{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T18:15:48Z","timestamp":1783534548722,"version":"3.55.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1006403","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000}}],"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1065638"],"award-info":[{"award-number":["1065638"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1006403","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T17:29:58Z","timestamp":1539278998000},"page":"e1006403","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":51,"title":["Seizure pathways: A model-based investigation"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9879-5854","authenticated-orcid":true,"given":"Philippa J.","family":"Karoly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levin","family":"Kuhlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Soudry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5497-7234","authenticated-orcid":true,"given":"David B.","family":"Grayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark J.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2411-5358","authenticated-orcid":true,"given":"Dean R.","family":"Freestone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,10,11]]},"reference":[{"issue":"5","key":"ref1","first-page":"314","article-title":"Early identification of refractory epilepsy","volume":"342","author":"Patrick Kwan","year":"2000"},{"issue":"5","key":"ref2","first-page":"1188","article-title":"Long-term seizure outcomes following epilepsy surgery: a systematic review and meta-analysis","volume":"128","author":"F T\u00e9llez-Zenteno Jos\u00e9","year":"2005"},{"issue":"3","key":"ref3","first-page":"279","article-title":"Treatment outcomes in patients with newly diagnosed epilepsy treated with established and new antiepileptic drugs: a 30-year longitudinal cohort study","volume":"75","author":"Zhibin Chen","year":"2018"},{"issue":"3","key":"ref4","first-page":"340","article-title":"Dynamic models of large-scale brain activity","volume":"20","author":"Michael Breakspear","year":"2017"},{"key":"ref5","first-page":"161","article-title":"<italic>Validating Neuro-Computational Models of Neurological and Psychiatric Disorders<\/italic>","author":"Wessel Woldman","year":"2015"},{"issue":"16","key":"ref6","first-page":"5953","article-title":"Understanding epilepsy through network modeling","volume":"105","author":"Astrid A Prinz","year":"2008"},{"issue":"1","key":"ref7","first-page":"1","article-title":"Excitatory and inhibitory interactions in localized populations of model neurons","volume":"12","author":"Hugh R Wilson","year":"1972"},{"issue":"4","key":"ref8","first-page":"357","article-title":"Electroencephalogram and visual evoked potential generation in a mathematical model of coupled cortical columns","volume":"73","author":"Ben H Jansen","year":"1995"},{"issue":"2","key":"ref9","first-page":"2118","article-title":"The dynamics of neurological disease: integrating computational, experimental and clinical neuroscience","volume":"36","author":"Stephen Coombes","year":"2012"},{"issue":"9","key":"ref10","first-page":"1499","article-title":"Epileptic fast activity can be explained by a model of impaired gabaergic dendritic inhibition","volume":"15","author":"Wendling F","year":"2002"},{"issue":"3","key":"ref11","first-page":"1743","article-title":"A neural mass model for MEG\/EEG:: coupling and neuronal dynamics","volume":"20","author":"Olivier David","year":"2003"},{"issue":"s12","key":"ref12","first-page":"72","article-title":"Epilepsies as dynamical diseases of brain systems: basic models of the transition between normal and epileptic activity","volume":"44","author":"Fernando Lopes Da Silva","year":"2003"},{"issue":"3","key":"ref13","first-page":"2374","article-title":"Characterising the dynamics of EEG waveforms as the path through parameter space of a neural mass model: application to epilepsy seizure evolution","volume":"59","author":"Alejo J. Nevado-Holgado","year":"2012"},{"key":"ref14","first-page":"89","article-title":"Epilepsy: Ever-changing states of cortical excitability","volume":"222","author":"R. a. B. Badawy","year":"2012"},{"issue":"10","key":"ref15","article-title":"A computational biomarker of idiopathic generalized epilepsy from resting state EEG","volume":"57","author":"Helmut Schmidt","year":"2016"},{"issue":"5","key":"ref16","first-page":"1170","article-title":"Virtual cortical resection reveals push-pull network control preceding seizure evolution","volume":"91","author":"Ankit N Khambhati","year":"2016"},{"key":"ref17","first-page":"29215","article-title":"Estimation of brain network ictogenicity predicts outcome from epilepsy surgery","volume":"6","author":"M Goodfellow","year":"2016"},{"issue":"3","key":"ref18","first-page":"641","article-title":"Individual brain structure and modelling predict seizure propagation","volume":"140","author":"Timoth\u00e9e Proix","year":"2017"},{"issue":"2","key":"ref19","first-page":"319","article-title":"Predicting neurosurgical outcomes in focal epilepsy patients using computational modelling","volume":"140","author":"Nishant Sinha","year":"2016"},{"issue":"11","key":"ref20","first-page":"73","article-title":"Seizure prediction: science fiction or soon to become reality?","volume":"15","author":"Dean R Freestone","year":"2015"},{"issue":"3","key":"ref21","first-page":"220","article-title":"The role of multiple-scale modelling of epilepsy in seizure forecasting","volume":"32","author":"Levin Kuhlmann","year":"2015"},{"issue":"4","key":"ref22","first-page":"041928","article-title":"Bifurcation control of a seizing human cortex","volume":"73","author":"Mark A Kramer","year":"2006"},{"key":"ref23","first-page":"202","article-title":"Optimal control based seizure abatement using patient derived connectivity","volume":"9","author":"Peter N Taylor","year":"2015"},{"issue":"12","key":"ref24","first-page":"e114316","article-title":"A computational study of stimulus driven epileptic seizure abatement","volume":"9","author":"Peter Neal Taylor","year":"2014"},{"key":"ref25","article-title":"Estimation of effective connectivity via data-driven neural modeling","volume":"8","author":"Dean R. Freestone","year":"2014"},{"key":"ref26","article-title":"<italic>Neural control engineering: the emerging intersection between control theory and neuroscience<\/italic>","author":"Steven J Schiff","year":"2012"},{"key":"ref27","article-title":"<italic>Optimal state estimation Kalman H infinity and nonlinear approaches<\/italic>","author":"Dan Simon","year":"2006"},{"issue":"2","key":"ref28","first-page":"312","article-title":"Dynamic causal modelling: a critical review of the biophysical and statistical foundations","volume":"58","author":"Jean Daunizeau","year":"2011"},{"issue":"4","key":"ref29","first-page":"1273","article-title":"Dynamic causal modelling","volume":"19","author":"Karl J. Friston","year":"2003"},{"issue":"1","key":"ref30","first-page":"35","article-title":"A new approach to linear filtering and prediction problems","volume":"82","author":"Rudolph Emil Kalman","year":"1960"},{"issue":"01","key":"ref31","first-page":"1650045","article-title":"Statistical performance analysis of data-driven neural models","volume":"27","author":"Dean R Freestone","year":"2017"},{"key":"ref32","first-page":"563","article-title":"Model-based estimation of intra-cortical connectivity using electrophysiological data","volume":"118","author":"Parham Aram","year":"2015"},{"issue":"3","key":"ref33","first-page":"1043","article-title":"A data-driven framework for neural field modeling","volume":"56","author":"Dean R Freestone","year":"2011"},{"key":"ref34","first-page":"438","article-title":"Neural mass model-based tracking of anesthetic brain states","volume":"133","author":"Levin Kuhlmann","year":"2016"},{"key":"ref35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0192842","article-title":"Bifurcation analysis of two coupled jansen-rit neural mass models","author":"Saeed Ahmadizadeh","year":"2018"},{"issue":"3","key":"ref36","first-page":"524","article-title":"Dynamics of epileptic phenomena determined from statistics of ictal transitions","volume":"53","author":"Piotr Suffczynski","year":"2006"},{"issue":"3","key":"ref37","first-page":"359","article-title":"Human focal seizures are characterized by populations of fixed duration and interval","volume":"57","author":"Mark J. Cook","year":"2016"},{"issue":"6","key":"ref38","first-page":"563","article-title":"Prediction of seizure likelihood with a long-term, implanted seizure advisory system in patients with drug-resistant epilepsy: a first-in-man study","volume":"12","author":"Mark J. Cook","year":"2013"},{"issue":"2","key":"ref39","first-page":"411","article-title":"Estimating the number of clusters in a data set via the gap statistic","volume":"63","author":"Robert Tibshirani","year":"2001"},{"issue":"5","key":"ref40","first-page":"930","article-title":"Seizure prediction in hippocampal and neocortical epilepsy using a model-based approach","volume":"125","author":"Ardalan Aarabi","year":"2014"},{"issue":"3","key":"ref41","first-page":"920","article-title":"Intermittent spike\u2013wave dynamics in a heterogeneous, spatially extended neural mass model","volume":"55","author":"Marc Goodfellow","year":"2011"},{"issue":"1","key":"ref42","first-page":"17","article-title":"Mechanisms of intermittent state transitions in a coupled heterogeneous oscillator model of epilepsy","volume":"3","author":"Marc Goodfellow","year":"2013"},{"issue":"8","key":"ref43","first-page":"2210","article-title":"On the nature of seizure dynamics","volume":"137","author":"Viktor K. Jirsa","year":"2014"},{"issue":"51","key":"ref44","first-page":"21116","article-title":"Human seizures self-terminate across spatial scales via a critical transition","volume":"109","author":"Mark A. Kramer","year":"2012"},{"issue":"7260","key":"ref45","first-page":"53","article-title":"Early-warning signals for critical transitions","volume":"461","author":"Marten Scheffer","year":"2009"},{"issue":"1","key":"ref46","first-page":"1","article-title":"A phenomenological model of seizure initiation suggests network structure may explain seizure frequency in idiopathic generalised epilepsy","volume":"2","author":"Oscar Benjamin","year":"2012"},{"issue":"2","key":"ref47","first-page":"467","article-title":"Dynamics of non-convulsive epileptic phenomena modeled by a bistable neuronal network","volume":"126","author":"Suffczynski P.","year":"2004"},{"issue":"2","key":"ref48","first-page":"261","article-title":"Seizure severity and duration in the cortical stimulation model of experimental epilepsy in rats: A longitudinal study","volume":"89","author":"Timothy S Nelson","year":"2010"},{"issue":"5","key":"ref49","first-page":"e1005475","article-title":"Mechanisms underlying different onset patterns of focal seizures","volume":"13","author":"Yujiang Wang","year":"2017"},{"issue":"5","key":"ref50","first-page":"1027","article-title":"Postictal suppression and seizure durations: A patient-specific, long-term ieeg analysis","volume":"59","author":"Daniel E Payne","year":"2018"},{"key":"ref51","article-title":"Seizure onset predicts its type","author":"Cristian Donos","year":"2018"},{"issue":"3","key":"ref52","first-page":"511","article-title":"An open hypothesis: is epilepsy learned, and can it be unlearned?","volume":"13","author":"David Hsu","year":"2008"},{"key":"ref53","article-title":"Dynamics underlying interictal to ictal transition in temporal lobe epilepsy: insights from a neural mass model","author":"Xiaoya Fan","year":"2017"},{"issue":"2","key":"ref54","first-page":"2188","article-title":"The dynamic evolution of focal-onset epilepsies\u2013combining theoretical and clinical observations","volume":"36","author":"Alex Blenkinsop","year":"2012"},{"key":"ref55","first-page":"1142","article-title":"Dynamic causal modelling of electrographic seizure activity using bayesian belief updating","volume":"125","author":"Gerald K Cooray","year":"2016"},{"issue":"3","key":"ref56","first-page":"1634","article-title":"Dynamic causal modelling of epileptic seizure propagation pathways: a combined eeg\u2013fmri study","volume":"62","author":"Teresa Murta","year":"2012"},{"key":"ref57","first-page":"117","article-title":"Tracking slow modulations in synaptic gain using dynamic causal modelling: validation in epilepsy","volume":"107","author":"Margarita Papadopoulou","year":"2015"},{"key":"ref58","first-page":"377","article-title":"The virtual epileptic patient: individualized whole-brain models of epilepsy spread","volume":"145","author":"Viktor K. Jirsa","year":"2017"},{"issue":"11","key":"ref59","article-title":"Quantifying antiepileptic drug effects using intrinsic excitability measures","volume":"57","author":"Christian Meisel","year":"2016"},{"issue":"47","key":"ref60","first-page":"14694","article-title":"Intrinsic excitability measures track antiepileptic drug action and uncover increasing\/decreasing excitability over the wake\/sleep cycle","volume":"112","author":"Christian Meisel","year":"2015"},{"issue":"2","key":"ref61","first-page":"203","article-title":"Neural mass models as a tool to investigate neural dynamics during seizures","volume":"42","author":"Tatiana Kameneva","year":"2017"},{"issue":"3","key":"ref62","first-page":"235","article-title":"Collaborating and sharing data in epilepsy research","volume":"32","author":"Joost B Wagenaar","year":"2015"},{"issue":"12","key":"ref63","first-page":"3232","article-title":"Neural mass activity, bifurcations, and epilepsy","volume":"23","author":"Jonathan Touboul","year":"2011"},{"key":"ref64","article-title":"<italic>Mass action in the nervous system<\/italic>","author":"J Walter","year":"1975"},{"issue":"8","key":"ref65","first-page":"e1000092","article-title":"The dynamic brain: from spiking neurons to neural masses and cortical fields","volume":"4","author":"Gustavo Deco","year":"2008"},{"issue":"4","key":"ref66","first-page":"360","article-title":"Epilepsy as a disorder of cortical network organization","volume":"18","author":"Mark A. Kramer","year":"2012"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1006403","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006403","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T15:59:38Z","timestamp":1589039978000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006403"}},"subtitle":[],"editor":[{"given":"Daniele","family":"Marinazzo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,10,11]]},"references-count":66,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1006403","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1006403","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,11]]}}}