{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T08:50:53Z","timestamp":1772873453306,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1007077","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T00:00:00Z","timestamp":1560470400000}}],"reference-count":91,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000005","name":"Department of Defense Army Research Office -MURI grant","doi-asserted-by":"publisher","award":["W911NF1410403"],"award-info":[{"award-number":["W911NF1410403"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMR-1420709"],"award-info":[{"award-number":["DMR-1420709"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1007077","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T13:24:11Z","timestamp":1559654651000},"page":"e1007077","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":45,"title":["Multiscale model of integrin adhesion assembly"],"prefix":"10.1371","volume":"15","author":[{"given":"Tamara C.","family":"Bidone","sequence":"first","affiliation":[]},{"given":"Austin V.","family":"Skeeters","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9951-1318","authenticated-orcid":true,"given":"Patrick W.","family":"Oakes","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3267-6748","authenticated-orcid":true,"given":"Gregory A.","family":"Voth","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1092053","article-title":"Cell Migration: Integrating Signals from Front to Back","volume":"302","author":"AJ Ridley","year":"2003","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"E97","DOI":"10.1038\/ncb0402-e97","article-title":"Adhesion assembly, disassembly and turnover in migrating cells\u2013over and over and over again","volume":"4","author":"DJ Webb","year":"2002","journal-title":"Nat Cell Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a005033","article-title":"Molecular architecture and function of matrix adhesions","volume":"3","author":"B Geiger","year":"2011","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref4","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a023234","article-title":"Actin-based adhesion modules mediate cell interactions with the extracellular matrix and neighboring cells","volume":"9","author":"AI Bachir","year":"2017","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"ref5","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1715869115","article-title":"Lamellipodium is a myosin-independent mechanosensor","volume":"115","author":"PW Oakes","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1083\/jcb.200908134","article-title":"New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control \u03b23-integrin clustering","volume":"187","author":"F Saltel","year":"2009","journal-title":"J Cell Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1083\/jcb.200503017","article-title":"The mechanisms and dynamics of \u03b1v\u03b23 integrin clustering in living cells","volume":"171","author":"C Cluzel","year":"2005","journal-title":"J Cell Biol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1016\/j.cub.2013.09.050","article-title":"The mechanism of kindlin-mediated activation of integrin??iIb??3","volume":"23","author":"F Ye","year":"2013","journal-title":"Curr Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nature13535","article-title":"The cancer glycocalyx mechanically primes integrin-mediated growth and survival","volume":"511","author":"MJ Paszek","year":"2014","journal-title":"Nature"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.cub.2014.07.011","article-title":"Integrin-associated complexes form hierarchically with variable stoichiometry in nascent adhesions","volume":"24","author":"AI Bachir","year":"2014","journal-title":"Curr Biol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1242\/jcs.115.12.2581","article-title":"Trimers of the fibronectin cell adhesion domain localize to actin filament bundles and undergo rearward translocation","volume":"115","author":"F Coussen","year":"2002","journal-title":"J Cell Sci"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nrm2871","article-title":"The final steps of integrin activation: the end game","volume":"11","author":"SJ Shattil","year":"2010","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpj.2014.10.034","article-title":"Dynamic network morphology and tension buildup in a 3D model of cytokinetic ring assembly","volume":"107","author":"TC Bidone","year":"2014","journal-title":"Biophys J"},{"key":"ref14","doi-asserted-by":"crossref","DOI":"10.1002\/cm.21258","article-title":"Computational model of polarized actin cables and cytokinetic actin ring formation in budding yeast","volume":"72","author":"H Tang","year":"2015","journal-title":"Cytoskeleton"},{"key":"ref15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005277","article-title":"Morphological Transformation and Force Generation of Active Cytoskeletal Networks","volume":"13","author":"TC Bidone","year":"2017","journal-title":"PLoS Comput Biol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e49174","DOI":"10.1371\/journal.pone.0049174","article-title":"Dynamic mechanisms of cell rigidity sensing: insights from a computational model of actomyosin networks","author":"C Borau","year":"2012","journal-title":"PloS one"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.cub.2015.12.070","article-title":"ER-PM Contacts Define Actomyosin Kinetics for Proper Contractile Ring Assembly","volume":"26","author":"D Zhang","year":"2016","journal-title":"Curr Biol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1083\/jcb.200509075","article-title":"Paxillin phosphorylation at Ser273 localizes a GIT1-PIX-PAK complex and regulates adhesion and protrusion dynamics","volume":"173","author":"A Nayal","year":"2006","journal-title":"J Cell Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1083\/jcb.200612043","article-title":"Regulation of protrusion, adhesion dynamics, and polarity by myosins IIA and IIB in migrating cells","volume":"176","author":"M Vicente-Manzanares","year":"2007","journal-title":"J Cell Biol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"4605","DOI":"10.1242\/jcs.00792","article-title":"Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells","volume":"116","author":"R. Zaidel-Bar","year":"2003","journal-title":"J Cell Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.devcel.2015.11.001","article-title":"Nascent Integrin Adhesions Form on All Matrix Rigidities after Integrin Activation","volume":"35","author":"R Changede","year":"2015","journal-title":"Dev Cell. Elsevier"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1242\/jcs.03314","article-title":"A paxillin tyrosine phosphorylation switch regulates the assembly and form of cell-matrix adhesions","volume":"120","author":"R Zaidel-Bar","year":"2006","journal-title":"J Cell Sci"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"23258","DOI":"10.1038\/srep23258","article-title":"Substrate engagement of integrins \u03b15\u03b21 and \u03b1v\u03b23 is necessary, but not sufficient, for high directional persistence in migration on fibronectin","volume":"6","author":"D Missirlis","year":"2016","journal-title":"Sci Rep"},{"key":"ref24","article-title":"Integrin alphaIIb-beta3 activation in Chinese hamster ovary cells and platelets increases clustering rather than affinity","author":"TA Bunch","year":"2010","journal-title":"J Biol Chem"},{"key":"ref25","article-title":"Beta 1 and beta 3 integrins have different roles in the adhesion and migration of vascular smooth muscle cells on extracellular matrix","author":"RI Clyman","year":"1992","journal-title":"Exp Cell Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"RO Hynes","year":"2002","journal-title":"Cell"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1083\/jcb.153.7.1427","article-title":"Differential dynamics of??5 integrin, paxillin, and??-actinin during formation and disassembly of adhesions in migrating cells","volume":"153","author":"CM Laukaitis","year":"2001","journal-title":"J Cell Biol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/35060120","article-title":"Rac recruits high-affinity integrin \u03b1v\u03b23 to lamellipodia in endothelial cell migration","volume":"3","author":"W Kiosses","year":"2001","journal-title":"Nat Cell Biol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1161\/01.RES.83.3.241","article-title":"Role of beta1 and beta3 integrins in human smooth muscle cell adhesion to and contraction of fibrin clots in vitro","volume":"83","author":"KO Yee","year":"1998","journal-title":"Circ Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"4539","DOI":"10.1038\/emboj.2011.332","article-title":"Integrin adhesion and force coupling are independently regulated by localized PtdIns(4,5) 2 synthesis","volume":"30","author":"KR Legate","year":"2011","journal-title":"EMBO J"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.yjmcc.2010.10.003","article-title":"Fibronectin increases the force production of mouse papillary muscles via??5??1 integrin","volume":"50","author":"X Wu","year":"2011","journal-title":"J Mol Cell Cardiol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.febslet.2013.01.068","article-title":"Activation of beta 1 but not beta 3 integrin increases cell traction forces","volume":"587","author":"GL Lin","year":"2013","journal-title":"FEBS Lett"},{"key":"ref33","article-title":"Implications of the differing roles of the \u03b21 and \u03b23 transmembrane and cytosplasmic domains for integrin function","author":"Z Lu","year":"2016","journal-title":"Elife"},{"key":"ref34","article-title":"\u03b21- and \u03b23-class integrins mediate fibronectin binding activity at the surface of developing mouse peri-implantation blastocysts: Regulation by ligand-induced mobilization of stored receptor","author":"JF Schultz","year":"1995","journal-title":"J Biol Chem"},{"key":"ref35","article-title":"Beta3-integrins rather than beta1-integrins dominate integrin-matrix interactions involved in postinjury smooth muscle cell migration","author":"MJ Slepian","year":"1998","journal-title":"Circulation"},{"key":"ref36","article-title":"The fibronectin-binding integrins \u03b15\u03b21 and \u03b1v\u03b23 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis","author":"EHJ Danen","year":"2002","journal-title":"J Cell Biol"},{"key":"ref37","article-title":"Rigidity sensing and adaptation through regulation of integrin types","author":"A Elosegui-Artola","year":"2014","journal-title":"Nat Mater"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"16245","DOI":"10.1073\/pnas.0902818106","article-title":"Clustering of alpha(5)beta(1) integrins determines adhesion strength whereas alpha(v)beta(3) and talin enable mechanotransduction","volume":"106","author":"P Roca-Cusachs","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1091\/mbc.E16-01-0018","article-title":"Changes in single-molecule integrin dynamics linked to local cellular behavior","volume":"27","author":"K Jaqaman","year":"2016","journal-title":"Mol Biol Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"20585","DOI":"10.1073\/pnas.1109485108","article-title":"Early integrin binding to Arg-Gly-Asp peptide activates actin polymerization and contractile movement that stimulates outward translocation","volume":"108","author":"C -h. Yu","year":"2011","journal-title":"Proc Natl Acad Sci"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1083\/jcb.200703036","article-title":"Vinculin controls focal adhesion formation by direct interactions with talin and actin","volume":"179","author":"JD Humphries","year":"2007","journal-title":"J Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1083\/jcb.200204153","article-title":"The relationship between force and focal complex development","volume":"159","author":"CG Galbraith","year":"2002","journal-title":"J Cell Biol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/ncb2588","article-title":"Integrins \u03b21 and \u03b23 exhibit distinct dynamic nanoscale organizations inside focal adhesions","volume":"14","author":"O Rossier","year":"2012","journal-title":"Nat Cell Biol"},{"key":"ref44","article-title":"Conformational equilibria and intrinsic affinities define integrin activation","author":"J Li","year":"2017","journal-title":"EMBO J"},{"key":"ref45","article-title":"Identification of a region in the integrin \u03b23 subunit that confers ligand binding specificity","author":"ECK Lin","year":"1997","journal-title":"J Biol Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1021\/la8026804","article-title":"How focal adhesion size depends on integrin affinity","volume":"25","author":"T Zhao","year":"2009","journal-title":"Langmuir"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1126\/science.1168441","article-title":"Mechanically Activated Integrin Switch Controls 5 1 Function","volume":"323","author":"JC Friedland","year":"2009","journal-title":"Science"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"10988","DOI":"10.1074\/jbc.273.18.10988","article-title":"Force required to break??5??1 integrin-fibronectin bonds in intact adherent cells is sensitive to integrin activation state","volume":"273","author":"AJ Garc\u00eda","year":"1998","journal-title":"J Biol Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/S0006-3495(03)74940-6","article-title":"Force measurements of the alpha5beta1 integrin-fibronectin interaction","volume":"84","author":"F Li","year":"2003","journal-title":"Biophys J"},{"key":"ref50","article-title":"Tension is required but not sufficient for focal adhesion maturation without a stress fiber template","author":"PW Oakes","year":"2012","journal-title":"J Cell Biol"},{"key":"ref51","article-title":"WJG. T cell receptor-dependent, antigen-specific stimulation of a murine T cell clone induces a transient, VLA protein-mediated binding to extracellular matrix","author":"A Chan BM Rao","year":"1991","journal-title":"J Immunol"},{"key":"ref52","article-title":"A mechanism for divalent cation regulation of beta 3-integrins","author":"JW Smith","year":"1994","journal-title":"J Biol Chem"},{"key":"ref53","article-title":"Receptor functions for the integrin VLA-3: Fibronectin, collagen, and laminin binding are differentially influenced by ARG-GLY-ASP peptide and by divalent cations","author":"MJ Elices","year":"1991","journal-title":"J Cell Biol"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.biophys.31.101101.140922","article-title":"Conformational Regulation of Integrin Structure and Function","volume":"31","author":"M Shimaoka","year":"2002","journal-title":"Annu Rev Biophys Biomol Struct"},{"key":"ref55","article-title":"Demonstration of catch bonds between an integrin and its ligand","author":"F Kong","year":"2009","journal-title":"J Cell Biol"},{"key":"ref56","article-title":"Model for how retrograde actin flow regulates adhesion traction stresses","volume":"22","author":"Y Li","year":"2010","journal-title":"J Phys Condens Matter"},{"key":"ref57","article-title":"Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function","author":"S Miyamoto","year":"1995","journal-title":"Science"},{"key":"ref58","article-title":"Focal adhesions are sites of integrin extension","author":"JA Askari","year":"2010","journal-title":"J Cell Biol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/19336918.2016.1163453","article-title":"Selective binding and lateral clustering of \u03b15\u03b21 and \u03b1v\u03b23 integrins: Unraveling the spatial requirements for cell spreading and focal adhesion assembly","author":"V Schaufler","year":"2016","journal-title":"Cell Adhesion and Migration"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1083\/jcb.200810060","article-title":"Traction stress in focal adhesions correlates biphasically with actin retrograde fl ow speed","volume":"183","author":"ML Gardel","year":"2008","journal-title":"J Cell Biol"},{"key":"ref61","doi-asserted-by":"crossref","DOI":"10.1088\/1478-3975\/12\/3\/035002","article-title":"Model for adhesion clutch explains biphasic relationship between actin flow and traction at the cell leading edge","volume":"12","author":"EM Craig","year":"2015","journal-title":"Phys Biol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1529\/biophysj.106.089730","article-title":"Cell Spreading and Focal Adhesion Dynamics Are Regulated by Spacing of Integrin Ligands","volume":"92","author":"EA Cavalcanti-Adam","year":"2007","journal-title":"Biophys J"},{"key":"ref63","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13119","article-title":"Coordinated integrin activation by actin-dependent force during T-cell migration","volume":"7","author":"P Nordenfelt","year":"2016","journal-title":"Nat Commun"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1126\/science.1137904","article-title":"Polymerizing Actin Fibers Position Integrins Primed to Probe for Adhesion Sites","volume":"315","author":"CG Galbraith","year":"2007","journal-title":"Science"},{"key":"ref65","article-title":"A structural mechanism of integrin \u03b1IIb\u03b23"inside-out" activation as regulated by its cytoplasmic face","author":"O Vinogradova","year":"2002","journal-title":"Cell"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"e1001086","DOI":"10.1371\/journal.pcbi.1001086","article-title":"Molecular Dynamics Simulations of Forced Unbending of Integrin \u03b1V\u03b23","volume":"7","author":"W Chen","year":"2011","journal-title":"PLoS Comput Biol"},{"key":"ref67","article-title":"Conversion between three conformational states of integrin I domains with a C-terminal pull spring studied with molecular dynamics","author":"M Jin","year":"2004","journal-title":"Structure"},{"key":"ref68","article-title":"On the contributing role of the transmembrane domain for subunit-specific sensitivity of integrin activation","author":"G Pagani","year":"2018","journal-title":"Sci Rep"},{"key":"ref69","article-title":"Multiscale simulations suggest a mechanism for integrin inside-out activation","author":"AC Kalli","year":"2011","journal-title":"Proc Natl Acad Sci"},{"key":"ref70","article-title":"The Integrin Receptor in Biologically Relevant Bilayers: Insights from Molecular Dynamics Simulations","author":"AC Kalli","year":"2017","journal-title":"J Membr Biol"},{"key":"ref71","article-title":"Dynamics of \u03b23 integrin I-like and Hybrid domains: Insight from simulations on the mechanism of transition between open and closed forms","author":"T Gaillard","year":"2009","journal-title":"Proteins Struct Funct Bioinforma"},{"key":"ref72","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1000604","article-title":"Integrin clustering is driven by mechanical resistance from the glycocalyx and the substrate","volume":"5","author":"MJ Paszek","year":"2009","journal-title":"PLoS Comput Biol"},{"key":"ref73","article-title":"Clustered diffusion of integrins","author":"D Lepzelter","year":"2010","journal-title":"Biophys J"},{"key":"ref74","article-title":"Coarse-Grained Simulation of Full-Length Integrin Activation","author":"TC Bidone","year":"2019","journal-title":"Biophys J"},{"key":"ref75","article-title":"Simulations of cell-surface integrin binding to nanoscale-clustered adhesion ligands","author":"DJ Irvine","year":"2002","journal-title":"Biophys J"},{"key":"ref76","article-title":"Integrin Dimerization and Ligand Organization: Key Components in Integrin Clustering for Cell Adhesion","author":"CJ Brinkerhoff","year":"2005","journal-title":"Tissue Eng"},{"key":"ref77","article-title":"A spatial model for integrin clustering as a result of feedback between integrin activation and integrin binding","author":"ES Welf","year":"2012","journal-title":"Biophys J"},{"key":"ref78","article-title":"Integrin clustering in two and three dimensions","author":"D Lepzelter","year":"2012","journal-title":"Langmuir"},{"key":"ref79","article-title":"Collective Langevin dynamics of flexible cytoskeletal fibers","author":"F Nedelec","year":"2007","journal-title":"New J Phys"},{"key":"ref80","article-title":"MEDYAN: Mechanochemical Simulations of Contraction and Polarity Alignment in Actomyosin Networks","author":"K Popov","year":"2016","journal-title":"PLoS Comput Biol"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"13119","DOI":"10.1038\/ncomms13119","article-title":"Coordinated integrin activation by actin-dependent force during T-cell migration","volume":"7","author":"P Nordenfelt","year":"2016","journal-title":"Nat Commun"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1016\/j.bpj.2016.01.016","article-title":"Three-Dimensional Structures of Full-Length, Membrane-Embedded Human \u03b1(IIb)\u03b2(3) Integrin Complexes","volume":"110","author":"X-P Xu","year":"2016","journal-title":"Biophys J"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1091\/mbc.e14-05-0965","article-title":"Actin cable distribution and dynamics arising from cross-linking, motor pulling, and filament turnover","volume":"25","author":"H Tang","year":"2014","journal-title":"Mol Biol Cell"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"208021","DOI":"10.1103\/PhysRevE.64.020802","article-title":"Viscoelasticity of dilute solutions of semiflexible polymers","volume":"64","author":"M Pasquali","year":"2001","journal-title":"Phys Rev E\u2014Stat Nonlinear, Soft Matter Phys"},{"key":"ref85","article-title":"Direct measurement of stiffness of single actin filaments with and without tropomyosin by in vitro nanomanipulation","author":"H Kojima","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1016\/j.bpj.2011.05.023","article-title":"Spatiotemporal constraints on the force-dependent growth of focal adhesions","volume":"100","author":"J Stricker","year":"2011","journal-title":"Biophys J"},{"key":"ref87","article-title":"Functional atlas of the integrin adhesome","author":"R Zaidel-Bar","year":"2007","journal-title":"Nat Cell Biol"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jnnfm.2003.10.006","article-title":"On the coarse-graining of polymers into bead-spring chains","volume":"122","author":"PT Underhill","year":"2004","journal-title":"J Nonnewton Fluid Mech"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/ncb1763","article-title":"Actin and \u03b1-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner","volume":"10","author":"CK Choi","year":"2008","journal-title":"Nat Cell Biol"},{"key":"ref90","article-title":"Distinctive features of the biological catch bond in the jump-ramp force regime predicted by the two-pathway model","author":"V. Pereverzev Y","year":"2005","journal-title":"Phys Rev E\u2014Stat Nonlinear, Soft Matter Phys"},{"key":"ref91","article-title":"The two-pathway model for the catch-slip transition in biological adhesion","author":"Y V. Pereverzev","year":"2005","journal-title":"Biophys J"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1007077","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2019,6,14]],"date-time":"2019-06-14T00:00:00Z","timestamp":1560470400000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007077","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T09:00:37Z","timestamp":1663578037000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007077"}},"subtitle":[],"editor":[{"given":"Qiang","family":"Cui","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2019,6,4]]},"references-count":91,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1007077","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/542266","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,4]]}}}