{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:27:57Z","timestamp":1780730877892,"version":"3.54.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1007998","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:00:00Z","timestamp":1594166400000}}],"reference-count":95,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["286526"],"award-info":[{"award-number":["286526"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["322423"],"award-info":[{"award-number":["322423"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","award":["324529"],"award-info":[{"award-number":["324529"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008413","name":"Instrumentariumin Tiedes\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008413","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["702586;713645"],"award-info":[{"award-number":["702586;713645"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1007998","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T18:00:26Z","timestamp":1593108026000},"page":"e1007998","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Mechanobiological model for simulation of injured cartilage degradation via pro-inflammatory cytokines and mechanical stimulus"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1516-3083","authenticated-orcid":true,"given":"Atte S. A.","family":"Eskelinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9684-6902","authenticated-orcid":true,"given":"Petri","family":"Tanska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7719-2600","authenticated-orcid":true,"given":"Cristina","family":"Florea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo A.","family":"Orozco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0461-1058","authenticated-orcid":true,"given":"Petro","family":"Julkunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan J.","family":"Grodzinsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3486-7855","authenticated-orcid":true,"given":"Rami K.","family":"Korhonen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,6,25]]},"reference":[{"key":"pcbi.1007998.ref001","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.joca.2005.08.005","article-title":"Early post-traumatic osteoarthritis-like changes in human articular cartilage following rupture of the anterior cruciate ligament","volume":"14","author":"F Nelson","year":"2006","journal-title":"Osteoarthr Cartil"},{"key":"pcbi.1007998.ref002","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1302\/2046-3758.32.2000241","article-title":"Basic science of anterior cruciate ligament injury and repair","volume":"3","author":"AM Kiapour","year":"2014","journal-title":"Bone Joint Res"},{"key":"pcbi.1007998.ref003","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1016\/j.joca.2015.08.015","article-title":"Inflammation in Joint Injury and Post-Traumatic Osteoarthritis","volume":"23","author":"J Lieberthal","year":"2015","journal-title":"Osteoarthr Cartil"},{"key":"pcbi.1007998.ref004","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/jor.23341","article-title":"Review of current understanding of post-traumatic osteoarthritis resulting from sports injuries","volume":"35","author":"A Carbone","year":"2017","journal-title":"J Orthop Res"},{"key":"pcbi.1007998.ref005","first-page":"1","article-title":"Towards secondary prevention of early knee osteoarthritis","volume":"4","author":"A Mahmoudian","year":"2018","journal-title":"RMD Open"},{"key":"pcbi.1007998.ref006","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.joca.2012.11.012","article-title":"Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)","volume":"21","author":"F. Berenbaum","year":"2013","journal-title":"Osteoarthr Cartil"},{"key":"pcbi.1007998.ref007","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/s10439-014-1117-2","article-title":"A Systems View of Risk Factors for Knee Osteoarthritis Reveals Insights into the Pathogenesis of the Disease","volume":"43","author":"T Andriacchi","year":"2015","journal-title":"Ann Biomed Eng"},{"key":"pcbi.1007998.ref008","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: A disease of the joint as an organ","volume":"64","author":"RF Loeser","year":"2012","journal-title":"Arthritis Rheum"},{"key":"pcbi.1007998.ref009","first-page":"1","article-title":"Systems based study of the therapeutic potential of small charged molecules for the inhibition of IL-1 mediated cartilage degradation","volume":"11","author":"S Kar","year":"2016","journal-title":"PLoS One"},{"key":"pcbi.1007998.ref010","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.abb.2016.02.008","article-title":"Modeling IL-1 induced degradation of articular cartilage","volume":"594","author":"S Kar","year":"2016","journal-title":"Arch Biochem Biophys"},{"key":"pcbi.1007998.ref011","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.matbio.2018.05.005","article-title":"Cartilage diseases","volume":"71\u201372","author":"Y Krishnan","year":"2018","journal-title":"Matrix Biol"},{"key":"pcbi.1007998.ref012","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.berh.2011.11.013","article-title":"Biomechanical factors in osteoarthritis","volume":"25","author":"F. Guilak","year":"2011","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"pcbi.1007998.ref013","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1002\/art.21262","article-title":"Secondary gait changes in patients with medial compartment knee osteoarthritis: Increased load at the ankle, knee, and hip during walking","volume":"52","author":"A M\u00fcndermann","year":"2005","journal-title":"Arthritis Rheum"},{"key":"pcbi.1007998.ref014","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.joca.2012.08.004","article-title":"Body mass index affects knee joint mechanics during gait differently with and without moderate knee osteoarthritis","volume":"20","author":"GT Harding","year":"2012","journal-title":"Osteoarthr Cartil"},{"key":"pcbi.1007998.ref015","doi-asserted-by":"crossref","first-page":"e0187583","DOI":"10.1371\/journal.pone.0187583","article-title":"Medial knee loading is altered in subjects with early osteoarthritis during gait but not during step-up-and-over task","volume":"12","author":"S Meireles","year":"2017","journal-title":"PLoS One"},{"key":"pcbi.1007998.ref016","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/j.joca.2018.08.013","article-title":"Functional assessment of strains around a full-thickness and critical sized articular cartilage defect under compressive loading using MRI","volume":"26","author":"L Zevenbergen","year":"2018","journal-title":"Osteoarthr Cartil"},{"key":"pcbi.1007998.ref017","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s10237-018-01113-1","article-title":"Maximum shear strain-based algorithm can predict proteoglycan loss in damaged articular cartilage","volume":"18","author":"A Eskelinen","year":"2019","journal-title":"Biomech Model Mechanobiol"},{"key":"pcbi.1007998.ref018","first-page":"1","article-title":"Computational evaluation of altered biomechanics related to articular cartilage lesions observed in vivo","author":"KAH Myller","year":"2019","journal-title":"J Orthop Res"},{"key":"pcbi.1007998.ref019","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s10237-016-0815-0","article-title":"The effect of loading rate on the development of early damage in articular cartilage","volume":"16","author":"J P\u00e1rraga Quiroga","year":"2017","journal-title":"Biomech Model Mechanobiol"},{"key":"pcbi.1007998.ref020","doi-asserted-by":"crossref","first-page":"9177","DOI":"10.1038\/s41598-017-09013-7","article-title":"Simulation of subject-specific progression of knee osteoarthritis and comparison to experimental follow-up data: Data from the osteoarthritis initiative","volume":"7","author":"M Liukkonen","year":"2017","journal-title":"Sci Rep"},{"key":"pcbi.1007998.ref021","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s10439-018-02184-y","article-title":"Utilizing Atlas-Based Modeling to Predict Knee Joint Cartilage Degeneration: Data from the Osteoarthritis Initiative","volume":"47","author":"M Mononen","year":"2019","journal-title":"Ann Biomed Eng"},{"key":"pcbi.1007998.ref022","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1745-6150-7-9","article-title":"Reaction-Diffusion-Delay Model for EPO\/TNF-\u03b1 Interaction in articular cartilage lesion abatement","volume":"7","author":"JM Graham","year":"2012","journal-title":"Biol Direct"},{"key":"pcbi.1007998.ref023","first-page":"jor.24304","article-title":"Designer stem cells: Genome engineering and the next generation of cell\u2010based therapies","author":"F Guilak","year":"2019","journal-title":"J Orthop Res"},{"key":"pcbi.1007998.ref024","doi-asserted-by":"crossref","first-page":"341","DOI":"10.22203\/eCM.v034a21","article-title":"Sustained intra-cartilage delivery of low dose dexamethasone using a cationic carrier for treatment of post traumatic osteoarthritis","volume":"34","author":"AG Bajpayee","year":"2017","journal-title":"Eur Cell Mater"},{"key":"pcbi.1007998.ref025","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/jor.23295","article-title":"Intra-articular dexamethasone to inhibit the development of post-traumatic osteoarthritis","volume":"35","author":"AJ Grodzinsky","year":"2017","journal-title":"J Orthop Res"},{"key":"pcbi.1007998.ref026","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fbioe.2016.00080","article-title":"Linking Cellular and Mechanical Processes in Articular Cartilage Lesion Formation: A Mathematical Model","volume":"4","author":"G Kapitanov","year":"2016","journal-title":"Front Bioeng Biotechnol"},{"key":"pcbi.1007998.ref027","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1177\/036354659502300622","article-title":"Immunohistologic Analysis of Synovium in Infrapatellar Fat Pad After Anterior Cruciate Ligament Injury","volume":"23","author":"S Murakami","year":"1995","journal-title":"Am J Sports Med"},{"key":"pcbi.1007998.ref028","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2011.00052","article-title":"Macrophages in synovial inflammation","volume":"2","author":"A Kennedy","year":"2011","journal-title":"Front Immunol"},{"key":"pcbi.1007998.ref029","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1136\/ard.2008.098764","article-title":"Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism","volume":"67","author":"MB Goldring","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"pcbi.1007998.ref030","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.3390\/ijms19082282","article-title":"Onset and Progression of Human Osteoarthritis\u2014Can Growth Factors, Inflammatory Cytokines, or Differential miRNA Expression Concomitantly Induce Proliferation, ECM Degradation, and Inflammation in Articular Cartilage?","volume":"19","author":"KA Boehme","year":"2018","journal-title":"Int J Mol Sci"},{"key":"pcbi.1007998.ref031","doi-asserted-by":"crossref","first-page":"091005","DOI":"10.1115\/1.4027937","article-title":"The Regional Sensitivity of Chondrocyte Gene Expression to Coactive Mechanical Load and Exogenous TNF-\u03b1 Stimuli","volume":"136","author":"SL Bevill","year":"2014","journal-title":"J Biomech Eng"},{"key":"pcbi.1007998.ref032","doi-asserted-by":"crossref","first-page":"349","DOI":"10.4049\/jimmunol.1301906","article-title":"IL-6-Mediated Induction of Matrix Metalloproteinase-9 Is Modulated by JAK-Dependent IL-10 Expression in Macrophages","volume":"192","author":"P Kothari","year":"2014","journal-title":"J Immunol"},{"key":"pcbi.1007998.ref033","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4049\/jimmunol.148.2.466","article-title":"Cartilage and joint inflammation. Regulation of IL-8 expression by human articular chondrocytes","volume":"148","author":"M Lotz","year":"1992","journal-title":"J Immunol"},{"key":"pcbi.1007998.ref034","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1002\/art.24857","article-title":"Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor \u03b1 in immature bovine and adult human articular cartilage","volume":"60","author":"Y Sui","year":"2009","journal-title":"Arthritis Rheum"},{"key":"pcbi.1007998.ref035","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.joca.2004.10.023","article-title":"Analysis of ADAMTS4 and MT4-MMP indicates that both are involved in aggrecanolysis in interleukin-1-treated bovine cartilage","volume":"13","author":"P Patwari","year":"2005","journal-title":"Osteoarthr Cartil"},{"key":"pcbi.1007998.ref036","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1074\/mcp.M800181-MCP200","article-title":"Mechanical Injury and Cytokines Cause Loss of Cartilage Integrity and Upregulate Proteins Associated with Catabolism, Immunity, Inflammation, and Repair","volume":"8","author":"AL Stevens","year":"2009","journal-title":"Mol Cell Proteomics"},{"key":"pcbi.1007998.ref037","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bbapap.2011.06.020","article-title":"Proteases involved in cartilage matrix degradation in osteoarthritis","volume":"1824","author":"L Troeberg","year":"2012","journal-title":"Biochim Biophys Acta\u2014Proteins Proteomics"},{"key":"pcbi.1007998.ref038","doi-asserted-by":"crossref","first-page":"12501","DOI":"10.1074\/jbc.C000848200","article-title":"TIMP-3 Is a Potent Inhibitor of Aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5)","volume":"276","author":"M Kashiwagi","year":"2001","journal-title":"J Biol Chem"},{"key":"pcbi.1007998.ref039","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s002960050083","article-title":"Expression of the tissue inhibitor of metalloproteinases (TIMP) gene family in normal and osteoarthritic joints","volume":"18","author":"S Su","year":"1999","journal-title":"Rheumatol Int"},{"key":"pcbi.1007998.ref040","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.joca.2014.11.006","article-title":"Effects of insulin-like growth factor-1 and dexamethasone on cytokine-challenged cartilage: Relevance to post-traumatic osteoarthritis","volume":"23","author":"Y Li","year":"2015","journal-title":"Osteoarthr Cartil"},{"key":"pcbi.1007998.ref041","article-title":"The effect of fibrillar degradation on the mechanics of articular cartilage: a computational model","author":"TR Faisal","year":"2019","journal-title":"Biomech Model Mechanobiol"},{"key":"pcbi.1007998.ref042","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.joca.2012.09.012","article-title":"Osteoarthritis as a disease of mechanics","volume":"21","author":"DT Felson","year":"2013","journal-title":"Osteoarthr Cartil"},{"key":"pcbi.1007998.ref043","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.clinbiomech.2016.10.006","article-title":"Varus thrust in women with early medial knee osteoarthritis and its relation with the external knee adduction moment","volume":"39","author":"A Mahmoudian","year":"2016","journal-title":"Clin Biomech"},{"key":"pcbi.1007998.ref044","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jmbbm.2017.08.036","article-title":"Effect of frequency on crack growth in articular cartilage","volume":"77","author":"H Sadeghi","year":"2018","journal-title":"J Mech Behav Biomed Mater"},{"key":"pcbi.1007998.ref045","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/j.jbiomech.2005.01.026","article-title":"Effects of damage in the articular surface on the cartilage response to injurious compression in vitro","volume":"39","author":"V Morel","year":"2006","journal-title":"J Biomech"},{"key":"pcbi.1007998.ref046","doi-asserted-by":"crossref","first-page":"21415","DOI":"10.1038\/srep21415","article-title":"A novel method to simulate the progression of collagen degeneration of cartilage in the knee: Data from the osteoarthritis initiative","volume":"6","author":"M Mononen","year":"2016","journal-title":"Sci Rep"},{"key":"pcbi.1007998.ref047","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.joca.2013.10.010","article-title":"A numerical model to study mechanically induced initiation and progression of damage in articular cartilage","volume":"22","author":"S Hosseini","year":"2014","journal-title":"Osteoarthr Cartil"},{"key":"pcbi.1007998.ref048","doi-asserted-by":"crossref","first-page":"081010","DOI":"10.1115\/1.4030744","article-title":"An Equilibrium Constitutive Model of Anisotropic Cartilage Damage to Elucidate Mechanisms of Damage Initiation and Progression","volume":"137","author":"M Stender","year":"2015","journal-title":"J Biomech Eng"},{"key":"pcbi.1007998.ref049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-33759-3","article-title":"A novel mechanobiological model can predict how physiologically relevant dynamic loading causes proteoglycan loss in mechanically injured articular cartilage","volume":"8","author":"GA Orozco","year":"2018","journal-title":"Sci Rep"},{"key":"pcbi.1007998.ref050","doi-asserted-by":"crossref","first-page":"20141090","DOI":"10.1098\/rsif.2014.1090","article-title":"Altered swelling and ion fluxes in articular cartilage as a biomarker in osteoarthritis and joint immobilization: A computational analysis","volume":"12","author":"S Manzano","year":"2014","journal-title":"J R Soc Interface"},{"key":"pcbi.1007998.ref051","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/jor.23811","article-title":"New algorithm for simulation of proteoglycan loss and collagen degeneration in the knee joint: Data from the osteoarthritis initiative","volume":"36","author":"M Mononen","year":"2018","journal-title":"J Orthop Res"},{"key":"pcbi.1007998.ref052","article-title":"Moderate Dynamic Compression Inhibits Pro-Catabolic Response of Cartilage to Mechanical Injury, TNF-\u03b1 and IL-6, but Accentuates Degradation Above a Strain Threshold","volume":"21","author":"Y Li","year":"2013","journal-title":"Osteoarthr Cartil"},{"key":"pcbi.1007998.ref053","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.joca.2006.05.006","article-title":"Prediction of collagen orientation in articular cartilage by a collagen remodeling algorithm","volume":"14","author":"W Wilson","year":"2006","journal-title":"Osteoarthr Cartil"},{"key":"pcbi.1007998.ref054","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s10237-017-0986-3","article-title":"A computational algorithm to simulate disorganization of collagen network in injured articular cartilage","volume":"17","author":"P Tanska","year":"2018","journal-title":"Biomech Model Mechanobiol"},{"key":"pcbi.1007998.ref055","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/j.joca.2014.04.010","article-title":"Site-dependent changes in structure and function of lapine articular cartilage 4 weeks after anterior cruciate ligament transection","volume":"22","author":"JTA M\u00e4kel\u00e4","year":"2014","journal-title":"Osteoarthr Cartil"},{"key":"pcbi.1007998.ref056","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jbiomech.2013.11.050","article-title":"An in vitro model for the pathological degradation of articular cartilage in osteoarthritis","volume":"47","author":"S Grenier","year":"2014","journal-title":"J Biomech"},{"key":"pcbi.1007998.ref057","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/j.1749-6632.1999.tb07700.x","article-title":"Physical and biological regulation of proteoglycan turnover around chondrocytes in cartilage explants. Implications for tissue degradation and repair","volume":"878","author":"TM Quinn","year":"1999","journal-title":"Ann N Y Acad Sci"},{"key":"pcbi.1007998.ref058","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s10237-006-0037-y","article-title":"Analysis of the relationship between peak stress and proteoglycan loss following injurious compression of human post-mortem knee and ankle cartilage","volume":"6","author":"P Patwari","year":"2007","journal-title":"Biomech Model Mechanobiol"},{"key":"pcbi.1007998.ref059","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/BF00501401","article-title":"Microspectrophotometric quantitation of glycosaminoglycans in articular cartilage sections stained with Safranin O","volume":"82","author":"I Kiviranta","year":"1985","journal-title":"Histochemistry"},{"key":"pcbi.1007998.ref060","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/BF02331378","article-title":"Application of selected cationic dyes for the semiquantitative estimation of glycosaminoglycans in histological sections of articular cartilage by microspectrophotometry","volume":"28","author":"K Kir\u00e1ly","year":"1996","journal-title":"Histochem J"},{"key":"pcbi.1007998.ref061","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s10439-008-9587-8","article-title":"A simple mathematical model of cytokine capture using a hemoadsorption device","volume":"37","author":"MV. Dileo","year":"2009","journal-title":"Ann Biomed Eng"},{"key":"pcbi.1007998.ref062","doi-asserted-by":"crossref","first-page":"13464","DOI":"10.1016\/S0021-9258(19)76449-7","article-title":"Hydrodynamics of concentrated proteoglycan solutions","volume":"262","author":"WD Comper","year":"1987","journal-title":"J Biol Chem"},{"key":"pcbi.1007998.ref063","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1023\/A:1020677829069","article-title":"Dependence of cartilage matrix composition on biosynthesis, diffusion, and reaction","volume":"50","author":"MA DiMicco","year":"2003","journal-title":"Transp Porous Media"},{"key":"pcbi.1007998.ref064","doi-asserted-by":"crossref","first-page":"377","DOI":"10.22203\/eCM.v022a28","article-title":"Mathematical modelling of tissue formation in chondrocyte filter cultures","volume":"22","author":"CJ Catt","year":"2011","journal-title":"Eur Cells Mater"},{"key":"pcbi.1007998.ref065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011860","article-title":"Quantifying the proteolytic release of extracellular matrix-sequestered VEGF with a computational model","volume":"5","author":"P Vempati","year":"2010","journal-title":"PLoS One"},{"key":"pcbi.1007998.ref066","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1098\/rstb.1975.0054","article-title":"Glycosaminoglycan turn-over in articular cartilage","volume":"271","author":"A. Maroudas","year":"1975","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"pcbi.1007998.ref067","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/0014-5793(94)00994-5","article-title":"Nitric oxide and proteoglycan biosynthesis by human articular chondrocytes in alginate culture","volume":"352","author":"H H\u00e4uselmann","year":"1994","journal-title":"FEBS Lett"},{"key":"pcbi.1007998.ref068","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/art.1780390316","article-title":"The superficial layer of human articular cartilage is more susceptible to interleukin-1-induced damage than the deeper layers","volume":"39","author":"H H\u00e4uselmann","year":"1996","journal-title":"Arthritis Rheum"},{"key":"pcbi.1007998.ref069","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/ar630","article-title":"Aggrecanases and cartilage matrix degradation","volume":"5","author":"H Nagase","year":"2003","journal-title":"Arthritis Res Ther"},{"key":"pcbi.1007998.ref070","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jbiomech.2005.11.002","article-title":"Depth-dependent biomechanical and biochemical properties of fetal, newborn, and tissue-engineered articular cartilage","volume":"40","author":"TJ Klein","year":"2007","journal-title":"J Biomech"},{"key":"pcbi.1007998.ref071","doi-asserted-by":"crossref","first-page":"6393","DOI":"10.1021\/bi7000642","article-title":"Substrate-dependent inhibition kinetics of an active site-directed inhibitor of ADAMTS-4 (aggrecanase 1)","volume":"46","author":"AJ Wittwer","year":"2007","journal-title":"Biochemistry"},{"key":"pcbi.1007998.ref072","doi-asserted-by":"crossref","first-page":"6462","DOI":"10.1074\/jbc.M113.545376","article-title":"Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): Functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding","volume":"289","author":"K Yamamoto","year":"2014","journal-title":"J Biol Chem"},{"key":"pcbi.1007998.ref073","doi-asserted-by":"crossref","first-page":"4170","DOI":"10.1002\/anie.200905513","article-title":"Reaction -Diffusion Systems in Intracellular Molecular Transport and Control","volume":"49","author":"S Soh","year":"2010","journal-title":"Angew Chem Int Ed Engl"},{"key":"pcbi.1007998.ref074","first-page":"1329","article-title":"Short-term gene expression changes in cartilage explants stimulated with interleukin 1\u03b2 plus glucosamine and chondroitin sulfate","volume":"33","author":"PS Chan","year":"2006","journal-title":"J Rheumatol"},{"key":"pcbi.1007998.ref075","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1369\/jhc.4A6511.2005","article-title":"Depth-varying density and organization of chondrocytes in immature and mature bovine articular cartilage assessed by 3D imaging and analysis","volume":"53","author":"KD Jadin","year":"2005","journal-title":"J Histochem Cytochem"},{"key":"pcbi.1007998.ref076","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/term.1751","article-title":"Computational model for the analysis of cartilage and cartilage tissue constructs","volume":"10","author":"D Smith","year":"2016","journal-title":"J Tissue Eng Regen Med"},{"key":"pcbi.1007998.ref077","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/jor.20762","article-title":"The Effects of Focal Articular Defects on Cartilage Contact Mechanics","volume":"27","author":"K Gratz","year":"2009","journal-title":"J Orthop Res"},{"key":"pcbi.1007998.ref078","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/S0736-0266(00)00025-5","article-title":"Matrix and cell injury due to sub-impact loading of adult bovine articular cartilage explants: Effects of strain rate and peak stress","volume":"19","author":"T Quinn","year":"2001","journal-title":"J Orthop Res"},{"key":"pcbi.1007998.ref079","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.joca.2003.11.004","article-title":"Ultrastructural quantification of cell death after injurious compression of bovine calf articular cartilage","volume":"12","author":"P Patwari","year":"2004","journal-title":"Osteoarthr Cartil"},{"key":"pcbi.1007998.ref080","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jbiomech.2018.04.020","article-title":"Microscale frictional strains determine chondrocyte fate in loaded cartilage","volume":"74","author":"E Bonnevie","year":"2018","journal-title":"J Biomech"},{"key":"pcbi.1007998.ref081","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.jbiomech.2004.07.003","article-title":"A fibril-reinforced poroviscoelastic swelling model for articular cartilage","volume":"38","author":"W Wilson","year":"2005","journal-title":"J Biomech"},{"key":"pcbi.1007998.ref082","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1177\/1947603510368689","article-title":"Specificity of fourier transform infrared (FTIR) microspectroscopy to estimate depth-wise proteoglycan content in normal and osteoarthritic human articular cartilage","volume":"1","author":"S Saarakkala","year":"2010","journal-title":"Cartilage"},{"key":"pcbi.1007998.ref083","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.1002\/art.27610","article-title":"Vulnerability of the superficial zone of immature articular cartilage to compressive injury","volume":"62","author":"B Rolauffs","year":"2010","journal-title":"Arthritis Rheum"},{"key":"pcbi.1007998.ref084","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.jbiomech.2004.07.003","article-title":"A fibril-reinforced poroviscoelastic swelling model for articular cartilage","volume":"38","author":"W Wilson","year":"2005","journal-title":"J Biomech"},{"key":"pcbi.1007998.ref085","doi-asserted-by":"crossref","first-page":"e37538","DOI":"10.1371\/journal.pone.0037538","article-title":"Chondrocyte deformations as a function of tibiofemoral joint loading predicted by a generalized high-throughput pipeline of multi-scale simulations","volume":"7","author":"S Sibole","year":"2012","journal-title":"PLoS One"},{"key":"pcbi.1007998.ref086","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0736-0266(02)00070-0","article-title":"Cyclic compression of cartilage\/bone explants in vitro leads to physical weakening, mechanical breakdown of collagen and release of matrix fragments","volume":"20","author":"M Thibault","year":"2002","journal-title":"J Orthop Res"},{"key":"pcbi.1007998.ref087","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/art.20101","article-title":"Mechanisms and Kinetics of Glycosaminoglycan Release Following In Vitro Cartilage Injury","volume":"50","author":"M DiMicco","year":"2004","journal-title":"Arthritis Rheum"},{"key":"pcbi.1007998.ref088","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.joca.2014.06.032","article-title":"A high-throughput model of post-traumatic osteoarthritis using engineered cartilage tissue analogs","volume":"22","author":"B Mohanraj","year":"2014","journal-title":"Osteoarthr Cartil"},{"key":"pcbi.1007998.ref089","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/jor.22334","article-title":"Synovial fluid concentrations and relative potency of interleukin-1 alpha and beta in cartilage and meniscus degradation","volume":"31","author":"AL McNulty","year":"2013","journal-title":"J Orthop Res"},{"key":"pcbi.1007998.ref090","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/S0736-0266(01)00033-X","article-title":"Biosynthetic response and mechanical properties of articular cartilage after injurious compression","volume":"19","author":"B Kurz","year":"2001","journal-title":"J Orthop Res"},{"key":"pcbi.1007998.ref091","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1097\/01.mco.0000068964.34812.2b","article-title":"Signal transduction by mechanical strain in chondrocytes","volume":"6","author":"J Deschner","year":"2003","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"pcbi.1007998.ref092","article-title":"New developments in osteoarthritis. Posttraumatic osteoarthritis: Pathogenesis and pharmacological treatment options","volume":"12","author":"MK Lotz","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"pcbi.1007998.ref093","doi-asserted-by":"crossref","first-page":"R229","DOI":"10.1186\/ar3216","article-title":"Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254)","volume":"12","author":"JB Catterall","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"pcbi.1007998.ref094","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1177\/0363546517749834","article-title":"Synovial Fluid Profile at the Time of Anterior Cruciate Ligament Reconstruction and Its Association With Cartilage Matrix Composition 3 Years After Surgery","volume":"46","author":"K Amano","year":"2018","journal-title":"Am J Sports Med"},{"key":"pcbi.1007998.ref095","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1302\/2046-3758.74.BJR-2017-0201.R2","article-title":"High-fat\/high-sucrose diet-induced obesity results in joint-specific development of osteoarthritis-like degeneration in a rat model","volume":"7","author":"K Collins","year":"2018","journal-title":"Bone Joint Res"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1007998","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T00:00:00Z","timestamp":1594166400000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T23:06:41Z","timestamp":1696288001000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1007998"}},"subtitle":[],"editor":[{"given":"Alison","family":"Marsden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,6,25]]},"references-count":95,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,6,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1007998","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1007998","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,25]]}}}