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of Fixed Obstacles","volume":"55","author":"PG de Gennes","year":"1971","journal-title":"J Chem Phys"},{"key":"ref57","article-title":"The Theory of Polymer Dynamics (International Series of Monographs on Physics)","author":"M Doi","year":"1988"},{"issue":"10","key":"ref58","doi-asserted-by":"crossref","first-page":"7726","DOI":"10.1063\/1.461346","article-title":"Dynamics of polymer solutions and melts. Reptation predictions and scaling of relaxation times","volume":"95","author":"W Paul","year":"1991","journal-title":"J Chem Phys"},{"key":"ref59","article-title":"Theory of Simple Liquids","author":"JP Hansen","year":"2006"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"011913","DOI":"10.1103\/PhysRevE.82.011913","article-title":"Subdiffusive motion of a polymer composed of subdiffusive monomers","volume":"82","author":"SC Weber","year":"2010","journal-title":"Phys Rev E"},{"issue":"2","key":"ref61","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.bpj.2015.11.3520","article-title":"Physical Modeling of Dynamic Coupling between Chromosomal Loci","volume":"110","author":"TJ Lampo","year":"2016","journal-title":"Biophys J"},{"key":"ref62","article-title":"Cell Biology by the numbers","author":"R Milo","year":"2016"},{"issue":"4","key":"ref63","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1021\/acs.macromol.6b02685","article-title":"Heterogeneous 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