{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:08:50Z","timestamp":1772172530464,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1007605","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000}}],"reference-count":88,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["CB-2015-01"],"award-info":[{"award-number":["CB-2015-01"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["255914-F7"],"award-info":[{"award-number":["255914-F7"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["CB-2015-01 255914-F7"],"award-info":[{"award-number":["CB-2015-01 255914-F7"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["275795"],"award-info":[{"award-number":["275795"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["EPE-2017 291231"],"award-info":[{"award-number":["EPE-2017 291231"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005635","name":"Funda\u00e7\u00e3o Calouste Gulbenkian","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005635","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1007605","type":"journal-article","created":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T13:35:01Z","timestamp":1583156101000},"page":"e1007605","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Modular analysis of the control of flagellar Ca2+-spike trains produced by CatSper and CaV channels in sea urchin sperm"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5780-8789","authenticated-orcid":true,"given":"Daniel A.","family":"Priego-Espinosa","sequence":"first","affiliation":[]},{"given":"Alberto","family":"Darszon","sequence":"additional","affiliation":[]},{"given":"Ad\u00e1n","family":"Guerrero","sequence":"additional","affiliation":[]},{"given":"Ana Laura","family":"Gonz\u00e1lez-Cota","sequence":"additional","affiliation":[]},{"given":"Takuya","family":"Nishigaki","sequence":"additional","affiliation":[]},{"given":"Gustavo","family":"Mart\u00ednez-Mekler","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7520-3406","authenticated-orcid":true,"given":"Jorge","family":"Carneiro","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2020,3,2]]},"reference":[{"issue":"1","key":"pcbi.1007605.ref001","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/35036035","article-title":"The versatility and universality of calcium signalling","volume":"1","author":"MJ Berridge","year":"2000","journal-title":"Nature reviews Molecular cell biology"},{"issue":"6","key":"pcbi.1007605.ref002","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.bbamcr.2008.10.005","article-title":"Inositol trisphosphate and calcium signalling mechanisms","volume":"1793","author":"MJ Berridge","year":"2009","journal-title":"Biochimica et Biophysica Acta\u2014Molecular Cell Research"},{"issue":"4","key":"pcbi.1007605.ref003","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1073\/pnas.87.4.1461","article-title":"Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation","volume":"87","author":"A Goldbeter","year":"1990","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"2","key":"pcbi.1007605.ref004","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1002\/dvdy.20238","article-title":"Role of a spatial distribution of IP3 receptors in the Ca2+ dynamics of the Xenopus embryo at the mid-blastula transition stage","volume":"232","author":"J D\u00edaz","year":"2005","journal-title":"Developmental dynamics: an official publication of the American Association of Anatomists"},{"issue":"4","key":"pcbi.1007605.ref005","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0959-4388(99)80063-4","article-title":"Calcium signalling and regulation in olfactory neurons","volume":"9","author":"A Menini","year":"1999","journal-title":"Current Opinion in Neurobiology"},{"issue":"3","key":"pcbi.1007605.ref006","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1152\/physrev.00008.2002","article-title":"Cyclic nucleotide-gated ion channels","volume":"82","author":"UB Kaupp","year":"2002","journal-title":"Physiological reviews"},{"issue":"5-6","key":"pcbi.1007605.ref007","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1387\/ijdb.072550ad","article-title":"Sperm-activating peptides in the regulation of ion fluxes, signal transduction and motility","volume":"52","author":"A Darszon","year":"2008","journal-title":"The International journal of developmental biology"},{"issue":"2","key":"pcbi.1007605.ref008","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.tcb.2016.10.002","article-title":"Signaling in Sperm: More Different than Similar","volume":"27","author":"UB Kaupp","year":"2017","journal-title":"Trends in Cell Biology"},{"issue":"15","key":"pcbi.1007605.ref009","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1038\/sj.emboj.7600744","article-title":"Ca2+ spikes in the flagellum control chemotactic behavior of sperm","volume":"24","author":"M B\u00f6hmer","year":"2005","journal-title":"The EMBO journal"},{"issue":"10","key":"pcbi.1007605.ref010","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1038\/ncb1473","article-title":"A K+-selective cGMP-gated ion channel controls chemosensation of sperm","volume":"8","author":"T Str\u00fcnker","year":"2006","journal-title":"Nature cell biology"},{"issue":"2","key":"pcbi.1007605.ref011","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.ydbio.2007.03.036","article-title":"Altering the speract-induced ion permeability changes that generate flagellar Ca2+ spikes regulates their kinetics and sea urchin sperm motility","volume":"306","author":"CD Wood","year":"2007","journal-title":"Developmental Biology"},{"key":"pcbi.1007605.ref012","doi-asserted-by":"crossref","first-page":"379","DOI":"10.15252\/embj.201489376","article-title":"The CatSper channel controls chemosensation in sea urchin sperm","volume":"34","author":"R Seifert","year":"2014","journal-title":"The EMBO Journal"},{"issue":"12","key":"pcbi.1007605.ref013","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/ncb1072","article-title":"A new sperm-specific Na+\/H+ exchanger required for sperm motility and fertility","volume":"5","author":"D Wang","year":"2003","journal-title":"Nature cell biology"},{"issue":"1","key":"pcbi.1007605.ref014","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1083\/jcb.200212053","article-title":"Speract induces calcium oscillations in the sperm tail","volume":"161","author":"CD Wood","year":"2003","journal-title":"The Journal of cell biology"},{"issue":"5","key":"pcbi.1007605.ref015","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1083\/jcb.200411001","article-title":"Real-time analysis of the role of Ca(2+) in flagellar movement and motility in single sea urchin sperm","volume":"169","author":"CD Wood","year":"2005","journal-title":"The Journal of cell biology"},{"issue":"29","key":"pcbi.1007605.ref016","doi-asserted-by":"crossref","first-page":"6667","DOI":"10.1016\/j.febslet.2005.10.035","article-title":"Identification of voltage-dependent Ca2+ channels in sea urchin sperm","volume":"579","author":"G Granados-Gonzalez","year":"2005","journal-title":"FEBS letters"},{"issue":"8","key":"pcbi.1007605.ref017","doi-asserted-by":"crossref","first-page":"e22619","DOI":"10.1371\/journal.pone.0022619","article-title":"Discrete dynamics model for the speract-activated Ca2+ signaling network relevant to sperm motility","volume":"6","author":"J Espinal","year":"2011","journal-title":"PloS one"},{"issue":"1","key":"pcbi.1007605.ref018","doi-asserted-by":"crossref","first-page":"4236","DOI":"10.1038\/s41598-017-03857-9","article-title":"Network model predicts that CatSper is the main Ca2+channel in the regulation of sea urchin sperm motility","volume":"7","author":"J Espinal-Enr\u00edquez","year":"2017","journal-title":"Scientific reports"},{"key":"pcbi.1007605.ref019","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cophys.2018.02.004","article-title":"CatSper: a unique calcium channel of the sperm flagellum","volume":"2","author":"PV Lishko","year":"2018","journal-title":"Current Opinion in Physiology"},{"issue":"8","key":"pcbi.1007605.ref020","doi-asserted-by":"crossref","first-page":"e104451","DOI":"10.1371\/journal.pone.0104451","article-title":"In silico determination of the effect of multi-target drugs on calcium dynamics signaling network underlying sea urchin spermatozoa motility","volume":"9","author":"J Espinal-Enr\u00edquez","year":"2014","journal-title":"PloS one"},{"issue":"11","key":"pcbi.1007605.ref021","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1016\/j.bpj.2012.03.075","article-title":"What is the core oscillator in the speract-activated pathway of the Strongylocentrotus purpuratus sperm flagellum?","volume":"102","author":"LU Aguilera","year":"2012","journal-title":"Biophysical journal"},{"issue":"2","key":"pcbi.1007605.ref022","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/ncb915","article-title":"The signal flow and motor response controling chemotaxis of sea urchin sperm","volume":"5","author":"UB Kaupp","year":"2003","journal-title":"Nature cell biology"},{"issue":"2","key":"pcbi.1007605.ref023","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1152\/physrev.00030.2010","article-title":"Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions","volume":"91","author":"SH Francis","year":"2011","journal-title":"Physiological Reviews"},{"key":"pcbi.1007605.ref024","doi-asserted-by":"crossref","DOI":"10.1137\/1.9780898718195","volume-title":"Simulating, Analyzing, and Animating Dynamical Systems. Society for Industrial and Applied Mathematics","author":"B Ermentrout","year":"2002"},{"issue":"11","key":"pcbi.1007605.ref025","doi-asserted-by":"crossref","first-page":"e1005820","DOI":"10.1371\/journal.pcbi.1005820","article-title":"Competitive tuning: Competition\u2019s role in setting the frequency-dependence of Ca2+-dependent proteins","volume":"13","author":"DR Romano","year":"2017","journal-title":"PLOS Computational Biology"},{"key":"pcbi.1007605.ref026","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.02038","article-title":"A Sensitivity Analysis Comparison of Three Models for the Dynamics of Germinal Centers","volume":"10","author":"J Faro","year":"2019","journal-title":"Frontiers in Immunology"},{"issue":"6","key":"pcbi.1007605.ref027","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1083\/jcb.201204024","article-title":"Temporal sampling, resetting, and adaptation orchestrate gradient sensing in sperm","volume":"198","author":"ND Kashikar","year":"2012","journal-title":"The Journal of cell biology"},{"issue":"4","key":"pcbi.1007605.ref028","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1083\/jcb.201402027","article-title":"High density and ligand affinity confer ultrasensitive signal detection by a guanylyl cyclase chemoreceptor","volume":"206","author":"M Pichlo","year":"2014","journal-title":"The Journal of cell biology"},{"key":"pcbi.1007605.ref029","doi-asserted-by":"crossref","first-page":"7985","DOI":"10.1038\/ncomms8985","article-title":"Sperm navigation along helical paths in 3D chemoattractant landscapes","volume":"6","author":"JF Jikeli","year":"2015","journal-title":"Nature communications"},{"issue":"1","key":"pcbi.1007605.ref030","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1091\/mbc.e05-08-0820","article-title":"Cyclic GMP-specific phosphodiesterase-5 regulates motility of sea urchin spermatozoa","volume":"17","author":"YH Su","year":"2006","journal-title":"Molecular biology of the cell"},{"issue":"5","key":"pcbi.1007605.ref031","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1083\/jcb.201106096","article-title":"The rate of change in Ca2+ concentration controls sperm chemotaxis","volume":"196","author":"L Alvarez","year":"2012","journal-title":"The Journal of cell biology"},{"issue":"16","key":"pcbi.1007605.ref032","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1016\/j.febslet.2015.06.024","article-title":"Single cell imaging reveals that the motility regulator speract induces a flagellar alkalinization that precedes and is independent of Ca2+ influx in sea urchin spermatozoa","volume":"589","author":"AL Gonz\u00e1lez-Cota","year":"2015","journal-title":"FEBS letters"},{"issue":"1","key":"pcbi.1007605.ref033","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1002\/1521-1878(200101)23:1<86::AID-BIES1011>3.0.CO;2-D","article-title":"Cellular oscillations and the regulation of growth: the pollen tube paradigm","volume":"23","author":"JA Feij\u00f3","year":"2001","journal-title":"BioEssays: news and reviews in molecular, cellular and developmental biology"},{"issue":"2","key":"pcbi.1007605.ref034","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.ydbio.2004.04.035","article-title":"A sea urchin egg jelly peptide induces a cGMP-mediated decrease in sperm intracellular Ca 2+ before its increase","volume":"272","author":"T Nishigaki","year":"2004","journal-title":"Developmental Biology"},{"issue":"24","key":"pcbi.1007605.ref035","doi-asserted-by":"crossref","first-page":"14881","DOI":"10.1016\/S0021-9258(18)33365-9","article-title":"Elevation of the intracellular pH activates respiration and motility of sperm of the sea urchin, Strongylocentrotus purpuratus","volume":"257","author":"R Christen","year":"1982","journal-title":"The Journal of biological chemistry"},{"issue":"9","key":"pcbi.1007605.ref036","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1016\/S0021-9258(20)81902-4","article-title":"Metabolism of sea urchin sperm. Interrelationships between intracellular pH, ATPase activity, and mitochondrial respiration","volume":"258","author":"R Christen","year":"1983","journal-title":"The Journal of biological chemistry"},{"issue":"5616","key":"pcbi.1007605.ref037","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1126\/science.1083628","article-title":"Cell biology. Apoptosis\u2013the calcium connection","volume":"300","author":"N Demaurex","year":"2003","journal-title":"Science (New York, NY)"},{"key":"pcbi.1007605.ref038","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1196\/annals.1329.050","article-title":"Mitochondria of human spermatozoa are preferentially susceptible to apoptosis","volume":"1030","author":"U Paasch","year":"2004","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"13","key":"pcbi.1007605.ref039","doi-asserted-by":"crossref","first-page":"4904","DOI":"10.1073\/pnas.1120680109","article-title":"Mitochondrial pathway of apoptosis is ancestral in metazoans","volume":"109","author":"CE Bender","year":"2012","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"pcbi.1007605.ref040","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1113\/jphysiol.1986.sp016080","article-title":"Action potentials, macroscopic and single channel currents recorded from growth cones of Aplysia neurones in culture","volume":"374","author":"F Belardetti","year":"1986","journal-title":"The Journal of physiology"},{"key":"pcbi.1007605.ref041","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1113\/jphysiol.1993.sp019676","article-title":"Large conductance Ca(2+)-activated K+ channels are involved in both spike shaping and firing regulation in Helix neurones","volume":"465","author":"M Crest","year":"1993","journal-title":"The Journal of physiology"},{"issue":"4","key":"pcbi.1007605.ref042","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1152\/jn.1999.82.4.1655","article-title":"Fast BK-type channel mediates the Ca(2+)-activated K(+) current in crayfish muscle","volume":"82","author":"A Araque","year":"1999","journal-title":"Journal of neurophysiology"},{"issue":"1-2","key":"pcbi.1007605.ref043","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF01870671","article-title":"Conduction and selectivity in potassium channels","volume":"71","author":"R Latorre","year":"1983","journal-title":"The Journal of Membrane Biology"},{"issue":"6","key":"pcbi.1007605.ref044","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1242\/jcs.121442","article-title":"Niflumic acid disrupts marine spermatozoan chemotaxis without impairing the spatiotemporal detection of chemoattractant gradients","volume":"126","author":"A Guerrero","year":"2013","journal-title":"Journal of cell science"},{"issue":"4","key":"pcbi.1007605.ref045","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.cell.2014.02.056","article-title":"Structurally distinct Ca2+ signaling domains of sperm flagella orchestrate tyrosine phosphorylation and motility","volume":"157","author":"JJ Chung","year":"2014","journal-title":"Cell"},{"issue":"10","key":"pcbi.1007605.ref046","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1016\/j.celrep.2018.08.016","article-title":"Asymmetrically Positioned Flagellar Control Units Regulate Human Sperm Rotation","volume":"24","author":"MR Miller","year":"2018","journal-title":"Cell Reports"},{"issue":"4","key":"pcbi.1007605.ref047","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1113\/jphysiol.1952.sp004764","article-title":"A quantitative description of membrane current and its application to conduction and excitation in nerve","volume":"117","author":"AL HODGKIN","year":"1952","journal-title":"The Journal of physiology"},{"issue":"94","key":"pcbi.1007605.ref048","doi-asserted-by":"crossref","first-page":"ra68","DOI":"10.1126\/scisignal.2000516","article-title":"An atypical CNG channel activated by a single cGMP molecule controls sperm chemotaxis","volume":"2","author":"W B\u00f6nigk","year":"2009","journal-title":"Science signaling"},{"issue":"1","key":"pcbi.1007605.ref049","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1006\/dbio.2000.9734","article-title":"Real-time measurements of the interactions between fluorescent speract and its sperm receptor","volume":"223","author":"T Nishigaki","year":"2000","journal-title":"Developmental biology"},{"issue":"2","key":"pcbi.1007605.ref050","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1006\/bbrc.2001.5000","article-title":"Time-resolved sperm responses to an egg peptide measured by stopped-flow fluorometry","volume":"284","author":"T Nishigaki","year":"2001","journal-title":"Biochemical and biophysical research communications"},{"issue":"5","key":"pcbi.1007605.ref051","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1095\/biolreprod35.5.1249","article-title":"Receptor-mediated responses of plasma membranes isolated from Lytechinus pictus spermatozoa","volume":"35","author":"JK Bentley","year":"1986","journal-title":"Biology of reproduction"},{"issue":"1","key":"pcbi.1007605.ref052","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1083\/jcb.103.1.95","article-title":"Phosphorylation of membrane-bound guanylate cyclase of sea urchin spermatozoa","volume":"103","author":"GE Ward","year":"1986","journal-title":"The Journal of cell biology"},{"issue":"3","key":"pcbi.1007605.ref053","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/S0021-9258(19)57335-5","article-title":"Purification and properties of the phosphorylated form of guanylate cyclase","volume":"263","author":"CS Ramarao","year":"1988","journal-title":"The Journal of biological chemistry"},{"issue":"11","key":"pcbi.1007605.ref054","doi-asserted-by":"crossref","first-page":"e1003274","DOI":"10.1371\/journal.pcbi.1003274","article-title":"A Tunable Coarse-Grained Model for Ligand-Receptor Interaction","volume":"9","author":"T Ruiz-Herrero","year":"2013","journal-title":"PLoS Computational Biology"},{"issue":"22","key":"pcbi.1007605.ref055","doi-asserted-by":"crossref","first-page":"13712","DOI":"10.1016\/S0021-9258(18)89803-9","article-title":"Identification and partial characterization of the receptor for speract","volume":"259","author":"LJ Dangott","year":"1984","journal-title":"The Journal of biological chemistry"},{"issue":"32","key":"pcbi.1007605.ref056","doi-asserted-by":"crossref","first-page":"14859","DOI":"10.1016\/S0021-9258(18)66793-6","article-title":"Receptor-mediated activation of spermatozoan guanylate cyclase","volume":"261","author":"JK Bentley","year":"1986","journal-title":"The Journal of biological chemistry"},{"issue":"33","key":"pcbi.1007605.ref057","doi-asserted-by":"crossref","first-page":"15778","DOI":"10.1016\/S0021-9258(18)66786-9","article-title":"Covalent coupling of a resact analogue to guanylate cyclase","volume":"261","author":"H Shimomura","year":"1986","journal-title":"The Journal of biological chemistry"},{"issue":"6184","key":"pcbi.1007605.ref058","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/334708a0","article-title":"Membrane guanylate cyclase is a cell-surface receptor with homology to protein kinases","volume":"334","author":"S Singh","year":"1988","journal-title":"Nature"},{"issue":"3","key":"pcbi.1007605.ref059","first-page":"668","article-title":"Sp-tetraKCNG: A novel cyclic nucleotide gated K+ channel","volume":"354","author":"BBE Galindo","year":"2007","journal-title":"Biochemical and \u2026"},{"issue":"1","key":"pcbi.1007605.ref060","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tibs.2010.07.004","article-title":"Cooperative and uncooperative cyclic-nucleotide-gated ion channels","volume":"36","author":"A Cukkemane","year":"2011","journal-title":"Trends in biochemical sciences"},{"issue":"2","key":"pcbi.1007605.ref061","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1006\/dbio.1996.0072","article-title":"A cAMP regulated K+-selective channel from the sea urchin sperm plasma membrane","volume":"174","author":"P Labarca","year":"1996","journal-title":"Developmental biology"},{"issue":"6685","key":"pcbi.1007605.ref062","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/31248","article-title":"Molecular identification of a hyperpolarization-activated channel in sea urchin sperm","volume":"393","author":"R Gauss","year":"1998","journal-title":"Nature"},{"issue":"1","key":"pcbi.1007605.ref063","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0014-5793(01)02713-2","article-title":"Sea urchin sperm cation-selective channels directly modulated by cAMP","volume":"503","author":"D S\u00e1nchez","year":"2001","journal-title":"FEBS letters"},{"issue":"5","key":"pcbi.1007605.ref064","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0896-6273(04)00083-2","article-title":"Inactivation in HCN channels results from reclosure of the activation gate: desensitization to voltage","volume":"41","author":"KS Shin","year":"2004","journal-title":"Neuron"},{"issue":"9","key":"pcbi.1007605.ref065","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/cm.20147","article-title":"Proteins associated with soluble adenylyl cyclase in sea urchin sperm flagella","volume":"63","author":"M Nomura","year":"2006","journal-title":"Cell motility and the cytoskeleton"},{"issue":"24","key":"pcbi.1007605.ref066","doi-asserted-by":"crossref","first-page":"15315","DOI":"10.1016\/S0021-9258(17)42551-8","article-title":"A membrane potential-sensitive Na+-H+ exchange system in flagella isolated from sea urchin spermatozoa","volume":"259","author":"HC Lee","year":"1984","journal-title":"The Journal of biological chemistry"},{"issue":"8","key":"pcbi.1007605.ref067","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.1016\/S0021-9258(17)42939-5","article-title":"Sodium and proton transport in flagella isolated from sea urchin spermatozoa","volume":"259","author":"HC Lee","year":"1984","journal-title":"The Journal of biological chemistry"},{"issue":"1-2","key":"pcbi.1007605.ref068","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/0014-5793(93)80223-H","article-title":"Ionic bases of the membrane potential and intracellular pH changes induced by speract in swollen sea urchin sperm","volume":"329","author":"E Reynaud","year":"1993","journal-title":"FEBS letters"},{"issue":"34","key":"pcbi.1007605.ref069","doi-asserted-by":"crossref","first-page":"16026","DOI":"10.1016\/S0021-9258(18)66670-0","article-title":"Modulation of the voltage-sensitive Na+\/H+ exchange in sea urchin spermatozoa through membrane potential changes induced by the egg peptide speract","volume":"261","author":"HC Lee","year":"1986","journal-title":"The Journal of biological chemistry"},{"issue":"13","key":"pcbi.1007605.ref070","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1113\/jphysiol.2008.151977","article-title":"Analysis of cardiac mitochondrial Na+-Ca2+ exchanger kinetics with a biophysical model of mitochondrial Ca2+ handling suggests a 3:1 stoichiometry","volume":"586","author":"RK Dash","year":"2008","journal-title":"The Journal of physiology"},{"issue":"10","key":"pcbi.1007605.ref071","doi-asserted-by":"crossref","first-page":"e3569","DOI":"10.1371\/journal.pone.0003569","article-title":"Evolutionary genomics reveals lineage-specific gene loss and rapid evolution of a sperm-specific ion channel complex: CatSpers and CatSperbeta","volume":"3","author":"X Cai","year":"2008","journal-title":"PloS one"},{"issue":"7077","key":"pcbi.1007605.ref072","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nature04417","article-title":"Whole-cell patch-clamp measurements of spermatozoa reveal an alkaline-activated Ca2+ channel","volume":"439","author":"Y Kirichok","year":"2006","journal-title":"Nature"},{"issue":"7338","key":"pcbi.1007605.ref073","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nature09767","article-title":"Progesterone activates the principal Ca2+ channel of human sperm","volume":"471","author":"PV Lishko","year":"2011","journal-title":"Nature"},{"issue":"7338","key":"pcbi.1007605.ref074","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/nature09769","article-title":"The CatSper channel mediates progesterone-induced Ca2+ influx in human sperm","volume":"471","author":"T Str\u00fcnker","year":"2011","journal-title":"Nature"},{"issue":"9","key":"pcbi.1007605.ref075","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v033.i09","article-title":"Solving Differential Equations in R: Package deSolve","volume":"33","author":"K Soetaert","year":"2010","journal-title":"Journal of Statistical Software"},{"issue":"2","key":"pcbi.1007605.ref076","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1085\/jgp.117.2.91","article-title":"Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate","volume":"117","author":"KS Shin","year":"2001","journal-title":"The Journal of general physiology"},{"issue":"2","key":"pcbi.1007605.ref077","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ceca.2006.04.013","article-title":"Biophysics and structure-function relationship of T-type Ca2+ channels","volume":"40","author":"K Talavera","year":"2006","journal-title":"Cell Calcium"},{"issue":"1","key":"pcbi.1007605.ref078","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ydbio.2010.04.013","article-title":"Tuning sperm chemotaxis by calcium burst timing","volume":"344","author":"A Guerrero","year":"2010","journal-title":"Developmental Biology"},{"issue":"1","key":"pcbi.1007605.ref079","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0012-1606(83)90004-0","article-title":"Changes in internal pH associated with initiation of motility and acrosome reaction of sea urchin sperm","volume":"95","author":"HC Lee","year":"1983","journal-title":"Developmental biology"},{"issue":"13","key":"pcbi.1007605.ref080","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1073\/pnas.89.13.6001","article-title":"Early persistent activation of sperm K+ channels by the egg peptide speract","volume":"89","author":"DF Babcock","year":"1992","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"Pt 1","key":"pcbi.1007605.ref081","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1113\/jphysiol.2002.030510","article-title":"Intracellular sodium changes during the speract response and the acrosome reaction in sea urchin sperm","volume":"546","author":"E Rodr\u00edguez","year":"2003","journal-title":"The Journal of physiology"},{"issue":"1","key":"pcbi.1007605.ref082","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1113\/jphysiol.1992.sp019335","article-title":"Macroscopic and unitary properties of physiological ion flux through T-type Ca2+ channels in guinea-pig heart cells","volume":"456","author":"CW Balke","year":"1992","journal-title":"The Journal of Physiology"},{"key":"pcbi.1007605.ref083","volume-title":"Pathologies of Calcium Channels","author":"T Nishigaki","year":"2014"},{"issue":"1","key":"pcbi.1007605.ref084","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0012-1606(92)90018-C","article-title":"A depolarization can trigger Ca2+ uptake and the acrosome reaction when preceded by a hyperpolarization in L. pictus sea urchin sperm","volume":"150","author":"MT Gonz\u00e1lez-Mart\u00ednez","year":"1992","journal-title":"Developmental biology"},{"issue":"23","key":"pcbi.1007605.ref085","doi-asserted-by":"crossref","first-page":"7591","DOI":"10.1021\/bi952806v","article-title":"Membrane potential regulates sea urchin sperm adenylylcyclase","volume":"35","author":"C Beltr\u00e1n","year":"1996","journal-title":"Biochemistry"},{"key":"pcbi.1007605.ref086","volume-title":"Ion Channels of Excitable Membranes (3rd Edition)","author":"B Hille","year":"2001"},{"key":"pcbi.1007605.ref087","volume-title":"Formulae and Methods VI of the Marine Biological Laboratory Chemical Room","author":"GM Cavanaugh","year":"1956"},{"issue":"2","key":"pcbi.1007605.ref088","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0092-8674(86)90392-2","article-title":"Retention of a functional resact receptor in isolated sperm plasma membranes","volume":"45","author":"JK Bentley","year":"1986","journal-title":"Cell"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1007605","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007605","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T21:07:18Z","timestamp":1614632838000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007605"}},"subtitle":[],"editor":[{"given":"David","family":"Umulis","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2020,3,2]]},"references-count":88,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1007605","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/415687","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,2]]}}}