{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:00:25Z","timestamp":1758816025622,"version":"3.37.3"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science London","doi-asserted-by":"publisher","award":["16K17643"],"award-info":[{"award-number":["16K17643"]}],"id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","award":["JPMJPR16E2"],"award-info":[{"award-number":["JPMJPR16E2"]}],"id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1007590","type":"journal-article","created":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T18:44:33Z","timestamp":1579113873000},"page":"e1007590","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["A single reaction-diffusion equation for the multifarious eruptions of urticaria"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8466-8037","authenticated-orcid":true,"given":"Sungrim","family":"Seirin-Lee","sequence":"first","affiliation":[]},{"given":"Yuhki","family":"Yanase","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9951-1342","authenticated-orcid":true,"given":"Shunsuke","family":"Takahagi","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1569-6034","authenticated-orcid":true,"given":"Michihiro","family":"Hide","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2020,1,15]]},"reference":[{"key":"pcbi.1007590.ref001","doi-asserted-by":"crossref","first-page":"212","DOI":"10.4168\/aair.2017.9.3.212","article-title":"Prevalence and Risk Factors of Urticaria With a Focus on Chronic Urticaria in Children","volume":"9","author":"SJ Lee","year":"2017","journal-title":"Allergy Asthma Immunol Res"},{"key":"pcbi.1007590.ref002","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.jaad.2018.02.026","article-title":"Global burden of urticaria: Insights from the 2016 Global Burden of Disease Study","volume":"79","author":"E Maxim","year":"2018","journal-title":"J. Am. Acad. Dermatol"},{"issue":"3","key":"pcbi.1007590.ref003","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1398-9995.2010.02496.x","article-title":"Unmet clinical needs in chronic spontaneous urticaria. A GA2LEN task force report","volume":"66","author":"M Maurer","year":"2011","journal-title":"Allergy"},{"key":"pcbi.1007590.ref004","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/imr.12632","article-title":"The role and relevance of mast cells in urticaria","volume":"282","author":"MK Church","year":"2018","journal-title":"Immunological Reviews"},{"key":"pcbi.1007590.ref005","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/1346-8138.14502","article-title":"Impact of chronic urticaria on quality of life and work in Japan: Results of a real-world study","volume":"45","author":"A Itakura","year":"2018","journal-title":"Journal of Dermatology"},{"key":"pcbi.1007590.ref006","article-title":"Pathogenesis of chronic urticaria: an overview","author":"S Jain","year":"2014","journal-title":"Dermatol Res Pract"},{"key":"pcbi.1007590.ref007","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/BF01968999","article-title":"Histamine secretion from mast cells stimulated with ATP","volume":"30","author":"Z. H. Jaffar","year":"1990","journal-title":"Agent and Actions"},{"key":"pcbi.1007590.ref008","doi-asserted-by":"crossref","first-page":"e83","DOI":"10.1038\/emm.2014.7","article-title":"New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development","volume":"46","author":"Y. Kurashima","year":"2014","journal-title":"Experimental & Molecular Medicine"},{"issue":"11","key":"pcbi.1007590.ref009","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1111\/all.13555","article-title":"Neuromedin-U directly induces degranulation of skin mast cells, presumably via MRGPRX2","volume":"73","author":"Y Matsuo","year":"2018","journal-title":"Allergy"},{"issue":"1","key":"pcbi.1007590.ref010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/imr.12629","article-title":"Non-IgE mediated mast cell activation","volume":"282","author":"FA Redegeld","year":"2018","journal-title":"Immunol Rev"},{"key":"pcbi.1007590.ref011","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/DAD.0000000000000786","article-title":"The Histopathology of Urticaria Revisited-Clinical Pathological Study","volume":"39","author":"A Bazilai","year":"2017","journal-title":"Am J Dermatopathology"},{"key":"pcbi.1007590.ref012","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/0091-6749(78)90113-6","article-title":"Assessment of tissue fluid histamine levels in patients with urticaria","volume":"61","author":"AP Kaplan","year":"1978","journal-title":"J Allergy Clin Immunol"},{"issue":"2","key":"pcbi.1007590.ref013","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/sj.ejcn.1600911","article-title":"Histamine plasma levels and elimination diet in chronic idiopathic urticaria","volume":"54","author":"B Guida","year":"2000","journal-title":"Eur J Clin Nutr"},{"issue":"1","key":"pcbi.1007590.ref014","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/imr.12632","article-title":"The role and relevance of mast cells in urticaria","volume":"282","author":"MK Church","year":"2018","journal-title":"Immunol Rev"},{"key":"pcbi.1007590.ref015","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1046\/j.1365-2133.2001.04175.x","article-title":"Management and diagnostic guidelines for urticaria and angiooedema","volume":"144","author":"British Association of Dermatologists","year":"2001","journal-title":"Br J Dermatol"},{"issue":"1","key":"pcbi.1007590.ref016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.iac.2013.07.009","article-title":"Pathology and classification of urticaria","volume":"34","author":"MW Greaves","year":"2014","journal-title":"Immunol Allergy Clin North Am"},{"key":"pcbi.1007590.ref017","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.1365-2222.1997.tb00707.x","article-title":"Histamine is released in the wheal but not the flare following challenge of human skin in vivo: a microdialysis study","volume":"27","author":"L. J. Petersen","year":"1997","journal-title":"Chemical and Experimental Allergy"},{"key":"pcbi.1007590.ref018","first-page":"684","volume-title":"Urticaria and Angioedema in Fitzpatrick's dermatology","author":"M Hide","year":"2019"},{"key":"pcbi.1007590.ref019","article-title":"Efficacy of increased dose of rupatadine up to 20 mg on itching in Japanese patients due to chronic spontaneous urticaria, dermatitis, or pruritus: A post hoc analysis of phase III clinical trial","author":"M Hide","year":"2019","journal-title":"Journal of Cutaneous Immunology and Allergy"},{"issue":"1","key":"pcbi.1007590.ref020","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/bph.12266","article-title":"The role of histamine in neurogenic inflammation","volume":"170","author":"AC Rosa","year":"2013","journal-title":"Br J Pharmacol"},{"key":"pcbi.1007590.ref021","doi-asserted-by":"crossref","DOI":"10.1007\/b98869","volume-title":"Mathematical Biology II: Spatial Models and Biomedical Applications","author":"JD Murray","year":"2003"},{"issue":"4","key":"pcbi.1007590.ref022","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.alit.2018.03.007","article-title":"The role of adenosine for IgE receptor-dependent degranulation of human peripheral basophils and skin mast cells","volume":"67","author":"Y Matsuo","year":"2018","journal-title":"Allergol Int"},{"issue":"1","key":"pcbi.1007590.ref023","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1111\/exd.13407","article-title":"Mast cells are critical for the limitation of thrombin-induced skin inflammation","volume":"27","author":"CA Suender","year":"2018","journal-title":"Exp Dermatol"},{"key":"pcbi.1007590.ref024","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-58194-1","volume-title":"Histamine and histamine receptors in health and disease (Part IV: Church MK, Allergy, histamine and antihistamines)","author":"Y Hattori","year":"2017"},{"issue":"3","key":"pcbi.1007590.ref025","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.jaci.2017.07.026","article-title":"Histamine and TLR ligands synergistically induce endothelial-cell gap-formation by the extrinsic coagulating pathway","volume":"141","author":"Y Yanase","year":"2018","journal-title":"J Allergy Clin Immunol"},{"key":"pcbi.1007590.ref026","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.alit.2017.09.003","article-title":"Chronic spontaneous urticaria and the extrinsic coagulation system","volume":"67","author":"Y Yanase","year":"2018","journal-title":"Allergol Int"},{"key":"pcbi.1007590.ref027","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1046\/j.0022-202x.2001.00023.x","article-title":"Definition, classification, and routine diagnosis of urticaria: a consensus report","volume":"6","author":"T Zuberbier","year":"2001","journal-title":"J Invest Dermatol Symposium Proceedings"},{"issue":"2","key":"pcbi.1007590.ref028","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/00015550310006860","article-title":"Food-dependent exercise-induced anaphylaxis due to ingestion of orange","volume":"84","author":"K Morimoto","year":"2004","journal-title":"Acta Derm Venereol"},{"issue":"4","key":"pcbi.1007590.ref029","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/ams2.114","article-title":"Diagnosis and long-term management of hydrolyzed wheat protein wheat-dependent exercise-induced anaphylaxis","volume":"2","author":"JI Hirata","year":"2015","journal-title":"Acute Med Surg"},{"issue":"5","key":"pcbi.1007590.ref030","doi-asserted-by":"crossref","first-page":"310","DOI":"10.18176\/jiaci.0051","article-title":"Detection of low-molecular-weight mast cell-activating factors in serum from patients with chronic spontaneous urticaria","volume":"26","author":"M Cugno","year":"2016","journal-title":"J. Investig Allergol Clin Immunol"},{"issue":"Suppl 2","key":"pcbi.1007590.ref031","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1159\/000350388","article-title":"Significantly high levels of anti-dsDNA immunoglobulin E in sera and the ability of dsDNA to induce the degranulation of basophils from chronic urticaria patients","volume":"161","author":"Y Hatada","year":"2013","journal-title":"Int Arch Allergy Immunol"},{"issue":"5","key":"pcbi.1007590.ref032","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1745-7254.2005.00079.x","article-title":"Activation of human tonsil and skin mast cells by agonists of proteinase activated receptor-2","volume":"26","author":"SH He","year":"2005","journal-title":"Acta Pharmacol Sin"},{"issue":"22","key":"pcbi.1007590.ref033","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1056\/NEJM199306033282204","article-title":"Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria","volume":"328","author":"M Hide","year":"1993","journal-title":"N Engl J Med"},{"issue":"10","key":"pcbi.1007590.ref034","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1056\/NEJMoa1215372","article-title":"Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria","volume":"368","author":"M Maurer","year":"2013","journal-title":"N Engl J Med"},{"journal-title":"J Allergy Clin Immunol","article-title":"IL-24 is a common and specific autoantigen of IgE in patients with chronic spontaneous urticaria","author":"O Schmetzer","key":"pcbi.1007590.ref035"},{"issue":"1","key":"pcbi.1007590.ref036","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.jdermsci.2017.02.283","article-title":"Management of chronic inducible urticaria according to the guidelines: A prospective controlled study","volume":"87","author":"E Kocat\u00fcrk","year":"2017","journal-title":"J Dermatol Sci"},{"key":"pcbi.1007590.ref037","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.jtbi.2016.02.032","article-title":"Mathematical model for calcium-assisted epidermal homeostasis","volume":"397","author":"Y. Kobayashi","year":"2016","journal-title":"Journal of Theoretical Biology"},{"issue":"4","key":"pcbi.1007590.ref038","doi-asserted-by":"crossref","first-page":"470","DOI":"10.4168\/aair.2019.11.4.470","article-title":"Emerging Therapies in Chronic Spontaneous Urticaria","volume":"11","author":"TK Min","year":"2019","journal-title":"Allergy Asthma Immunol Res"},{"key":"pcbi.1007590.ref039","article-title":"New biological treatments for asthma and skin allergies","author":"S Eyerich","year":"2019","journal-title":"Allergy"}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T06:08:01Z","timestamp":1613974081000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007590"}},"subtitle":[],"editor":[{"given":"Roeland M.H.","family":"Merks","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2020,1,15]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1007590","relation":{},"ISSN":["1553-7358"],"issn-type":[{"type":"electronic","value":"1553-7358"}],"subject":[],"published":{"date-parts":[[2020,1,15]]}}}