{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T22:17:41Z","timestamp":1790461061908,"version":"4.1.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1006513","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000}}],"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universit\u00e9 de Recherche Paris Sciences et Lettres (FR)","award":["PSL IDEX REFLEX"],"award-info":[{"award-number":["PSL IDEX REFLEX"]}]},{"DOI":"10.13039\/501100004097","name":"Fondation ARC pour la Recherche sur le Cancer","doi-asserted-by":"publisher","award":["PJA20151203341"],"award-info":[{"award-number":["PJA20151203341"]}],"id":[{"id":"10.13039\/501100004097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-11-LABX-0044 DEEP"],"award-info":[{"award-number":["ANR-11-LABX-0044 DEEP"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009517","name":"Universit\u00e9 de Recherche Paris Sciences et Lettres","doi-asserted-by":"publisher","award":["ANR-10-IDEX-0001-02"],"award-info":[{"award-number":["ANR-10-IDEX-0001-02"]}],"id":[{"id":"10.13039\/501100009517","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1006513","type":"journal-article","created":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T13:30:11Z","timestamp":1539264611000},"page":"e1006513","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":38,"title":["Precision in a rush: Trade-offs between reproducibility and steepness of the hunchback expression pattern"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9057-060X","authenticated-orcid":true,"given":"Huy","family":"Tran","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7112-3217","authenticated-orcid":true,"given":"Jonathan","family":"Desponds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1696-4368","authenticated-orcid":true,"given":"Carmina Angelica","family":"Perez Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8924-3233","authenticated-orcid":true,"given":"Mathieu","family":"Coppey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-4953","authenticated-orcid":true,"given":"Cecile","family":"Fradin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Dostatni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2686-5702","authenticated-orcid":true,"given":"Aleksandra M.","family":"Walczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,10,11]]},"reference":[{"issue":"23","key":"ref1","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1016\/j.cub.2012.09.051","article-title":"Precision of hunchback expression in the Drosophila embryo","volume":"22","author":"MW Perry","year":"2012","journal-title":"Current Biology"},{"issue":"33","key":"ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1073\/pnas.1109873108","article-title":"Multiple enhancers ensure precision of gap gene-expression patterns in the Drosophila embryo","volume":"108","author":"MW Perry","year":"2011","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6873","key":"ref3","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1038\/415798a","article-title":"Establishment of developmental precision and proportions in the early Drosophila embryo","volume":"415","author":"B Houchmandzadeh","year":"2002","journal-title":"Nature"},{"issue":"51","key":"ref4","doi-asserted-by":"crossref","first-page":"18403","DOI":"10.1073\/pnas.0509483102","article-title":"Diffusion and scaling during early embryonic pattern formation","volume":"102","author":"T Gregor","year":"2005","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cell.2007.05.026","article-title":"Stability and nuclear dynamics of the Bicoid morphogen gradient","volume":"130","author":"T Gregor","year":"2007","journal-title":"Cell"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0092-8674(88)90183-3","article-title":"The Bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner","volume":"54","author":"W Driever","year":"1988","journal-title":"Cell"},{"issue":"6232","key":"ref7","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/340363a0","article-title":"Determination of spatial domains of zygotic gene expression in the Drosophila embryo by the affinity of binding sites for the bicoid morphogen","volume":"340","author":"W Driever","year":"1989","journal-title":"Nature"},{"issue":"21","key":"ref8","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cub.2005.09.046","article-title":"Bicoid determines sharp and precise target gene expression in the Drosophila embryo","volume":"15","author":"O Crauk","year":"2005","journal-title":"Current Biology"},{"issue":"16","key":"ref9","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1242\/dev.051300","article-title":"The time to measure positional information: maternal hunchback is required for the synchrony of the Bicoid transcriptional response at the onset of zygotic transcription","volume":"137","author":"A Porcher","year":"2010","journal-title":"Development"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00018-010-0536-y","article-title":"The gap gene network","volume":"68","author":"J Jaeger","year":"2011","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cub.2010.01.026","article-title":"The Bicoid morphogen system","volume":"20","author":"A Porcher","year":"2010","journal-title":"Current Biology"},{"issue":"21","key":"ref12","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1016\/j.cub.2013.08.053","article-title":"Live imaging of Bicoid-dependent transcription in Drosophila embryos","volume":"23","author":"T Lucas","year":"2013","journal-title":"Current Biology"},{"key":"ref13","article-title":"Precision in a rush: trade-offs between positioning and steepness of the hunchback expression pattern","author":"T Lucas","year":"2018","journal-title":"bioRxiv"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S1097-2765(00)80143-4","article-title":"Localization of ASH1 mRNA particles in living yeast","volume":"2","author":"E Bertrand","year":"1998","journal-title":"Molecular Cell"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.cell.2007.05.025","article-title":"Probing the limits to positional information","volume":"130","author":"T Gregor","year":"2007","journal-title":"Cell"},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nmeth.3446","article-title":"Combining protein and mRNA quantification to decipher transcriptional regulation","volume":"12","author":"H Xu","year":"2015","journal-title":"Nature methods"},{"issue":"2","key":"ref17","first-page":"181","article-title":"The role of Bicoid cooperative binding in the patterning of sharp borders in Drosophila melanogaster","volume":"72","author":"FJ Lopes","year":"2011","journal-title":"Developmental Biology"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.cell.2016.06.012","article-title":"Information integration and energy expenditure in gene regulation","volume":"166","author":"J Estrada","year":"2016","journal-title":"Cell"},{"issue":"14","key":"ref19","doi-asserted-by":"crossref","first-page":"4960","DOI":"10.1073\/pnas.0500373102","article-title":"The role of binding site cluster strength in Bicoid-dependent patterning in Drosophila","volume":"102","author":"A Ochoa-Espinosa","year":"2005","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1242\/dev.122.4.1195","article-title":"The Drosophila morphogenetic protein Bicoid binds DNA cooperatively","volume":"122","author":"X Ma","year":"1996","journal-title":"Development (Cambridge, England)"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1073\/pnas.011589998","article-title":"Receptor sensitivity in bacterial chemotaxis","volume":"99","author":"V Sourjik","year":"2002","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6680","key":"ref22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/30018","article-title":"Receptor clustering as a cellular mechanism to control sensitivity","volume":"393","author":"D Bray","year":"1998","journal-title":"Nature"},{"issue":"6976","key":"ref23","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nature02298","article-title":"Multistability in the lactose utilization network of Escherichia coli","volume":"427","author":"EM Ozbudak","year":"2004","journal-title":"Nature"},{"issue":"21","key":"ref24","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1016\/j.cub.2013.08.054","article-title":"Quantitative imaging of transcription in living Drosophila embryos links polymerase activity to patterning","volume":"23","author":"HG Garcia","year":"2013","journal-title":"Current Biology"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"e1005256","DOI":"10.1371\/journal.pcbi.1005256","article-title":"Precision of readout at the hunchback gene: analyzing short transcription time traces in living fly embryos","volume":"12","author":"J Desponds","year":"2016","journal-title":"PLOS Computational Biology"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0006-3495(77)85544-6","article-title":"Physics of chemoreception","volume":"20","author":"HC Berg","year":"1977","journal-title":"Biophysical Journal"},{"issue":"29","key":"ref27","doi-asserted-by":"crossref","first-page":"10040","DOI":"10.1073\/pnas.0504321102","article-title":"Physical limits to biochemical signaling","volume":"102","author":"W Bialek","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"12","key":"ref28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1063\/1.4816105","article-title":"Effect of ligand diffusion on occupancy fluctuations of cell-surface receptors","volume":"139","author":"AM Berezhkovskii","year":"2013","journal-title":"Journal of Chemical Physics"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.bpj.2013.12.030","article-title":"The Berg-Purcell limit revisited","volume":"106","author":"K Kaizu","year":"2014","journal-title":"Biophysical Journal"},{"issue":"17","key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1103\/PhysRevLett.107.178101","article-title":"Dynamics of cooperativity in chemical sensing among cell-surface receptors","volume":"107","author":"M Skoge","year":"2011","journal-title":"Physical Review Letters"},{"issue":"25","key":"ref31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1103\/PhysRevLett.100.258101","article-title":"Cooperativity, sensitivity, and noise in biochemical signaling","volume":"100","author":"W Bialek","year":"2008","journal-title":"Physical Review Letters"},{"key":"ref32","first-page":"4","article-title":"The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curves","volume":"40","author":"AV Hill","year":"1910","journal-title":"Journal of Physiology"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bpj.2010.05.031","article-title":"High mobility of bicoid captured by fluorescence correlation spectroscopy: Implication for the rapid establishment of its gradient","volume":"99","author":"A Abu-Arish","year":"2010","journal-title":"Biophysical Journal"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s10955-015-1440-5","article-title":"Fundamental limits to cellular sensing","volume":"162","author":"PR ten Wolde","year":"2016","journal-title":"Journal of Statistical Physics"},{"issue":"25","key":"ref35","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1103\/PhysRevLett.103.258101","article-title":"Role of spatial averaging in the precision of gene expression patterns","volume":"103","author":"T Erdmann","year":"2009","journal-title":"Physical Review Letters"},{"issue":"7","key":"ref36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cell.2018.03.069","article-title":"LlamaTags: A versatile tool to image transcription factor dynamics in live embryos","volume":"173","author":"JP Bothma","year":"2018","journal-title":"Cell"},{"issue":"41","key":"ref37","doi-asserted-by":"crossref","first-page":"16301","DOI":"10.1073\/pnas.1315642110","article-title":"Positional information, in bits","volume":"110","author":"JO Dubuis","year":"2013","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1534\/genetics.114.171850","article-title":"Positional information, positional error, and readout precision in morphogenesis: A mathematical framework","volume":"199","author":"G Tkacik","year":"2015","journal-title":"Genetics"},{"issue":"8","key":"ref39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002654","article-title":"Mutual repression enhances the steepness and precision of gene expression boundaries","volume":"8","author":"TR Sokolowski","year":"2012","journal-title":"PLoS Computational Biology"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1101\/gad.14.2.224","article-title":"Relief of gene repression by Torso RTK signaling: Role of capicua in Drosophila terminal and dorsoventral patterning","volume":"14","author":"G Jim\u00e9nez","year":"2000","journal-title":"Genes and Development"},{"issue":"20","key":"ref41","doi-asserted-by":"crossref","first-page":"5998","DOI":"10.1093\/emboj\/17.20.5998","article-title":"Cooperative DNA-binding by Bicoid provides a mechanism for threshold-dependent gene activation in the Drosophila embryo","volume":"17","author":"DS Burz","year":"1998","journal-title":"EMBO Journal"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"052707","DOI":"10.1103\/PhysRevE.91.052707","article-title":"Properties of cooperatively induced phases in sensing models","volume":"91","author":"SA Sevier","year":"2015","journal-title":"Physical Review E"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e28275:1","DOI":"10.7554\/eLife.28275","article-title":"Concentration dependent chromatin states induced by the bicoid morphogen gradient","volume":"6","author":"CE Hannon","year":"2017","journal-title":"eLife"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1529\/biophysj.104.050765","article-title":"Kinetics of protein-DNA interaction: Facilitated target location in sequence-dependent potential","volume":"87","author":"M Slutsky","year":"2004","journal-title":"Biophysical Journal"},{"key":"ref45","unstructured":"Zoller B, Little SC, Gregor T. Diverse spatial expression patterns emerge from common transcription bursting kinetics."},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.03939","article-title":"Kinetic competition during the transcription cycle results in stochastic RNA processing","volume":"3","author":"A Coulon","year":"2014","journal-title":"eLife"},{"issue":"12","key":"ref47","first-page":"1","article-title":"Stochastic kinetics of nascent RNA","volume":"117","author":"H Xu","year":"2016","journal-title":"Physical Review Letters"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.celrep.2012.06.004","article-title":"Operator sequence alters gene expression independently of transcription factor occupancy in bacteria","volume":"2","author":"HG Garcia","year":"2012","journal-title":"Cell Reports"},{"issue":"6216","key":"ref49","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1126\/science.1255301","article-title":"Promoter architecture dictates cell-to-cell variability in gene expression","volume":"346","author":"DL Jones","year":"2014","journal-title":"Science"},{"key":"ref50","first-page":"1","article-title":"Temperature-dependent model of multi-step transcription initiation in Escherichia coli based on live single-cell measurements","author":"SMD Oliveira","year":"2016","journal-title":"PLoS computational biology"},{"issue":"5717","key":"ref51","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1126\/science.1106914","article-title":"Gene regulation at the single-cell level","volume":"307","author":"N Rosenfeld","year":"2005","journal-title":"Science"},{"issue":"12","key":"ref52","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1038\/ng.281","article-title":"Regulatory activity revealed by dynamic correlations in gene expression noise","volume":"40","author":"MJ Dunlop","year":"2008","journal-title":"Nature genetics"},{"issue":"2","key":"ref53","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1242\/dev.109.2.271","article-title":"Effects of ectopic expression of caudal during Drosophila development","volume":"109","author":"M Mlodzik","year":"1990","journal-title":"Development"},{"issue":"20","key":"ref54","doi-asserted-by":"crossref","first-page":"3973","DOI":"10.1242\/dev.02576","article-title":"A caudal mRNA gradient controls posterior development in the wasp Nasonia","volume":"133","author":"EC Olesnicky","year":"2006","journal-title":"Development"},{"issue":"6345","key":"ref55","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1126\/science.aam5887","article-title":"Decoding of position in the developing neural tube from antiparallel morphogen gradients","volume":"356","author":"M Zagorski","year":"2017","journal-title":"Science"},{"issue":"51","key":"ref56","doi-asserted-by":"crossref","first-page":"21695","DOI":"10.1073\/pnas.0910225106","article-title":"Antagonistic action of Bicoid and the repressor Capicua determines the spatial limits of Drosophila head gene expression domains","volume":"106","author":"U L\u00f6hr","year":"2009","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"3","key":"ref57","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4161\/fly.4.3.11862","article-title":"Bicoid\u2014morphogen function revisited","volume":"4","author":"U L\u00f6hr","year":"2010","journal-title":"Fly"},{"issue":"3","key":"ref58","doi-asserted-by":"crossref","first-page":"032702","DOI":"10.1103\/PhysRevE.90.032702","article-title":"How input noise limits biochemical sensing in ultrasensitive systems","volume":"90","author":"B Hu","year":"2014","journal-title":"Physical Review E"},{"key":"ref59","article-title":"An energy-speed-accuracy relation in complex networks for biological discrimination","author":"F Wong","year":"2017","journal-title":"arXiv"},{"issue":"5","key":"ref60","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1007\/s10955-015-1332-8","article-title":"Trade-offs in delayed information transmission in biochemical networks","volume":"162","author":"F Mancini","year":"2015","journal-title":"Journal of Statistical Physics"},{"issue":"17","key":"ref61","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1101\/gad.305078.117","article-title":"Dense bicoid hubs accentuate binding along the morphogen gradient","volume":"31","author":"M Mir","year":"2017","journal-title":"Genes and Development"},{"issue":"9","key":"ref62","doi-asserted-by":"crossref","first-page":"3067","DOI":"10.1242\/dev.121.9.3067","article-title":"Posterior stripe expression of hunchback is driven from two promoters by a common enhancer element","volume":"121","author":"JS Margolis","year":"1995","journal-title":"Development"},{"issue":"2","key":"ref63","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1101\/gad.12.2.246","article-title":"Regulation of POU genes by castor and hunchback establishes layered compartments in the Drosophila CNS","volume":"12","author":"R Kambadur","year":"1998","journal-title":"Genes & Development"},{"issue":"5462","key":"ref64","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1126\/science.287.5462.2476","article-title":"bicoid-independent formation of thoracic segments in Drosophila","volume":"287","author":"EA Wimmer","year":"2000","journal-title":"Science"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.26258","article-title":"Decoding temporal interpretation of the morphogen bicoid in the early drosophila embryo","volume":"6","author":"A Huang","year":"2017","journal-title":"eLife"},{"issue":"5","key":"ref66","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036321","article-title":"A linear framework for time-scale separation in nonlinear biochemical systems","volume":"7","author":"J Gunawardena","year":"2012","journal-title":"PLoS ONE"},{"issue":"4","key":"ref67","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0021-9991(76)90041-3","article-title":"A general method for numerically simulating the stochastic time evolution of coupled chemical reactions","volume":"22","author":"DT Gillespie","year":"1976","journal-title":"Journal of Computational Physics"},{"issue":"25","key":"ref68","doi-asserted-by":"crossref","first-page":"2340","DOI":"10.1021\/j100540a008","article-title":"Exact stochastic simulation of coupled chemical reactions","volume":"81","author":"DT Gillespie","year":"1977","journal-title":"Journal of Physical Chemistry"},{"issue":"22","key":"ref69","doi-asserted-by":"crossref","first-page":"3004","DOI":"10.1093\/bioinformatics\/bts556","article-title":"SGNS2: A compartmentalized stochastic chemical kinetics simulator for dynamic cell populations","volume":"28","author":"J Lloyd-Price","year":"2012","journal-title":"Bioinformatics"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1006513","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T00:00:00Z","timestamp":1540252800000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T17:06:24Z","timestamp":1662224784000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006513"}},"subtitle":[],"editor":[{"given":"James","family":"Briscoe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,10,11]]},"references-count":69,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1006513","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/305532","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,11]]}}}