{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T06:51:31Z","timestamp":1772952691703,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1007768","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000}}],"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T00:00:00Z","timestamp":1587081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2016YFC0902403(Yu)"],"award-info":[{"award-number":["2016YFC0902403(Yu)"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11671256(Yu)"],"award-info":[{"award-number":["11671256(Yu)"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Michigan and Shanghai Jiao Tong University Collaboration Grant"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1007768","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T17:45:02Z","timestamp":1587145502000},"page":"e1007768","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["High-dimensional mediation analysis in survival models"],"prefix":"10.1371","volume":"16","author":[{"given":"Chengwen","family":"Luo","sequence":"first","affiliation":[]},{"given":"Botao","family":"Fa","sequence":"additional","affiliation":[]},{"given":"Yuting","family":"Yan","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6948-0909","authenticated-orcid":true,"given":"Yang","family":"Wang","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8023-205X","authenticated-orcid":true,"given":"Yiwang","family":"Zhou","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0603-6536","authenticated-orcid":true,"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[]},{"given":"Zhangsheng","family":"Yu","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2020,4,17]]},"reference":[{"issue":"6","key":"pcbi.1007768.ref001","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1037\/0022-3514.51.6.1173","article-title":"The moderator-mediator variable distinction in social psychological research: conceptual, strategic, and stastical consideration","volume":"51","author":"RM Baron","year":"1986","journal-title":"J Pers Soc Psychol"},{"key":"pcbi.1007768.ref002","author":"DP Mackinnon","year":"2008"},{"issue":"3","key":"pcbi.1007768.ref003","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3758\/BRM.40.3.879","article-title":"Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models","volume":"40","author":"KJ Preacher","year":"2008","journal-title":"Behav Res Methods"},{"issue":"4","key":"pcbi.1007768.ref004","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1037\/a0036434","article-title":"Interpretation and identification of causal mediation","volume":"19","author":"J Pearl","year":"2014","journal-title":"Psychological Methods"},{"issue":"2","key":"pcbi.1007768.ref005","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/00001648-199203000-00013","article-title":"Identifiability and exchangeability for direct and indirect effects","volume":"3","author":"JM Robins","year":"1992","journal-title":"Epidemiology"},{"issue":"3","key":"pcbi.1007768.ref006","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1111\/j.1541-0420.2007.00766.x","article-title":"Causal mediation analyses with rank preserving models","volume":"63","author":"TR Ten Have","year":"2007","journal-title":"Biometrics"},{"issue":"2","key":"pcbi.1007768.ref007","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3102\/1076998607307239","article-title":"Identification of causal parameters in randomized studies with mediating variables","volume":"33","author":"ME Sobel","year":"2008","journal-title":"Journal of Educational & Behavioral Statistics"},{"issue":"3","key":"pcbi.1007768.ref008","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1111\/j.1541-0420.2010.01547.x","article-title":"Generalized causal mediation analysis","volume":"67","author":"JM Albert","year":"2011","journal-title":"Biometrics"},{"issue":"2","key":"pcbi.1007768.ref009","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s10742-008-0028-9","article-title":"Causal mediation analyses for randomized trials","volume":"8","author":"KG Lynch","year":"2008","journal-title":"Health Services & Outcomes Research Methodology"},{"issue":"2","key":"pcbi.1007768.ref010","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1467-9469.2004.02-123.x","article-title":"Direct and indirect causal effects via potential outcomes","volume":"31","author":"DB Rubin","year":"2010","journal-title":"Scandinavian Journal of Statistics"},{"issue":"12","key":"pcbi.1007768.ref011","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/aje\/kwq332","article-title":"Odds ratios for mediation analysis for a dichotomous outcome","volume":"172","author":"TJ VanderWeele","year":"2010","journal-title":"American Journal of Epidemiology"},{"issue":"28","key":"pcbi.1007768.ref012","doi-asserted-by":"crossref","first-page":"4875","DOI":"10.1002\/sim.6295","article-title":"Mediation analysis when a continuous mediator is measured with error and the outcome follows a generalized linear model","volume":"33","author":"L Valeri","year":"2014","journal-title":"Statistics in Medicine"},{"issue":"1","key":"pcbi.1007768.ref013","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1080\/10705511.2011.534324","article-title":"Estimating and testing mediation effects with censored data","volume":"18","author":"L Wang","year":"2011","journal-title":"Structural Equation Modeling A Multidisciplinary Journal"},{"issue":"1","key":"pcbi.1007768.ref014","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2202\/1557-4679.1351","article-title":"On causal mediation analysis with a survival outcome","volume":"7","author":"EJ Tchetgen Tchetgen","year":"2011","journal-title":"International Journal of Biostatistics"},{"issue":"4","key":"pcbi.1007768.ref015","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1097\/EDE.0b013e31821c680c","article-title":"Direct and indirect effects in a survival context","volume":"22","author":"T Lange","year":"2011","journal-title":"Epidemiology"},{"issue":"4","key":"pcbi.1007768.ref016","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1097\/EDE.0b013e31821db37e","article-title":"Causal mediation analysis with survival data","volume":"22","author":"TJ Vanderweele","year":"2011","journal-title":"Epidemiology"},{"issue":"1","key":"pcbi.1007768.ref017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/biom.12248","article-title":"Causal mediation analysis with multiple mediators","volume":"71","author":"RM Daniel","year":"2015","journal-title":"Biometrics"},{"issue":"1","key":"pcbi.1007768.ref018","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1515\/em-2012-0010","article-title":"Mediation analysis with multiple mediators","volume":"2","author":"T VanderWeele","year":"2014","journal-title":"Epidemiologic Methods"},{"issue":"3","key":"pcbi.1007768.ref019","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/EDE.0000000000000651","article-title":"Causal mediation analysis of survival outcome with multiple mediators","volume":"28","author":"YT Huang","year":"2017","journal-title":"Epidemiology"},{"issue":"20","key":"pcbi.1007768.ref020","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1093\/bioinformatics\/btw351","article-title":"Estimating and testing high-dimensional mediation effects in epigenetic studies","volume":"32","author":"H Zhang","year":"2016","journal-title":"Bioinformatics"},{"issue":"2","key":"pcbi.1007768.ref021","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1111\/biom.12421","article-title":"Hypothesis test of mediation effect in causal mediation model with high-dimensional continuous mediators","volume":"72","author":"Y-T Huang","year":"2016","journal-title":"Biometrics"},{"issue":"2","key":"pcbi.1007768.ref022","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/biostatistics\/kxx027","article-title":"High-dimensional multivariate mediation with application to neuroimaging data","volume":"19","author":"OY Ch\u00e9n","year":"2018","journal-title":"Biostatistics"},{"key":"pcbi.1007768.ref023","article-title":"Pathway lasso: estimate and select sparse mediation pathways with high-dimensional mediators","volume":"2016","author":"Y Zhao","year":"2016","journal-title":"arXiv e-prints"},{"key":"pcbi.1007768.ref024","article-title":"Multimodal neuroimaging data integration and pathway analysis","author":"Y Zhao","year":"2019","journal-title":"arXiv e-prints"},{"key":"pcbi.1007768.ref025","doi-asserted-by":"crossref","first-page":"106835","DOI":"10.1016\/j.csda.2019.106835","article-title":"Sparse principal component based high-dimensional mediation analysis","volume":"142","author":"Y Zhao","year":"2020","journal-title":"Computational Statistics and Data Analysis"},{"issue":"1","key":"pcbi.1007768.ref026","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1214\/18-AOAS1210","article-title":"Compositional mediation analysis for microbiome studies","volume":"13","author":"MB Sohn","year":"2019","journal-title":"The Annals of Applied Statistics"},{"issue":"5","key":"pcbi.1007768.ref027","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1080\/10705511.2019.1588124","article-title":"Exploratory mediation analysis with many potential mediators","volume":"26","author":"E-J van Kesteren","year":"2019","journal-title":"Structural Equation Modeling: A Multidisciplinary Journal"},{"key":"pcbi.1007768.ref028","article-title":"Inference for individual mediation effects and interventional effects in sparse high-dimensional causal graphical models","volume":"2018","author":"A Chakrabortty","year":"2018","journal-title":"arXiv e-prints"},{"key":"pcbi.1007768.ref029","article-title":"Non-linear mediation analysis with high-dimensional mediators whose causal structure is unknown","volume":"2020","author":"WW Loh","year":"2020","journal-title":"arXiv e-prints"},{"issue":"13","key":"pcbi.1007768.ref030","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1056\/NEJMra0802714","article-title":"Lung cancer","volume":"359","author":"RS Herbst","year":"2008","journal-title":"New England Journal of Medicine"},{"issue":"4","key":"pcbi.1007768.ref031","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.ajhg.2011.03.003","article-title":"Tobacco-smoking-related differential DNA methylation: 27k discovery and replication","volume":"88","author":"LP Breitling","year":"2011","journal-title":"American Journal of Human Genetics"},{"issue":"7","key":"pcbi.1007768.ref032","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1289\/ehp.1307480","article-title":"CpG sites associated with cigarette smoking: analysis of epigenome-wide data from the sister study","volume":"122","author":"S Harlid","year":"2014","journal-title":"Environmental Health Perspectives"},{"issue":"1","key":"pcbi.1007768.ref033","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s13148-015-0148-3","article-title":"DNA methylation changes of whole blood cells in response to active smoking exposure in adults: a systematic review of DNA methylation studies","volume":"7","author":"X Gao","year":"2015","journal-title":"Clinical Epigenetics"},{"issue":"12","key":"pcbi.1007768.ref034","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1080\/15592294.2017.1403692","article-title":"Tobacco exposure-related alterations in DNA methylation and gene expression in human monocytes: the Multi-Ethnic Study of Atherosclerosis (MESA)","volume":"12","author":"L Reynolds","year":"2017","journal-title":"Epigenetics"},{"issue":"5","key":"pcbi.1007768.ref035","doi-asserted-by":"crossref","first-page":"e63812","DOI":"10.1371\/journal.pone.0063812","article-title":"Tobacco smoking leads to extensive genome-wide changes in DNA methylation","volume":"8","author":"S Zeilinger","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"pcbi.1007768.ref036","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ygeno.2011.07.007","article-title":"High density DNA methylation array with single CpG site resolution","volume":"98","author":"M Bibikova","year":"2011","journal-title":"Genomics"},{"issue":"5","key":"pcbi.1007768.ref037","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1111\/j.1467-9868.2008.00674.x","article-title":"Sure independence screening for ultrahigh dimensional feature space","volume":"70","author":"J Fan","year":"2008","journal-title":"Journal of the Royal Statistical Society"},{"issue":"2","key":"pcbi.1007768.ref038","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1214\/09-AOS729","article-title":"Nearly unbiased variable selection under minimax concave penalty","volume":"38","author":"CH Zhang","year":"2010","journal-title":"Annals of Statistics"},{"issue":"35","key":"pcbi.1007768.ref039","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1038\/sj.onc.1205605","article-title":"DNA methylation analysis: a powerful new tool for lung cancer diagnosis","volume":"21","author":"JA Tsou","year":"2002","journal-title":"Oncogene"},{"issue":"1","key":"pcbi.1007768.ref040","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12967-015-0467-3","article-title":"The non-coding RNAs of the H19-IGF2 imprinted loci: a focus on biological roles and therapeutic potential in lung cancer","volume":"13","author":"IJ Matouk","year":"2015","journal-title":"Journal of Translational Medicine"},{"issue":"1","key":"pcbi.1007768.ref041","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/s13148-015-0115-z","article-title":"Prenatal parental tobacco smoking, gene specific DNA methylation, and newborns size: the generation R study","volume":"7","author":"MI Bouwland-Both","year":"2015","journal-title":"Clinical Epigenetics"},{"issue":"7","key":"pcbi.1007768.ref042","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.jtho.2017.04.018","article-title":"Expression of CDCA3 is a prognostic biomarker and potential therapeutic target in non-small cell lung cancer","volume":"12","author":"MN Adams","year":"2017","journal-title":"Journal of Thoracic Oncology"},{"issue":"3","key":"pcbi.1007768.ref043","doi-asserted-by":"crossref","first-page":"e92395","DOI":"10.1371\/journal.pone.0092395","article-title":"Cancer-risk module identification and module-based disease risk evaluation: a case study on lung cancer","volume":"9","author":"X Jia","year":"2014","journal-title":"Plos One"},{"issue":"6","key":"pcbi.1007768.ref044","doi-asserted-by":"crossref","first-page":"6977","DOI":"10.18632\/oncotarget.24059","article-title":"Distinct expression of CDCA3, CDCA5, and CDCA8 leads to shorter relapse free survival in breast cancer patient","volume":"9","author":"NN Phan","year":"2018","journal-title":"Oncotarget"},{"issue":"4","key":"pcbi.1007768.ref045","first-page":"1","article-title":"Case report: whole exome sequencing of circulating cell-free tumor DNA in a follicular thyroid carcinoma patient with lung and bone metastases","volume":"7","author":"J Song","year":"2018","journal-title":"Journal of Circulating Biomarkers"},{"issue":"22","key":"pcbi.1007768.ref046","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1042\/BCJ20170348","article-title":"Depletion of MUC5B mucin in gastrointestinal cancer cells alters their tumorigenic properties: implication of the Wnt\/\u03b2-catenin pathway","volume":"474","author":"F Lahdaoui","year":"2017","journal-title":"Biochemical Journal"},{"issue":"1","key":"pcbi.1007768.ref047","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/biostatistics\/kxv031","article-title":"Personalized screening intervals for biomarkers using joint models for longitudinal and survival data","volume":"17","author":"D Rizopoulos","year":"2016","journal-title":"Biostatistics"},{"issue":"6","key":"pcbi.1007768.ref048","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1177\/0962280211425578","article-title":"A joint model for the dependence between clustered times to tumour progression and deaths: a meta-analysis of chemotherapy in head and neck cancer","volume":"24","author":"V Rondeau","year":"2011","journal-title":"Statistical Methods in Medical Research"},{"issue":"4","key":"pcbi.1007768.ref049","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1093\/biostatistics\/kxl043","article-title":"Joint frailty models for recurring events and death using maximum penalized likelihood estimation: application on cancer events","volume":"8","author":"V Rondeau","year":"2006","journal-title":"Biostatistics"},{"issue":"2","key":"pcbi.1007768.ref050","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"D COX","year":"1972","journal-title":"Journal of the Royal Statistical Society"},{"issue":"1","key":"pcbi.1007768.ref051","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/EDE.0b013e31818f69ce","article-title":"Marginal structural models for the estimation of direct and indirect effects","volume":"20","author":"TJ VanderWeele","year":"2009","journal-title":"Epidemiology"},{"issue":"4","key":"pcbi.1007768.ref052","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/(SICI)1097-0258(19970228)16:4<385::AID-SIM380>3.0.CO;2-3","article-title":"The lasso method for variable selection in the cox model","volume":"16","author":"R Tibshirani","year":"1997","journal-title":"Statistics in Medicine"},{"issue":"1","key":"pcbi.1007768.ref053","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1214\/10-AOAS388","article-title":"Coordinate descent algorithms for nonconvex penalized regression, with applications to biological feature selection","volume":"5","author":"P Breheny","year":"2011","journal-title":"Annals of Applied Statistics"},{"issue":"13","key":"pcbi.1007768.ref054","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2307\/270723","article-title":"Asymptotic confidence intervals for indirect effects in structural equation models","volume":"13","author":"ME Sobel","year":"1982","journal-title":"Sociological Methodology"},{"issue":"1","key":"pcbi.1007768.ref055","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1037\/1082-989X.7.1.83","article-title":"A comparison of methods to test mediation and other intervening variable effects","volume":"7","author":"DP MacKinnon","year":"2002","journal-title":"Psychological Methods"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1007768","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007768","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T06:42:30Z","timestamp":1722753750000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007768"}},"subtitle":[],"editor":[{"given":"Benjamin","family":"Althouse","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2020,4,17]]},"references-count":55,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1007768","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1007768","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,17]]}}}