{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:11:20Z","timestamp":1772172680240,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1007728","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000}}],"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T00:00:00Z","timestamp":1600905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008666","name":"Fundaci\u00f3 la Marat\u00f3 de TV3","doi-asserted-by":"publisher","award":["20151110"],"award-info":[{"award-number":["20151110"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010198","name":"Ministerio de Econom\u00eda, Industria y Competitividad, Gobierno de Espa\u00f1a","doi-asserted-by":"publisher","award":["SAF2017-88019-C3-2-R"],"award-info":[{"award-number":["SAF2017-88019-C3-2-R"]}],"id":[{"id":"10.13039\/501100010198","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01-HL119095"],"award-info":[{"award-number":["R01-HL119095"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1007728","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T14:09:03Z","timestamp":1600956543000},"page":"e1007728","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Buffering and total calcium levels determine the presence of oscillatory regimes in cardiac cells"],"prefix":"10.1371","volume":"16","author":[{"given":"Miquel","family":"Marchena","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0503-1781","authenticated-orcid":true,"given":"Blas","family":"Echebarria","sequence":"additional","affiliation":[]},{"given":"Yohannes","family":"Shiferaw","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6824-6857","authenticated-orcid":true,"given":"Enrique","family":"Alvarez-Lacalle","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2020,9,24]]},"reference":[{"key":"pcbi.1007728.ref001","volume-title":"Global atlas on cardiovascular disease prevention and control","author":"Organization WH","year":"2011"},{"issue":"20","key":"pcbi.1007728.ref002","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1056\/NEJMra000650","article-title":"Sudden death due to cardiac arrhythmias","volume":"345","author":"HV Huikuri","year":"2001","journal-title":"New England Journal of Medicine"},{"key":"pcbi.1007728.ref003","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev-physiol-021014-071622","article-title":"Mechanisms of ventricular arrhythmias: from molecular fluctuations to electrical turbulence","volume":"77","author":"Z Qu","year":"2015","journal-title":"Annual review of physiology"},{"issue":"9","key":"pcbi.1007728.ref004","doi-asserted-by":"crossref","first-page":"096601","DOI":"10.1088\/0034-4885\/79\/9\/096601","article-title":"Nonlinear physics of electrical wave propagation in the heart: a review","volume":"79","author":"S Alonso","year":"2016","journal-title":"Reports on Progress in Physics"},{"issue":"3","key":"pcbi.1007728.ref005","doi-asserted-by":"crossref","first-page":"E270","DOI":"10.1073\/pnas.1614051114","article-title":"Stochastic initiation and termination of calcium-mediated triggered activity in cardiac myocytes","volume":"114","author":"Z Song","year":"2017","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"8","key":"pcbi.1007728.ref006","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1007260","article-title":"Arrhythmia mechanisms and spontaneous calcium release: Bi-directional coupling between re-entrant and focal excitation","volume":"15","author":"MA Colman","year":"2019","journal-title":"PLoS computational biology"},{"issue":"4","key":"pcbi.1007728.ref007","doi-asserted-by":"crossref","first-page":"H1235","DOI":"10.1152\/ajpheart.01320.2008","article-title":"Spontaneous calcium release in tissue from the failing canine heart","volume":"297","author":"GS Hoeker","year":"2009","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"issue":"22","key":"pcbi.1007728.ref008","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1161\/01.CIR.98.22.2404","article-title":"Mechanisms underlying spontaneous and induced ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy","volume":"98","author":"SM Pogwizd","year":"1998","journal-title":"Circulation"},{"issue":"3","key":"pcbi.1007728.ref009","doi-asserted-by":"crossref","first-page":"H1244","DOI":"10.1152\/ajpheart.01109.2001","article-title":"Nonreentrant focal activations in pulmonary veins in canine model of sustained atrial fibrillation","volume":"283","author":"S Zhou","year":"2002","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"issue":"5928","key":"pcbi.1007728.ref010","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/304735a0","article-title":"Oscillations of intracellular Ca2+ in mammalian cardiac muscle","volume":"304","author":"C Orchard","year":"1983","journal-title":"Nature"},{"issue":"4","key":"pcbi.1007728.ref011","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1161\/01.RES.54.4.396","article-title":"Calcium-dependent mechanical oscillations occur spontaneously in unstimulated mammalian cardiac tissues","volume":"54","author":"AA Kort","year":"1984","journal-title":"Circulation research"},{"issue":"1","key":"pcbi.1007728.ref012","doi-asserted-by":"crossref","first-page":"C148","DOI":"10.1152\/ajpcell.1996.270.1.C148","article-title":"Calcium sparks and [Ca2+] i waves in cardiac myocytes","volume":"270","author":"H Cheng","year":"1996","journal-title":"American Journal of Physiology-Cell Physiology"},{"issue":"1-2","key":"pcbi.1007728.ref013","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/emboj\/20.1.65","article-title":"Role of elementary Ca 2+ puffs in generating repetitive Ca 2+ oscillations","volume":"20","author":"JS Marchant","year":"2001","journal-title":"The EMBO Journal"},{"issue":"1","key":"pcbi.1007728.ref014","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbrc.2010.02.117","article-title":"Biochemistry of calcium oscillations","volume":"396","author":"P Uhl\u00e9n","year":"2010","journal-title":"Biochemical and biophysical research communications"},{"issue":"3","key":"pcbi.1007728.ref015","doi-asserted-by":"crossref","first-page":"a004226","DOI":"10.1101\/cshperspect.a004226","article-title":"Calcium oscillations","volume":"3","author":"G Dupont","year":"2011","journal-title":"Cold Spring Harbor perspectives in biology"},{"issue":"5","key":"pcbi.1007728.ref016","doi-asserted-by":"crossref","first-page":"H1822","DOI":"10.1152\/ajpheart.00766.2010","article-title":"Spontaneous calcium oscillations during diastole in the whole heart: the influence of ryanodine reception function and gap junction coupling","volume":"300","author":"BN Plummer","year":"2011","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"issue":"5","key":"pcbi.1007728.ref017","doi-asserted-by":"crossref","first-page":"H2144","DOI":"10.1152\/ajpheart.00924.2006","article-title":"Ryanodine receptor dysfunction and triggered activity in the heart","volume":"292","author":"RP Katra","year":"2007","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"issue":"2","key":"pcbi.1007728.ref018","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1161\/01.CIR.103.2.196","article-title":"Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia","volume":"103","author":"SG Priori","year":"2001","journal-title":"Circulation"},{"issue":"6","key":"pcbi.1007728.ref019","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1113\/jphysiol.2014.280784","article-title":"Alternating membrane potential\/calcium interplay underlies repetitive focal activity in a genetic model of calcium-dependent atrial arrhythmias","volume":"593","author":"Q Lou","year":"2015","journal-title":"The Journal of physiology"},{"issue":"38","key":"pcbi.1007728.ref020","doi-asserted-by":"crossref","first-page":"31624","DOI":"10.1074\/jbc.R112.349068","article-title":"Ryanodine receptors: structure and function","volume":"287","author":"F Van Petegem","year":"2012","journal-title":"Journal of Biological Chemistry"},{"issue":"3","key":"pcbi.1007728.ref021","doi-asserted-by":"crossref","first-page":"H997","DOI":"10.1152\/ajpheart.00390.2009","article-title":"Arrhythmogenic consequences of intracellular calcium waves","volume":"297","author":"LH Xie","year":"2009","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"key":"pcbi.1007728.ref022","doi-asserted-by":"crossref","unstructured":"Shiferaw Y, Aistrup GL, Wasserstrom JA. Intracellular Ca2+ waves, afterdepolarizations, and triggered arrhythmias; 2012.","DOI":"10.1093\/cvr\/cvs155"},{"issue":"20","key":"pcbi.1007728.ref023","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1113\/jphysiol.2009.175547","article-title":"Intra-sarcoplasmic reticulum Ca2+ oscillations are driven by dynamic regulation of ryanodine receptor function by luminal Ca2+ in cardiomyocytes","volume":"587","author":"SC Stevens","year":"2009","journal-title":"The Journal of physiology"},{"issue":"3-4","key":"pcbi.1007728.ref024","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/0167-2789(93)90131-J","article-title":"Dynamics of the calcium subsystem in cardiac Purkinje fibers","volume":"68","author":"A Varghese","year":"1993","journal-title":"Physica D: Nonlinear Phenomena"},{"issue":"1339","key":"pcbi.1007728.ref025","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1098\/rspb.1993.0126","article-title":"Generation and propagation of ectopic beats induced by spatially localized Na\u2013K pump inhibition in atrial network models","volume":"254","author":"RL Winslow","year":"1993","journal-title":"Proceedings of the Royal Society of London Series B: Biological Sciences"},{"key":"pcbi.1007728.ref026","doi-asserted-by":"crossref","unstructured":"Benson AP, Holden AV. Calcium oscillations and ectopic beats in virtual ventricular myocytes and tissues: bifurcations, autorhythmicity and propagation. In: International Workshop on Functional Imaging and Modeling of the Heart. Springer; 2005. p. 304\u2013313.","DOI":"10.1007\/11494621_31"},{"issue":"3","key":"pcbi.1007728.ref027","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/S0021-9258(19)57313-6","article-title":"Ca2+ binding effects on protein conformation and protein interactions of canine cardiac calsequestrin","volume":"263","author":"RD Mitchell","year":"1988","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"pcbi.1007728.ref028","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1083\/jcb.98.4.1597","article-title":"Evidence for the presence of calsequestrin in two structurally different regions of myocardial sarcoplasmic reticulum","volume":"98","author":"AO Jorgensen","year":"1984","journal-title":"The Journal of cell biology"},{"issue":"1","key":"pcbi.1007728.ref029","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1083\/jcb.105.1.49","article-title":"The structure of calsequestrin in triads of vertebrate skeletal muscle: a deep-etch study","volume":"105","author":"C Franzini-Armstrong","year":"1987","journal-title":"The Journal of cell biology"},{"issue":"4","key":"pcbi.1007728.ref030","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/S0006-3495(04)74271-X","article-title":"The role of calsequestrin, triadin, and junctin in conferring cardiac ryanodine receptor responsiveness to luminal calcium","volume":"86","author":"I Gy\u00f6rke","year":"2004","journal-title":"Biophysical journal"},{"issue":"9","key":"pcbi.1007728.ref031","first-page":"2510","article-title":"Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca 2+ release, and catecholaminergic polymorphic ventricular tachycardia","volume":"116","author":"BC Knollmann","year":"2006","journal-title":"The Journal of clinical investigation"},{"issue":"7","key":"pcbi.1007728.ref032","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1172\/JCI31080","article-title":"Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia","volume":"117","author":"L Song","year":"2007","journal-title":"The Journal of clinical investigation"},{"issue":"1","key":"pcbi.1007728.ref033","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S0006-3495(02)75396-4","article-title":"Calsequestrin is an inhibitor of skeletal muscle ryanodine receptor calcium release channels","volume":"82","author":"NA Beard","year":"2002","journal-title":"Biophysical journal"},{"issue":"1","key":"pcbi.1007728.ref034","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.pbiomolbio.2003.07.001","article-title":"Calsequestrin and the calcium release channel of skeletal and cardiac muscle","volume":"85","author":"N Beard","year":"2004","journal-title":"Progress in biophysics and molecular biology"},{"issue":"5","key":"pcbi.1007728.ref035","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1529\/biophysj.104.051441","article-title":"Regulation of ryanodine receptors by calsequestrin: effect of high luminal Ca2+ and phosphorylation","volume":"88","author":"NA Beard","year":"2005","journal-title":"Biophysical journal"},{"issue":"1","key":"pcbi.1007728.ref036","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cardiores.2007.03.002","article-title":"A mutation in calsequestrin, CASQ2D307H, impairs Sarcoplasmic Reticulum Ca2+ handling and causes complex ventricular arrhythmias in mice","volume":"75","author":"WP Dirksen","year":"2007","journal-title":"Cardiovascular research"},{"issue":"3","key":"pcbi.1007728.ref037","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1161\/CIRCRESAHA.108.171660","article-title":"Unexpected structural and functional consequences of the R33Q homozygous mutation in cardiac calsequestrin: a complex arrhythmogenic cascade in a knock in mouse model","volume":"103","author":"N Rizzi","year":"2008","journal-title":"Circulation research"},{"key":"pcbi.1007728.ref038","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.3389\/fphys.2018.01760","article-title":"Computational model of calcium signaling in cardiac atrial cells at the submicron scale","volume":"9","author":"M Marchena","year":"2018","journal-title":"Frontiers in physiology"},{"issue":"1","key":"pcbi.1007728.ref039","doi-asserted-by":"crossref","first-page":"e1004671","DOI":"10.1371\/journal.pcbi.1004671","article-title":"Long-lasting sparks: Multi-metastability and release competition in the calcium release unit network","volume":"12","author":"Z Song","year":"2016","journal-title":"PLoS computational biology"},{"issue":"38","key":"pcbi.1007728.ref040","doi-asserted-by":"crossref","first-page":"14958","DOI":"10.1073\/pnas.0703016104","article-title":"Analysis of ryanodine receptor clusters in rat and human cardiac myocytes","volume":"104","author":"C Soeller","year":"2007","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"pcbi.1007728.ref041","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1529\/biophysj.105.077180","article-title":"Three-dimensional distribution of ryanodine receptor clusters in cardiac myocytes","volume":"91","author":"Y Chen-Izu","year":"2006","journal-title":"Biophysical journal"},{"issue":"3","key":"pcbi.1007728.ref042","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0006-3495(81)84868-0","article-title":"The time-course of Ca2+ exchange with calmodulin, troponin, parvalbumin, and myosin in response to transient increases in Ca2+","volume":"34","author":"S Robertson","year":"1981","journal-title":"Biophysical journal"},{"issue":"5","key":"pcbi.1007728.ref043","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0006-3495(84)84238-1","article-title":"Model of calcium movements during activation in the sarcomere of frog skeletal muscle","volume":"45","author":"M Cannell","year":"1984","journal-title":"Biophysical Journal"},{"issue":"2","key":"pcbi.1007728.ref044","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/S0006-3495(95)80212-2","article-title":"Luminal calcium regulates calcium release in triads isolated from frog and rabbit skeletal muscle","volume":"68","author":"P Donoso","year":"1995","journal-title":"Biophysical journal"},{"issue":"1","key":"pcbi.1007728.ref045","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/S0006-3495(94)80500-4","article-title":"Effects of rapid buffers on Ca2+ diffusion and Ca2+ oscillations","volume":"67","author":"J Wagner","year":"1994","journal-title":"Biophysical Journal"},{"issue":"6","key":"pcbi.1007728.ref046","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1529\/biophysj.104.049973","article-title":"A simplified local control model of calcium-induced calcium release in cardiac ventricular myocytes","volume":"87","author":"R Hinch","year":"2004","journal-title":"Biophysical journal"},{"key":"pcbi.1007728.ref047","doi-asserted-by":"crossref","unstructured":"Ermentrout B. Simulating, analyzing, and animating dynamical systems: a guide to XPPAUT for researchers and students. vol. 14. Siam; 2002.","DOI":"10.1137\/1.9780898718195"},{"issue":"10","key":"pcbi.1007728.ref048","doi-asserted-by":"crossref","first-page":"108101","DOI":"10.1103\/PhysRevLett.114.108101","article-title":"Calcium alternans is due to an order-disorder phase transition in cardiac cells","volume":"114","author":"E Alvarez-Lacalle","year":"2015","journal-title":"Physical review letters"},{"issue":"3","key":"pcbi.1007728.ref049","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1529\/biophysj.104.057216","article-title":"Transition from stochastic to deterministic behavior in calcium oscillations","volume":"89","author":"U Kummer","year":"2005","journal-title":"Biophysical journal"},{"issue":"2","key":"pcbi.1007728.ref050","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2976\/1.3385660","article-title":"Spatiotemporal organization of Ca2+ dynamics: A modeling-based approach","volume":"4","author":"G Dupont","year":"2010","journal-title":"HFSP journal"},{"issue":"2","key":"pcbi.1007728.ref051","doi-asserted-by":"crossref","first-page":"021103","DOI":"10.1103\/PhysRevE.70.021103","article-title":"Effects of noise near a homoclinic bifurcation in an electrochemical system","volume":"70","author":"GJE Santos","year":"2004","journal-title":"Physical Review E"},{"issue":"8","key":"pcbi.1007728.ref052","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1161\/CIRCRESAHA.109.206698","article-title":"Spontaneous calcium oscillations regulate human cardiac progenitor cell growth","volume":"105","author":"J Ferreira-Martins","year":"2009","journal-title":"Circulation research"},{"issue":"14","key":"pcbi.1007728.ref053","doi-asserted-by":"crossref","first-page":"8259","DOI":"10.1073\/pnas.96.14.8259","article-title":"Intracellular Ca2+ oscillations drive spontaneous contractions in cardiomyocytes during early development","volume":"96","author":"S Viatchenko-Karpinski","year":"1999","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"2","key":"pcbi.1007728.ref054","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1085\/jgp.200609575","article-title":"Intracellular Ca 2+ oscillations, a potential pacemaking mechanism in early embryonic heart cells","volume":"130","author":"P Sasse","year":"2007","journal-title":"The Journal of general physiology"},{"issue":"4","key":"pcbi.1007728.ref055","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1161\/CIRCRESAHA.109.206078","article-title":"A coupled SYSTEM of intracellular Ca2+ clocks and surface membrane voltage clocks controls the timekeeping mechanism of the heart\u2019s pacemaker","volume":"106","author":"EG Lakatta","year":"2010","journal-title":"Circulation research"},{"issue":"6","key":"pcbi.1007728.ref056","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1161\/01.RES.0000122045.55331.0F","article-title":"Rhythmic ryanodine receptor Ca2+ releases during diastolic depolarization of sinoatrial pacemaker cells do not require membrane depolarization","volume":"94","author":"TM Vinogradova","year":"2004","journal-title":"Circulation research"},{"issue":"4","key":"pcbi.1007728.ref057","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/01.RES.0000204575.94040.d1","article-title":"High basal protein kinase A\u2013dependent phosphorylation drives rhythmic internal Ca2+ store oscillations and spontaneous beating of cardiac pacemaker cells","volume":"98","author":"TM Vinogradova","year":"2006","journal-title":"Circulation research"},{"issue":"6","key":"pcbi.1007728.ref058","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1016\/S0006-3495(01)76241-8","article-title":"Markovian models of low and high activity levels of cardiac ryanodine receptors","volume":"80","author":"E Saftenku","year":"2001","journal-title":"Biophysical journal"},{"key":"pcbi.1007728.ref059","unstructured":"Alvarez-Lacalle E, Penaranda A, Cantalapiedra IR, Hove-Madsen L, Echebarria B. Effect of RyR2 refractoriness and hypercalcemia on calcium overload, spontaneous release, and calcium alternans. In: Computing in Cardiology 2013. IEEE; 2013. p. 683\u2013686."},{"issue":"4","key":"pcbi.1007728.ref060","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1006\/jtbi.1994.1121","article-title":"Dynamics of abnormal pacemaking activity in cardiac Purkinje fibers","volume":"168","author":"A Varghese","year":"1994","journal-title":"Journal of theoretical biology"},{"issue":"2","key":"pcbi.1007728.ref061","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.mbs.2012.02.005","article-title":"Instabilities of the resting state in a mathematical model of calcium handling in cardiac myocytes","volume":"236","author":"A Tveito","year":"2012","journal-title":"Mathematical biosciences"},{"issue":"5","key":"pcbi.1007728.ref062","doi-asserted-by":"crossref","first-page":"052715","DOI":"10.1103\/PhysRevE.92.052715","article-title":"Role of connectivity and fluctuations in the nucleation of calcium waves in cardiac cells","volume":"92","author":"G Hernandez-Hernandez","year":"2015","journal-title":"Physical Review E"},{"issue":"3","key":"pcbi.1007728.ref063","doi-asserted-by":"crossref","first-page":"032405","DOI":"10.1103\/PhysRevE.94.032405","article-title":"Nonlinear onset of calcium wave propagation in cardiac cells","volume":"94","author":"Y Shiferaw","year":"2016","journal-title":"Physical Review E"},{"issue":"12","key":"pcbi.1007728.ref064","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1016\/j.hrthm.2010.09.017","article-title":"Early afterdepolarizations and cardiac arrhythmias","volume":"7","author":"JN Weiss","year":"2010","journal-title":"Heart rhythm"},{"issue":"4","key":"pcbi.1007728.ref065","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1161\/01.RES.0000115944.10681.EB","article-title":"Abnormal calcium signaling and sudden cardiac death associated with mutation of calsequestrin","volume":"94","author":"S Viatchenko-Karpinski","year":"2004","journal-title":"Circulation research"},{"issue":"9","key":"pcbi.1007728.ref066","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1161\/01.RES.0000220647.93982.08","article-title":"Abnormal interactions of calsequestrin with the ryanodine receptor calcium release channel complex linked to exercise-induced sudden cardiac death","volume":"98","author":"D Terentyev","year":"2006","journal-title":"Circulation research"},{"issue":"9","key":"pcbi.1007728.ref067","doi-asserted-by":"crossref","first-page":"093928","DOI":"10.1063\/1.5000709","article-title":"Minimal model for calcium alternans due to SR release refractoriness","volume":"27","author":"IR Cantalapiedra","year":"2017","journal-title":"Chaos: An Interdisciplinary Journal of Nonlinear Science"},{"issue":"7","key":"pcbi.1007728.ref068","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1073\/pnas.1614613114","article-title":"On the dynamical structure of calcium oscillations","volume":"114","author":"J Sneyd","year":"2017","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"pcbi.1007728.ref069","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1209\/epl\/i2001-00482-6","article-title":"Stochastic resonance as a collective property of ion channel assemblies","volume":"56","author":"G Schmid","year":"2001","journal-title":"EPL (Europhysics Letters)"},{"issue":"6","key":"pcbi.1007728.ref070","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.physrep.2003.10.015","article-title":"Effects of noise in excitable systems","volume":"392","author":"B Lindner","year":"2004","journal-title":"Physics reports"},{"key":"pcbi.1007728.ref071","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-3-319-33054-9_6","volume-title":"Nonlinear Dynamics in Biological Systems","author":"B Echebarria","year":"2016"},{"issue":"2","key":"pcbi.1007728.ref072","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055042","article-title":"Dependency of calcium alternans on ryanodine receptor refractoriness","volume":"8","author":"E Alvarez-Lacalle","year":"2013","journal-title":"PloS one"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1007728","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,10,6]],"date-time":"2020-10-06T00:00:00Z","timestamp":1601942400000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T19:30:41Z","timestamp":1617478241000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007728"}},"subtitle":[],"editor":[{"given":"Andrew D.","family":"McCulloch","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2020,9,24]]},"references-count":72,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1007728","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.02.14.949180","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,24]]}}}