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OpenMP Compilers &amp; Tools [Internet]. OpenMP. [cited 2018 Mar 1]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.openmp.org\/resources\/openmp-compilers\/\" xlink:type=\"simple\">http:\/\/www.openmp.org\/resources\/openmp-compilers\/<\/ext-link>"},{"issue":"3","key":"ref55","first-page":"356","article-title":"Atrial Tachycardia Originating from the Pulmonary Vein","volume":"35","author":"W Moreira","year":"2008","journal-title":"Tex Heart Inst J"},{"issue":"6","key":"ref56","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/FJC.0b013e318207a35f","article-title":"Fibrosis and cardiac arrhythmias","volume":"57","author":"S de Jong","year":"2011","journal-title":"J Cardiovasc Pharmacol"},{"issue":"6","key":"ref57","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1161\/01.RES.75.6.1014","article-title":"Wave-front curvature as a cause of slow conduction and block in isolated cardiac muscle","volume":"75","author":"C Cabo","year":"1994","journal-title":"Circ Res"},{"issue":"4","key":"ref58","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1161\/01.RES.86.4.396","article-title":"Enhanced Dispersion of Repolarization and Refractoriness in Transgenic Mouse Hearts Promotes Reentrant Ventricular Tachycardia","volume":"86","author":"LC Baker","year":"2000","journal-title":"Circ Res"},{"issue":"4","key":"ref59","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1056\/NEJM199401273300402","article-title":"Electrical Alternans and Vulnerability to Ventricular Arrhythmias","volume":"330","author":"DS Rosenbaum","year":"1994","journal-title":"N Engl J Med"},{"key":"ref60","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2013.00071","article-title":"Effects of Pacing Site and Stimulation History on Alternans Dynamics and the Development of Complex Spatiotemporal Patterns in Cardiac Tissue","volume":"4","author":"A Gizzi","year":"2013","journal-title":"Front Physiol"},{"issue":"4","key":"ref61","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ancard.2011.05.001","article-title":"What is the origin of this arrhythmia?","volume":"60","author":"L Muresan","year":"2011","journal-title":"Ann Cardiol Angeiol (Paris)"},{"issue":"7","key":"ref62","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1172\/JCI200318062","article-title":"Congenital sick sinus syndrome caused by recessive mutations in the cardiac sodium channel gene (SCN5A)","volume":"112","author":"DW Benson","year":"2003","journal-title":"J Clin Invest"},{"issue":"6823","key":"ref63","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/35059090","article-title":"A sodium-channel mutation causes isolated cardiac conduction disease","volume":"409","author":"HL Tan","year":"2001","journal-title":"Nature"},{"issue":"1","key":"ref64","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/cvr\/cvn274","article-title":"Intracellular calcium modulation of voltage-gated sodium channels in ventricular myocytes","volume":"81","author":"S Casini","year":"2009","journal-title":"Cardiovasc Res"},{"issue":"1","key":"ref65","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1161\/01.RES.81.1.110","article-title":"Alterations of Na+ currents in myocytes from epicardial border zone of the infarcted heart. A possible ionic mechanism for reduced excitability and postrepolarization refractoriness","volume":"81","author":"J Pu","year":"1997","journal-title":"Circ Res"},{"issue":"6","key":"ref66","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.yjmcc.2005.02.024","article-title":"A mutation in the human cardiac sodium channel (E161K) contributes to sick sinus syndrome, conduction disease and Brugada syndrome in two families","volume":"38","author":"JPP Smits","year":"2005","journal-title":"J Mol Cell Cardiol"},{"issue":"20","key":"ref67","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1161\/CIRCULATIONAHA.107.703330","article-title":"Mutation in glycerol-3-phosphate dehydrogenase 1 like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias","volume":"116","author":"B London","year":"2007","journal-title":"Circulation"},{"issue":"5","key":"ref68","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0092-8674(95)90359-3","article-title":"SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome","volume":"80","author":"Q Wang","year":"1995","journal-title":"Cell"},{"issue":"2","key":"ref69","doi-asserted-by":"crossref","first-page":"e0172683","DOI":"10.1371\/journal.pone.0172683","article-title":"Effects of Na+ channel blockers on the restitution of refractory period, conduction time, and excitation wavelength in perfused guinea-pig heart","volume":"12","author":"OE Osadchii","year":"2017","journal-title":"PLOS ONE"},{"issue":"5","key":"ref70","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1529\/biophysj.104.047449","article-title":"A Mathematical Treatment of Integrated Ca Dynamics within the Ventricular Myocyte","volume":"87","author":"TR Shannon","year":"2004","journal-title":"Biophys J"},{"issue":"8","key":"ref71","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1161\/01.RES.0000125629.72053.95","article-title":"Role of calcium cycling versus restitution in the mechanism of repolarization alternans","volume":"94","author":"EJ Pruvot","year":"2004","journal-title":"Circ Res"},{"issue":"2","key":"ref72","doi-asserted-by":"crossref","first-page":"H598","DOI":"10.1152\/ajpheart.01086.2007","article-title":"Alternans of cardiac calcium cycling in a cluster of ryanodine receptors: a simulation study","volume":"295","author":"T Tao","year":"2008","journal-title":"AJP Heart Circ Physiol"},{"key":"ref73","doi-asserted-by":"crossref","unstructured":"Wang W, Ni H, Zhang H. Investigation of the mechanisms underlying cardiac alternans\u2014insights from a computational study. 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Phys"},{"issue":"6","key":"ref77","doi-asserted-by":"crossref","first-page":"H2332","DOI":"10.1152\/ajpheart.00747.2003","article-title":"Suppression of alternans and conduction blocks despite steep APD restitution: electrotonic, memory, and conduction velocity restitution effects","volume":"286","author":"EM Cherry","year":"2004","journal-title":"Am J Physiol-Heart Circ Physiol"},{"issue":"6","key":"ref78","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.hrthm.2006.02.1034","article-title":"Importance of spatiotemporal heterogeneity of cellular restitution in mechanism of arrhythmogenic discordant alternans","volume":"3","author":"JM Pastore","year":"2006","journal-title":"Heart Rhythm"},{"issue":"12","key":"ref79","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1161\/01.RES.87.12.1157","article-title":"Role of Structural Barriers in the Mechanism of Alternans-Induced Reentry","volume":"87","author":"JM Pastore","year":"2000","journal-title":"Circ Res"},{"key":"ref80","article-title":"Mechanisms linking T-wave alternans to spontaneous initiation of ventricular arrhythmias in rabbit models of long QT syndrome","author":"W Liu","year":"2018","journal-title":"J Physiol"},{"issue":"5","key":"ref81","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.bpj.2010.06.042","article-title":"So Little Source, So Much Sink: Requirements for Afterdepolarizations to Propagate in Tissue","volume":"99","author":"Y Xie","year":"2010","journal-title":"Biophys J"},{"issue":"6","key":"ref82","doi-asserted-by":"crossref","first-page":"H1470","DOI":"10.1152\/ajpheart.00500.2016","article-title":"Spontaneous initiation of premature ventricular complexes and arrhythmias in type 2 long QT syndrome","volume":"311","author":"X Huang","year":"2016","journal-title":"Am J Physiol-Heart Circ Physiol"},{"issue":"1","key":"ref83","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.pbiomolbio.2016.01.008","article-title":"Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve","volume":"120","author":"S Dutta","year":"2016","journal-title":"Prog Biophys Mol Biol"},{"issue":"7","key":"ref84","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1114\/1.1289474","article-title":"Origins of Spiral Wave Meander and Breakup in a Two-Dimensional Cardiac Tissue Model","volume":"28","author":"Z Qu","year":"2000","journal-title":"Ann Biomed Eng"},{"issue":"6","key":"ref85","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1016\/S0006-3495(00)76821-4","article-title":"Scroll Wave Dynamics in a Three-Dimensional Cardiac Tissue Model: Roles of Restitution, Thickness, and Fiber Rotation","volume":"78","author":"Z Qu","year":"2000","journal-title":"Biophys J"},{"issue":"4","key":"ref86","doi-asserted-by":"crossref","first-page":"H1310","DOI":"10.1152\/ajpheart.00561.2003","article-title":"Effects of Na(+) channel and cell coupling abnormalities on vulnerability to reentry: a simulation study","volume":"286","author":"Z Qu","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"16","key":"ref87","article-title":"Mechanism for Amplitude Alternans in Electrocardiograms and the Initiation of Spatiotemporal Chaos","volume":"118","author":"DD Chen","year":"2017","journal-title":"Phys Rev Lett"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1006594","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000}}],"container-title":["PLOS Computational 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