferent neurons","volume":"96","author":"R Cordoba-Rodriguez","year":"1999","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"3","key":"ref121","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1177\/1073858403009003011","article-title":"Calcium-activated potassium channels: multiple contributions to neuronal function","volume":"9","author":"EL Faber","year":"2003","journal-title":"The Neuroscientist"},{"issue":"6","key":"ref122","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1124\/mol.110.069807","article-title":"Negative gating modulation by (R)-N-(benzimidazol-2-yl)-1, 2, 3, 4-tetrahydro-1-naphthylamine (NS8593) depends on residues in the inner pore vestibule: pharmacological evidence of deep-pore gating of KCa2 channels","volume":"79","author":"DP Jenkins","year":"2011","journal-title":"Molecular pharmacology"},{"issue":"1","key":"ref123","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neuroscience.2004.09.062","article-title":"The distribution of small and intermediate conductance calcium-activated potassium channels in the rat sensory nervous system","volume":"131","author":"L Mongan","year":"2005","journal-title":"Neuroscience"},{"issue":"3","key":"ref124","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1113\/jphysiol.2005.086199","article-title":"Electrophysiological differences between nociceptive and non-nociceptive dorsal root ganglion neurones in the rat in vivo","volume":"565","author":"X Fang","year":"2005","journal-title":"The Journal of physiology"},{"issue":"6","key":"ref125","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1152\/jn.01267.2004","article-title":"A-type voltage-gated K+ currents influence firing properties of isolectin B 4-positive but not isolectin B 4-negative primary sensory neurons","volume":"93","author":"A Vydyanathan","year":"2005","journal-title":"Journal of neurophysiology"},{"issue":"2","key":"ref126","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1460-9568.2004.03508.x","article-title":"Effects of isolectin B4-conjugated saporin, a targeting cytotoxin, on bladder overactivity induced by bladder irritation","volume":"20","author":"J Nishiguchi","year":"2004","journal-title":"European Journal of Neuroscience"},{"issue":"2","key":"ref127","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.expneurol.2008.06.006","article-title":"IB4 afferent sprouting contributes to bladder dysfunction in spinal rats","volume":"213","author":"N Zinck","year":"2008","journal-title":"Experimental neurology"},{"issue":"27","key":"ref128","doi-asserted-by":"crossref","first-page":"7281","DOI":"10.1523\/JNEUROSCI.1072-06.2006","article-title":"Intense isolectin-B4 binding in rat dorsal root ganglion neurons distinguishes C-fiber nociceptors with broad action potentials and high Nav1. 9 expression","volume":"26","author":"X Fang","year":"2006","journal-title":"Journal of Neuroscience"},{"issue":"23","key":"ref129","doi-asserted-by":"crossref","first-page":"13373","DOI":"10.1073\/pnas.231376298","article-title":"Distinct potassium channels on pain-sensing neurons","volume":"98","author":"MN Rasband","year":"2001","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"ref130","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1085\/jgp.118.1.113","article-title":"Selective open-channel block of Shaker (Kv1) potassium channels by s-nitrosodithiothreitol (SNDTT)","volume":"118","author":"MW Brock","year":"2001","journal-title":"The Journal of general physiology"},{"issue":"1","key":"ref131","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bpj.2010.11.011","article-title":"A model of the interaction between N-type and C-type inactivation in Kv1. 4 channels","volume":"100","author":"GC Bett","year":"2011","journal-title":"Biophysical journal"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1006293","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T20:46:12Z","timestamp":1661633172000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006293"}},"subtitle":[],"editor":[{"given":"William W","family":"Lytton","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2018,7,18]]},"references-count":131,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1006293","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1006293","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,18]]}}}