{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T10:16:34Z","timestamp":1779099394787,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1008086","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000}}],"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"crossref","award":["PG\/15\/8\/31138"],"award-info":[{"award-number":["PG\/15\/8\/31138"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/L015226\/1"],"award-info":[{"award-number":["EP\/L015226\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT 203148\/Z\/16\/Z"],"award-info":[{"award-number":["WT 203148\/Z\/16\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1008086","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T17:36:37Z","timestamp":1600882597000},"page":"e1008086","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":32,"title":["Identifying locations of re-entrant drivers from patient-specific distribution of fibrosis in the left atrium"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8922-7970","authenticated-orcid":true,"given":"Aditi","family":"Roy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4057-7851","authenticated-orcid":true,"given":"Marta","family":"Varela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2859-3536","authenticated-orcid":true,"given":"Henry","family":"Chubb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0000-0356","authenticated-orcid":true,"given":"Robert","family":"MacLeod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jules C.","family":"Hancox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1310-2631","authenticated-orcid":true,"given":"Tobias","family":"Schaeffter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4813-7682","authenticated-orcid":true,"given":"Oleg","family":"Aslanidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"issue":"8","key":"pcbi.1008086.ref001","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1161\/CIRCULATIONAHA.113.005119","article-title":"Worldwide Epidemiology of Atrial Fibrillation","volume":"129","author":"SS Chugh","year":"2014","journal-title":"Circulation"},{"issue":"38","key":"pcbi.1008086.ref002","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1093\/eurheartj\/ehw210","article-title":"ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS","volume":"37","author":"P Kirchhof","year":"2016","journal-title":"Eur Heart J"},{"issue":"20","key":"pcbi.1008086.ref003","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1161\/CIRCULATIONAHA.111.019893","article-title":"Atrial fibrillation pathophysiology: Implications for management","volume":"124","author":"YK Iwasaki","year":"2011","journal-title":"Circulation"},{"issue":"22","key":"pcbi.1008086.ref004","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1016\/j.jacc.2014.02.555","article-title":"Atrial remodeling and atrial fibrillation: Recent advances and translational perspectives","volume":"63","author":"S Nattel","year":"2014","journal-title":"J Am Coll Cardiol"},{"issue":"10","key":"pcbi.1008086.ref005","doi-asserted-by":"crossref","first-page":"e275","DOI":"10.1016\/j.hrthm.2017.05.012","article-title":"2017 Expert Consensus Statement on Catheter and Surgical Ablation of Af.","volume":"20","author":"H Calkins","year":"2017","journal-title":"Hear Rhythm."},{"issue":"4","key":"pcbi.1008086.ref006","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/157340312803760802","article-title":"Current Hot Potatoes in Atrial Fibrillation Ablation.","volume":"8","author":"L Roten","year":"2012","journal-title":"Curr Cardiol Rev."},{"issue":"5","key":"pcbi.1008086.ref007","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1001\/jama.2014.3","article-title":"Association of atrial tissue fibrosis identified by delayed enhancement MRI and atrial fibrillation catheter ablation: The DECAAF study.","volume":"311","author":"NNF Marrouche","year":"2014","journal-title":"JAMA\u2014J Am Med Assoc."},{"key":"pcbi.1008086.ref008","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.yjmcc.2013.10.018","article-title":"Cardiac fibrosis and arrhythmogenesis: The road to repair is paved with perils","volume":"70","author":"TP Nguyen","year":"2014","journal-title":"J Mol Cell Cardiol"},{"issue":"1","key":"pcbi.1008086.ref009","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1161\/CIRCEP.113.000689","article-title":"Atrial fibrillation ablation outcome is predicted by left atrial remodeling on MRI.","volume":"7","author":"C McGann","year":"2014","journal-title":"Circ Arrhythmia Electrophysiol"},{"issue":"5","key":"pcbi.1008086.ref010","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/jce.12650","article-title":"MRI assessment of ablation-induced scarring in atrial fibrillation: Analysis from the DECAAF study","volume":"26","author":"N Akoum","year":"2015","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"3","key":"pcbi.1008086.ref011","doi-asserted-by":"crossref","first-page":"e002962","DOI":"10.1161\/CIRCEP.115.002962","article-title":"Ablation of Persistent Atrial Fibrillation Targeting Low-Voltage Areas with Selective Activation Characteristics.","volume":"9","author":"AS Jadidi","year":"2016","journal-title":"Circ Arrhythmia Electrophysiol."},{"issue":"2","key":"pcbi.1008086.ref012","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/pace.13015","article-title":"Left Atrial Substrate Modification Targeting Low-Voltage Areas for Catheter Ablation of Atrial Fibrillation: A Systematic Review and Meta-Analysis.","volume":"40","author":"A Blandino","year":"2017","journal-title":"PACE\u2014Pacing Clin Electrophysiol."},{"issue":"1","key":"pcbi.1008086.ref013","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/jce.12870","article-title":"Box isolation of fibrotic areas (BIFA): A patient-tailored substrate modification approach for ablation of atrial fibrillation.","volume":"27","author":"H Kottkamp","year":"2016","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"2","key":"pcbi.1008086.ref014","doi-asserted-by":"crossref","first-page":"e0117110","DOI":"10.1371\/journal.pone.0117110","article-title":"Virtual electrophysiological study of atrial fibrillation in fibrotic remodeling.","volume":"10","author":"KS McDowell","year":"2015","journal-title":"PLoS One."},{"issue":"3","key":"pcbi.1008086.ref015","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/cvr\/cvw073","article-title":"Patient-derived models link re-entrant driver localization in atrial fibrillation to fibrosis spatial pattern","volume":"110","author":"S Zahid","year":"2016","journal-title":"Cardiovasc Res"},{"issue":"OCT","key":"pcbi.1008086.ref016","first-page":"1","article-title":"Slow conduction in the border zones of patchy fibrosis stabilizes the drivers for atrial fibrillation: Insights from multi-scale human atrial modeling.","volume":"7","author":"R Morgan","year":"2016","journal-title":"Front Physiol."},{"issue":"OCT","key":"pcbi.1008086.ref017","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.3389\/fphys.2018.01352","article-title":"Image-based computational evaluation of the effects of atrial wall thickness and fibrosis on re-entrant drivers for atrial fibrillation.","volume":"9","author":"A Roy","year":"2018","journal-title":"Front Physiol."},{"issue":"1","key":"pcbi.1008086.ref018","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jacep.2017.07.019","article-title":"Relationship Between Fibrosis Detected on Late Gadolinium-Enhanced Cardiac Magnetic Resonance and Re-Entrant Activity Assessed With Electrocardiographic Imaging in Human Persistent Atrial Fibrillation.","volume":"4","author":"H Cochet","year":"2018","journal-title":"JACC Clin Electrophysiol."},{"key":"pcbi.1008086.ref019","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3389\/fphys.2018.00414","article-title":"Comparing reentrant drivers predicted by image-based computational modeling and mapped by electrocardiographic imaging in persistent atrial fibrillation.","volume":"9","author":"PM Boyle","year":"2018","journal-title":"Front Physiol."},{"key":"pcbi.1008086.ref020","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.3389\/fphys.2018.01151","article-title":"The Fibrotic Substrate in Persistent Atrial Fibrillation Patients: Comparison Between Predictions From Computational Modeling and Measurements From Focal Impulse and Rotor Mapping.","volume":"9","author":"PM Boyle","year":"2018","journal-title":"Front Physiol."},{"issue":"1","key":"pcbi.1008086.ref021","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1063\/1.166311","article-title":"Vortex dynamics in three-dimensional continuous myocardium with fiber rotation: Filament instability and fibrillation","volume":"8","author":"FH Fenton","year":"1998","journal-title":"Chaos An Interdiscip J Nonlinear Sci"},{"issue":"SUPPL. 2","key":"pcbi.1008086.ref022","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.eupc.2005.04.010","article-title":"A membrane model of electrically remodelled atrial myocardium derived from in vivo measurements","volume":"7","author":"AM Goodman","year":"2005","journal-title":"Europace"},{"issue":"1","key":"pcbi.1008086.ref023","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.pbiomolbio.2011.06.011","article-title":"3D virtual human atria: A computational platform for studying clinical atrial fibrillation","volume":"107","author":"O Aslanidi","year":"2011","journal-title":"Prog Biophys Mol Biol"},{"issue":"17","key":"pcbi.1008086.ref024","doi-asserted-by":"crossref","first-page":"4249","DOI":"10.1113\/jphysiol.2013.254987","article-title":"Pro-arrhythmogenic effects of atrial fibrillation-induced electrical remodelling: Insights from the three-dimensional virtual human atria","volume":"591","author":"MA Colman","year":"2013","journal-title":"J Physiol"},{"issue":"6","key":"pcbi.1008086.ref025","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1111\/cpf.12342","article-title":"Atrial average conduction velocity in patients with and without paroxysmal atrial fibrillation.","volume":"37","author":"Y Zheng","year":"2017","journal-title":"Clin Physiol Funct Imaging."},{"issue":"10","key":"pcbi.1008086.ref026","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1111\/jce.14111","article-title":"A comprehensive multi-index cardiac magnetic resonance-guided assessment of atrial fibrillation substrate prior to ablation: Prediction of long-term outcomes","volume":"30","author":"H Chubb","year":"2019","journal-title":"J Cardiovasc Electrophysiol"},{"issue":"6","key":"pcbi.1008086.ref027","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.media.2005.04.005","article-title":"The medical imaging interaction toolkit","volume":"9","author":"I Wolf","year":"2005","journal-title":"Med Image Anal"},{"issue":"8","key":"pcbi.1008086.ref028","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1109\/TMI.2017.2671839","article-title":"Novel MRI Technique Enables Non-Invasive Measurement of Atrial Wall Thickness","volume":"36","author":"M Varela","year":"2017","journal-title":"IEEE Trans Med Imaging"},{"issue":"1","key":"pcbi.1008086.ref029","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.hrthm.2013.10.007","article-title":"Magnetic resonance image intensity ratio, a normalized measure to enable interpatient comparability of left atrial fibrosis.","volume":"11","author":"IM Khurram","year":"2014","journal-title":"Hear Rhythm.Jan"},{"issue":"8","key":"pcbi.1008086.ref030","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1093\/europace\/euw219","article-title":"Left atrial fibrosis quantification by late gadolinium-enhanced magnetic resonance: A new method to standardize the thresholds for reproducibility.","volume":"19","author":"EM Benito","year":"2017","journal-title":"Europace"},{"issue":"2","key":"pcbi.1008086.ref031","first-page":"117","article-title":"Diagnosis of cochleovestibular neurovascular compression syndrome: A scoring system based on five clinical characteristics.","volume":"45","author":"T Okamura","year":"2017","journal-title":"Neurol Surg.Feb"},{"issue":"3","key":"pcbi.1008086.ref032","doi-asserted-by":"crossref","first-page":"e002897","DOI":"10.1161\/CIRCEP.115.002897","article-title":"Association of Left Atrial Local Conduction Velocity With Late Gadolinium Enhancement on Cardiac Magnetic Resonance in Patients With Atrial Fibrillation.","volume":"9","author":"K Fukumoto","year":"2016","journal-title":"Circ Arrhythmia Electrophysiol."},{"issue":"3","key":"pcbi.1008086.ref033","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2307\/1932409","article-title":"Measures of the Amount of Ecologic Association Between Species","volume":"26","author":"LR Dice","year":"1945","journal-title":"Ecology"},{"issue":"2","key":"pcbi.1008086.ref034","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1109\/TBME.2007.912672","article-title":"Preventive Ablation Strategies in a Biophysical Model of Atrial Fibrillation Based on Realistic Anatomical Data","volume":"55","author":"M Reumann","year":"2008","journal-title":"IEEE Trans Biomed Eng"},{"issue":"24","key":"pcbi.1008086.ref035","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1161\/01.CIR.0000130645.95357.97","article-title":"Changes in atrial fibrillation cycle length and inducibility during catheter ablation and their relation to outcome","volume":"109","author":"M Ha\u00efssaguerre","year":"2004","journal-title":"Circulation"},{"issue":"1","key":"pcbi.1008086.ref036","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1253\/circj.CJ-18-0615","article-title":"Pro-Arrhythmogenic Effects of Heterogeneous Tissue Curvature \u2015 A Suggestion for Role of Left Atrial Appendage in Atrial Fibrillation \u2015","volume":"83","author":"J-S Song","year":"2018","journal-title":"Circ J."},{"issue":"1","key":"pcbi.1008086.ref037","doi-asserted-by":"crossref","first-page":"012908","DOI":"10.1103\/PhysRevE.88.012908","article-title":"Drift laws for spiral waves on curved anisotropic surfaces","volume":"88","author":"H Dierckx","year":"2013","journal-title":"Phys Rev E\u2014Stat Nonlinear, Soft Matter Phys."},{"key":"pcbi.1008086.ref038","doi-asserted-by":"crossref","first-page":"iv3","DOI":"10.1093\/europace\/euu251","article-title":"Structural contributions to fibrillatory rotors in a patient-derived computational model of the atria.","volume":"16","author":"MJ Gonzales","year":"2014","journal-title":"Europace"},{"issue":"7","key":"pcbi.1008086.ref039","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1016\/j.hrthm.2016.03.019","article-title":"Percolation as a mechanism to explain atrial fractionated electrograms and reentry in a fibrosis model based on imaging data.","volume":"13","author":"E Vigmond","year":"2016","journal-title":"Hear Rhythm."},{"issue":"3","key":"pcbi.1008086.ref040","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1109\/TBME.2013.2292320","article-title":"An efficient finite element approach for modeling fibrotic clefts in the heart","volume":"61","author":"CM Costa","year":"2014","journal-title":"IEEE Trans Biomed Eng"},{"issue":"8","key":"pcbi.1008086.ref041","doi-asserted-by":"crossref","first-page":"e005922","DOI":"10.1161\/JAHA.117.005922","article-title":"Three-dimensional integrated functional, structural, and computational mapping to define the structural \u201cfingerprints\u201d of heart-specific atrial fibrillation drivers in human heart ex vivo.","volume":"6","author":"J Zhao","year":"2017","journal-title":"J Am Heart Assoc"},{"key":"pcbi.1008086.ref042","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.3389\/fphys.2018.01207","article-title":"Wavelength and fibrosis affect phase singularity locations during atrial fibrillation.","volume":"9","author":"M Saha","year":"2018","journal-title":"Front Physiol."},{"key":"pcbi.1008086.ref043","doi-asserted-by":"crossref","first-page":"iv146","DOI":"10.1093\/europace\/euw365","article-title":"Modelling methodology of atrial fibrosis affects rotor dynamics and electrograms.","volume":"18","author":"CH Roney","year":"2016","journal-title":"Europace"},{"issue":"12","key":"pcbi.1008086.ref044","doi-asserted-by":"crossref","first-page":"e1006637","DOI":"10.1371\/journal.pcbi.1006637","article-title":"Dynamical anchoring of distant arrhythmia sources by fibrotic regions via restructuring of the activation pattern.","volume":"14","author":"N Vandersickel","year":"2018","journal-title":"PLOS Comput Biol."},{"issue":"2","key":"pcbi.1008086.ref045","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10840-012-9672-7","article-title":"HRS\/EHRA\/ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design","volume":"33","author":"H Calkins","year":"2012","journal-title":"J Interv Card Electrophysiol"},{"issue":"4","key":"pcbi.1008086.ref046","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1161\/CIRCEP.108.774885","article-title":"Long-Term Clinical Results of 2 Different Ablation Strategies in Patients With Paroxysmal and Persistent Atrial Fibrillation.","volume":"1","author":"F Gaita","year":"2008","journal-title":"Circ Arrhythmia Electrophysiol."},{"key":"pcbi.1008086.ref047","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3389\/fphys.2016.00108","article-title":"Novel Radiofrequency Ablation Strategies for Terminating Atrial Fibrillation in the Left Atrium: A Simulation Study.","volume":"7","author":"JD Bayer","year":"2016","journal-title":"Front Physiol."},{"issue":"12","key":"pcbi.1008086.ref048","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.117.005740","article-title":"Ablation of Rotor Domains Effectively Modulates Dynamics of Human: Long-Standing Persistent Atrial Fibrillation.","volume":"10","author":"D Calvo","year":"2017","journal-title":"Circ Arrhythmia Electrophysiol."},{"issue":"2","key":"pcbi.1008086.ref049","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1161\/CIRCEP.111.967950","article-title":"An image-based model of atrial muscular architecture effects of structural anisotropy on electrical activation.","volume":"5","author":"J Zhao","year":"2012","journal-title":"Circ Arrhythmia Electrophysiol."},{"issue":"12","key":"pcbi.1008086.ref050","doi-asserted-by":"crossref","first-page":"e1005245","DOI":"10.1371\/journal.pcbi.1005245","article-title":"Atrial Heterogeneity Generates Re-entrant Substrate during Atrial Fibrillation and Anti-arrhythmic Drug Action: Mechanistic Insights from Canine Atrial Models.","volume":"12","author":"M Varela","year":"2016","journal-title":"PLoS Comput Biol."},{"issue":"1","key":"pcbi.1008086.ref051","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/ca.20634","article-title":"The importance of atrial structure and fibers","volume":"22","author":"SY Ho","year":"2009","journal-title":"Clin Anat"},{"key":"pcbi.1008086.ref052","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.media.2018.04.001","article-title":"Personalized computational modeling of left atrial geometry and transmural myofiber architecture","volume":"47","author":"TE Fastl","year":"2018","journal-title":"Med Image Anal"},{"issue":"11","key":"pcbi.1008086.ref053","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/s41551-019-0437-9","article-title":"Computationally guided personalized targeted ablation of persistent atrial fibrillation.","volume":"3","author":"PM Boyle","year":"2019","journal-title":"Nat Biomed Eng"},{"issue":"1 Pt 2","key":"pcbi.1008086.ref054","first-page":"H301","article-title":"Ionic mechanisms underlying human atrial action potential properties: insights from a mathematical model","volume":"275","author":"M Courtemanche","year":"1998","journal-title":"Am J Physiol"},{"issue":"2 56\u20132","key":"pcbi.1008086.ref055","article-title":"Direction-dependent conduction abnormalities in a canine model of atrial fibrillation due to chronic atrial dilatation.","volume":"287","author":"S Verheule","year":"2004","journal-title":"Am J Physiol\u2014Hear Circ Physiol."},{"issue":"1","key":"pcbi.1008086.ref056","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1161\/CIRCEP.112.975144","article-title":"Loss of continuity in the thin epicardial layer because of endomysial fibrosis increases the complexity of atrial fibrillatory conduction.","volume":"6","author":"S Verheule","year":"2013","journal-title":"Circ Arrhythmia Electrophysiol."},{"key":"pcbi.1008086.ref057","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fphys.2020.00068","article-title":"Epicardial Fibrosis Explains Increased Endo\u2013Epicardial Dissociation and Epicardial Breakthroughs in Human Atrial Fibrillation.","volume":"11","author":"A Gharaviri","journal-title":"Front Physiol. 2020"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1008086","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1008086","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T18:47:29Z","timestamp":1617475649000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1008086"}},"subtitle":[],"editor":[{"given":"Alexander V.","family":"Panfilov","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2020,9,23]]},"references-count":57,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1008086","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1008086","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,23]]}}}