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The chemical synapse network of\n                    <jats:italic>Caenorhabditis elegans<\/jats:italic>\n                    is a well-reconstructed directed network, but the signs of its connections are yet to be elucidated. Here, we present the gene expression-based sign prediction of the ionotropic chemical synapse connectome of\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>elegans<\/jats:italic>\n                    (3,638 connections and 20,589 synapses total), incorporating available presynaptic neurotransmitter and postsynaptic receptor gene expression data for three major neurotransmitter systems. We made predictions for more than two-thirds of these chemical synapses and observed an excitatory-inhibitory (E:I) ratio close to 4:1 which was found similar to that observed in many real-world networks. Our open source tool (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/EleganSign.linkgroup.hu\" xlink:type=\"simple\">http:\/\/EleganSign.linkgroup.hu<\/jats:ext-link>\n                    ) is simple but efficient in predicting polarities by integrating neuronal connectome and gene expression data.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1007974","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T14:37:37Z","timestamp":1608561457000},"page":"e1007974","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Synaptic polarity and sign-balance prediction using gene expression data in the Caenorhabditis elegans chemical synapse neuronal connectome network"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2374-7513","authenticated-orcid":true,"given":"B\u00e1nk G.","family":"Fenyves","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0205-5796","authenticated-orcid":true,"given":"G\u00e1bor S.","family":"Szil\u00e1gyi","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1370-0877","authenticated-orcid":true,"given":"Zsolt","family":"Vassy","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4057-7678","authenticated-orcid":true,"given":"Csaba","family":"S\u0151ti","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9234-0659","authenticated-orcid":true,"given":"Peter","family":"Csermely","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"key":"pcbi.1007974.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1098\/rstb.1986.0056","article-title":"The structure of the nervous system of the nematode Caenorhabditis elegans","volume":"314","author":"JG White","year":"1986","journal-title":"Philos Trans R Soc London B, Biol 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