{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:41:42Z","timestamp":1779248502904,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1007927","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000}}],"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T00:00:00Z","timestamp":1591574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL122712"],"award-info":[{"award-number":["R01HL122712"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["W911NF1410333"],"award-info":[{"award-number":["W911NF1410333"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1P50MH094267"],"award-info":[{"award-number":["1P50MH094267"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01HL108634-01"],"award-info":[{"award-number":["U01HL108634-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Liz and Kent Dauten"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1007927","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T17:34:22Z","timestamp":1591637662000},"page":"e1007927","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["Measurable health effects associated with the daylight saving time shift"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5069-634X","authenticated-orcid":true,"given":"Hanxin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torsten","family":"Dahl\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6006-2620","authenticated-orcid":true,"given":"Atif","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustaf","family":"Edgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6959-7405","authenticated-orcid":true,"given":"Andrey","family":"Rzhetsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,6,8]]},"reference":[{"key":"pcbi.1007927.ref001","volume-title":"How much electricity is used for lighting in the United States?\u2014FAQ\u2014U.S","author":"US Energy Information Administration","year":"2016"},{"key":"pcbi.1007927.ref002","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1016\/j.cub.2007.10.025","article-title":"The Human Circadian Clock\u2019s Seasonal Adjustment Is Disrupted by Daylight Saving Time","volume":"17","author":"T Kantermann","year":"2007","journal-title":"Curr Biol"},{"key":"pcbi.1007927.ref003","article-title":"Does Daylight Savings Time Save Energy? Evidence from Ontario","author":"N. Rivers","year":"2016","journal-title":"SSRN Electron J"},{"key":"pcbi.1007927.ref004","article-title":"Does Daylight Saving Time Save Energy? Evidence from a Natural Experiment in Indiana [Internet]","author":"M Kotchen","year":"2008","journal-title":"National Bureau of Economic Research"},{"key":"pcbi.1007927.ref005","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/261688a0","article-title":"Adjusting to the changes to and from Daylight Saving Time","volume":"261","author":"TH Mink","year":"1976","journal-title":"Nature"},{"key":"pcbi.1007927.ref006","first-page":"e44","article-title":"Excess Risk of Fatal Road Traffic Accidents on the Day of Daylight Saving Time Change","volume":"29","author":"A Prats-Uribe","year":"2018","journal-title":"Epidemiology. Ovid Technologies (Wolters Kluwer Health)"},{"key":"pcbi.1007927.ref007","first-page":"1305","article-title":"Changing to daylight saving time cuts into sleep and increases workplace injuries","volume":"200994","author":"CM Barnes","journal-title":"Journal of Applied Psychology"},{"key":"pcbi.1007927.ref008","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.sleep.2011.07.019","article-title":"Daylight saving time shifts and incidence of acute myocardial infarction\u2013Swedish Register of Information and Knowledge About Swedish Heart Intensive Care Admissions (RIKS-HIA)","volume":"13","author":"I Janszky","year":"2012","journal-title":"Sleep Med"},{"key":"pcbi.1007927.ref009","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2458-8-74","article-title":"Daylight saving time transitions and hospital treatments due to accidents or manic episodes","volume":"8","author":"TA Lahti","year":"2008","journal-title":"BMC Public Health"},{"key":"pcbi.1007927.ref010","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.ajem.2018.10.056","article-title":"Effects of seasonality and daylight savings time on emergency department visits for mental health disorders","volume":"37","author":"V Heboyan","year":"2019","journal-title":"Am J Emerg Med"},{"key":"pcbi.1007927.ref011","article-title":"Neurobiology of the sleep-wake cycle: Sleep architecture, circadian regulation, and regulatory feedback","author":"PM Fuller","year":"2006","journal-title":"Journal of Biological Rhythms"},{"key":"pcbi.1007927.ref012","article-title":"Daylight saving time and artificial time zones\u2014A battle between biological and social times","author":"T Roenneberg","year":"2019","journal-title":"Frontiers in Physiology"},{"key":"pcbi.1007927.ref013","article-title":"Are Daylight Saving Time Changes Bad for the Brain?","author":"BA Malow","year":"2019","journal-title":"JAMA Neurology"},{"key":"pcbi.1007927.ref014","unstructured":"IBM MarketScan Research Databases [Internet]. 2018. Available: https:\/\/www.ibm.com\/downloads\/cas\/4QD5ADRL"},{"key":"pcbi.1007927.ref015","first-page":"11","article-title":"External review and validation of the Swedish national inpatient register","author":"JF Ludvigsson","year":"2011","journal-title":"BMC Public Health"},{"key":"pcbi.1007927.ref016","author":"World Health Organization","year":"2016","journal-title":"International statistical classification of diseases and related health problems, 10th revision (ICD-10)World Heal Organ"},{"key":"pcbi.1007927.ref017","first-page":"189","article-title":"Why We (Usually) Don\u2019t Have to Worry About Multiple Comparisons","volume":"5","author":"A Gelman","year":"2012","journal-title":"J Res Educ Eff"},{"key":"pcbi.1007927.ref018","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1198\/016214504000001907","article-title":"False Discovery Rate\u2013Adjusted Multiple Confidence Intervals for Selected Parameters","volume":"100","author":"Y Benjamini","year":"2005","journal-title":"J Am Stat Assoc"},{"key":"pcbi.1007927.ref019","article-title":"Shifts to and from daylight saving time and incidence of myocardial infarction","author":"I Janszky","year":"2008","journal-title":"New England Journal of Medicine"},{"key":"pcbi.1007927.ref020","article-title":"Daylight saving time and myocardial infarction: Should we be worried? A review of the evidence","author":"R Manfredini","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"pcbi.1007927.ref021","article-title":"Impact of Daylight Saving Time on circadian timing system: An expert statement","author":"M Meira e Cruz","year":"2019","journal-title":"European Journal of Internal Medicine"},{"key":"pcbi.1007927.ref022","article-title":"Accident rates and the impact of daylight saving time transitions","author":"D Robb","year":"2018","journal-title":"Accid Anal Prev"},{"key":"pcbi.1007927.ref023","article-title":"When brain clocks lose track of time: Cause or consequence of neuropsychiatric disorders","author":"JS Menet","year":"2011","journal-title":"Current Opinion in Neurobiology"},{"key":"pcbi.1007927.ref024","article-title":"Circadian rhythms and risk for substance use disorders in adolescence","author":"BP Hasler","year":"2014","journal-title":"Current Opinion in Psychiatry"},{"key":"pcbi.1007927.ref025","article-title":"Circadian Rhythms and Substance Abuse: Chronobiological Considerations for the Treatment of Addiction","author":"IC Webb","year":"2017","journal-title":"Current Psychiatry Reports"},{"key":"pcbi.1007927.ref026","article-title":"Circadian rhythms, sleep, and substance abuse","author":"BP Hasler","year":"2012","journal-title":"Sleep Medicine Reviews"},{"key":"pcbi.1007927.ref027","article-title":"Circadian rhythms and addiction: Mechanistic insights and future directions","author":"RW Logan","year":"2014","journal-title":"Behav Neurosci"},{"key":"pcbi.1007927.ref028","article-title":"A role for the circadian genes in drug addiction","author":"E Falc\u00f3n","year":"2009","journal-title":"Neuropharmacology"},{"key":"pcbi.1007927.ref029","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/0748730415575246","article-title":"Influence of the Cardiomyocyte Circadian Clock on Cardiac Physiology and Pathophysiology","volume":"30","author":"TA Martino","year":"2015","journal-title":"J Biol Rhythms"},{"key":"pcbi.1007927.ref030","doi-asserted-by":"crossref","DOI":"10.1210\/js.2019-OR04-4","article-title":"Cardiomyocyte Transcription Is Controlled By Combined Mr And Circadian Clock Signalling","volume":"3","author":"E Fletcher","year":"2019","journal-title":"J Endocr Soc"},{"key":"pcbi.1007927.ref031","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.trecan.2019.07.002","article-title":"Interplay between Circadian Clock and Cancer: New Frontiers for Cancer Treatment","volume":"5","author":"G Sulli","year":"2019","journal-title":"Trends in Cancer. Elsevier BV"},{"key":"pcbi.1007927.ref032","doi-asserted-by":"crossref","first-page":"e475","DOI":"10.1016\/j.wneu.2019.06.122","article-title":"Regulation of Circadian Clock Genes on Sleep Disorders in Traumatic Brain Injury Patients","volume":"130","author":"N Zhanfeng","year":"2019","journal-title":"World Neurosurg"},{"key":"pcbi.1007927.ref033","first-page":"19","article-title":"Circadian Clock Genes in Diabetic Kidney Disease (DKD)","author":"OA Olaoye","year":"2019","journal-title":"Curr Diab Rep"},{"key":"pcbi.1007927.ref034","article-title":"Circadian Clock Genes in the Metabolism of Non-alcoholic Fatty Liver Disease","volume":"10","author":"D Shi","year":"2019","journal-title":"Front Physiol"},{"key":"pcbi.1007927.ref035","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-43612-w","article-title":"Mutant huntingtin disturbs circadian clock gene expression and sleep patterns in Drosophila","volume":"9","author":"A Farag\u00f3","year":"2019","journal-title":"Sci Rep"},{"key":"pcbi.1007927.ref036","volume-title":"Timing gone awry: distinct tumour suppressive and oncogenic roles of the circadian clock and crosstalk with hypoxia signalling in diverse malignancies","author":"WH Chang","year":"2019"},{"key":"pcbi.1007927.ref037","first-page":"1","article-title":"Expressions of circadian clock genes represent disease activities of RA patients treated with biological DMARDs","author":"K Kaneshiro","year":"2019","journal-title":"Mod Rheumatol"},{"key":"pcbi.1007927.ref038","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.3390\/ijms20071597","article-title":"Off the Clock: From Circadian Disruption to Metabolic Disease","volume":"20","author":"E. Maury","year":"2019","journal-title":"Int J Mol Sci"},{"key":"pcbi.1007927.ref039","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jhep.2019.03.020","article-title":"The circadian clock and liver function in health and disease","volume":"71","author":"A Mukherji","year":"2019","journal-title":"J Hepatol"},{"key":"pcbi.1007927.ref040","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41569-019-0167-4","article-title":"Circadian rhythms and the molecular clock in cardiovascular biology and disease","volume":"16","author":"S Crnko","year":"2019","journal-title":"Nat Rev Cardiol"},{"key":"pcbi.1007927.ref041","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/iub.2005","article-title":"The tumour suppressing role of the circadian clock","volume":"71","author":"K Davis","year":"2019","journal-title":"IUBMB Life"},{"key":"pcbi.1007927.ref042","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s12640-018-9968-1","article-title":"Low-Grade Inflammation Aggravates Rotenone Neurotoxicity and Disrupts Circadian Clock Gene Expression in Rats","volume":"35","author":"H Li","year":"2018","journal-title":"Neurotox Res"},{"key":"pcbi.1007927.ref043","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1210\/er.2018-00049","article-title":"Coupling the Circadian Clock to Homeostasis: The Role of Period in Timing Physiology","volume":"40","author":"P Kim","year":"2018","journal-title":"Endocr Rev"},{"key":"pcbi.1007927.ref044","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s12026-014-8517-0","article-title":"Effects of stress on immune function: the good, the bad, and the beautiful","volume":"58","author":"FS Dhabhar","year":"2014","journal-title":"Immunol Res"},{"key":"pcbi.1007927.ref045","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.bbi.2009.09.004","article-title":"Short-term stress enhances cellular immunity and increases early resistance to squamous cell carcinoma","volume":"24","author":"FS Dhabhar","year":"2010","journal-title":"Brain Behav Immun"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1007927","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T00:00:00Z","timestamp":1592438400000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007927","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,18]],"date-time":"2020-06-18T20:49:25Z","timestamp":1592513365000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007927"}},"subtitle":[],"editor":[{"given":"Lars Juhl","family":"Jensen","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,8]]},"references-count":45,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1007927","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1007927","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,8]]}}}