{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:06:22Z","timestamp":1772172382415,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1006535","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000}}],"reference-count":99,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1006535","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T13:26:47Z","timestamp":1542029207000},"page":"e1006535","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":83,"title":["Visual physiology of the layer 4 cortical circuit in silico"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1106-8310","authenticated-orcid":true,"given":"Anton","family":"Arkhipov","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8429-4090","authenticated-orcid":true,"given":"Nathan W.","family":"Gouwens","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5200-4992","authenticated-orcid":true,"given":"Yazan N.","family":"Billeh","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8911-2321","authenticated-orcid":true,"given":"Sergey","family":"Gratiy","sequence":"additional","affiliation":[]},{"given":"Ramakrishnan","family":"Iyer","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8694-1260","authenticated-orcid":true,"given":"Ziqiang","family":"Wei","sequence":"additional","affiliation":[]},{"given":"Zihao","family":"Xu","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7824-4628","authenticated-orcid":true,"given":"Reza","family":"Abbasi-Asl","sequence":"additional","affiliation":[]},{"given":"Jim","family":"Berg","sequence":"additional","affiliation":[]},{"given":"Michael","family":"Buice","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5848-199X","authenticated-orcid":true,"given":"Nicholas","family":"Cain","sequence":"additional","affiliation":[]},{"given":"Nuno","family":"da Costa","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3704-3499","authenticated-orcid":true,"given":"Saskia","family":"de Vries","sequence":"additional","affiliation":[]},{"given":"Daniel","family":"Denman","sequence":"additional","affiliation":[]},{"given":"Severine","family":"Durand","sequence":"additional","affiliation":[]},{"given":"David","family":"Feng","sequence":"additional","affiliation":[]},{"given":"Tim","family":"Jarsky","sequence":"additional","affiliation":[]},{"given":"J\u00e9r\u00f4me","family":"Lecoq","sequence":"additional","affiliation":[]},{"given":"Brian","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Lu","family":"Li","sequence":"additional","affiliation":[]},{"given":"Stefan","family":"Mihalas","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9627-9576","authenticated-orcid":true,"given":"Gabriel K.","family":"Ocker","sequence":"additional","affiliation":[]},{"given":"Shawn R.","family":"Olsen","sequence":"additional","affiliation":[]},{"given":"R. Clay","family":"Reid","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1838-401X","authenticated-orcid":true,"given":"Gilberto","family":"Soler-Llavina","sequence":"additional","affiliation":[]},{"given":"Staci A.","family":"Sorensen","sequence":"additional","affiliation":[]},{"given":"Quanxin","family":"Wang","sequence":"additional","affiliation":[]},{"given":"Jack","family":"Waters","sequence":"additional","affiliation":[]},{"given":"Massimo","family":"Scanziani","sequence":"additional","affiliation":[]},{"given":"Christof","family":"Koch","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"ref1","unstructured":"California Institute of Technology. Caltech Library Archives [Internet]. Available from: http:\/\/archives-dc.library.caltech.edu\/islandora\/object\/ct1:483<\/ext-link>"},{"key":"ref2","first-page":"456","article-title":"Reconstruction and Simulation of Neocortical Microcircuitry","volume":"163","author":"H. Markram","year":"2015"},{"key":"ref3","first-page":"2194","article-title":"Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts","volume":"93","author":"R.D. Traub","year":"2005"},{"key":"ref4","first-page":"271","article-title":"A neuronal network model of primary visual cortex explains spatial frequency selectivity","volume":"26","author":"W Zhu","year":"2009"},{"key":"ref5","first-page":"264","article-title":"The log-dynamic brain: how skewed distributions affect network operations","volume":"15","author":"G. Buzsaki","year":"2014"},{"key":"ref6","first-page":"7520","article-title":"Highly selective receptive fields in mouse visual cortex","volume":"28","author":"CM Niell","year":"2008"},{"key":"ref7","first-page":"12144","article-title":"A comparison of visual response properties in the lateral geniculate nucleus and primary visual cortex of awake and anesthetized mice","volume":"36","author":"S. Durand","year":"2016"},{"key":"ref8","first-page":"16466","article-title":"Broadening of Inhibitory Tuning Underlies Contrast-Dependent Sharpening of Orientation Selectivity in Mouse Visual Cortex","volume":"32","author":"Y. Li","year":"2012"},{"key":"ref9","first-page":"137","article-title":"The emergence of contrast-invariant orientation tuning in simple cells of cat visual cortex","volume":"54","author":"I.M. Finn","year":"2007"},{"key":"ref10","first-page":"1821","article-title":"Sensory-driven and spontaneous gamma oscillations engage distinct cortical circuitry","volume":"115","author":"CG Welle","year":"2016"},{"key":"ref11","first-page":"415","article-title":"What Determines the Frequency of Fast Network Oscillations with Irregular Neural Discharges?","volume":"90","author":"N. Brunel","year":"2003"},{"key":"ref12","first-page":"509","article-title":"Synchronization in Networks of Excitatory and Inhibitory Neurons with Sparse, Random Connectivity","volume":"15","author":"C. Borgers","year":"2003"},{"key":"ref13","first-page":"727","article-title":"Cortical enlightenment: are attentional gamma oscillations driven by ING or PING?","volume":"63","author":"P Tiesinga","year":"2009"},{"key":"ref14","first-page":"203","article-title":"Mechanisms of gamma oscillations","volume":"35","author":"G. Buzsaki","year":"2012"},{"key":"ref15","first-page":"e1005132","article-title":"Identifying Anatomical Origins of Coexisting Oscillations in the Cortical Microcircuit","volume":"12","author":"H. Bos","year":"2016"},{"key":"ref16","first-page":"851","article-title":"Population code in mouse V1 facilitates readout of natural scenes through increased sparseness","volume":"17","author":"E. Froudarakis","year":"2014"},{"key":"ref17","first-page":"1315","article-title":"Tuned thalamic excitation is amplified by visual cortical circuits","volume":"16","author":"AD Lien","year":"2013"},{"key":"ref18","first-page":"1789","article-title":"Distinct recurrent versus afferent dynamics in cortical visual processing","volume":"18","author":"K. Reinhold","year":"2015"},{"key":"ref19","first-page":"316","article-title":"Laminar differences in the orientation selectivity of geniculate afferents in mouse primary visual cortex","volume":"19","author":"S Kondo","year":"2016"},{"key":"ref20","first-page":"308","article-title":"Thalamus provides layer 4 of primary visual cortex with orientation- and direction-tuned inputs","volume":"19","author":"W. Sun","year":"2016"},{"key":"ref21","first-page":"1324","article-title":"Linear Transformation of Thalamocortical input by Intracortical Excitation","volume":"16","author":"Y. Li","year":"2013"},{"key":"ref22","first-page":"1034","article-title":"Multilaminar networks of cortical neurons integrate common inputs from sensory thalamus","volume":"19","author":"N.A. Morgenstern","year":"2016"},{"key":"ref23","first-page":"80","article-title":"Cortical direction selectivity emerges at convergence of thalamic synapses","volume":"558","author":"A.D. Lien","year":"2018"},{"key":"ref24","first-page":"87","article-title":"Functional specificity of local synaptic connections in neocortical networks","volume":"473","author":"H. Ko","year":"2011"},{"key":"ref25","first-page":"399","article-title":"Functional organization of excitatory synaptic strength in primary visual cortex","volume":"518","author":"L Cossell","year":"2015"},{"key":"ref26","first-page":"370","article-title":"Anatomy and function of an excitatory network in the visual cortex","volume":"532","author":"W.C. Lee","year":"2016"},{"key":"ref27","first-page":"868","article-title":"Excitatory cortical neurons form fine-scale functional networks","volume":"433","author":"Y. Yoshimura","year":"2005"},{"key":"ref28","first-page":"158360","article-title":"Cortical circuits implement optimal context integration","author":"R. Iyer","year":"2017"},{"key":"ref29","first-page":"70","article-title":"Single-cell\u2013initiated monosynaptic tracing reveals layer-specific cortical network modules","volume":"349","author":"A. Wertz","year":"2015"},{"key":"ref30","article-title":"Automated point-neuron simplification of data-driven microcircuit models","author":"C. R\u00f6ssert","journal-title":"Automated point-neuron simplification of data-driven microcircuit models"},{"key":"ref31","first-page":"710","article-title":"Systematic generation of biophysically detailed models for diverse cortical neuron types","volume":"9","author":"N. W. Gouwens","year":"2018"},{"key":"ref32","unstructured":"Allen Institute for Brain Science. Allen Cell Types Database [Internet]. Available from: http:\/\/celltypes.brain-map.org<\/ext-link>."},{"key":"ref33","article-title":"Cortex<\/italic>: Statistics and Geometry of Neuronal Connectivity<\/italic>","author":"V. Braitenberg","year":"1998"},{"key":"ref34","first-page":"260","article-title":"GABAergic Interneurons in the Neocortex: From Cellular Properties to Circuits","volume":"91","author":"R. Tremblay","year":"2016"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"e0201630","DOI":"10.1371\/journal.pone.0201630","article-title":"BioNet: a Python interface to NEURON for modeling large-scale networks","volume":"13","author":"S.L. Gratiy","year":"2018","journal-title":"PLoS ONE"},{"key":"ref36","first-page":"1179","article-title":"The NEURON simulation environment","volume":"9","author":"ML Hines","year":"1997"},{"key":"ref37","first-page":"5419","article-title":"A synaptic organizing principle for cortical neuronal groups","volume":"108","author":"R Perin","year":"2011"},{"key":"ref38","first-page":"5908","article-title":"Contrast-invariant orientation tuning in cat visual cortex: Feedforward tuning and correlation-based intracortical connectivity","volume":"18","author":"T.W. Troyer","year":"1998"},{"key":"ref39","first-page":"424","article-title":"Thalamocortical NMDA Conductances and Intracortical Inhibition Can Explain Cortical Temporal Tuning","volume":"4","author":"A.E. Krukowski","year":"2001"},{"key":"ref40","first-page":"327","article-title":"The Cognitive Neurosciences<\/italic>","author":"E. P. Simoncelli","year":"2004"},{"key":"ref41","first-page":"3594","article-title":"Quantitative characterization of visual response properties in the mouse dorsal lateral geniculate nucleus","volume":"90","author":"M.S. Grubb","year":"2003"},{"key":"ref42","first-page":"4642","article-title":"Diverse Visual Features Encoded in Mouse Lateral Geniculate Nucleus","volume":"33","author":"D.M. Piscopo","year":"2013"},{"key":"ref43","first-page":"2435","article-title":"An Ultrastructural Study of the Thalamic Input to Layer 4 of Primary Motor and Primary Somatosensory Cortex in the Mouse","volume":"37","author":"R. Bopp","year":"2017"},{"key":"ref44","first-page":"8441","article-title":"A quantitative map of the circuit of cat primary visual cortex","volume":"29","author":"T. Binzegger","year":"2004"},{"key":"ref45","first-page":"218","article-title":"Traveling waves in visual cortex","volume":"75","author":"TK Sato","year":"2012"},{"key":"ref46","first-page":"226","article-title":"Sensory stimulation shifts visual cortex from synchronous to asynchronous states","volume":"509","author":"AY Tan","year":"2014"},{"key":"ref47","first-page":"1143","article-title":"Waking State: Rapid Variations Modulate Neural and Behavioral Responses","volume":"87","author":"MJ McGinley","year":"2015"},{"key":"ref48","first-page":"509","article-title":"Cortical state and attention","volume":"12","author":"K.D. Harris","year":"2011"},{"key":"ref49","first-page":"32","article-title":"Characterization of intracortical synaptic connections in the mouse anterior cingulate cortex using dual patch clamp recording","volume":"2","author":"L-J Wu","year":"2009"},{"key":"ref50","first-page":"1345","article-title":"Similar network activity from disparate circuit parameters","volume":"7","author":"A. A. Prinz","year":"2004"},{"key":"ref51","first-page":"301","article-title":"The Excitatory Neuronal Network of the C2 Barrel Column in Mouse Primary Somatosensory Cortex","volume":"61","author":"S. Lefort","year":"2009"},{"key":"ref52","first-page":"16217","article-title":"On the Distribution of Firing Rates in Networks of Cortical Neurons","volume":"31","author":"A. Roxin","year":"2011"},{"key":"ref53","first-page":"10230","article-title":"A biologically realistic model of contrast invariant orientation tuning by thalamocortical synaptic depression","volume":"27","author":"Y. Banitt","year":"2007"},{"key":"ref54","first-page":"13537","article-title":"Luminance-Evoked Inhibition in Primary Visual Cortex: A Transient Veto of Simultaneous and Ongoing Response","volume":"26","author":"T.R. Tucker","year":"2006"},{"key":"ref55","first-page":"775","article-title":"The spatial and temporal effects of lateral inhibitory networks and their relevance to the visibility of spatiotemporal edges","volume":"58\u201360","author":"S. L. Macknik","year":"2004"},{"key":"ref56","first-page":"2904","article-title":"Natural stimulation of the nonclassical receptive field increases information transmission efficiency in V1","volume":"22","author":"WE Vinje","year":"2002"},{"key":"ref57","first-page":"369","article-title":"Stimulus onset quenches neural variability: a widespread cortical phenomenon","volume":"13","author":"M.M. Churchland","year":"2010"},{"key":"ref58","first-page":"981","article-title":"Recurrent excitation in neocortical circuits","volume":"269","author":"R.J. Douglas","year":"1995"},{"key":"ref59","first-page":"1724","article-title":"Chaos in neuronal networks with balanced excitatory and inhibitory activity","volume":"274","author":"C van Vreeswijk","year":"1996"},{"key":"ref60","first-page":"e1004196","article-title":"Emergence of Slow Switching Assemblies in Structured Neuronal Networks","volume":"11","author":"M.T. Schaub","year":"2015"},{"key":"ref61","first-page":"47","article-title":"Gain control by layer six in cortical circuits of vision","volume":"483","author":"S.R. Olsen","year":"2012"},{"key":"ref62","first-page":"303","article-title":"Approximations by superpositions of sigmoidal functions","volume":"2","author":"G. Cybenko","year":"1989"},{"key":"ref63","first-page":"359","article-title":"Multilayer feedforward networks are universal approximators","volume":"2","author":"K. Hornik","year":"1989"},{"key":"ref64","first-page":"709","article-title":"Generalized leaky integrate-and-fire models classify multiple neuron types","volume":"9","author":"C. Teeter","year":"2018"},{"key":"ref65","first-page":"e1004090","article-title":"Physiology of Layer 5 Pyramidal Neurons in Mouse Primary Visual Cortex: Coincidence Detection through Bursting","volume":"11","author":"A. S. Shai","year":"2015"},{"key":"ref66","first-page":"989","article-title":"Pyramidal Neuron as Two-Layer Neural Network","volume":"37","author":"P. Poirazi","year":"2003"},{"key":"ref67","first-page":"7337","article-title":"Inferring cortical function in the mouse visual system through large-scale systems neuroscience","volume":"113","author":"M. Hawrylycz","year":"2016"},{"key":"ref68","first-page":"e1005045","article-title":"The Computational Properties of a Simplified Cortical Column Model","volume":"12","author":"N. Cain","year":"2016"},{"key":"ref69","unstructured":"Allen Institute for Brain Science. Allen Brain Observatory\u2013Visual Coding [Internet]. Available from: http:\/\/observatory.brain-map.org\/visualcoding\/<\/ext-link>."},{"key":"ref70","first-page":"1981","article-title":"High-Probability Uniquantal Transmission at Excitatory Synapses in Barrel Cortex","volume":"302","author":"R.A. Silver","year":"2003"},{"key":"ref71","first-page":"2925","article-title":"How Thalamus Connects to Spiny Stellate Cells in the Cat\u2019s Visual Cortex","volume":"31","author":"N. da Costa","year":"2011"},{"key":"ref72","first-page":"6406","article-title":"Connectivity Patterns Revealed by Mapping of Active Inputs on Dendrites of Thalamorecipient Neurons in the Auditory Cortex","volume":"29","author":"R.J. Richardson","year":"2009"},{"key":"ref73","first-page":"6746","article-title":"Comparative Strength and Dendritic Organization of Thalamocortical and Corticocortical Synapses onto Excitatory Layer 4 Neurons","volume":"34","author":"C.E. Schoonover","year":"2014"},{"key":"ref74","first-page":"R398","article-title":"Inhibition in cortical circuits","volume":"19","author":"R.J. Douglas","year":"2009"},{"key":"ref75","first-page":"206","article-title":"Pyramidal neurons: dendritic structure and synaptic integration","volume":"9","author":"N. Spruston","year":"2008"},{"key":"ref76","first-page":"1068","article-title":"Inhibition of inhibition in visual cortex: the logic of connections between molecularly distinct interneurons","volume":"16","author":"C.K. Pfeffer","year":"2013"},{"key":"ref77","first-page":"2987","article-title":"Two Dynamically Distinct Inhibitory Networks in Layer 4 of the Neocortex","volume":"90","author":"M. Beierlein","year":"2003"},{"key":"ref78","article-title":"The New Visual Neurosciences<\/italic>","author":"C.M. Niell","year":"2013"},{"key":"ref79","first-page":"10520","article-title":"Visual Receptive Field Structure of Cortical Inhibitory Neurons Revealed by Two-Photon Imaging Guided Recording","volume":"29","author":"B. Liu","year":"2009"},{"key":"ref80","article-title":"Touch of Evil","author":"O. Welles","year":"1958"},{"key":"ref81","first-page":"416","article-title":"A database of human segmented natural images and its application to evaluating segmentation algorithms and measuring ecological statistics","volume":"2","author":"D. Martin","year":"2001"},{"key":"ref82","first-page":"359","article-title":"Independent component filters of natural images compared with simple cells in primary visual cortex","volume":"265","author":"J.H. van Hateren","year":"1998"},{"key":"ref83","first-page":"77","article-title":"A systematic random sampling scheme optimized to detect the proportion of rare synapses in the neuropil","volume":"180","author":"N. M. da Costa","year":"2009"},{"issue":"Pt 2","key":"ref84","first-page":"127","article-title":"The unbiased estimation of number and sizes of arbitrary particles using the disector","volume":"134","author":"D. Sterio","year":"1984"},{"key":"ref85","first-page":"9670","article-title":"Rapid Structural Remodeling of Thalamocortical Synapses Parallels Experience-Dependent Functional Plasticity in Mouse Primary Visual Cortex","volume":"30","author":"J.E. Coleman","year":"2010"},{"key":"ref86","doi-asserted-by":"crossref","unstructured":"Howard, C., and Reed, M. Unbiased stereology (2nd ed.). New York. (2005).","DOI":"10.4324\/9780203006399"},{"key":"ref87","first-page":"1592","article-title":"Electron microscopy of synaptic contacts on dendrite spines of the cerebral cortex","volume":"183","author":"E. G. Gray","year":"1959"},{"key":"ref88","first-page":"268","article-title":"Synaptic patterns on different cell types in the different laminae of the cat visual cortex. An electron microscope study","volume":"9","author":"M. Colonnier","year":"1968"},{"key":"ref89","first-page":"267","article-title":"Theta oscillations provide temporal windows for local circuit computation in the entorhinal-hippocampal loop","volume":"64","author":"K Mizuseki","year":"2009"},{"key":"ref90","first-page":"401","article-title":"Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements","volume":"84","author":"KD Harris","year":"2000"},{"key":"ref91","doi-asserted-by":"crossref","DOI":"10.1101\/061481","article-title":"Kilosort: realtime spike-sorting for extracellular electrophysiology with hundreds of channels","author":"M Pachitariu","year":"2016"},{"key":"ref92","first-page":"207","article-title":"Klusters, NeuroScope, NDManager: a free software suite for neurophysiological data processing and visualization","volume":"155","author":"L Hazan","year":"2006"},{"key":"ref93","first-page":"634","article-title":"Spike sorting for large, dense electrode arrays","volume":"19","author":"C. Rossant","year":"2016"},{"key":"ref94","first-page":"61","article-title":"Targeted patch-clamp recordings and single-cell electroporation of unlabeled neurons in vivo","volume":"5","author":"K Kitamura","year":"2008"},{"key":"ref95","first-page":"862","article-title":"Targeted single-cell electroporation of mammalian neurons in vivo","volume":"4","author":"B Judkewitz","year":"2009"},{"key":"ref96","first-page":"18426","article-title":"3D Image-Guided Automatic Pipette Positioning for Single Cell Experiments in vivo","volume":"5","author":"B Long","year":"2015"},{"key":"ref97","first-page":"433","article-title":"The Psychophysics Toolbox","volume":"10","author":"D.H. Brainard","year":"1997"},{"key":"ref98","first-page":"175","article-title":"Automatic sorting of multiple unit neuronal signals in the presence of anisotropic and non-Gaussian variability","volume":"69","author":"M.S. Fee","year":"1996"},{"key":"ref99","first-page":"169","article-title":"Electrical interactions via the extracellular potential near cell bodies","volume":"6","author":"G.R. Holt","year":"1999"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1006535","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T22:34:57Z","timestamp":1605393297000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006535"}},"subtitle":[],"editor":[{"given":"Brent","family":"Doiron","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2018,11,12]]},"references-count":99,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1006535","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/292839","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,12]]}}}