{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:09:37Z","timestamp":1780081777732,"version":"3.54.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1006515","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000}}],"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"L\u2019Or\u00e9al-UNESCO"},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/K020420"],"award-info":[{"award-number":["MR\/K020420"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["400760\/2014-2"],"award-info":[{"award-number":["400760\/2014-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1U01CA207160)"],"award-info":[{"award-number":["1U01CA207160)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005285","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Goi\u00e1s","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1006515","type":"journal-article","created":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T17:28:59Z","timestamp":1540229339000},"page":"e1006515","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Computationally-guided drug repurposing enables the discovery of kinase targets and inhibitors as new schistosomicidal agents"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2302-414X","authenticated-orcid":true,"given":"Sandra","family":"Giuliani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9866-3344","authenticated-orcid":true,"given":"Arthur C.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce V. V. B.","family":"Borba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9075-7861","authenticated-orcid":true,"given":"Pablo I. P.","family":"Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross A.","family":"Paveley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene N.","family":"Muratov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0101-1492","authenticated-orcid":true,"given":"Carolina Horta","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7532-1269","authenticated-orcid":true,"given":"Nicholas","family":"Furnham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,10,22]]},"reference":[{"issue":"9936","key":"ref1","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1016\/S0140-6736(13)61949-2","article-title":"Human schistosomiasis","volume":"383","author":"DG Colley","year":"2014","journal-title":"Lancet"},{"key":"ref2","unstructured":"World Health Organization. Schistosomiasis 2015;Fact sheet N\u00b0115."},{"issue":"14","key":"ref3","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.ijpara.2014.07.009","article-title":"Trends in schistosomiasis-related mortality in Brazil, 2000\u20132011","volume":"44","author":"FR Martins-Melo","year":"2014","journal-title":"Int J Parasitol"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.pt.2003.11.010","article-title":"Schistosomiasis control: keep taking the tablets","volume":"20","author":"P Hagan","year":"2004","journal-title":"Trends Parasitol"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00436-012-3151-z","article-title":"Susceptibility or resistance of praziquantel in human schistosomiasis: a review","volume":"111","author":"W Wang","year":"2012","journal-title":"Parasitol Res"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"e3435","DOI":"10.1371\/journal.pntd.0003435","article-title":"<italic>In silico<\/italic> repositioning-chemogenomics strategy identifies new drugs with potential activity against multiple life stages of <italic>Schistosoma mansoni<\/italic>","volume":"9","author":"BJ Neves","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1039\/C5MD00596E","article-title":"The antidepressant drug paroxetine as a new lead candidate in schistosome drug discovery","volume":"7","author":"BJ Neves","year":"2016","journal-title":"MedChemComm"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1089\/adt.2015.29011.tiodrrr","article-title":"Computational and practical aspects of drug repositioning","volume":"13","author":"TI Oprea","year":"2015","journal-title":"Assay Drug Dev Technol"},{"issue":"8","key":"ref9","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrd1468","article-title":"Drug repositioning: identifying and developing new uses for existing drugs","volume":"3","author":"TT Ashburn","year":"2004","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/cbdd.12209","article-title":"Screening of drug target proteins by 2D ligand matching approach","volume":"83","author":"J Feng","year":"2014","journal-title":"Chem Biol Drug Des"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"e1000423","DOI":"10.1371\/journal.pcbi.1000423","article-title":"Drug discovery using chemical systems biology: repositioning the safe medicine Comtan to treat multi-drug and extensively drug resistant tuberculosis","volume":"5","author":"SL Kinnings","year":"2009","journal-title":"PLoS Comput Biol"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"e1002037","DOI":"10.1371\/journal.pcbi.1002037","article-title":"Drug discovery using chemical systems biology: weak inhibition of multiple kinases may contribute to the anti-cancer effect of nelfinavir","volume":"7","author":"L Xie","year":"2011","journal-title":"PLoS Comput Biol"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"e1000387","DOI":"10.1371\/journal.pcbi.1000387","article-title":"Drug discovery using chemical systems biology: identification of the protein-ligand binding network to explain the side effects of CETP inhibitors","volume":"5","author":"L Xie","year":"2009","journal-title":"PLoS Comput Biol"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nbt1284","article-title":"Relating protein pharmacology by ligand chemistry","volume":"25","author":"MJ Keiser","year":"2007","journal-title":"Nat Biotechnol"},{"issue":"10","key":"ref15","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/cmdc.200600147","article-title":"Predicting compound selectivity by self-organizing maps: cross-activities of metabotropic glutamate receptor antagonists","volume":"1","author":"T Noeske","year":"2006","journal-title":"ChemMedChem"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1186\/s13071-015-1023-y","article-title":"Repurposing of anticancer drugs: in vitro and in vivo activities against <italic>Schistosoma mansoni<\/italic>","volume":"8","author":"N Cowan","year":"2015","journal-title":"Parasit Vectors"},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","first-page":"e0003962","DOI":"10.1371\/journal.pntd.0003962","article-title":"Activity profile of an FDA-approved compound Library against <italic>Schistosoma mansoni<\/italic>","volume":"9","author":"G Panic","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"727","DOI":"10.4155\/fmc.15.26","article-title":"Repurposing pharma assets: an accelerated mechanism for strengthening the schistosomiasis drug development pipeline","volume":"7","author":"R Ramamoorthi","year":"2015","journal-title":"Future Med Chem"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.pt.2010.09.001","article-title":"Piggy-backing the concept of cancer drugs for schistosomiasis treatment: a tangible perspective?","volume":"27","author":"C Dissous","year":"2011","journal-title":"Trends Parasitol"},{"issue":"24","key":"ref20","first-page":"3595","article-title":"The redox biology of schistosome parasites and applications for drug development","volume":"18","author":"HH Huang","year":"2012","journal-title":"Curr Pharm Des"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"707","DOI":"10.4155\/fmc.14.164","article-title":"Repurposing apoptosis-inducing cancer drugs to treat schistosomiasis","volume":"7","author":"EF Lee","year":"2015","journal-title":"Future Med Chem"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1021\/acs.jcim.6b00055","article-title":"QSAR-Driven discovery of novel chemical scaffolds active against <italic>Schistosoma mansoni<\/italic>","volume":"56","author":"CC Melo-Filho","year":"2016","journal-title":"J Chem Inf Model"},{"issue":"15","key":"ref23","doi-asserted-by":"crossref","first-page":"7075","DOI":"10.1021\/acs.jmedchem.5b02038","article-title":"Discovery of new anti-Schistosomal hits by Integration of QSAR-based virtual screening and high content screening","volume":"59","author":"BJ Neves","year":"2016","journal-title":"J Med Chem"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"e0004659","DOI":"10.1371\/journal.pntd.0004659","article-title":"High throughput screening identifies novel lead compounds with activity against larval, juvenile and adult <italic>Schistosoma mansoni<\/italic>","volume":"10","author":"NR Mansour","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1038\/nrd1600","article-title":"Targeting protein kinases","volume":"3","author":"I Melnikova","year":"2004","journal-title":"Nat Rev Drug Discov"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/1471-2164-12-215","article-title":"Eukaryotic Protein kinases (ePKs) of the helminth parasite <italic>Schistosoma mansoni<\/italic>","volume":"12","author":"LF Andrade","year":"2011","journal-title":"BMC Genomics"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.pt.2017.12.001","article-title":"Kinases: Molecular stage directors for Schistosome development and differentiation","volume":"34","author":"CG Grevelding","year":"2018","journal-title":"Trends Parasitol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"17759","DOI":"10.1038\/srep17759","article-title":"Defining the <italic>Schistosoma haematobium<\/italic> kinome enables the prediction of essential kinases as anti-schistosome drug targets","volume":"5","author":"AJ Stroehlein","year":"2015","journal-title":"Scientific Reports"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/j.bbapap.2015.03.002","article-title":"Targeting kinases in <italic>Plasmodium<\/italic> and <italic>Schistosoma<\/italic>: Same goals, different challenges","volume":"1854","author":"C Doerig","year":"2015","journal-title":"Biochimica et Biophysica Acta (BBA)\u2014Proteins and Proteomics"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40360-017-0128-7","article-title":"Large-scale detection of drug off-targets: hypotheses for drug repurposing and understanding side-effects","volume":"18","author":"M Chartier","year":"2017","journal-title":"BMC Pharmacol Toxicol"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"e1762","DOI":"10.1371\/journal.pntd.0001762","article-title":"Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases","volume":"6","author":"RA Paveley","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"D1","key":"ref32","doi-asserted-by":"crossref","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible","volume":"45","author":"D Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/1752-0509-3-102","article-title":"How to identify essential genes from molecular networks?","volume":"3","author":"G del Rio","year":"2009","journal-title":"BMC systems biology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1093\/bioinformatics\/btp517","article-title":"Analyzing biological network parameters with CentiScaPe","volume":"25","author":"G Scardoni","year":"2009","journal-title":"Bioinformatics"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ijpara.2010.01.007","article-title":"Imatinib has a fatal impact on morphology, pairing stability and survival of adult <italic>Schistosoma mansoni<\/italic> in vitro","volume":"40","author":"S Beckmann","year":"2010","journal-title":"Int J Parasitol"},{"issue":"7253","key":"ref36","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/nature08160","article-title":"The genome of the blood fluke <italic>Schistosoma mansoni<\/italic>","volume":"460","author":"M Berriman","year":"2009","journal-title":"Nature"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1590\/0074-0276130207","article-title":"Imatinib activity on <italic>Schistosoma mansoni<\/italic>","volume":"108","author":"N Katz","year":"2013","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1186\/s13071-016-1616-0","article-title":"Evaluation of an FDA approved library against laboratory models of human intestinal nematode infections","volume":"9","author":"J Keiser","year":"2016","journal-title":"Parasit Vectors"},{"issue":"24","key":"ref39","first-page":"3579","article-title":"Protein kinases as potential targets for novel anti-schistosomal strategies","volume":"18","author":"S Beckmann","year":"2012","journal-title":"Curr Pharm Des"},{"issue":"12","key":"ref40","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1002\/bies.20662","article-title":"Protein tyrosine kinases as new potential targets against human schistosomiasis","volume":"29","author":"C Dissous","year":"2007","journal-title":"Bioessays"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1586\/14787210.4.2.199","article-title":"Praziquantel for the treatment of schistosomiasis: its use for control in areas with endemic disease and prospects for drug resistance","volume":"4","author":"MJ Doenhoff","year":"2006","journal-title":"Expert Rev Anti Infect Ther"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/j.bbapap.2013.02.022","article-title":"Nima- and Aurora-related kinases of malaria parasites","volume":"1834","author":"TG Carvalho","year":"2013","journal-title":"Biochimica et Biophysica Acta\u2014Proteins and Proteomics"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"11280","DOI":"10.1021\/cr500197d","article-title":"Kinases as druggable targets in Trypanosomatid protozoan parasites","volume":"114","author":"C Merritt","year":"2014","journal-title":"Chemical Reviews"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"e1988","DOI":"10.1371\/journal.pntd.0001988","article-title":"Functional mapping of protein kinase A reveals its importance in adult <italic>Schistosoma mansoni<\/italic> motor activity","volume":"7","author":"PSR de Saram","year":"2013","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1590\/S0001-37652011000200022","article-title":"<italic>Schistosoma mansoni<\/italic> Polo-like kinases and their function in control of mitosis and parasite reproduction","volume":"83","author":"C Dissous","year":"2011","journal-title":"Anais da Academia Brasileira de Ci\u00eancias"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"737","DOI":"10.4155\/fmc.15.31","article-title":"Re-positioning protein-kinase inhibitors against schistosomiasis","volume":"7","author":"V Gelmedin","year":"2015","journal-title":"Future Medicinal Chemistry"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"e40045","DOI":"10.1371\/journal.pone.0040045","article-title":"SmSak, the second Polo-like kinase of the helminth parasite <italic>Schistosoma mansoni<\/italic>: Conserved and unexpected roles in meiosis","volume":"7","author":"T Long","year":"2012","journal-title":"PLoS ONE"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e2949","DOI":"10.1371\/journal.pntd.0002949","article-title":"Regulation of <italic>Schistosoma mansoni<\/italic> development and reproduction by the mitogen-activated protein kinase signaling pathway","volume":"8","author":"LFD Andrade","year":"2014","journal-title":"PLoS neglected tropical diseases"},{"key":"ref49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002924","article-title":"Protein linase C and extracellular signal-regulated kiinase regulate movement, attachment, pairing and egg release in <italic>Schistosoma mansoni<\/italic>","volume":"8","author":"M Ressurrei\u00e7\u00e3o","year":"2014","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.molbiopara.2011.07.002","article-title":"A role for p38 mitogen-activated protein kinase in early post-embryonic development of <italic>Schistosoma mansoni<\/italic>","volume":"180","author":"M Ressurrei\u00e7\u00e3o","year":"2011","journal-title":"Molecular and Biochemical Parasitology"},{"issue":"7253","key":"ref51","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature08140","article-title":"The <italic>Schistosoma japonicum<\/italic> genome reveals features of host-parasite interplay","volume":"460","year":"2009","journal-title":"Nature"},{"issue":"Database issue","key":"ref52","doi-asserted-by":"crossref","first-page":"D1083","DOI":"10.1093\/nar\/gkt1031","article-title":"The ChEMBL bioactivity database: an update","volume":"42","author":"AP Bento","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1.28.1","DOI":"10.1002\/0471250953.bi0128s50","article-title":"Using CATH-Gene3D to analyze the sequence, structure, and function of proteins","volume":"50","author":"I Sillitoe","year":"2015","journal-title":"Curr Protoc Bioinformatics"},{"issue":"D1","key":"ref54","doi-asserted-by":"crossref","first-page":"D279","DOI":"10.1093\/nar\/gkv1344","article-title":"The Pfam protein families database: towards a more sustainable future","volume":"44","author":"RD Finn","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"9","key":"ref55","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/bioinformatics\/btq119","article-title":"ArchSchema: a tool for interactive graphing of related Pfam domain architectures","volume":"26","author":"AU Tamuri","year":"2010","journal-title":"Bioinformatics"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1.29.1","DOI":"10.1002\/0471250953.bi0129s53","article-title":"UniProt tools","volume":"53","author":"S Pundir","year":"2016","journal-title":"Curr Protoc Bioinformatics"},{"issue":"D1","key":"ref57","doi-asserted-by":"crossref","first-page":"D317","DOI":"10.1093\/nar\/gkv1274","article-title":"FunTree: advances in a resource for exploring and contextualising protein function evolution","volume":"44","author":"I Sillitoe","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"D1","key":"ref58","doi-asserted-by":"crossref","first-page":"D385","DOI":"10.1093\/nar\/gkv1047","article-title":"PDBe: improved accessibility of macromolecular structure data from PDB and EMDB","volume":"44","author":"S Velankar","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1758-2946-1-12","article-title":"Small Molecule Subgraph Detector (SMSD) toolkit","volume":"1","author":"SA Rahman","year":"2009","journal-title":"J Cheminform"},{"issue":"Database issue","key":"ref60","doi-asserted-by":"crossref","first-page":"D292","DOI":"10.1093\/nar\/gkt940","article-title":"PDBsum additions","volume":"42","author":"TA de Beer","year":"2014","journal-title":"Nucleic Acids Res"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev.biophys.29.1.291","article-title":"Comparative protein structure modeling of genes and genomes","volume":"29","author":"MA Marti-Renom","year":"2000","journal-title":"Annu Rev Biophys Biomol Struct"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1093\/bioinformatics\/btt419","article-title":"Kinannote, a computer program to identify and classify members of the eukaryotic protein kinase superfamily","volume":"29","author":"JM Goldberg","year":"2013","journal-title":"Bioinformatics"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"D363","DOI":"10.1093\/nar\/gkj123","article-title":"OrthoMCL-DB: querying a comprehensive multi-species collection of ortholog groups","volume":"34","author":"F Chen","year":"2006","journal-title":"Nucleic acids research"},{"issue":"9","key":"ref64","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1093\/bioinformatics\/btu031","article-title":"InterProScan 5: genome-scale protein function classification","volume":"30","author":"P Jones","year":"2014","journal-title":"Bioinformatics"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1093\/nar\/gkf436","article-title":"MAFFT: a novel method for rapid multiple sequence alignment based on fast Fourier transform","volume":"30","author":"K Katoh","year":"2002","journal-title":"Nucleic acids research"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"RC Edgar","year":"2004","journal-title":"Nucleic Acids Research"},{"key":"ref67","doi-asserted-by":"crossref","unstructured":"Darriba D, Taboada GL, Doallo R, Posada D. ProtTest-HPC: Fast selection of best-fit models of protein evolution. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 2011;6586 LNCS:177\u201384. 10.1007\/978-3-642-21878-1_22. 21335321.","DOI":"10.1007\/978-3-642-21878-1_22"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1093\/sysbio\/syq010","article-title":"New algorithms and methods to estimate maximum-likelihood phylogenies: Assessing the performance of PhyML 3.0","volume":"59","author":"S Guindon","year":"2010","journal-title":"Systematic Biology"},{"issue":"D1","key":"ref69","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"M Kanehisa","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"W1","key":"ref70","doi-asserted-by":"crossref","first-page":"W78","DOI":"10.1093\/nar\/gkv487","article-title":"OrthoVenn: a web server for genome wide comparison and annotation of orthologous clusters across multiple species","volume":"43","author":"Y Wang","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"ref71","doi-asserted-by":"crossref","first-page":"D433","DOI":"10.1093\/nar\/gki005","article-title":"STRING: known and predicted protein-protein associations, integrated and transferred across organisms","volume":"33","author":"C von Mering","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1038\/nprot.2007.324","article-title":"Integration of biological networks and gene expression data using Cytoscape","volume":"2","author":"M Cline","year":"2007","journal-title":"Nature protocols"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.biosystems.2014.11.005","article-title":"CytoNCA: A cytoscape plugin for centrality analysis and evaluation of protein interaction networks","volume":"127","author":"Y Tang","year":"2015","journal-title":"BioSystems"},{"issue":"s1","key":"ref74","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1517\/17460441.2.S1.S53","article-title":"Schistosomes: challenges in compound screening","volume":"2","author":"B Ramirez","year":"2007","journal-title":"Expert Opin Drug Discov"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1006515","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006515","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,13]],"date-time":"2020-11-13T20:00:16Z","timestamp":1605297616000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006515"}},"subtitle":[],"editor":[{"given":"James M.","family":"Briggs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,10,22]]},"references-count":74,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2018,10,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1006515","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1006515","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,22]]}}}