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Liu","year":"2010","journal-title":"Free Radic Biol Med"},{"key":"pcbi.1008069.ref079","first-page":"H1705","article-title":"Effective diffusion distance of nitric oxide in the microcirculation","volume":"274","author":"MW Vaughn","year":"1998","journal-title":"Am J Physiol"},{"issue":"1","key":"pcbi.1008069.ref080","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mvr.2004.03.001","article-title":"Interactions between NO and O2 in the microcirculation: A mathematical analysis","volume":"68","author":"KA Lamkin-Kennard","year":"2004","journal-title":"Microvasc Res"},{"issue":"12","key":"pcbi.1008069.ref081","doi-asserted-by":"crossref","first-page":"8831","DOI":"10.1074\/jbc.M611684200","article-title":"Estimation of nitric oxide concentration in blood for different rates of generation: Evidence that intravascular nitric oxide levels are too low to exert physiological effects","volume":"282","author":"X Liu","year":"2007","journal-title":"J Biol Chem"},{"issue":"1","key":"pcbi.1008069.ref082","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1152\/japplphysiol.00049.2004","article-title":"Contribution of nNOS- and eNOS-derived NO to microvascular smooth muscle NO exposure","volume":"97","author":"M Kavdia","year":"2004","journal-title":"J Appl Physiol"},{"issue":"3","key":"pcbi.1008069.ref083","doi-asserted-by":"crossref","first-page":"H1526","DOI":"10.1152\/ajpheart.01090.2006","article-title":"Temporal and spatial variations of cell-free layer width in arterioles","volume":"293","author":"S Kim","year":"2007","journal-title":"AJP Hear Circ Physiol"},{"issue":"5\u20136","key":"pcbi.1008069.ref084","first-page":"415","article-title":"A two-phase model for flow of blood in narrow tubes with increased effective viscosity near the wall","volume":"38","author":"M Sharan","year":"2001","journal-title":"Biorheology"},{"issue":"5","key":"pcbi.1008069.ref085","doi-asserted-by":"crossref","first-page":"H1959","DOI":"10.1152\/ajpheart.1995.268.5.H1959","article-title":"Quantitative evaluation of flow dynamics of erythrocytes in microvessels: Influence of erythrocyte aggregation","volume":"268","author":"M Soutani","year":"1995","journal-title":"Am J Physiol\u2014Hear Circ Physiol"},{"issue":"1","key":"pcbi.1008069.ref086","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev-fluid-010816-060302","article-title":"Blood Flow in the Microcirculation","volume":"49","author":"TW Secomb","year":"2017","journal-title":"Annu Rev Fluid Mech"},{"issue":"1","key":"pcbi.1008069.ref087","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1152\/japplphysiol.00631.2001","article-title":"Footstrike is the major cause of hemolysis during running","volume":"94","author":"RD Telford","year":"2003","journal-title":"J Appl 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Med"},{"key":"pcbi.1008069.ref091","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/CRD.0b013e31819f1a83","article-title":"Hemolysis associated with prosthetic heart valves: A review","volume":"17","author":"Y Shapira","year":"2009","journal-title":"Cardiology in Review"},{"issue":"3","key":"pcbi.1008069.ref092","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/MAT.0000000000000801","article-title":"Predicting plasma free hemoglobin levels in patients due to medical device-related hemolysis","volume":"65","author":"DM Saylor","year":"2019","journal-title":"ASAIO J"},{"issue":"12","key":"pcbi.1008069.ref093","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1038\/nm1499","article-title":"Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria","volume":"12","author":"I Gramaglia","year":"2006","journal-title":"Nat 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Chen","year":"2009","journal-title":"Biorheology"},{"issue":"6","key":"pcbi.1008069.ref100","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/sj.mn.7800210","article-title":"A model of nitric oxide capillary exchange","volume":"10","author":"NM Tsoukias","year":"2003","journal-title":"Microcirculation"},{"issue":"6","key":"pcbi.1008069.ref101","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1152\/ajpheart.00972.2001","article-title":"Model of nitric oxide diffusion in an arteriole: Impact of hemoglobin-based blood substitutes","volume":"282","author":"M Kavdia","year":"2002","journal-title":"Am J Physiol\u2014Hear Circ Physiol"},{"issue":"1","key":"pcbi.1008069.ref102","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0304-4165(98)00065-8","article-title":"Diffusion of nitric oxide and scavenging by blood in the vasculature","volume":"1425","author":"AR Butler","year":"1998","journal-title":"Biochim Biophys Acta\u2014Gen 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Shih","year":"2015","journal-title":"Microcirculation"},{"issue":"1","key":"pcbi.1008069.ref112","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nn.3278","article-title":"The smallest stroke: Occlusion of one penetrating vessel leads to infarction and a cognitive deficit","volume":"16","author":"AY Shih","year":"2013","journal-title":"Nat Neurosci"},{"issue":"7","key":"pcbi.1008069.ref113","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nn.3426","article-title":"The cortical angiome: An interconnected vascular network with noncolumnar patterns of blood flow","volume":"16","author":"P Blinder","year":"2013","journal-title":"Nat Neurosci"},{"issue":"6","key":"pcbi.1008069.ref114","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/jcbfm.2012.39","article-title":"Topology and hemodynamics of the cortical cerebrovascular system","volume":"32","author":"S Hirsch","year":"2012","journal-title":"J Cereb Blood Flow 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Res"},{"issue":"25","key":"pcbi.1008069.ref118","doi-asserted-by":"crossref","first-page":"26149","DOI":"10.1074\/jbc.M400916200","article-title":"Kinetics of a cellular nitric oxide\/cGMP\/phosphodiesterase-5 pathway","volume":"279","author":"E Mo","year":"2004","journal-title":"J Biol Chem"},{"issue":"6","key":"pcbi.1008069.ref119","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1073\/pnas.97.6.2928","article-title":"Rapid desensitization of the nitric oxide receptor, soluble guanylyl cyclase, underlies diversity of cellular cGMP responses","volume":"97","author":"TC Bellamy","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pcbi.1008069.ref120","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.neuroimage.2016.11.069","article-title":"Time to wake up: Studying neurovascular coupling and brain-wide circuit function in the un-anesthetized animal","volume":"153","author":"YR Gao","year":"2017","journal-title":"Neuroimage"},{"issue":"2","key":"pcbi.1008069.ref121","first-page":"H799","article-title":"Nitric oxide: a modulator, but not a mediator, of neurovascular coupling in rat somatosensory cortex","volume":"277","author":"U Lindauer","year":"1999","journal-title":"Am J Physiol"},{"issue":"1","key":"pcbi.1008069.ref122","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0304-3940(00)01521-4","article-title":"Fluorescent imaging of nitric oxide production in neuronal varicosities associated with intraparenchymal arterioles in rat hippocampal slices","volume":"294","author":"LA Brown","year":"2000","journal-title":"Neurosci Lett"},{"issue":"12","key":"pcbi.1008069.ref123","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1161\/01.RES.0000047529.26278.4D","article-title":"Nonendothelial source of nitric oxide in arterioles but not in venules: Alternative source revealed in vivo by diaminofluorescein 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Li","year":"2019","journal-title":"Elife"},{"key":"pcbi.1008069.ref133","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.47324","article-title":"In vivo imaging with a water immersion objective affects brain temperature, blood flow and oxygenation","volume":"8","author":"M Roche","year":"2019","journal-title":"Elife"},{"key":"pcbi.1008069.ref134","article-title":"Blood Flow and metabolism of the human brain in health and disease","volume":"18","author":"SS Kety","year":"1951","journal-title":"Trans Stud Coll Phys Philad"},{"key":"pcbi.1008069.ref135","volume":"81","author":"DD Clarke","year":"1999","journal-title":"Circulation and energy metabolism in the brain \/ Recommended Citation \"Circulation and energy metabolism in the brain"},{"key":"pcbi.1008069.ref136","author":"S Sakad\u017ei\u0107","journal-title":"Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and 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\u2026"},{"issue":"6","key":"pcbi.1008069.ref158","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1002\/mrm.21246","article-title":"Functional MRI impulse response for BOLD and CBV contrast in rat somatosensory cortex","volume":"57","author":"AC Silva","year":"2007","journal-title":"Magn Reson Med"},{"key":"pcbi.1008069.ref159","volume-title":"merican Journal of Physiology-Heart and Circulatory Physiology","author":"A Colantuoni","year":"1984"},{"issue":"3","key":"pcbi.1008069.ref160","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1152\/jappl.2000.88.3.1119","article-title":"University of Texas Southwestern Medical Center DTUSA williams ryburn swmed edu. 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Stuehr","year":"2004","journal-title":"Journal of Biological Chemistry"},{"key":"pcbi.1008069.ref219","first-page":"1690","volume-title":"Antioxidants and Redox Signaling","author":"M Umbrello","year":"2013"},{"issue":"3","key":"pcbi.1008069.ref220","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0735-1097(96)00218-5","article-title":"Endothelium-derived nitric oxide regulates systemic and pulmonary vascular resistance during acute hypoxia in humans","volume":"28","author":"ML Blitzer","year":"1996","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"pcbi.1008069.ref221","article-title":"Estimation of shear and flow rates in pial arterioles during somatosensory stimulation","volume":"270","author":"ALC Ngai","year":"1996","journal-title":"Am J Physiol\u2014Hear Circ Physiol"},{"issue":"2","key":"pcbi.1008069.ref222","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.cell.2017.09.020","article-title":"Brain-wide Maps Reveal Stereotyped Cell-Type-Based 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Physiol"},{"issue":"9","key":"pcbi.1008069.ref232","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/0021-9290(94)90052-3","article-title":"Flow dynamics of erythrocytes in microvessels of isolated rabbit mesentery: Cell-free layer and flow resistance","volume":"27","author":"N Tateishi","year":"1994","journal-title":"J Biomech"},{"key":"pcbi.1008069.ref233","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/0-387-26206-7_52","article-title":"Mechanisms for vasoconstriction and decreased blood flow following intravenous administration of cell-free native hemoglobin solutions","volume":"566","author":"HW Kim","year":"2005","journal-title":"Adv Exp Med Biol"},{"issue":"8","key":"pcbi.1008069.ref234","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1152\/japplphysiol.01173.2011","article-title":"Low micromolar intravascular cell-free hemoglobin concentration affects vascular NO bioavailability in sickle cell disease: a computational 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mitochondrial respiratory chain, by nitric oxide. Implications for neurodegenerative diseases","volume":"345","author":"MW Cleeter","year":"1994","journal-title":"FEBS Lett"},{"issue":"1","key":"pcbi.1008069.ref244","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1242\/jcs.03308","article-title":"Cytochrome c oxidase maintains mitochondrial respiration during partial inhibition by nitric oxide","volume":"120","author":"M Palacios-Callender","year":"2006","journal-title":"J Cell Sci"},{"key":"pcbi.1008069.ref245","first-page":"1","volume-title":"Arbitrary Lagrangian-Eulerian Methods. In: Encyclopedia of Computational Mechanics Second Edition","author":"J Donea","year":"2017"},{"issue":"7","key":"pcbi.1008069.ref246","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1152\/ajpheart.00417.2011","article-title":"In vivo two-photon excited fluorescence microscopy reveals cardiac- and respiration-dependent pulsatile blood flow in cortical blood vessels in mice","volume":"302","author":"TP Santisakultarm","year":"2012","journal-title":"Am J Physiol\u2014Hear Circ Physiol"},{"issue":"1","key":"pcbi.1008069.ref247","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/jcbfm.1984.15","article-title":"Blood flow velocity in the pial arteries of cats, with particular reference to the vessel diameter","volume":"4","author":"M Kobari","year":"1984","journal-title":"J Cereb Blood Flow Metab"},{"issue":"1","key":"pcbi.1008069.ref248","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0304-3940(00)01521-4","article-title":"Fluorescent imaging of nitric oxide production in neuronal varicosities associated with intraparenchymal arterioles in rat hippocampal slices","volume":"294","author":"LA Brown","year":"2000","journal-title":"Neurosci Lett"},{"issue":"4","key":"pcbi.1008069.ref249","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.phrs.2007.01.001","article-title":"Potency of authentic nitric oxide in inducing aortic relaxation","volume":"55","author":"Q Yan","year":"2007","journal-title":"Pharmacol Res"},{"issue":"38","key":"pcbi.1008069.ref250","doi-asserted-by":"crossref","first-page":"13676","DOI":"10.1523\/JNEUROSCI.1968-11.2011","article-title":"\u201cOvershoot\u201d of O2 is required to maintain baseline tissue oxygenation at locations distal to blood vessels","volume":"31","author":"A Devor","year":"2011","journal-title":"J Neurosci"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1008069","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T00:00:00Z","timestamp":1596672000000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1008069","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,6]],"date-time":"2020-08-06T15:24:11Z","timestamp":1596727451000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1008069"}},"subtitle":[],"editor":[{"given":"Alison","family":"Marsden","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2020,7,27]]},"references-count":250,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,7,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1008069","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/836148","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,27]]}}}