{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:09:39Z","timestamp":1772172579917,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1007702","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000}}],"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","award":["1016747"],"award-info":[{"award-number":["1016747"]}],"id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01HL139337"],"award-info":[{"award-number":["5R01HL139337"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AI057919"],"award-info":[{"award-number":["R01 AI057919"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1007702","type":"journal-article","created":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T16:36:13Z","timestamp":1587486973000},"page":"e1007702","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Accounting for red blood cell accessibility reveals distinct invasion strategies in Plasmodium falciparum strains"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4718-9632","authenticated-orcid":true,"given":"Francisco Y.","family":"Cai","sequence":"first","affiliation":[]},{"given":"Tiffany M.","family":"DeSimone","sequence":"additional","affiliation":[]},{"given":"Elsa","family":"Hansen","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9447-4260","authenticated-orcid":true,"given":"Cameron V.","family":"Jennings","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1159-760X","authenticated-orcid":true,"given":"Amy K.","family":"Bei","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7009-8408","authenticated-orcid":true,"given":"Ambroise D.","family":"Ahouidi","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7968-3320","authenticated-orcid":true,"given":"Souleymane","family":"Mboup","sequence":"additional","affiliation":[]},{"given":"Manoj T.","family":"Duraisingh","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8386-5899","authenticated-orcid":true,"given":"Caroline O.","family":"Buckee","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"pcbi.1007702.ref001","article-title":"Risk factors for severe disease in adults with falciparum malaria","author":"A Phillips","year":"2009","journal-title":"Infectious Diseases"},{"issue":"3","key":"pcbi.1007702.ref002","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1751-553X.2011.01398.x","article-title":"Falciparum malaria parasitemia index for predicting severe malaria","volume":"34","author":"N Tangpukdee","year":"2012","journal-title":"Int J Lab Hematol. Blackwell Publishing Ltd"},{"issue":"4","key":"pcbi.1007702.ref003","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/j.cell.2006.02.006","article-title":"Invasion of red blood cells by malaria parasites","volume":"124","author":"AF Cowman","year":"2006","journal-title":"Cell"},{"issue":"8","key":"pcbi.1007702.ref004","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1371\/journal.ppat.0030107","article-title":"Epigenetic silencing of Plasmodium falciparum genes linked to erythrocyte invasion","volume":"3","author":"A Cort\u00e9s","year":"2007","journal-title":"PLoS Pathog."},{"issue":"5","key":"pcbi.1007702.ref005","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1073\/pnas.0913396107","article-title":"Epigenetic control of the variable expression of a Plasmodium falciparum receptor protein for erythrocyte invasion","volume":"107","author":"L Jiang","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"pcbi.1007702.ref006","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1073\/pnas.0307318101","article-title":"Polymorphism in the Plasmodium falciparum erythrocyte-binding ligand JESEBL\/EBA-181 alters its receptor specificity","volume":"101","author":"DCG Mayer","year":"2004","journal-title":"Proc Natl Acad Sci USA."},{"issue":"1","key":"pcbi.1007702.ref007","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1365-2958.2004.04388.x","article-title":"Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparum","volume":"55","author":"T Triglia","year":"2005","journal-title":"Mol Microbiol"},{"issue":"13\u201314","key":"pcbi.1007702.ref008","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.ijpara.2004.10.010","article-title":"Parasite ligand-host receptor interactions during invasion of erythrocytes by Plasmodium merozoites","volume":"34","author":"D Gaur","year":"2004","journal-title":"Int J Parasitol"},{"issue":"4857","key":"pcbi.1007702.ref009","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1136\/bmj.1.4857.290","article-title":"Protection afforded by sickle-cell trait against subtertian malareal infection","volume":"1","author":"AC Allison","year":"1954","journal-title":"British Medical Journal"},{"issue":"6537","key":"pcbi.1007702.ref010","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/376246a0","article-title":"Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria","volume":"376","author":"C Ruwende","year":"1995","journal-title":"Nature"},{"issue":"6557","key":"pcbi.1007702.ref011","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/378564a0","article-title":"Ovalocytosis and cerebral malaria","volume":"378","author":"B Genton","year":"1995","journal-title":"Nature."},{"issue":"26","key":"pcbi.1007702.ref012","doi-asserted-by":"crossref","first-page":"14736","DOI":"10.1073\/pnas.94.26.14736","article-title":"alpha+-Thalassemia protects children against disease caused by other infections as well as malaria","volume":"94","author":"SJ Allen","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"pcbi.1007702.ref013","article-title":"Influence of hemoglobin E trait on the severity of Falciparum malaria","author":"R Hutagalung","year":"1999","journal-title":"Journal of infectious \u2026"},{"issue":"7","key":"pcbi.1007702.ref014","first-page":"2358","article-title":"Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S. Blood","volume":"96","author":"A Agarwal","year":"2000","journal-title":"American Society of Hematology"},{"issue":"1","key":"pcbi.1007702.ref015","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nm807","article-title":"Plasmodium falciparum erythrocyte invasion through glycophorin C and selection for Gerbich negativity in human populations","volume":"9","author":"AG Maier","year":"2003","journal-title":"Nat Med."},{"issue":"1","key":"pcbi.1007702.ref016","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1073\/pnas.0305306101","article-title":"A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria","volume":"101","author":"IA Cockburn","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"pcbi.1007702.ref017","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.mib.2011.07.018","article-title":"Molecular interactions and signaling mechanisms during erythrocyte invasion by malaria parasites","volume":"14","author":"D Gaur","year":"2011","journal-title":"Curr Opin Microbiol"},{"issue":"1","key":"pcbi.1007702.ref018","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/cmi.12038","article-title":"The role of the reticulocyte-binding-like protein homologues of Plasmodium in erythrocyte sensing and invasion","volume":"15","author":"K Gunalan","year":"2013","journal-title":"Cell Microbiol"},{"issue":"1","key":"pcbi.1007702.ref019","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pt.2011.10.002","article-title":"Erythrocyte and reticulocyte binding-like proteins of Plasmodium falciparum","volume":"28","author":"W-H Tham","year":"2012","journal-title":"Trends in Parasitology"},{"issue":"7378","key":"pcbi.1007702.ref020","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nature10606","article-title":"Basigin is a receptor essential for erythrocyte invasion by Plasmodium falciparum","volume":"480","author":"C Crosnier","year":"2011","journal-title":"Nature"},{"issue":"3","key":"pcbi.1007702.ref021","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2302\/kjm.43.155","article-title":"Changes in human red blood cells during aging in vivo","volume":"43","author":"T Shinozuka","year":"1994","journal-title":"Keio J Med"},{"issue":"1","key":"pcbi.1007702.ref022","first-page":"229","article-title":"The role of sialoglycoconjugates in the aging and sequestration of red cells from circulation","volume":"14","author":"D Aminoff","year":"1988","journal-title":"Blood Cells"},{"issue":"22","key":"pcbi.1007702.ref023","doi-asserted-by":"crossref","first-page":"11177","DOI":"10.1016\/S0021-9258(19)86463-3","article-title":"Total sialic acid content of glycophorins during senescence of human red blood cells","volume":"254","author":"HU Lutz","year":"1979","journal-title":"J Biol Chem"},{"issue":"2","key":"pcbi.1007702.ref024","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0035-9203(99)90295-X","article-title":"Red cell selectivity in malaria: a study of multiple-infected erythrocytes","volume":"93","author":"JA Simpson","year":"1999","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"3","key":"pcbi.1007702.ref025","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1645\/0022-3395(2002)088[0521:PVBSD]2.0.CO;2","article-title":"PLASMODIUM VIVAX BLOOD-STAGE DYNAMICS","volume":"88","author":"FE McKenzie","year":"2002","journal-title":"J Parasitol"},{"issue":"2","key":"pcbi.1007702.ref026","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/j.1365-2141.1980.tb07148.x","article-title":"The increased susceptibility of young red cells to invasion by the malarial parasite Plasmodium falciparum","volume":"45","author":"G Pasvol","year":"1980","journal-title":"Br J Haematol"},{"issue":"2","key":"pcbi.1007702.ref027","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/j.1365-2958.2007.05791.x","article-title":"Invasion of host cells by malaria parasites: a tale of two protein families","volume":"65","author":"J Iyer","year":"2007","journal-title":"Mol Microbiol"},{"issue":"40","key":"pcbi.1007702.ref028","doi-asserted-by":"crossref","first-page":"17327","DOI":"10.1073\/pnas.1008151107","article-title":"Complement receptor 1 is the host erythrocyte receptor for Plasmodium falciparum PfRh4 invasion ligand","volume":"107","author":"W-H Tham","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"issue":"2","key":"pcbi.1007702.ref029","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1172\/JCI114753","article-title":"Evidence for a switching mechanism in the invasion of erythrocytes by Plasmodium falciparum","volume":"86","author":"SA Dolan","year":"1990","journal-title":"J Clin Invest"},{"issue":"13","key":"pcbi.1007702.ref030","doi-asserted-by":"crossref","first-page":"7509","DOI":"10.1073\/pnas.97.13.7509","article-title":"Targeted disruption of an erythrocyte binding antigen in Plasmodium falciparum is associated with a switch toward a sialic acid-independent pathway of invasion","volume":"97","author":"MB Reed","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"pcbi.1007702.ref031","doi-asserted-by":"crossref","first-page":"4796","DOI":"10.1073\/pnas.0730883100","article-title":"Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways","volume":"100","author":"MT Duraisingh","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"pcbi.1007702.ref032","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1128\/IAI.00249-07","article-title":"Invasion pathways and malaria severity in Kenyan Plasmodium falciparum clinical isolates","volume":"75","author":"A-M Deans","year":"2007","journal-title":"Infect Immun"},{"issue":"6","key":"pcbi.1007702.ref033","doi-asserted-by":"crossref","first-page":"2575","DOI":"10.1128\/IAI.03009-14","article-title":"Variation in Plasmodium falciparum erythrocyte invasion phenotypes and merozoite ligand gene expression across different populations in areas of malaria endemicity","volume":"83","author":"PW Bowyer","year":"2015","journal-title":"Infect Immun"},{"issue":"4","key":"pcbi.1007702.ref034","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1128\/IAI.71.4.1856-1863.2003","article-title":"Erythrocyte invasion phenotypes of Plasmodium falciparum in The Gambia","volume":"71","author":"J Baum","year":"2003","journal-title":"Infect Immun."},{"issue":"3","key":"pcbi.1007702.ref035","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ijpara.2008.10.006","article-title":"Reticulocyte-binding protein homologue 5\u2014an essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum","volume":"39","author":"J Baum","year":"2009","journal-title":"Int J Parasitol"},{"issue":"Pt 3","key":"pcbi.1007702.ref036","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1017\/S0031182001001202","article-title":"Population dynamics of untreated Plasmodium falciparum malaria within the adult human host during the expansion phase of the infection","volume":"124","author":"JA Simpson","year":"2002","journal-title":"Parasitology"},{"issue":"3","key":"pcbi.1007702.ref037","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1086\/315353","article-title":"Parasite multiplication potential and the severity of Falciparum malaria","volume":"181","author":"K Chotivanich","year":"2000","journal-title":"J Infect Dis"},{"issue":"4","key":"pcbi.1007702.ref038","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4269\/ajtmh.2006.74.554","article-title":"Low multiplication rates of African Plasmodium falciparum isolates and lack of association of multiplication rate and red blood cell selectivity with malaria virulence","volume":"74","author":"A-M Deans","year":"2006","journal-title":"Am J Trop Med Hyg"},{"key":"pcbi.1007702.ref039","article-title":"Expansion of host cellular niche can drive adaptation of a zoonotic malaria parasite to humans","author":"C Lim","year":"2013","journal-title":"Nature"},{"issue":"2","key":"pcbi.1007702.ref040","doi-asserted-by":"crossref","first-page":"e57434","DOI":"10.1371\/journal.pone.0057434","article-title":"Preferential invasion by Plasmodium merozoites and the self-regulation of parasite burden","volume":"8","author":"DH Kerlin","year":"2013","journal-title":"PLoS ONE."},{"issue":"24","key":"pcbi.1007702.ref041","doi-asserted-by":"crossref","first-page":"9161","DOI":"10.1073\/pnas.0308256101","article-title":"Age-structured red blood cell susceptibility and the dynamics of malaria infections","volume":"101","author":"PG McQueen","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1641","key":"pcbi.1007702.ref042","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1098\/rspb.2008.0198","article-title":"The dynamics of acute malaria infections. I. Effect of the parasite's red blood cell preference","volume":"275","author":"R Antia","year":"2008","journal-title":"Proceedings of the Royal Society B: Biological Sciences"},{"issue":"5","key":"pcbi.1007702.ref043","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1086\/591684","article-title":"Understanding and predicting strain-specific patterns of pathogenesis in the rodent malaria Plasmodium chabaudi","volume":"172","author":"N Mideo","year":"2008","journal-title":"Am Nat"},{"issue":"1","key":"pcbi.1007702.ref044","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0025-5564(00)00025-0","article-title":"An intuitive formulation for the reproductive number for the spread of diseases in heterogeneous populations","volume":"167","author":"JM Hyman","year":"2000","journal-title":"Math Biosci"},{"issue":"2","key":"pcbi.1007702.ref045","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0005-2736(76)90349-7","article-title":"Biochemical characterization of density-separated human erythrocytes","volume":"419","author":"NS Cohen","year":"1976","journal-title":"Biochim Biophys Acta"},{"issue":"1\u20132","key":"pcbi.1007702.ref046","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0009-8981(79)90172-4","article-title":"Human erythrocyte fraction in \u201cPercoll\u201d density gradients.","volume":"98","author":"CM Rennie","year":"1979","journal-title":"Clin Chim Acta"},{"issue":"1","key":"pcbi.1007702.ref047","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0005-2736(96)00141-1","article-title":"Ionic calcium content of light dense human red cells separated by Percoll density gradients","volume":"1323","author":"PJ Romero","year":"1997","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"pcbi.1007702.ref048","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0024-3205(98)00258-6","article-title":"Acetylcholinesterase: an enzymatic marker of human red blood cell aging","volume":"63","author":"YG Prall","year":"1998","journal-title":"Life Sci"},{"issue":"2","key":"pcbi.1007702.ref049","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1182\/blood-2002-08-2437","article-title":"Accelerated senescence of human erythrocytes cultured with Plasmodium falciparum","volume":"102","author":"F Omodeo-Sal\u00e8","year":"2003","journal-title":"Blood"},{"issue":"2","key":"pcbi.1007702.ref050","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0300-9084(98)80024-2","article-title":"Cellular and molecular mechanisms of senescent erythrocyte phagocytosis by macrophages. A review","volume":"80","author":"D Bratosin","year":"1998","journal-title":"Biochimie"},{"key":"pcbi.1007702.ref051","volume-title":"R: A Language and Environment for Statistical ComputingR Foundation for Statistical Computing","author":"null RCT","year":"2017"},{"key":"pcbi.1007702.ref052","unstructured":"Dinno A. dunn.test: Dunn's Test of Multiple Comparisons Using Rank Sums [Internet]. 1st ed. Available from: https:\/\/CRAN.R-project.org\/package=dunn.test"},{"issue":"6","key":"pcbi.1007702.ref053","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3109\/03014460.2013.807878","article-title":"An estimation of the number of cells in the human body","volume":"40","author":"E Bianconi","year":"2013","journal-title":"Ann Hum Biol"},{"issue":"3","key":"pcbi.1007702.ref054","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1152\/physrev.1959.39.3.577","article-title":"Life span of red blood cell","volume":"39","author":"NI Berlin","year":"1959","journal-title":"Physiological Reviews"},{"issue":"9","key":"pcbi.1007702.ref055","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.pt.2004.07.007","article-title":"Sneaking in through the back entrance: the biology of malaria liver stages","volume":"20","author":"U Frevert","year":"2004","journal-title":"Trends in Parasitology"},{"issue":"2","key":"pcbi.1007702.ref056","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0035-9203(90)90258-G","article-title":"An estimation of the number of malaria sporozoites ejected by a feeding mosquito","volume":"84","author":"R Rosenberg","year":"1990","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"5","key":"pcbi.1007702.ref057","doi-asserted-by":"crossref","first-page":"564","DOI":"10.4269\/ajtmh.1991.44.564","article-title":"Quantitation of Plasmodium falciparum sporozoites transmitted in vitro by experimentally infected Anopheles gambiae and Anopheles stephensi","volume":"44","author":"JC Beier","year":"1991","journal-title":"Am J Trop Med Hyg"},{"issue":"2","key":"pcbi.1007702.ref058","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4269\/ajtmh.1992.47.195","article-title":"Ingestion of Plasmodium falciparum sporozoites during transmission by anopheline mosquitoes","volume":"47","author":"MS Beier","year":"1992","journal-title":"Am J Trop Med Hyg"},{"issue":"4254","key":"pcbi.1007702.ref059","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous culture","volume":"193","author":"W Trager","year":"1976","journal-title":"Science"},{"issue":"14","key":"pcbi.1007702.ref060","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/j.ijpara.2007.05.003","article-title":"Quantitative dissection of clone-specific growth rates in cultured malaria parasites","volume":"37","author":"HB Reilly","year":"2007","journal-title":"Int J Parasitol"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1007702","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T21:52:27Z","timestamp":1615326747000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007702"}},"subtitle":[],"editor":[{"given":"Rustom","family":"Antia","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2020,4,21]]},"references-count":60,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1007702","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/626044","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,21]]}}}