{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T12:24:08Z","timestamp":1782303848663,"version":"3.54.5"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1008048","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000}}],"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T00:00:00Z","timestamp":1594598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61572152"],"award-info":[{"award-number":["61572152"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61601143"],"award-info":[{"award-number":["61601143"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61571165"],"award-info":[{"award-number":["61571165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770328"],"award-info":[{"award-number":["81770328"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1008048","type":"journal-article","created":{"date-parts":[[2020,7,13]],"date-time":"2020-07-13T17:33:42Z","timestamp":1594661622000},"page":"e1008048","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":11,"title":["Heart failure-induced atrial remodelling promotes electrical and conduction alternans"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3317-1389","authenticated-orcid":true,"given":"Na","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qince","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8074-8008","authenticated-orcid":true,"given":"Kevin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1347-3491","authenticated-orcid":true,"given":"Kuanquan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2137-8785","authenticated-orcid":true,"given":"Runnan","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0863-5807","authenticated-orcid":true,"given":"Henggui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2020,7,13]]},"reference":[{"issue":"16","key":"pcbi.1008048.ref001","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1161\/CIRCULATIONAHA.116.026054","article-title":"Treatment of Patients With Atrial Fibrillation and Heart Failure With Reduced Ejection Fraction","volume":"135","author":"A Verma","year":"2017","journal-title":"Circulation"},{"issue":"5","key":"pcbi.1008048.ref002","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/CIRCULATIONAHA.115.018614","article-title":"Atrial Fibrillation Begets Heart Failure and Vice Versa: Temporal Associations and Differences in Preserved Versus Reduced Ejection Fraction","volume":"133","author":"R Santhanakrishnan","year":"2016","journal-title":"Circulation"},{"issue":"3","key":"pcbi.1008048.ref003","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrcardio.2015.191","article-title":"Comorbidity of atrial fibrillation and heart failure","volume":"13","author":"LH Ling","year":"2016","journal-title":"Nat Rev Cardiol"},{"issue":"20","key":"pcbi.1008048.ref004","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/j.jacc.2016.08.048","article-title":"Heart Failure With Preserved Ejection Fraction and Atrial Fibrillation: Vicious Twins","volume":"68","author":"D Kotecha","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"pcbi.1008048.ref005","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.pharmthera.2016.10.019","article-title":"Atrial fibrillation in heart failure with preserved ejection fraction: Insights into mechanisms and therapeutics","volume":"176","author":"RB Patel","year":"2017","journal-title":"Pharmacol Ther"},{"key":"pcbi.1008048.ref006","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.3389\/fphys.2018.01380","article-title":"Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure","volume":"9","author":"NC Denham","year":"2018","journal-title":"Front Physiol"},{"issue":"46","key":"pcbi.1008048.ref007","first-page":"3250","article-title":"Atrial fibrillation in heart failure: what should we do?","volume":"36","author":"D Kotecha","year":"2015","journal-title":"Eur Heart J"},{"issue":"10","key":"pcbi.1008048.ref008","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association","volume":"139","author":"EJ Benjamin","year":"2019","journal-title":"Circulation"},{"issue":"6","key":"pcbi.1008048.ref009","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.1161\/CIR.0000000000000509","article-title":"2017 ACC\/AHA\/HFSA Focused Update of the 2013 ACCF\/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Failure Society of America","volume":"136","author":"CW Yancy","year":"2017","journal-title":"Circulation"},{"issue":"2","key":"pcbi.1008048.ref010","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/cvr\/cvp216","article-title":"Chronic heart failure and the substrate for atrial fibrillation","volume":"84","author":"A Sridhar","year":"2009","journal-title":"Cardiovasc Res"},{"key":"pcbi.1008048.ref011","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.yjmcc.2014.11.017","article-title":"Perturbed atrial calcium handling in an ovine model of heart failure: potential roles for reductions in the L-type calcium current","volume":"79","author":"JD Clarke","year":"2015","journal-title":"J Mol Cell Cardiol"},{"issue":"4","key":"pcbi.1008048.ref012","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.hrthm.2008.12.028","article-title":"Atrial cellular electrophysiological changes in patients with ventricular dysfunction may predispose to AF","volume":"6","author":"AJ Workman","year":"2009","journal-title":"Heart Rhythm"},{"issue":"20","key":"pcbi.1008048.ref013","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1161\/CIRCULATIONAHA.111.019893","article-title":"Atrial fibrillation pathophysiology: implications for management","volume":"124","author":"YK Iwasaki","year":"2011","journal-title":"Circulation"},{"issue":"4","key":"pcbi.1008048.ref014","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrd3682","article-title":"Novel molecular targets for atrial fibrillation therapy","volume":"11","author":"D Dobrev","year":"2012","journal-title":"Nat Rev Drug Discov"},{"issue":"22","key":"pcbi.1008048.ref015","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1016\/j.jacc.2014.02.555","article-title":"Atrial remodeling and atrial fibrillation: recent advances and translational perspectives","volume":"63","author":"S Nattel","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"9","key":"pcbi.1008048.ref016","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrcardio.2017.37","article-title":"Demystifying rotors and their place in clinical translation of atrial fibrillation mechanisms","volume":"14","author":"S Nattel","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"pcbi.1008048.ref017","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.3389\/fphys.2018.01383","article-title":"Profibrotic, Electrical, and Calcium-Handling Remodeling of the Atria in Heart Failure Patients With and Without Atrial Fibrillation","volume":"9","author":"CE Molina","year":"2018","journal-title":"Front Physiol"},{"issue":"2","key":"pcbi.1008048.ref018","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1161\/CIRCEP.107.754788","article-title":"Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure","volume":"1","author":"YH Yeh","year":"2008","journal-title":"Circ Arrhythm Electrophysiol"},{"issue":"22","key":"pcbi.1008048.ref019","doi-asserted-by":"crossref","first-page":"2631","DOI":"10.1161\/01.CIR.101.22.2631","article-title":"Effects of experimental heart failure on atrial cellular and ionic electrophysiology","volume":"101","author":"D Li","year":"2000","journal-title":"Circulation"},{"issue":"5","key":"pcbi.1008048.ref020","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1161\/01.CIR.90.5.2213","article-title":"Alterations in muscarinic K+ channel response to acetylcholine and to G protein-mediated activation in atrial myocytes isolated from failing human hearts","volume":"90","author":"S Koumi","year":"1994","journal-title":"Circulation"},{"issue":"2","key":"pcbi.1008048.ref021","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.yjmcc.2011.04.016","article-title":"Effects of KATP channel openers diazoxide and pinacidil in coronary-perfused atria and ventricles from failing and non-failing human hearts","volume":"51","author":"VV Fedorov","year":"2011","journal-title":"J Mol Cell Cardiol"},{"issue":"12","key":"pcbi.1008048.ref022","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1161\/01.CIR.0000090688.49283.67","article-title":"Electrical remodeling of the atria in congestive heart failure: electrophysiological and electroanatomic mapping in humans","volume":"108","author":"P Sanders","year":"2003","journal-title":"Circulation"},{"key":"pcbi.1008048.ref023","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.yjmcc.2017.02.004","article-title":"Membrane potential determines calcium alternans through modulation of SR Ca(2+) load and L-type Ca(2+) current","volume":"105","author":"G Kanaporis","year":"2017","journal-title":"J Mol Cell Cardiol"},{"issue":"25","key":"pcbi.1008048.ref024","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1161\/CIRCULATIONAHA.110.977827","article-title":"Repolarization alternans reveals vulnerability to human atrial fibrillation","volume":"123","author":"SM Narayan","year":"2011","journal-title":"Circulation"},{"issue":"11","key":"pcbi.1008048.ref025","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1253\/circj.69.1368","article-title":"Discordant repolarization alternans-induced atrial fibrillation is suppressed by verapamil","volume":"69","author":"K Hiromoto","year":"2005","journal-title":"Circ J"},{"issue":"20","key":"pcbi.1008048.ref026","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/j.jacc.2011.07.039","article-title":"Mechanical stretch of atrial myocyte monolayer decreases sarcoplasmic reticulum calcium adenosine triphosphatase expression and increases susceptibility to repolarization alternans","volume":"58","author":"CT Tsai","year":"2011","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"pcbi.1008048.ref027","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/cvr\/cvt087","article-title":"Chronic myocardial infarction promotes atrial action potential alternans, afterdepolarizations, and fibrillation","volume":"99","author":"S Kettlewell","year":"2013","journal-title":"Cardiovasc Res"},{"issue":"1","key":"pcbi.1008048.ref028","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/cvr\/cvv045","article-title":"Early subcellular Ca2+ remodelling and increased propensity for Ca2+ alternans in left atrial myocytes from hypertensive rats","volume":"106","author":"F Pluteanu","year":"2015","journal-title":"Cardiovasc Res"},{"key":"pcbi.1008048.ref029","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.yjmcc.2017.11.020","article-title":"Progressive impairment of atrial myocyte function during left ventricular hypertrophy and heart failure","volume":"114","author":"F Pluteanu","year":"2018","journal-title":"J Mol Cell Cardiol"},{"issue":"14","key":"pcbi.1008048.ref030","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/01.CIR.102.14.1664","article-title":"Mechanisms of discordant alternans and induction of reentry in simulated cardiac tissue","volume":"102","author":"Z Qu","year":"2000","journal-title":"Circulation"},{"issue":"4","key":"pcbi.1008048.ref031","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1161\/01.RES.0000156891.66893.83","article-title":"Action potential duration restitution and alternans in rabbit ventricular myocytes: the key role of intracellular calcium cycling","volume":"96","author":"JI Goldhaber","year":"2005","journal-title":"Circ Res"},{"issue":"11","key":"pcbi.1008048.ref032","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1161\/CIRCULATIONAHA.104.502831","article-title":"Altered dynamics of action potential restitution and alternans in humans with structural heart disease","volume":"112","author":"ML Koller","year":"2005","journal-title":"Circulation"},{"issue":"10","key":"pcbi.1008048.ref033","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1161\/01.RES.0000224540.97431.f0","article-title":"From pulsus to pulseless: the saga of cardiac alternans","volume":"98","author":"JN Weiss","year":"2006","journal-title":"Circ Res"},{"issue":"5","key":"pcbi.1008048.ref034","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1161\/01.RES.0000119923.64774.72","article-title":"Sarcoplasmic reticulum calcium content fluctuation is the key to cardiac alternans","volume":"94","author":"ME Diaz","year":"2004","journal-title":"Circ Res"},{"issue":"3","key":"pcbi.1008048.ref035","doi-asserted-by":"crossref","first-page":"H341","DOI":"10.1152\/ajpheart.00302.2012","article-title":"Calcium alternans in a couplon network model of ventricular myocytes: role of sarcoplasmic reticulum load","volume":"303","author":"M Nivala","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"10","key":"pcbi.1008048.ref036","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1161\/CIRCRESAHA.109.213975","article-title":"Spark-induced sparks as a mechanism of intracellular calcium alternans in cardiac myocytes","volume":"106","author":"R Rovetti","year":"2010","journal-title":"Circ Res"},{"issue":"5","key":"pcbi.1008048.ref037","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1161\/CIRCHEARTFAILURE.109.852228","article-title":"Characterization of an extensive transverse tubular network in sheep atrial myocytes and its depletion in heart failure","volume":"2","author":"KM Dibb","year":"2009","journal-title":"Circ Heart Fail"},{"issue":"7","key":"pcbi.1008048.ref038","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.bpj.2012.03.007","article-title":"Mechanisms by which cytoplasmic calcium wave propagation and alternans are generated in cardiac atrial myocytes lacking T-tubules-insights from a simulation study","volume":"102","author":"Q Li","year":"2012","journal-title":"Biophys J"},{"issue":"3","key":"pcbi.1008048.ref039","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.medici.2017.04.004","article-title":"Alternans in atria: Mechanisms and clinical relevance","volume":"53","author":"G Kanaporis","year":"2017","journal-title":"Medicina (Kaunas)"},{"issue":"12","key":"pcbi.1008048.ref040","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1161\/01.CIR.0000142052.03565.87","article-title":"Atrial ionic remodeling induced by atrial tachycardia in the presence of congestive heart failure","volume":"110","author":"TJ Cha","year":"2004","journal-title":"Circulation"},{"issue":"4","key":"pcbi.1008048.ref041","doi-asserted-by":"crossref","first-page":"H1767","DOI":"10.1152\/ajpheart.2000.279.4.H1767","article-title":"Mathematical analysis of canine atrial action potentials: rate, regional factors, and electrical remodeling","volume":"279","author":"RJ Ramirez","year":"2000","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"pcbi.1008048.ref042","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1085\/jgp.117.2.119","article-title":"Allosteric regulation of Na\/Ca exchange current by cytosolic Ca in intact cardiac myocytes","volume":"117","author":"CR Weber","year":"2001","journal-title":"J Gen Physiol"},{"issue":"2","key":"pcbi.1008048.ref043","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1161\/CIRCULATIONAHA.113.006641","article-title":"Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation","volume":"129","author":"N Voigt","year":"2014","journal-title":"Circulation"},{"issue":"4","key":"pcbi.1008048.ref044","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.bpj.2008.10.056","article-title":"Parameter sensitivity analysis in electrophysiological models using multivariable regression","volume":"96","author":"EA Sobie","year":"2009","journal-title":"Biophys J"},{"key":"pcbi.1008048.ref045","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.yjmcc.2015.07.016","article-title":"There and back again: Iterating between population-based modeling and experiments reveals surprising regulation of calcium transients in rat cardiac myocytes","volume":"96","author":"RA Devenyi","year":"2016","journal-title":"J Mol Cell Cardiol"},{"issue":"6","key":"pcbi.1008048.ref046","doi-asserted-by":"crossref","first-page":"H1227","DOI":"10.1152\/ajpheart.00185.2017","article-title":"Ca2+\/calmodulin-dependent kinase II-dependent regulation of atrial myocyte late Na+ current, Ca2+ cycling, and excitability: a mathematical modeling study","volume":"313","author":"B Onal","year":"2017","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1\u20133","key":"pcbi.1008048.ref047","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pbiomolbio.2010.05.008","article-title":"Models of cardiac tissue electrophysiology: progress, challenges and open questions","volume":"104","author":"RH Clayton","year":"2011","journal-title":"Prog Biophys Mol Biol"},{"issue":"9","key":"pcbi.1008048.ref048","doi-asserted-by":"crossref","first-page":"E73","DOI":"10.1161\/01.RES.0000019783.88094.BA","article-title":"Cholinergic atrial fibrillation in a computer model of a two-dimensional sheet of canine atrial cells with realistic ionic properties","volume":"90","author":"J Kneller","year":"2002","journal-title":"Circ Res"},{"issue":"3","key":"pcbi.1008048.ref049","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1063\/1.1497505","article-title":"Development of a computer algorithm for the detection of phase singularities and initial application to analyze simulations of atrial fibrillation","volume":"12","author":"R Zou","year":"2002","journal-title":"Chaos"},{"issue":"5","key":"pcbi.1008048.ref050","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.bpj.2012.01.032","article-title":"In silico optimization of atrial fibrillation-selective sodium channel blocker pharmacodynamics","volume":"102","author":"M Aguilar-Shardonofsky","year":"2012","journal-title":"Biophys J"},{"issue":"Suppl 4","key":"pcbi.1008048.ref051","doi-asserted-by":"crossref","first-page":"iv11","DOI":"10.1093\/europace\/euu255","article-title":"Dynamics of atrial arrhythmias modulated by time-dependent acetylcholine concentration: a simulation study","volume":"16","author":"E Matene","year":"2014","journal-title":"Europace"},{"issue":"6","key":"pcbi.1008048.ref052","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.hrthm.2009.02.026","article-title":"Genesis of complex fractionated atrial electrograms in zones of slow conduction: a computer model of microfibrosis","volume":"6","author":"V Jacquemet","year":"2009","journal-title":"Heart Rhythm"},{"issue":"11","key":"pcbi.1008048.ref053","doi-asserted-by":"crossref","first-page":"e1006594","DOI":"10.1371\/journal.pcbi.1006594","article-title":"Mechanistic insight into spontaneous transition from cellular alternans to arrhythmia-A simulation study","volume":"14","author":"W Wang","year":"2018","journal-title":"PLoS Comput Biol"},{"issue":"5","key":"pcbi.1008048.ref054","first-page":"H1635","article-title":"Dynamic restitution of action potential duration during electrical alternans and ventricular fibrillation","volume":"275","author":"ML Koller","year":"1998","journal-title":"Am J Physiol"},{"key":"pcbi.1008048.ref055","doi-asserted-by":"crossref","DOI":"10.22489\/CinC.2019.124","article-title":"Effect of Blocking IKur on the Genesis of Action Potential Alternans in Canine Atrium","author":"N Zhao","year":"2019","journal-title":"Computing in Cardiology (CinC)"},{"issue":"2","key":"pcbi.1008048.ref056","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/CIRCRESAHA.115.307836","article-title":"In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular Cardiomyocytes","volume":"118","author":"X Zhou","year":"2016","journal-title":"Circ Res"},{"issue":"6","key":"pcbi.1008048.ref057","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1161\/01.RES.53.6.815","article-title":"Electrical and mechanical restitution of the human heart at different rates of stimulation","volume":"53","author":"MR Franz","year":"1983","journal-title":"Circ Res"},{"issue":"2","key":"pcbi.1008048.ref058","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1046\/j.1540-8167.2001.00196.x","article-title":"Mechanisms for discordant alternans","volume":"12","author":"MA Watanabe","year":"2001","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"7","key":"pcbi.1008048.ref059","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1161\/hh1901.096702","article-title":"Mechanisms of L-type Ca(2+) current downregulation in rat atrial myocytes during heart failure","volume":"89","author":"C Boixel","year":"2001","journal-title":"Circ Res"},{"issue":"9","key":"pcbi.1008048.ref060","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1093\/eurheartj\/ehn140","article-title":"Downregulation of the calcium current in human right atrial myocytes from patients in sinus rhythm but with a high risk of atrial fibrillation","volume":"29","author":"S Dinanian","year":"2008","journal-title":"Eur Heart J"},{"issue":"2","key":"pcbi.1008048.ref061","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1097\/00005344-199502000-00014","article-title":"Calcium currents in diseased human cardiac cells","volume":"25","author":"H Ouadid","year":"1995","journal-title":"J Cardiovasc Pharmacol"},{"issue":"3","key":"pcbi.1008048.ref062","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1161\/01.CIR.0000109501.47603.0C","article-title":"Dissociation between ionic remodeling and ability to sustain atrial fibrillation during recovery from experimental congestive heart failure","volume":"109","author":"TJ Cha","year":"2004","journal-title":"Circulation"},{"issue":"13","key":"pcbi.1008048.ref063","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1093\/cvr\/cvx167","article-title":"Triggered intracellular calcium waves in dog and human left atrial myocytes from normal and failing hearts","volume":"113","author":"GL Aistrup","year":"2017","journal-title":"Cardiovasc Res"},{"issue":"1","key":"pcbi.1008048.ref064","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bbrc.2011.05.113","article-title":"Decreased sarcolipin protein expression and enhanced sarco(endo)plasmic reticulum Ca2+ uptake in human atrial fibrillation","volume":"410","author":"M Shanmugam","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"pcbi.1008048.ref065","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.hrthm.2008.11.008","article-title":"Heart failure enhances susceptibility to arrhythmogenic cardiac alternans","volume":"6","author":"LD Wilson","year":"2009","journal-title":"Heart Rhythm"},{"issue":"4","key":"pcbi.1008048.ref066","doi-asserted-by":"crossref","first-page":"H2109","DOI":"10.1152\/ajpheart.00609.2007","article-title":"Characterizing the contribution of voltage- and calcium-dependent coupling to action potential stability: implications for repolarization alternans","volume":"293","author":"PN Jordan","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"pcbi.1008048.ref067","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1529\/biophysj.105.071340","article-title":"Action potential morphology influences intracellular calcium handling stability and the occurrence of alternans","volume":"90","author":"PN Jordan","year":"2006","journal-title":"Biophys J"},{"key":"pcbi.1008048.ref068","doi-asserted-by":"crossref","first-page":"H2310","DOI":"10.1152\/ajpheart.00079.2012","article-title":"Refractoriness of sarcoplasmic reticulum Ca2+ release determines Ca2+ alternans in atrial myocytes","volume":"302","author":"VM Shkryl","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"16","key":"pcbi.1008048.ref069","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1161\/CIRCULATIONAHA.106.656504","article-title":"Mechanism underlying initiation of paroxysmal atrial flutter\/atrial fibrillation by ectopic foci: a simulation study","volume":"115","author":"Y Gong","year":"2007","journal-title":"Circulation"},{"issue":"1","key":"pcbi.1008048.ref070","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.hrthm.2015.07.023","article-title":"Gap junction modifier rotigaptide decreases the susceptibility to ventricular arrhythmia by enhancing conduction velocity and suppressing discordant alternans during therapeutic hypothermia in isolated rabbit hearts","volume":"13","author":"YC Hsieh","year":"2016","journal-title":"Heart Rhythm"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1008048","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1008048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T21:12:20Z","timestamp":1596575540000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1008048"}},"subtitle":[],"editor":[{"given":"Daniel A.","family":"Beard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2020,7,13]]},"references-count":70,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1008048","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1008048","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,13]]}}}