{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T07:55:12Z","timestamp":1769586912389,"version":"3.49.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1007671","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000}}],"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"crossref","award":["RGS\/R2\/180195"],"award-info":[{"award-number":["RGS\/R2\/180195"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/M017982\/1"],"award-info":[{"award-number":["BB\/M017982\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/N017846\/1"],"award-info":[{"award-number":["EP\/N017846\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/N014391\/1"],"award-info":[{"award-number":["EP\/N014391\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1007671","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T17:36:22Z","timestamp":1584380182000},"page":"e1007671","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["A simplified modelling framework facilitates more complex representations of plant circadian clocks"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1400-2659","authenticated-orcid":true,"given":"Mathias","family":"Foo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Declan G.","family":"Bates","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9320-5958","authenticated-orcid":true,"given":"Ozgur E.","family":"Akman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,3,16]]},"reference":[{"issue":"16","key":"pcbi.1007671.ref001","doi-asserted-by":"crossref","first-page":"R648","DOI":"10.1016\/j.cub.2012.07.025","article-title":"Complexity in the wiring and regulation of plant circadian networks","volume":"22","author":"DH Nagel","year":"2012","journal-title":"Curr Biol"},{"key":"pcbi.1007671.ref002","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1126\/science.180.4085.498","article-title":"Circadian rhythms in Neurospora: spatial differences in pyridine nucleotide levels","volume":"180","author":"S Broody","year":"1973","journal-title":"Science"},{"key":"pcbi.1007671.ref003","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1126\/science.8128246","article-title":"Loss of circadian behavioral rhythms and per RNA oscillations in the Drosophila mutant timeless","volume":"263","author":"A Sehgal","year":"1994","journal-title":"Science"},{"key":"pcbi.1007671.ref004","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1105\/tpc.106.040980","article-title":"Plant circadian rhythms","volume":"18","author":"R McClung","year":"2006","journal-title":"Plant Cell"},{"key":"pcbi.1007671.ref005","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1001\/archinte.166.16.1695","article-title":"Shift of monocyte function toward cellular immunity during sleep","volume":"166","author":"T Lange","year":"2006","journal-title":"Arch Intern Med"},{"key":"pcbi.1007671.ref006","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s11154-009-9122-8","article-title":"Effects of circadian disruption on the cardiometabolic system","volume":"10","author":"M Ruger","year":"2009","journal-title":"Rev Endocr Meta Disord"},{"key":"pcbi.1007671.ref007","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.3109\/07853890.2010.499134","article-title":"Circadian regulation of cell cycle: molecular connections between aging and the circadian clock","volume":"42","author":"RV Khapre","year":"2010","journal-title":"Ann Med"},{"key":"pcbi.1007671.ref008","first-page":"779","article-title":"Circadian rhythm dysregulation in bipolar disorder","volume":"11","author":"L Westrich","year":"2010","journal-title":"Curr Opin Invest Drugs"},{"key":"pcbi.1007671.ref009","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/nature.2017.22736","article-title":"Medicine Nobel awarded for work on circadian clocks","volume":"550","author":"E Callaway","year":"2017","journal-title":"Nature"},{"key":"pcbi.1007671.ref010","unstructured":"Ibanez C. Scientific background discoveries of molecular mechanisms controlling the circadian rhythm. The Nobel Assembly at Karolinska Institutet; 2017. Available from: https:\/\/www.nobelprize.org\/uploads\/2018\/06\/advanced-medicineprize2017.pdf."},{"key":"pcbi.1007671.ref011","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jtbi.2004.11.038","article-title":"Modelling genetic networks with noisy and varied experimental data: the circadian clock in Arabidopsis thaliana","volume":"234","author":"JCW Locke","year":"2005","journal-title":"J Theor Biol"},{"key":"pcbi.1007671.ref012","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1098\/rsif.2012.0080","article-title":"Digital clocks: simple Boolean models can qualitatively describe circadian systems","volume":"9","author":"OE Akman","year":"2012","journal-title":"J R Soc Interface"},{"issue":"5","key":"pcbi.1007671.ref013","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1093\/bioinformatics\/btt023","article-title":"SBSI: an extensible distributed software infrastructure for parameter estimation in systems biology","volume":"29","author":"R Adams","year":"2013","journal-title":"Bioinformatics"},{"issue":"74","key":"pcbi.1007671.ref014","article-title":"A compact model for the complex plant circadian clock","volume":"7","author":"J DeCaluwe","year":"2016","journal-title":"Front Plant Sci"},{"issue":"2","key":"pcbi.1007671.ref015","doi-asserted-by":"crossref","first-page":"e1004748","DOI":"10.1371\/journal.pcbi.1004748","article-title":"Kernel architecture of the genetic circuitry of the Arabidopsis circadian system","volume":"12","author":"M Foo","year":"2016","journal-title":"PLoS Comput Biol"},{"key":"pcbi.1007671.ref016","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jtbi.2018.12.014","article-title":"Reducing the complexity of mathematical models for the plant circadian clock by distributed delays","volume":"463","author":"IT Tokuda","year":"2019","journal-title":"J Theor Biol"},{"key":"pcbi.1007671.ref017","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1016\/S0006-3495(99)77078-5","article-title":"A simple model of circadian rhythms based on dimerization and proteolysis of PER and TIM","volume":"77","author":"JJ Tyson","year":"1999","journal-title":"Biophys J"},{"key":"pcbi.1007671.ref018","doi-asserted-by":"crossref","first-page":"7051","DOI":"10.1073\/pnas.1132112100","article-title":"Toward a detailed computational model for the mammalian circadian clock","volume":"100","author":"JC Leloup","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"pcbi.1007671.ref019","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1752-0509-4-88","article-title":"Robustness from flexibility in the fungal circadian clock","volume":"4","author":"OE Akman","year":"2010","journal-title":"BMC Syst Biol"},{"key":"pcbi.1007671.ref020","first-page":"370","article-title":"Biochemical systems analysis II. The steady state solutions for an n-pool system using a power-law approximation","volume":"25","author":"MA Savageau","year":"1969","journal-title":"J Theor Biol"},{"issue":"5","key":"pcbi.1007671.ref021","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/bioinformatics\/btg027","article-title":"Dynamic modeling of genetic networks using genetic algorithm and S-system","volume":"19","author":"S Kikuchi","year":"2003","journal-title":"Bioinformatics"},{"issue":"7","key":"pcbi.1007671.ref022","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1093\/bioinformatics\/bti071","article-title":"Inference of S-system models of genetic networks using a cooperative coevolutionary algorithm","volume":"21","author":"S Kimura","year":"2005","journal-title":"Bioinformatics"},{"key":"pcbi.1007671.ref023","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1063\/1.1349892","article-title":"Design principles for elementary gene circuits: elements, methods, and examples","volume":"11","author":"MA Savageau","year":"2001","journal-title":"Chaos"},{"key":"pcbi.1007671.ref024","doi-asserted-by":"crossref","first-page":"e1004012","DOI":"10.1371\/journal.pcbi.1004012","article-title":"150 years of mass action law","volume":"11","author":"E Voit","year":"2015","journal-title":"PLoS Comput Biol"},{"key":"pcbi.1007671.ref025","first-page":"69","article-title":"Analysis of signal transduction networks in Michaelis-Menten equations and S-systems","volume":"2","author":"CL Lin","year":"2008","journal-title":"Int J Biol Biomed Eng"},{"key":"pcbi.1007671.ref026","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jtice.2009.05.003","article-title":"Ensemble modeling and related mathematical modeling of metabolic networks","volume":"40","author":"ML Rizk","year":"2009","journal-title":"J Taiwan Inst Chem E"},{"key":"pcbi.1007671.ref027","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0025-5564(89)90064-3","article-title":"A comparison of variant theories of intact biochemical systems. I. enzyme-enzyme interactions and biochemical systems theory","volume":"94","author":"A Sorribas","year":"1989","journal-title":"Math Biosci"},{"key":"pcbi.1007671.ref028","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0025-5564(89)90065-5","article-title":"A comparison of variant theories of intact biochemical systems II: flux-oriented and metabolic control theories","volume":"94","author":"A Sorribas","year":"1989","journal-title":"Math Biosci"},{"key":"pcbi.1007671.ref029","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0025-5564(89)90066-7","article-title":"Strategies for representing metabolic pathways within biochemical systems theory: Reversible pathways","volume":"94","author":"A Sorribas","year":"1989","journal-title":"Math Biosci"},{"issue":"21","key":"pcbi.1007671.ref030","doi-asserted-by":"crossref","first-page":"6869","DOI":"10.1021\/bi00395a042","article-title":"Accuracy of alternative representations for integrated biochemical systems","volume":"26","author":"EO Voit","year":"1987","journal-title":"Biochemistry"},{"key":"pcbi.1007671.ref031","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0025-5564(94)00092-E","article-title":"Comparative characterization of the fermentation pathway of Saccharomyces cerevisiae using biochemical systems theory and metabolic control analysis: model definition and nomenclature","volume":"130","author":"R Curto","year":"1995","journal-title":"Math Biosci"},{"key":"pcbi.1007671.ref032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0025-5564(98)10001-9","article-title":"Mathematical models of purine metabolism in man","volume":"151","author":"R Curto","year":"1998","journal-title":"Math Biosci"},{"key":"pcbi.1007671.ref033","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.jtbi.2003.08.010","article-title":"Integration of kinetic information on yeast sphingolipid metabolism in dynamical pathway models","volume":"226","author":"F Alvarez-Vasquez","year":"2004","journal-title":"J Theor Biol"},{"key":"pcbi.1007671.ref034","article-title":"A model comparison study of the flowering time regulatory network in Arabidopsis","volume":"8","author":"CCN Wang","year":"2014","journal-title":"BMC Syst Biol"},{"key":"pcbi.1007671.ref035","volume-title":"Biochemical Systems Analysis: A Study of Function and Design in Molecular Biology","author":"M Savageau","year":"1976"},{"key":"pcbi.1007671.ref036","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/jmbi.1996.0011","article-title":"Rules for coupled expression of regulator and effector genes in inducible circuits","volume":"255","author":"WS Hlavacek","year":"1996","journal-title":"J Mol Biol"},{"key":"pcbi.1007671.ref037","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1046\/j.1365-2958.2003.03344.x","article-title":"Comparative analysis of prototype two-component systems with either bifunctional or monofunctional sensors: Differences in molecular structure and physiological function","volume":"48","author":"R Alves","year":"2003","journal-title":"Mol Microbiol"},{"issue":"2","key":"pcbi.1007671.ref038","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1006\/jtbi.2002.2546","article-title":"Comparative study of circadian clock models, in search of processes promoting oscillation","volume":"216","author":"G Kurosawa","year":"2002","journal-title":"J Theor Biol"},{"key":"pcbi.1007671.ref039","volume-title":"Computational analysis of biochemical systems. A practical guide for biochemists and molecular biologists","author":"EO Voit","year":"2000"},{"key":"pcbi.1007671.ref040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/897658","article-title":"Biochemical systems theory: a review","author":"E Voit","year":"2013","journal-title":"ISRN Biomath"},{"key":"pcbi.1007671.ref041","doi-asserted-by":"crossref","DOI":"10.1201\/9781420011432","volume-title":"An Introduction to Systems Biology: Design Principles of Biological Circuits","author":"U Alon","year":"2006"},{"issue":"9","key":"pcbi.1007671.ref042","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1073\/pnas.0930314100","article-title":"On schemes of combinatorial transcription logic","volume":"100","author":"N Buchler","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"issue":"59","key":"pcbi.1007671.ref043","article-title":"Experimental validation of a predicted feedback loop in the multi-oscillator clock of Arabidopsis thaliana","volume":"2","author":"JCW Locke","year":"2006","journal-title":"Mol Syst Biol"},{"issue":"574","key":"pcbi.1007671.ref044","article-title":"The clock gene circuit in Arabidopsis includes a repressilator with additional feedback loops","volume":"8","author":"A Pokhilko","year":"2012","journal-title":"Mol Syst Biol"},{"issue":"7","key":"pcbi.1007671.ref045","doi-asserted-by":"crossref","first-page":"e1003705","DOI":"10.1371\/journal.pcbi.1003705","article-title":"Rethinking transcriptional activation in the Arabidopsis circadian clock","volume":"10","author":"K Fogelmark","year":"2014","journal-title":"PLoS Comput Biol"},{"issue":"1","key":"pcbi.1007671.ref046","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1137\/S1052623496303470","article-title":"Convergence Properties of the Nelder\u2013Mead Simplex Method in Low Dimensions","volume":"9","author":"J Lagarias","year":"1998","journal-title":"SIAM J Optim"},{"key":"pcbi.1007671.ref047","volume-title":"Information and Likelihood Theory: A Practical Information-Theoretic Approach","author":"KP Burnham","year":"2002"},{"issue":"2","key":"pcbi.1007671.ref048","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1177\/0049124104268644","article-title":"Multimodel Inference: Understanding AIC and BIC in Model Selection","volume":"33","author":"KP Burnham","year":"2004","journal-title":"Sociol Methods Res"},{"key":"pcbi.1007671.ref049","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.aml.2017.05.005","article-title":"AIC under the framework of least squares estimation","volume":"74","author":"HT Banks","year":"2017","journal-title":"Appl Math Lett"},{"issue":"1","key":"pcbi.1007671.ref050","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3758\/BF03206482","article-title":"AIC model selection using Akaike weights","volume":"11","author":"EJ Wagenmakers","year":"2004","journal-title":"Psychon Bull Rev"},{"key":"pcbi.1007671.ref051","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.1219075","article-title":"Mapping the core of the Arabidopsis circadian clock defines the network structure of the oscillator","volume":"336","author":"W Huang","year":"2012","journal-title":"Science"},{"key":"pcbi.1007671.ref052","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1073\/pnas.1200355109","article-title":"Arabidopsis circadian clock protein, TOC1, is a DNA-binding transcription factor","volume":"109","author":"JM Gendron","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"pcbi.1007671.ref053","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.molcel.2008.09.026","article-title":"COP1 and ELF3 control circadian function and photoperiodic flowering by regulating GI stability","volume":"32","author":"JW Yu","year":"2008","journal-title":"Mol Cell"},{"key":"pcbi.1007671.ref054","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1038\/emboj.2010.76","article-title":"PRR5 regulates phosphorylation, nuclear import and subnuclear localization of TOC1 in the Arabidopsis circadian clock","volume":"29","author":"L Wang","year":"2010","journal-title":"EMBO J"},{"key":"pcbi.1007671.ref055","volume-title":"System Identification: Theory for the User","author":"L Ljung","year":"1999"},{"key":"pcbi.1007671.ref056","volume-title":"Control Systems Engineering","author":"N Nise","year":"2008"},{"key":"pcbi.1007671.ref057","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S1534-5807(02)00170-3","article-title":"LHY and CCA1 are partially redundant genes required to maintain circadian rhythms in Arabidopsis","volume":"2","author":"T Mizogushi","year":"2002","journal-title":"Dev Cell"},{"key":"pcbi.1007671.ref058","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1126\/science.289.5480.768","article-title":"Cloning of the Arabidopsis clock gene TOC1, an autoregulatory response regulator homolog","volume":"289","author":"C Strayer","year":"2000","journal-title":"Science"},{"key":"pcbi.1007671.ref059","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cub.2004.12.067","article-title":"Overlapping and distinct roles of PRR7 and PRR9 in the Arabidopsis circadian clock","volume":"15","author":"EM Farre","year":"2005","journal-title":"Curr Biol"},{"key":"pcbi.1007671.ref060","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0092-8674(00)80841-7","article-title":"ZEITLUPE encodes a novel clock-associated PAS protein from Arabidopsis","volume":"101","author":"DE Somers","year":"2000","journal-title":"Cell"},{"key":"pcbi.1007671.ref061","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1105\/tpc.105.039990","article-title":"The molecular basis of temperature compensation in the Arabidopsis circadian clock","volume":"18","author":"PD Gould","year":"2006","journal-title":"Plant Cell"},{"key":"pcbi.1007671.ref062","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1104\/pp.107.096206","article-title":"ELF4 is required for oscillatory properties of the circadian clock","volume":"144","author":"HG McWatters","year":"2007","journal-title":"Plant Physiol"},{"key":"pcbi.1007671.ref063","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/35047079","article-title":"The ELF3 zeitnehmer regulates light signalling to the circadian clock","volume":"408","author":"HG McWatters","year":"2000","journal-title":"Nature"},{"key":"pcbi.1007671.ref064","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/j.1365-2443.2005.00892.x","article-title":"PHYTOCLOCK 1 encoding a novel GARP protein essential for the Arabidopsis circadian clock","volume":"10","author":"K Onai","year":"2005","journal-title":"Genes Cells"},{"key":"pcbi.1007671.ref065","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1105\/tpc.111.093807","article-title":"EARLY FLOWERING4 recruitment of EARLY FLOWERING3 in the nucleus sustains the Arabidopsis circadian clock","volume":"24","author":"E Herero","year":"2012","journal-title":"Plant Cell"},{"key":"pcbi.1007671.ref066","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1104\/pp.106.088757","article-title":"GIGANTEA acts in blue light signaling and has biochemically separable roles in circadian clock and flowering time regulation","volume":"143","author":"EL Martin-Tryon","year":"2007","journal-title":"Plant Physiol"},{"key":"pcbi.1007671.ref067","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nature00954","article-title":"The ELF4 gene controls circadian rhythms and flowering time in Arabidopsis thaliana","volume":"419","author":"MR Doyle","year":"2002","journal-title":"Nature"},{"key":"pcbi.1007671.ref068","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1104\/pp.105.074864","article-title":"Forward genetic analysis of the circadian clock separates the multiple functions of ZEITLUPE","volume":"140","author":"E Kevei","year":"2006","journal-title":"Plant Physiol"},{"key":"pcbi.1007671.ref069","doi-asserted-by":"crossref","first-page":"e0143943","DOI":"10.1371\/journal.pone.0143943","article-title":"Revised morning loops of the Arabidopsis circadian clock based on analyses of direct regulatory interactions","volume":"10","author":"S Adams","year":"2015","journal-title":"PLoS One"},{"key":"pcbi.1007671.ref070","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1109\/TCBB.2017.2771775","article-title":"Modelling and control of gene regulatory networks for perturbation mitigation","volume":"16","author":"M Foo","year":"2018","journal-title":"IEEE\/ACM Trans Comput Biol Bioinform"},{"key":"pcbi.1007671.ref071","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jbiotec.2010.02.019","article-title":"Parameter identifiability of power-law biochemical system models","volume":"149","author":"S Srinath","year":"2010","journal-title":"J Biotechnol"},{"key":"pcbi.1007671.ref072","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/msb.2008.28","article-title":"Isoform switching facilitates period control in the Neurospora crassa circadian clock","volume":"4","author":"OE Akman","year":"2008","journal-title":"Mol Syst Biol"},{"key":"pcbi.1007671.ref073","volume-title":"Biological delay systems: linear stability theory","author":"N MacDonald","year":"2008"},{"issue":"1","key":"pcbi.1007671.ref074","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biosystems.2006.06.007","article-title":"Boolean networks with biologically relevant rules show ordered behavior","volume":"90","author":"S Nikolajewa","year":"2007","journal-title":"Biosystems"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1007671","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,3,26]],"date-time":"2020-03-26T00:00:00Z","timestamp":1585180800000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T14:14:55Z","timestamp":1614867295000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007671"}},"subtitle":[],"editor":[{"given":"Pedro","family":"Mendes","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,3,16]]},"references-count":74,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,3,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1007671","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1007671","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,3,16]]}}}