{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:11:15Z","timestamp":1772172675660,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1007751","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T00:00:00Z","timestamp":1587686400000}}],"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T00:00:00Z","timestamp":1586822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000181","name":"Air Force Office of Scientific Research","doi-asserted-by":"publisher","award":["FA9550-12-1-0232"],"award-info":[{"award-number":["FA9550-12-1-0232"]}],"id":[{"id":"10.13039\/100000181","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1544383"],"award-info":[{"award-number":["1544383"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1007751","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T13:36:12Z","timestamp":1586871372000},"page":"e1007751","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["A molecular odorant transduction model and the complexity of spatio-temporal encoding in the Drosophila antenna"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4261-8709","authenticated-orcid":true,"given":"Aurel A.","family":"Lazar","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1638-5465","authenticated-orcid":true,"given":"Chung-Heng","family":"Yeh","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2020,4,14]]},"reference":[{"issue":"2","key":"pcbi.1007751.ref001","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0896-6273(01)00289-6","article-title":"Odor coding in the Drosophila antenna","volume":"30","author":"M de Bruyne","year":"2001","journal-title":"Neuron"},{"issue":"1","key":"pcbi.1007751.ref002","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cell.2006.01.050","article-title":"Coding of odors by a receptor repertoire","volume":"125","author":"EA Hallem","year":"2006","journal-title":"Cell"},{"issue":"8","key":"pcbi.1007751.ref003","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.ibmb.2008.05.002","article-title":"Drosophila odorant receptors are novel seven transmembrane domain proteins that can signal independently of heterotrimeric G proteins","volume":"38","author":"R Smart","year":"2008","journal-title":"Insect Biochemistry and Molecular Biology"},{"issue":"7","key":"pcbi.1007751.ref004","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1093\/chemse\/bjq042","article-title":"Integrating heterogeneous odor response data into a common response model: a DoOR to the complete olfactome","volume":"35","author":"CG Galizia","year":"2010","journal-title":"Chemical senses"},{"key":"pcbi.1007751.ref005","doi-asserted-by":"crossref","DOI":"10.1038\/srep21841","article-title":"DoOR 2.0-comprehensive mapping of drosophila melanogaster odorant responses","volume":"6","author":"D M\u00fcnch","year":"2016","journal-title":"Scientific Reports"},{"issue":"41","key":"pcbi.1007751.ref006","doi-asserted-by":"crossref","first-page":"15985","DOI":"10.1073\/pnas.0804086105","article-title":"Distinct memories of odor intensity and quality in Drosophila","volume":"105","author":"P Masek","year":"2008","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"pcbi.1007751.ref007","first-page":"rspb20090705","article-title":"Odour intensity learning in fruit flies","author":"A Yarali","year":"2009","journal-title":"Proceedings of the Royal Society of London B: Biological Sciences"},{"issue":"2","key":"pcbi.1007751.ref008","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/nn.2725","article-title":"Biophysical mechanisms underlying olfactory receptor neuron dynamics","volume":"14","author":"KI Nagel","year":"2011","journal-title":"Nature Neuroscience"},{"key":"pcbi.1007751.ref009","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1146\/annurev-neuro-062111-150533","article-title":"Early olfactory processing in Drosophila: mechanisms and principles","volume":"36","author":"RI Wilson","year":"2013","journal-title":"Annual review of neuroscience"},{"issue":"15","key":"pcbi.1007751.ref010","doi-asserted-by":"crossref","first-page":"6285","DOI":"10.1523\/JNEUROSCI.0426-12.2013","article-title":"Intensity invariant dynamics and odor-specific latencies in olfactory receptor neuron response","volume":"33","author":"C Martelli","year":"2013","journal-title":"Journal of Neuroscience"},{"issue":"5440","key":"pcbi.1007751.ref011","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1126\/science.286.5440.723","article-title":"A systems perspective on early olfactory coding","volume":"286","author":"G Laurent","year":"1999","journal-title":"Science"},{"issue":"22","key":"pcbi.1007751.ref012","doi-asserted-by":"crossref","first-page":"12506","DOI":"10.1073\/pnas.96.22.12506","article-title":"Odor space and olfactory processing: collective algorithms and neural implementation","volume":"96","author":"J Hopfield","year":"1999","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"pcbi.1007751.ref013","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.physiol.010908.163209","article-title":"Sensing odorants and pheromones with chemosensory receptors","volume":"71","author":"K Touhara","year":"2009","journal-title":"Annual review of physiology"},{"issue":"5","key":"pcbi.1007751.ref014","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S0092-8674(00)80581-4","article-title":"Combinatorial receptor codes for odors","volume":"96","author":"B Malnic","year":"1999","journal-title":"Cell"},{"issue":"7","key":"pcbi.1007751.ref015","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.cell.2004.05.012","article-title":"The molecular basis of odor coding in the Drosophila antenna","volume":"117","author":"EA Hallem","year":"2004","journal-title":"Cell"},{"issue":"1","key":"pcbi.1007751.ref016","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s10827-010-0265-0","article-title":"System identification of Drosophila olfactory sensory neurons","volume":"30","author":"AJ Kim","year":"2011","journal-title":"Journal of computational neuroscience"},{"key":"pcbi.1007751.ref017","doi-asserted-by":"crossref","first-page":"e06651","DOI":"10.7554\/eLife.06651","article-title":"Projection neurons in Drosophila antennal lobes signal the acceleration of odor concentrations","volume":"4","author":"AJ Kim","year":"2015","journal-title":"Elife"},{"issue":"17","key":"pcbi.1007751.ref018","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.cub.2005.07.034","article-title":"Molecular, anatomical, and functional organization of the Drosophila olfactory system","volume":"15","author":"A Couto","year":"2005","journal-title":"Current Biology"},{"issue":"2","key":"pcbi.1007751.ref019","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.devcel.2011.12.015","article-title":"Determinants of the Drosophila odorant receptor pattern","volume":"22","author":"E Song","year":"2012","journal-title":"Developmental cell"},{"issue":"1","key":"pcbi.1007751.ref020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cub.2010.11.056","article-title":"Three-dimensional reconstruction of brain-wide wiring networks in Drosophila at single-cell resolution","volume":"21","author":"AS Chiang","year":"2011","journal-title":"Current Biology"},{"issue":"30","key":"pcbi.1007751.ref021","doi-asserted-by":"crossref","first-page":"10415","DOI":"10.1073\/pnas.0504099102","article-title":"Computational model of the cAMP-mediated sensory response and calcium-dependent adaptation in vertebrate olfactory receptor neurons","volume":"102","author":"DP Dougherty","year":"2005","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"pcbi.1007751.ref022","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/BF00158337","article-title":"Coding of odor intensity in a steady-state deterministic model of an olfactory receptor neuron","volume":"3","author":"JP Rospars","year":"1996","journal-title":"Journal of computational neuroscience"},{"issue":"10","key":"pcbi.1007751.ref023","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1523\/JNEUROSCI.4670-07.2008","article-title":"Competitive and noncompetitive odorant interactions in the early neural coding of odorant mixtures","volume":"28","author":"JP Rospars","year":"2008","journal-title":"The Journal of Neuroscience"},{"issue":"9","key":"pcbi.1007751.ref024","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/chemse\/27.9.789","article-title":"Oscillatory current responses of olfactory receptor neurons to odorants and computer simulation based on a cyclic AMP transduction model","volume":"27","author":"N Suzuki","year":"2002","journal-title":"Chemical senses"},{"issue":"12","key":"pcbi.1007751.ref025","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1016\/j.bpj.2012.04.040","article-title":"A dynamical feedback model for adaptation in the olfactory transduction pathway","volume":"102","author":"G De Palo","year":"2012","journal-title":"Biophysical Journal"},{"issue":"7","key":"pcbi.1007751.ref026","doi-asserted-by":"crossref","first-page":"E902","DOI":"10.1073\/pnas.1518329113","article-title":"Distinct signaling of Drosophila chemoreceptors in olfactory sensory neurons","volume":"113","author":"LH Cao","year":"2016","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"pcbi.1007751.ref027","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.27670","article-title":"Olfactory receptor neurons use gain control and complementary kinetics to encode intermittent odorant stimuli","volume":"6","author":"S Gorur-Shandilya","year":"2017","journal-title":"eLife"},{"key":"pcbi.1007751.ref028","doi-asserted-by":"crossref","DOI":"10.1038\/srep01251","article-title":"Common dynamical features of sensory adaptation in photoreceptors and olfactory sensory neurons","volume":"3","author":"G De Palo","year":"2013","journal-title":"Scientific Reports"},{"issue":"5","key":"pcbi.1007751.ref029","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.neuron.2004.08.019","article-title":"Or83b encodes a broadly expressed odorant receptor essential for Drosophila olfaction","volume":"43","author":"MC Larsson","year":"2004","journal-title":"Neuron"},{"issue":"2","key":"pcbi.1007751.ref030","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1371\/journal.pbio.0040020","article-title":"Atypical membrane topology and heteromeric function of Drosophila odorant receptors in vivo","volume":"4","author":"R Benton","year":"2006","journal-title":"PLoS biology"},{"issue":"1","key":"pcbi.1007751.ref031","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1113\/jphysiol.1971.sp009366","article-title":"Prediction of repetitive firing behaviour from voltage clamp data on an isolated neurone soma","volume":"213","author":"J Connor","year":"1971","journal-title":"The Journal of Physiology"},{"issue":"7190","key":"pcbi.1007751.ref032","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/nature06850","article-title":"Insect olfactory receptors are heteromeric ligand-gated ion channels","volume":"452","author":"K Sato","year":"2008","journal-title":"Nature"},{"issue":"7190","key":"pcbi.1007751.ref033","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/nature06861","article-title":"Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels","volume":"452","author":"D Wicher","year":"2008","journal-title":"Nature"},{"issue":"3","key":"pcbi.1007751.ref034","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/nrn2789","article-title":"Olfactory signalling in vertebrates and insects: differences and commonalities","volume":"11","author":"UB Kaupp","year":"2010","journal-title":"Nature Reviews Neuroscience"},{"issue":"11","key":"pcbi.1007751.ref035","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s00359-013-0812-z","article-title":"Kinetics of olfactory responses might largely depend on the odorant\u2013receptor interaction and the odorant deactivation postulated for flux detectors","volume":"199","author":"KE Kaissling","year":"2013","journal-title":"Journal of Comparative Physiology A"},{"key":"pcbi.1007751.ref036","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1146\/annurev-ento-120811-153635","article-title":"Odorant reception in insects: roles of receptors, binding proteins, and degrading enzymes","volume":"58","author":"WS Leal","year":"2013","journal-title":"Annual review of entomology"},{"key":"pcbi.1007751.ref037","first-page":"1","article-title":"Access to the odor world: olfactory receptors and their role for signal transduction in insects","author":"J Fleischer","year":"2017","journal-title":"Cellular and Molecular Life Sciences"},{"key":"pcbi.1007751.ref038","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9781107447615","volume-title":"Neuronal dynamics: From single neurons to networks and models of cognition","author":"W Gerstner","year":"2014"},{"key":"pcbi.1007751.ref039","article-title":"Investigating Odor Identity Encoding in Drosophila OSNs","author":"AJ Kim","year":"2011","journal-title":"Computational and Systems Neuroscience Meeting"},{"issue":"11","key":"pcbi.1007751.ref040","doi-asserted-by":"crossref","first-page":"4520","DOI":"10.1523\/JNEUROSCI.19-11-04520.1999","article-title":"Odor coding in a model olfactory organ: The Drosophila maxillary palp","volume":"19","author":"M de Bruyne","year":"1999","journal-title":"The Journal of neuroscience"},{"issue":"14","key":"pcbi.1007751.ref041","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/neu.20333","article-title":"The molecular receptive range of an olfactory receptor in vivo (Drosophila melanogaster Or22a)","volume":"66","author":"D Pelz","year":"2006","journal-title":"Developmental Neurobiology"},{"issue":"16","key":"pcbi.1007751.ref042","doi-asserted-by":"crossref","first-page":"R700","DOI":"10.1016\/j.cub.2009.06.026","article-title":"Olfactory information processing in Drosophila","volume":"19","author":"NY Masse","year":"2009","journal-title":"Current Biology"},{"issue":"1","key":"pcbi.1007751.ref043","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.cell.2009.09.015","article-title":"Olfactory perception: receptors, cells, and circuits","volume":"139","author":"CY Su","year":"2009","journal-title":"Cell"},{"key":"pcbi.1007751.ref044","article-title":"The Fruit Fly Brain Observatory: from structure to function","author":"NH Ukani","year":"2019","journal-title":"bioRxiv"},{"issue":"1","key":"pcbi.1007751.ref045","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neuron.2016.05.022","article-title":"Decoding of context-dependent olfactory behavior in Drosophila","volume":"91","author":"L Badel","year":"2016","journal-title":"Neuron"},{"issue":"4","key":"pcbi.1007751.ref046","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nn.3660","article-title":"Sparse, decorrelated odor coding in the mushroom body enhances learned odor discrimination","volume":"17","author":"AC Lin","year":"2014","journal-title":"Nature neuroscience"},{"issue":"5","key":"pcbi.1007751.ref047","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.neuron.2015.11.003","article-title":"Heterosynaptic plasticity underlies aversive olfactory learning in Drosophila","volume":"88","author":"T Hige","year":"2015","journal-title":"Neuron"},{"issue":"3","key":"pcbi.1007751.ref048","doi-asserted-by":"crossref","first-page":"e1000321","DOI":"10.1371\/journal.pcbi.1000321","article-title":"Computational model of the insect pheromone transduction cascade","volume":"5","author":"Y Gu","year":"2009","journal-title":"PLoS computational biology"},{"issue":"9","key":"pcbi.1007751.ref049","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/nn.3775","article-title":"An olfactory cocktail party: figure-ground segregation of odorants in rodents","volume":"17","author":"D Rokni","year":"2014","journal-title":"Nature neuroscience"},{"issue":"79","key":"pcbi.1007751.ref050","doi-asserted-by":"crossref","first-page":"20120835","DOI":"10.1098\/rsif.2012.0835","article-title":"On the binding affinity of macromolecular interactions: daring to ask why proteins interact","volume":"10","author":"PL Kastritis","year":"2013","journal-title":"Journal of The Royal Society Interface"},{"key":"pcbi.1007751.ref051","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1109\/NAFIPS.1996.534789","article-title":"On the usage of differential evolution for function optimization","author":"R Storn","year":"1996","journal-title":"Proceedings of North American Fuzzy Information Processing"},{"issue":"1","key":"pcbi.1007751.ref052","doi-asserted-by":"crossref","first-page":"e0146581","DOI":"10.1371\/journal.pone.0146581","article-title":"Neurokernel: an open source platform for emulating the fruit fly brain","volume":"11","author":"LE Givon","year":"2016","journal-title":"PloS one"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1007751","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T00:00:00Z","timestamp":1587686400000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007751","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,24]],"date-time":"2020-04-24T13:42:21Z","timestamp":1587735741000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007751"}},"subtitle":[],"editor":[{"given":"Matthieu","family":"Louis","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2020,4,14]]},"references-count":52,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1007751","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/237669","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,14]]}}}