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Bogardus","year":"1925","journal-title":"Journal of applied sociology"},{"key":"ref44","article-title":"Sociology & Social Research","author":"E Bogardus","year":"1938"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"306","DOI":"10.2307\/2785570","article-title":"Measurement of Personal-Group Relations","volume":"10","author":"ES Bogardus","year":"1947","journal-title":"Sociometry"},{"key":"ref46","author":"P Legendre","year":"2012"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1093\/bioinformatics\/btn129","article-title":"adegenet: a R package for the multivariate analysis of genetic markers","volume":"24","author":"T Jombart","year":"2008","journal-title":"Bioinformatics"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1471-8286.2004.00828.x","article-title":"hierfstat, a package for r to compute and test hierarchical F-statistics","volume":"5","author":"J Goudet","year":"2005","journal-title":"Mol Ecol 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Shumway","year":"2010"},{"key":"ref54","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4614-7618-4","article-title":"Applied Spatial Data Analysis with R","author":"RS Bivand","year":"2013"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/1755-0998.12559","article-title":"stratag: An r package for manipulating, summarizing and analysing population genetic data","volume":"17","author":"FI Archer","year":"2017","journal-title":"Mol Ecol Resour"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/bioinformatics\/btg412","article-title":"APE: Analyses of Phylogenetics and Evolution in R language","volume":"20","author":"E Paradis","year":"2004","journal-title":"Bioinformatics"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/1755-0998.12567","article-title":"apex: phylogenetics with multiple genes","volume":"17","author":"T Jombart","year":"2017","journal-title":"Mol Ecol 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time-varying reproduction numbers during epidemics","volume":"178","author":"A Cori","year":"2013","journal-title":"Am J Epidemiol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"e1006885","DOI":"10.1371\/journal.ppat.1006885","article-title":"When are pathogen genome sequences informative of transmission events?","volume":"14","author":"F Campbell","year":"2018","journal-title":"PLoS Pathog"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/biostatistics\/4.2.279","article-title":"Branching process models for surveillance of infectious diseases controlled by mass vaccination","volume":"4","author":"CP Farrington","year":"2003","journal-title":"Biostatistics"},{"key":"ref64","unstructured":"World Health Organization. WHO Expert Consultation on Rabies. Second report. World Health Organ Tech Rep Ser. 2013; 1\u2013139, back cover."},{"key":"ref65","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.actatropica.2012.04.005","article-title":"New introduction and spread of rabies among dog population in Bangui","volume":"123","author":"E Nakoun\u00e9","year":"2012","journal-title":"Acta Trop"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1086\/592969","article-title":"A reliable diagnosis of human rabies based on analysis of skin biopsy specimens","volume":"47","author":"L Dacheux","year":"2008","journal-title":"Clin Infect Dis"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"e2057","DOI":"10.1371\/journal.pone.0002057","article-title":"Genomic diversity and evolution of the lyssaviruses","volume":"3","author":"O Delmas","year":"2008","journal-title":"PLoS One"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"RC Edgar","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1371\/journal.pbio.1000053","article-title":"Transmission dynamics and prospects for the elimination of canine rabies","volume":"7","author":"K Hampson","year":"2009","journal-title":"PLoS Biol"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1080\/01621459.1971.10482356","article-title":"Objective Criteria for the Evaluation of Clustering Methods","volume":"66","author":"WM Rand","year":"1971","journal-title":"J Am Stat Assoc"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1006554","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T00:00:00Z","timestamp":1546214400000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T12:12:55Z","timestamp":1662639175000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006554"}},"subtitle":[],"editor":[{"given":"Mercedes","family":"Pascual","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,17]]},"references-count":70,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1006554","relation":{},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,17]]}}}