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A Tutorial on Bayesian Optimization of Expensive Cost Functions, with Application to Active User Modeling and Hierarchical Reinforcement Learning. arXiv. 2010;."},{"key":"ref41","article-title":"Gaussian processes for machine learning","volume":"2","author":"CE Rasmussen","year":"2004"},{"key":"ref42","unstructured":"Srinivas N, Krause A, Kakade SM, Seeger M. Gaussian Process Optimization in the Bandit Setting: No Regret and Experimental Design. arXiv. 2009;"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1093\/comjnl\/7.4.308","article-title":"A simplex method for function minimization","volume":"7","author":"JA Nelder","year":"1965","journal-title":"The Computer Journal"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/BF00941892","article-title":"Lipschitzian optimization without the Lipschitz constant","volume":"79","author":"DR Jones","year":"1993","journal-title":"Journal of Optimization Theory and Applications"},{"issue":"February","key":"ref45","first-page":"1","article-title":"Phase-dependent modulation as a novel approach for therapeutic brain stimulation","volume":"9","author":"R Azodi-Avval","year":"2015","journal-title":"Frontiers in Computational Neuroscience"},{"issue":"4","key":"ref46","first-page":"11","article-title":"Delayed feedback control of collective synchrony: An approach to suppression of pathological brain rhythms","volume":"70","author":"M Rosenblum","year":"2004","journal-title":"Physical Review E\u2014Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics"},{"issue":"11","key":"ref47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1103\/PhysRevLett.92.114102","article-title":"Controlling Synchronization in an Ensemble of Globally Coupled Oscillators","volume":"92","author":"MG Rosenblum","year":"2004","journal-title":"Physical Review Letters"},{"issue":"10","key":"ref48","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1093\/brain\/awt239","article-title":"Phase dependent modulation of tremor amplitude in essential tremor through thalamic stimulation","volume":"136","author":"H Cagnan","year":"2013","journal-title":"Brain"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1162\/neco.1996.8.5.979","article-title":"Type I Membranes, Phase Resetting Curves, and Synchrony","volume":"8","author":"B Ermentrout","year":"1996","journal-title":"Neural Computation"},{"issue":"1551","key":"ref50","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1098\/rstb.2009.0292","article-title":"Phase-response curves and synchronized neural networks","volume":"365","author":"RM Smeal","year":"2010","journal-title":"Philosophical Transactions of the Royal Society B: Biological Sciences"},{"issue":"7","key":"ref51","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/mds.26241","article-title":"Adaptive deep brain stimulation in a freely moving parkinsonian patient","volume":"30","author":"M Rosa","year":"2015","journal-title":"Movement Disorders"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/mds.26953","article-title":"Adaptive deep brain stimulation controls levodopa-induced side effects in Parkinsonian patients","volume":"32","author":"M Rosa","year":"2017","journal-title":"Movement Disorders"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1002\/mds.26482","article-title":"Kinematic Adaptive Deep Brain Stimulation for Resting Tremor in Parkinson\u2019s Disease","volume":"31","author":"M Malekmohammadi","year":"2016","journal-title":"Movement Disorders"},{"key":"ref54","unstructured":"Snoek J, Rippel O, Swersky K, Kiros R, Satish N, Sundaram N, et al. Scalable Bayesian Optimization Using Deep Neural Networks. arXiv. 2015;."},{"key":"ref55","first-page":"4134","article-title":"Bayesian Optimization with Robust Bayesian Neural Networks","author":"JT Springenberg","year":"2016","journal-title":"Nips"},{"issue":"37","key":"ref56","doi-asserted-by":"crossref","first-page":"11741","DOI":"10.1523\/JNEUROSCI.23-37-11741.2003","article-title":"Synchronous, focally modulated beta-band oscillations characterize local field potential activity in the striatum of awake behaving monkeys","volume":"23","author":"R Courtemanche","year":"2003","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"key":"ref57","first-page":"3","article-title":"Oscillations in the basal ganglia: the good, the bad, and the unexpected","author":"T Boraud","year":"2005","journal-title":"The basal ganglia VII"},{"issue":"3","key":"ref58","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.neuron.2011.11.032","article-title":"Basal ganglia beta oscillations accompany cue utilization","volume":"73","author":"DK Leventhal","year":"2012","journal-title":"Neuron"},{"issue":"4","key":"ref59","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1152\/jn.00333.2004","article-title":"Brain state-dependency of coherent oscillatory activity in the cerebral cortex and basal ganglia of the rat","volume":"92","author":"PJ Magill","year":"2004","journal-title":"Journal of neurophysiology"},{"issue":"4","key":"ref60","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/brain\/awh106","article-title":"Event-related beta desynchronization in human subthalamic nucleus correlates with motor performance","volume":"127","author":"AA K\u00fchn","year":"2004","journal-title":"Brain"},{"issue":"12","key":"ref61","doi-asserted-by":"crossref","first-page":"4780","DOI":"10.1073\/pnas.1214546110","article-title":"Exaggerated phase-amplitude coupling in the primary motor cortex in Parkinson disease","volume":"110","author":"C de Hemptinne","year":"2013","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"ref62","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/nn.3997","article-title":"Therapeutic deep brain stimulation reduces cortical phase-amplitude coupling in Parkinson\u2019s disease","volume":"18","author":"C de Hemptinne","year":"2015","journal-title":"Nature Neuroscience"},{"issue":"6","key":"ref63","doi-asserted-by":"crossref","first-page":"66013","DOI":"10.1088\/1741-2560\/12\/6\/066013","article-title":"A new biomarker for subthalamic deep brain stimulation for patients with advanced Parkinson\u2019s disease-a pilot study","volume":"12","author":"GE Gmel","year":"2015","journal-title":"Journal of neural engineering"},{"key":"ref64","article-title":"Reinforcement Learning: An Introduction","author":"RS Sutton","year":"2012"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1006606","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T00:00:00Z","timestamp":1545091200000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006606","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:27:00Z","timestamp":1588969620000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1006606"}},"subtitle":[],"editor":[{"given":"Sabato","family":"Santaniello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,6]]},"references-count":64,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1006606","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1006606","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,6]]}}}