{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T20:39:24Z","timestamp":1780778364527,"version":"3.54.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1007075","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000}}],"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T00:00:00Z","timestamp":1563235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Project number 210879364; TR124\/B1"],"award-info":[{"award-number":["Project number 210879364; TR124\/B1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Project number 210879364 TR124\/C6"],"award-info":[{"award-number":["Project number 210879364 TR124\/C6"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Project number 374031971; TR240\/INF"],"award-info":[{"award-number":["Project number 374031971; TR240\/INF"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1007075","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T17:22:57Z","timestamp":1563297777000},"page":"e1007075","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Analyzing pharmacological intervention points: A method to calculate external stimuli to switch between steady states in regulatory networks"],"prefix":"10.1371","volume":"15","author":[{"given":"Tim","family":"Breitenbach","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunguang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Beyersdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1886-7625","authenticated-orcid":true,"given":"Thomas","family":"Dandekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,7,16]]},"reference":[{"issue":"1","key":"ref1","first-page":"13","article-title":"A method for the generation of standardized qualitative dynamical systems of regulatory networks","volume":"3","author":"Luis Mendoza","year":"2006"},{"issue":"1","key":"ref2","first-page":"462","article-title":"Dynamic simulation of regulatory networks using SQUAD","volume":"8","author":"Alessandro Di Cara","year":"2007"},{"issue":"1","key":"ref3","first-page":"306","article-title":"Jimena: efficient computing and system state identification for genetic regulatory networks","volume":"14","author":"Stefan Karl","year":"2013"},{"issue":"5727","key":"ref4","first-page":"1472","article-title":"Mechanism of divergent growth factor effects in mesenchymal stem cell differentiation","volume":"308","author":"Irina Kratchmarova","year":"2005"},{"issue":"21","key":"ref5","first-page":"11307","article-title":"Effects of eight growth factors on the differentiation of cells derived from human embryonic stem cells","volume":"97","author":"Maya Schuldiner","year":"2000"},{"issue":"7299","key":"ref6","first-page":"704","article-title":"Nuclear reprogramming to a pluripotent state by three approaches","volume":"465","author":"Shinya Yamanaka","year":"2010"},{"issue":"2","key":"ref7","first-page":"433","article-title":"Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78","volume":"109","author":"Shaun Martin","year":"2013"},{"issue":"11","key":"ref8","first-page":"3799","article-title":"Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent","volume":"31","author":"Sandeep Sreevalsan","year":"2011"},{"issue":"8","key":"ref9","first-page":"2082","article-title":"A comparative analysis of the bistability switch for platelet aggregation by logic ODE based dynamical modeling","volume":"10","author":"Marcel Mischnik","year":"2014"},{"issue":"4","key":"ref10","first-page":"283","article-title":"A robust model to describe the differentiation of T-helper cells","volume":"129","author":"Luis Mendoza","year":"2010"},{"issue":"53","key":"ref11","article-title":"Regulation of p53 in response to DNA damage","volume":"18","author":"Nicholas D. Lakin","year":"1999"},{"issue":"39","key":"ref12","first-page":"14241","article-title":"RNA thermometer controls temperature-dependent virulence factor expression in vibrio cholerae","volume":"111","author":"Gregor G. Weber","year":"2014"},{"key":"ref13","article-title":"<italic>Foundations of Chemical Reaction Network Theory<\/italic>","author":"Martin Feinberg","year":"2019"},{"issue":"1","key":"ref14","first-page":"244","article-title":"Identifiability of chemical reaction networks","volume":"44","author":"Gheorghe Craciun","year":"2008"},{"issue":"4","key":"ref15","first-page":"e1005454","article-title":"Chemical reaction network theory elucidates sources of multistability in interferon signaling","volume":"13","author":"Otero-Muras Irene","year":"2017"},{"issue":"2","key":"ref16","first-page":"263","article-title":"Desmopressin for treatment of platelet dysfunction and reversal of antiplatelet agents: a systematic review and meta-analysis of randomized controlled trials","volume":"15","author":"MJR Desborough","year":"2017"},{"issue":"07","key":"ref17","first-page":"1249","article-title":"Platelet receptors as therapeutic targets: past, present and future","volume":"117","author":"Janina Jamasbi","year":"2017"},{"key":"ref18","first-page":"14649","article-title":"Suppressive IL-17A+ Foxp3+ and ex-Th17 IL-17A neg Foxp3+ T reg cells are a source of tumour-associated T reg cells","volume":"8","author":"Downs-Canner Stephanie","year":"2017"},{"issue":"10","key":"ref19","first-page":"e189","article-title":"Universally sloppy parameter sensitivities in systems biology models","volume":"3","author":"Ryan N. Gutenkunst","year":"2007"},{"key":"ref20","article-title":"B-cell maturation antigen is a promising target for adoptive T-cell therapy of multiple myeloma","author":"Robert O. Carpenter","year":"2013"},{"issue":"4","key":"ref21","first-page":"1351","article-title":"T cell adolescence: maturation events beyond positive selection","volume":"195","author":"Kristin A. Hogquist","year":"2015"},{"issue":"4","key":"ref22","first-page":"1578","article-title":"Histone deacetylase 3 is required for T cell maturation","volume":"195","author":"Fan-Chi Hsu","year":"2015"},{"issue":"3","key":"ref23","first-page":"319","article-title":"Transient inhibition of ROR-<italic>\u03b3<\/italic>t therapeutically limits intestinal inflammation by reducing T H 17 cells and preserving group 3 innate lymphoid cells","volume":"22","author":"David R. Withers","year":"2016"},{"issue":"4","key":"ref24","first-page":"477","article-title":"Small-molecule ROR<italic>\u03b3<\/italic>t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms","volume":"40","author":"Sheng Xiao","year":"2014"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1007075","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007075","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:45:13Z","timestamp":1589010313000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007075"}},"subtitle":[],"editor":[{"given":"Jason A.","family":"Papin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,7,16]]},"references-count":24,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1007075","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1007075","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,16]]}}}