{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T11:20:36Z","timestamp":1776856836080,"version":"3.51.2"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1008161","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000}}],"reference-count":88,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T00:00:00Z","timestamp":1598227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL105297"],"award-info":[{"award-number":["R01 HL105297"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 HL134605"],"award-info":[{"award-number":["P01 HL134605"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 HL142518"],"award-info":[{"award-number":["U01 HL142518"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL146723"],"award-info":[{"award-number":["R01 HL146723"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1008161","type":"journal-article","created":{"date-parts":[[2020,8,24]],"date-time":"2020-08-24T17:36:08Z","timestamp":1598290568000},"page":"e1008161","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":57,"title":["Cell signaling model for arterial mechanobiology"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8912-7400","authenticated-orcid":true,"given":"Linda","family":"Irons","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1011-2025","authenticated-orcid":true,"given":"Jay D.","family":"Humphrey","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2020,8,24]]},"reference":[{"issue":"2","key":"pcbi.1008161.ref001","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s12013-007-9002-3","article-title":"Vascular adaptation and mechanical homeostasis at tissue, cellular, and sub-cellular levels","volume":"50","author":"JD Humphrey","year":"2008","journal-title":"Cell Biochemistry and Biophysics"},{"issue":"32","key":"pcbi.1008161.ref002","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1098\/rsif.2008.0254","article-title":"Complementary vasoactivity and matrix remodelling in arterial adaptations to altered flow and pressure","volume":"6","author":"A Valentin","year":"2009","journal-title":"Journal of the Royal Society Interface"},{"issue":"9","key":"pcbi.1008161.ref003","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1080\/10255842.2010.495344","article-title":"A finite element model of stress-mediated vascular adaptation: application to abdominal aortic aneurysms","volume":"14","author":"S Zeinali-Davarani","year":"2011","journal-title":"Computer Methods in Biomechanics and Biomedical Engineering"},{"issue":"12","key":"pcbi.1008161.ref004","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1016\/j.jbiomech.2016.04.037","article-title":"A novel chemo-mechano-biological model of arterial tissue growth and remodelling","volume":"49","author":"P Apar\u00edcio","year":"2016","journal-title":"Journal of Biomechanics"},{"key":"pcbi.1008161.ref005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijengsci.2019.05.014","article-title":"Computational modeling predicts immuno-mechanical mechanisms of maladaptive aortic remodeling in hypertension","volume":"141","author":"M Latorre","year":"2019","journal-title":"International Journal of Engineering Science"},{"issue":"S1","key":"pcbi.1008161.ref006","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1186\/1471-2202-7-S1-S10","article-title":"Mathematical modeling of intracellular signaling pathways","volume":"7","author":"E Klipp","year":"2006","journal-title":"BMC Neuroscience"},{"issue":"17","key":"pcbi.1008161.ref007","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1101\/gad.1945410","article-title":"Classic and contemporary approaches to modeling biochemical reactions","volume":"24","author":"WW Chen","year":"2010","journal-title":"Genes & Development"},{"issue":"15","key":"pcbi.1008161.ref008","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1021\/bi902202q","article-title":"Logic-based models for the analysis of cell signaling networks","volume":"49","author":"MK Morris","year":"2010","journal-title":"Biochemistry"},{"key":"pcbi.1008161.ref009","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3389\/fgene.2016.00094","article-title":"Logical modeling and dynamical analysis of cellular networks","volume":"7","author":"W Abou-Jaoud\u00e9","year":"2016","journal-title":"Frontiers in Genetics"},{"issue":"6","key":"pcbi.1008161.ref010","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41569-019-0155-8","article-title":"Mechanical regulation of gene expression in cardiac myocytes and fibroblasts","volume":"16","author":"JJ Saucerman","year":"2019","journal-title":"Nature Reviews Cardiology"},{"issue":"1","key":"pcbi.1008161.ref011","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jmbbm.2008.05.002","article-title":"Adaptation and remodeling of vascular wall; biomechanical response to hypertension","volume":"2","author":"K Hayashi","year":"2009","journal-title":"Journal of the Mechanical Behavior of Biomedical Materials"},{"issue":"3","key":"pcbi.1008161.ref012","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1152\/physrev.1995.75.3.519","article-title":"Flow-mediated endothelial mechanotransduction","volume":"75","author":"PF Davies","year":"1995","journal-title":"Physiological Reviews"},{"issue":"2","key":"pcbi.1008161.ref013","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1161\/HYPERTENSIONAHA.107.103440","article-title":"Mechanisms of arterial remodeling in hypertension: coupled roles of wall shear and intramural stress","volume":"52","author":"JD Humphrey","year":"2008","journal-title":"Hypertension"},{"issue":"4","key":"pcbi.1008161.ref014","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1242\/dev.117572","article-title":"\u03b15 and \u03b1v integrins cooperate to regulate vascular smooth muscle and neural crest functions in vivo","volume":"142","author":"CJ Turner","year":"2015","journal-title":"Development"},{"issue":"2","key":"pcbi.1008161.ref015","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000025570","article-title":"Stretch-induced collagen synthesis in cultured smooth muscle cells from rabbit aortic media and a possible involvement of angiotensin II and transforming growth factor-\u03b2","volume":"35","author":"Q Li","year":"1998","journal-title":"Journal of Vascular Research"},{"issue":"3","key":"pcbi.1008161.ref016","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1083\/jcb.123.3.741","article-title":"Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF","volume":"123","author":"E Wilson","year":"1993","journal-title":"The Journal of Cell Biology"},{"issue":"2","key":"pcbi.1008161.ref017","doi-asserted-by":"crossref","first-page":"C389","DOI":"10.1152\/ajpcell.1992.263.2.C389","article-title":"Physiological fluid shear stress causes downregulation of endothelin-1 mRNA in bovine aortic endothelium","volume":"263","author":"A Malek","year":"1992","journal-title":"American Journal of Physiology-Cell Physiology"},{"issue":"6","key":"pcbi.1008161.ref018","doi-asserted-by":"crossref","first-page":"C1371","DOI":"10.1152\/ajpcell.1995.269.6.C1371","article-title":"Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress","volume":"269","author":"M Uematsu","year":"1995","journal-title":"American Journal of Physiology-Cell Physiology"},{"issue":"11","key":"pcbi.1008161.ref019","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"P Shannon","year":"2003","journal-title":"Genome Research"},{"key":"pcbi.1008161.ref020","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-21576-1","volume-title":"Cardiovascular solid mechanics: cells, tissues, and organs","author":"JD Humphrey","year":"2002"},{"issue":"03","key":"pcbi.1008161.ref021","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1142\/S0218202502001714","article-title":"A constrained mixture model for growth and remodeling of soft tissues","volume":"12","author":"JD Humphrey","year":"2002","journal-title":"Mathematical Models and Methods in Applied Sciences"},{"issue":"1902","key":"pcbi.1008161.ref022","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1098\/rsta.2009.0113","article-title":"Evaluation of fundamental hypotheses underlying constrained mixture models of arterial growth and remodelling","volume":"367","author":"A Valentin","year":"2009","journal-title":"Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences"},{"issue":"12","key":"pcbi.1008161.ref023","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1002\/zamm.201700302","article-title":"A mechanobiologically equilibrated constrained mixture model for growth and remodeling of soft tissues","volume":"98","author":"M Latorre","year":"2018","journal-title":"ZAMM-Journal of Applied Mathematics and Mechanics\/Zeitschrift f\u00fcr Angewandte Mathematik und Mechanik"},{"issue":"2","key":"pcbi.1008161.ref024","doi-asserted-by":"crossref","first-page":"L288","DOI":"10.1152\/ajplung.00417.2004","article-title":"Cyclic stretch increases VEGF expression in pulmonary arterial smooth muscle cells via TGF-\u03b21 and reactive oxygen species: a requirement for NAD (P) H oxidase","volume":"289","author":"E Mata-Greenwood","year":"2005","journal-title":"American Journal of Physiology-Lung Cellular and Molecular Physiology"},{"issue":"8","key":"pcbi.1008161.ref025","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1161\/01.ATV.17.8.1512","article-title":"Shear stress as an inhibitor of vascular smooth muscle cell proliferation: role of transforming growth factor-\u03b21 and tissue-type plasminogen activator","volume":"17","author":"H Ueba","year":"1997","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"4","key":"pcbi.1008161.ref026","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1161\/ATVBAHA.114.305115","article-title":"Divergent roles of matrix metalloproteinase 2 in pathogenesis of thoracic aortic aneurysm","volume":"35","author":"M Shen","year":"2015","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"8","key":"pcbi.1008161.ref027","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1161\/01.ATV.19.8.1843","article-title":"Angiotensin II stimulates collagen synthesis in human vascular smooth muscle cells: involvement of the AT1 receptor, transforming growth factor-\u03b2, and tyrosine phosphorylation","volume":"19","author":"CM Ford","year":"1999","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"3","key":"pcbi.1008161.ref028","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1016\/j.bbrc.2018.07.062","article-title":"Recombinant leptin attenuates abdominal aortic aneurysm formation in angiotensin II-infused apolipoprotein E-deficient mice","volume":"503","author":"Y Zhang","year":"2018","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"5","key":"pcbi.1008161.ref029","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1159\/000087451","article-title":"Angiotensin II stimulates matrix metalloproteinase secretion in human vascular smooth muscle cells via nuclear factor-\u03baB and activator protein 1 in a redox-sensitive manner","volume":"42","author":"M Browatzki","year":"2005","journal-title":"Journal of Vascular Research"},{"issue":"11","key":"pcbi.1008161.ref030","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1161\/01.RES.0000077044.60138.7C","article-title":"Mechanical stretch enhances mRNA expression and proenzyme release of matrix metalloproteinase-2 (MMP-2) via NAD (P) H oxidase\u2013derived reactive oxygen species","volume":"92","author":"K Grote","year":"2003","journal-title":"Circulation Research"},{"issue":"8","key":"pcbi.1008161.ref031","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1161\/01.CIR.0000115521.95662.7A","article-title":"Pressure-induced matrix metalloproteinase-9 contributes to early hypertensive remodeling","volume":"109","author":"S Lehoux","year":"2004","journal-title":"Circulation"},{"issue":"3","key":"pcbi.1008161.ref032","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1006\/exmp.1999.2260","article-title":"Mechanical stretching of human saphenous vein grafts induces expression and activation of matrix-degrading enzymes associated with vascular tissue injury and repair","volume":"66","author":"X Meng","year":"1999","journal-title":"Experimental and Molecular Pathology"},{"issue":"2","key":"pcbi.1008161.ref033","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1161\/01.CIR.102.2.225","article-title":"Shear stress downregulation of platelet-derived growth factor receptor-\u03b2 and matrix metalloprotease-2 is associated with inhibition of smooth muscle cell invasion and migration","volume":"102","author":"R Palumbo","year":"2000","journal-title":"Circulation"},{"issue":"5","key":"pcbi.1008161.ref034","doi-asserted-by":"crossref","first-page":"H2244","DOI":"10.1152\/ajpheart.00428.2003","article-title":"Shear stress inhibits smooth muscle cell migration via nitric oxide-mediated downregulation of matrix metalloproteinase-2 activity","volume":"288","author":"JS Garanich","year":"2005","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"issue":"5","key":"pcbi.1008161.ref035","doi-asserted-by":"crossref","first-page":"H2002","DOI":"10.1152\/ajpheart.1999.277.5.H2002","article-title":"Transmural pressure induces matrix-degrading activity in porcine arteries ex vivo","volume":"277","author":"NC Chesler","year":"1999","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"issue":"1","key":"pcbi.1008161.ref036","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1161\/HYPERTENSIONAHA.107.089631","article-title":"Role of matrix metalloproteinases in early hypertensive vascular remodeling","volume":"50","author":"M Flamant","year":"2007","journal-title":"Hypertension"},{"issue":"11","key":"pcbi.1008161.ref037","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1161\/ATVBAHA.109.192609","article-title":"Simvastatin inhibits angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-knockout mice: possible role of ERK","volume":"29","author":"Y Zhang","year":"2009","journal-title":"Arteriosclerosis, Thrombosis, and Vascular Biology"},{"issue":"5","key":"pcbi.1008161.ref038","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/00005344-200111000-00008","article-title":"Losartan Inhibits the Angiotensin II\u2013Induced Modifications on Fibrinolysis and Matrix Deposition by Primary Human Vascular Smooth Muscle Cells","volume":"38","author":"E Papakonstantinou","year":"2001","journal-title":"Journal of cardiovascular pharmacology"},{"issue":"11 suppl 1","key":"pcbi.1008161.ref039","doi-asserted-by":"crossref","first-page":"S262","DOI":"10.1161\/CIRCULATIONAHA.108.843581","article-title":"Differential effects of mechanical and biological stimuli on matrix metalloproteinase promoter activation in the thoracic aorta","volume":"120","author":"JM Ruddy","year":"2009","journal-title":"Circulation"},{"issue":"3","key":"pcbi.1008161.ref040","first-page":"63","article-title":"Induction of Timp1 in smooth muscle cells during development of abdominal aortic aneurysms","volume":"62","author":"B Bumdelger","year":"2013","journal-title":"Hiroshima J Med Sci"},{"issue":"6","key":"pcbi.1008161.ref041","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1161\/CIRCRESAHA.118.313105","article-title":"Role of thrombospondin-1 in mechanotransduction and development of thoracic aortic aneurysm in mouse and humans","volume":"123","author":"Y Yamashiro","year":"2018","journal-title":"Circulation Research"},{"key":"pcbi.1008161.ref042","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.biocel.2015.02.009","article-title":"Mechanical stretch promotes matrix metalloproteinase-2 and prolyl-4-hydroxylase \u03b11 production in human aortic smooth muscle cells via Akt-p38 MAPK-JNK signaling","volume":"62","author":"X Liu","year":"2015","journal-title":"The International Journal of Biochemistry & Cell Biology"},{"issue":"2","key":"pcbi.1008161.ref043","doi-asserted-by":"crossref","first-page":"H635","DOI":"10.1152\/ajpheart.00986.2001","article-title":"ANG II increases TIMP-1 expression in rat aortic smooth muscle cells in vivo","volume":"284","author":"G Castoldi","year":"2003","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"issue":"15","key":"pcbi.1008161.ref044","doi-asserted-by":"crossref","first-page":"3911","DOI":"10.1113\/jphysiol.2009.172916","article-title":"Endothelial nitric oxide synthase phosphorylation in treadmill-running mice: role of vascular signalling kinases","volume":"587","author":"QJ Zhang","year":"2009","journal-title":"The Journal of Physiology"},{"issue":"12","key":"pcbi.1008161.ref045","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1182\/blood-2005-06-2326","article-title":"Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique","volume":"106","author":"C Cheng","year":"2005","journal-title":"Blood"},{"issue":"7","key":"pcbi.1008161.ref046","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1096\/fasebj.14.7.991","article-title":"Stretch-induced endothelin B receptor-mediated apoptosis in vascular smooth muscle cells","volume":"14","author":"M Cattaruzza","year":"2000","journal-title":"The FASEB Journal"},{"issue":"1","key":"pcbi.1008161.ref047","doi-asserted-by":"crossref","first-page":"H150","DOI":"10.1152\/ajpheart.1993.264.1.H150","article-title":"Shear stress regulates endothelin-1 release via protein kinase C and cGMP in cultured endothelial cells","volume":"264","author":"MJ Kuchan","year":"1993","journal-title":"American Journal of Physiology-Heart and Circulatory Physiology"},{"issue":"23","key":"pcbi.1008161.ref048","doi-asserted-by":"crossref","first-page":"19199","DOI":"10.1074\/jbc.M112.341073","article-title":"MicroRNAs are essential for stretch-induced vascular smooth muscle contractile differentiation via microRNA (miR)-145-dependent expression of L-type calcium channels","volume":"287","author":"KM Turczy\u0144ska","year":"2012","journal-title":"Journal of Biological Chemistry"},{"issue":"2","key":"pcbi.1008161.ref049","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/jcp.21404","article-title":"Laminar shear stress stimulates vascular smooth muscle cell apoptosis via the Akt pathway","volume":"216","author":"TN Fitzgerald","year":"2008","journal-title":"Journal of Cellular Physiology"},{"issue":"8","key":"pcbi.1008161.ref050","doi-asserted-by":"crossref","first-page":"698","DOI":"10.5551\/jat.42481","article-title":"Suppression of Abdominal Aortic Aneurysm Formation in Mice by Teneligliptin, a Dipeptidyl Peptidase-4 Inhibitor","volume":"25","author":"Y Takahara","year":"2018","journal-title":"Journal of Atherosclerosis and Thrombosis"},{"issue":"52","key":"pcbi.1008161.ref051","doi-asserted-by":"crossref","first-page":"36843","DOI":"10.1074\/jbc.274.52.36843","article-title":"Intracellular Signaling of Angiotensin II-induced p70 S6 Kinase Phosphorylation at Ser411 in Vascular Smooth Muscle Cells: Possible requirement of epidermal growth factor receptor, RAS, extracellular signal-regulated kinase, and AKT","volume":"274","author":"S Eguchi","year":"1999","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"pcbi.1008161.ref052","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1161\/CIRCRESAHA.114.302157","article-title":"Inflammation and mechanical stretch promote aortic stiffening in hypertension through activation of p38 mitogen-activated protein kinase","volume":"114","author":"J Wu","year":"2014","journal-title":"Circulation Research"},{"issue":"1","key":"pcbi.1008161.ref053","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3317\/jraas.2000.007","article-title":"Mechanical strain-induced human vascular matrix synthesis: the role of angiotensin II","volume":"1","author":"AG Stanley","year":"2000","journal-title":"Journal of the Renin-Angiotensin-Aldosterone System"},{"issue":"33","key":"pcbi.1008161.ref054","doi-asserted-by":"crossref","first-page":"34849","DOI":"10.1074\/jbc.M403370200","article-title":"Stretch of the vascular wall induces smooth muscle differentiation by promoting actin polymerization","volume":"279","author":"S Albinsson","year":"2004","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"pcbi.1008161.ref055","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/ajh.2007.72","article-title":"Effects of reduced cyclic stretch on vascular smooth muscle cell function of pig carotids perfused ex vivo","volume":"21","author":"V Gambillara","year":"2008","journal-title":"American Journal of Hypertension"},{"issue":"1","key":"pcbi.1008161.ref056","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/cvr\/cvr059","article-title":"Vascular smooth muscle Jak2 mediates angiotensin II-induced hypertension via increased levels of reactive oxygen species","volume":"91","author":"A Kirabo","year":"2011","journal-title":"Cardiovascular Research"},{"issue":"6","key":"pcbi.1008161.ref057","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.jvs.2012.09.061","article-title":"\u03b11-Adrenergic receptors mediate combined signals initiated by mechanical stretch stress and norepinephrine leading to accelerated mouse vein graft atherosclerosis","volume":"57","author":"S Liu","year":"2013","journal-title":"Journal of Vascular Surgery"},{"issue":"4","key":"pcbi.1008161.ref058","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.bbrc.2019.01.047","article-title":"MicroRNA-27a regulates angiotensin II-induced vascular smooth muscle cell proliferation and migration by targeting \u03b1-smooth muscle-actin in vitro","volume":"509","author":"MM Xu","year":"2019","journal-title":"Biochemical and Biophysical Research Communications"},{"issue":"8","key":"pcbi.1008161.ref059","doi-asserted-by":"crossref","first-page":"e12323","DOI":"10.1371\/journal.pone.0012323","article-title":"Different effects of angiotensin II and angiotensin-(1-7) on vascular smooth muscle cell proliferation and migration","volume":"5","author":"F Zhang","year":"2010","journal-title":"PLoS One"},{"issue":"7","key":"pcbi.1008161.ref060","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1006\/jmcc.1996.0480","article-title":"Nitric oxide modulates basal and endothelin-induced coronary artery vascular smooth muscle cell proliferation and collagen levels","volume":"29","author":"MAD Rizvi","year":"1997","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"5","key":"pcbi.1008161.ref061","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4196\/kjpp.2010.14.5.299","article-title":"Losartan inhibits vascular smooth muscle cell proliferation through activation of AMP-activated protein kinase","volume":"14","author":"JE Kim","year":"2010","journal-title":"The Korean Journal of Physiology & Pharmacology"},{"issue":"5","key":"pcbi.1008161.ref062","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1097\/01.hjh.0000166845.49850.39","article-title":"Negative regulation of RhoA\/Rho kinase by angiotensin II type 2 receptor in vascular smooth muscle cells: role in angiotensin II-induced vasodilation in stroke-prone spontaneously hypertensive rats","volume":"23","author":"C Savoia","year":"2005","journal-title":"Journal of Hypertension"},{"issue":"19","key":"pcbi.1008161.ref063","doi-asserted-by":"crossref","first-page":"PL289","DOI":"10.1016\/S0024-3205(98)00448-2","article-title":"Angiotensin II type 2 receptor mediates vascular smooth muscle cell apoptosis and antagonizes angiotensin II type 1 receptor action: an in vitro gene transfer study","volume":"63","author":"T Yamada","year":"1998","journal-title":"Life Sciences"},{"issue":"2","key":"pcbi.1008161.ref064","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/jmcc.1996.0023","article-title":"The effects of endothelin-1 on collagen type I and type III synthesis in cultured porcine coronary artery vascular smooth muscle cells","volume":"28","author":"MAD Rizvi","year":"1996","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"5","key":"pcbi.1008161.ref065","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10237-006-0062-x","article-title":"Computational modeling of arterial wall growth","volume":"6","author":"E Kuhl","year":"2007","journal-title":"Biomechanics and modeling in mechanobiology"},{"issue":"10","key":"pcbi.1008161.ref066","doi-asserted-by":"crossref","DOI":"10.1115\/1.3192141","article-title":"Coupling the hemodynamic environment to the evolution of cerebral aneurysms: computational framework and numerical examples","volume":"131","author":"PN Watton","year":"2009","journal-title":"Journal of Biomechanical Engineering"},{"issue":"6","key":"pcbi.1008161.ref067","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1098\/rsif.2005.0073","article-title":"Hyperelastic modelling of arterial layers with distributed collagen fibre orientations","volume":"3","author":"TC Gasser","year":"2006","journal-title":"Journal of the Royal Society Interface"},{"issue":"1","key":"pcbi.1008161.ref068","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jtbi.2003.08.004","article-title":"A computational model for collagen fibre remodelling in the arterial wall","volume":"226","author":"NJB Driessen","year":"2004","journal-title":"Journal of Theoretical Biology"},{"issue":"3","key":"pcbi.1008161.ref069","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1115\/1.2798001","article-title":"A model for aortic growth based on fluid shear and fiber stresses","volume":"120","author":"LA Taber","year":"1998","journal-title":"Journal of Biomechanical Engineering"},{"key":"pcbi.1008161.ref070","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.cobme.2019.11.005","article-title":"Modeling biological growth and remodeling: contrasting methods, contrasting needs","volume":"15","author":"M Latorre","year":"2020","journal-title":"Current Opinion in Biomedical Engineering"},{"issue":"1","key":"pcbi.1008161.ref071","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1115\/1.2132374","article-title":"A theoretical model of enlarging intracranial fusiform aneurysms","volume":"128","author":"S Baek","year":"2006","journal-title":"Journal of Biomechanical Engineering"},{"issue":"2150","key":"pcbi.1008161.ref072","doi-asserted-by":"crossref","DOI":"10.1098\/rspa.2012.0556","article-title":"Humphrey JD. Parametric study of effects of collagen turnover on the natural history of abdominal aortic aneurysms","volume":"469","author":"JS Wilson","year":"2013","journal-title":"Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences"},{"issue":"9","key":"pcbi.1008161.ref073","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1016\/j.jbiomech.2013.10.009","article-title":"Computational model of the in vivo development of a tissue engineered vein from an implanted polymeric construct","volume":"47","author":"KS Miller","year":"2014","journal-title":"Journal of Biomechanics"},{"issue":"537","key":"pcbi.1008161.ref074","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aax6919","article-title":"Spontaneous reversal of stenosis in tissue-engineered vascular grafts","volume":"12","author":"JD Drews","year":"2020","journal-title":"Science Translational Medicine"},{"issue":"4","key":"pcbi.1008161.ref075","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1365-2796.2006.01624.x","article-title":"Molecular mechanisms of the vascular responses to haemodynamic forces","volume":"259","author":"S Lehoux","year":"2006","journal-title":"Journal of Internal Medicine"},{"issue":"3","key":"pcbi.1008161.ref076","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1161\/hy09t1.096249","article-title":"Vascular remodeling in hypertension: roles of apoptosis, inflammation, and fibrosis","volume":"38","author":"HD Intengan","year":"2001","journal-title":"Hypertension"},{"issue":"12","key":"pcbi.1008161.ref077","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/nrm3896","article-title":"Mechanotransduction and extracellular matrix homeostasis","volume":"15","author":"JD Humphrey","year":"2014","journal-title":"Nature Reviews Molecular Cell Biology"},{"key":"pcbi.1008161.ref078","article-title":"Computational Systems Mechanobiology of Growth and Remodeling: Integration of Tissue Mechanics and Cell Regulatory Network Dynamics","author":"VD Sree","year":"2020","journal-title":"Current Opinion in Biomedical Engineering"},{"issue":"136","key":"pcbi.1008161.ref079","doi-asserted-by":"crossref","first-page":"20170615","DOI":"10.1098\/rsif.2017.0615","article-title":"A chemo-mechano-biological formulation for the effects of biochemical alterations on arterial mechanics: the role of molecular transport and multiscale tissue remodelling","volume":"14","author":"M Marino","year":"2017","journal-title":"Journal of The Royal Society Interface"},{"issue":"3","key":"pcbi.1008161.ref080","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1093\/intbio\/zyaa004","article-title":"A computational bio-chemo-mechanical model of in vivo tissue-engineered vascular graft development","volume":"12","author":"R Khosravi","year":"2020","journal-title":"Integrative Biology"},{"key":"pcbi.1008161.ref081","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.yjmcc.2016.03.008","article-title":"A computational model of cardiac fibroblast signaling predicts context-dependent drivers of myofibroblast differentiation","volume":"94","author":"AC Zeigler","year":"2016","journal-title":"Journal of Molecular and Cellular Cardiology"},{"issue":"50","key":"pcbi.1008161.ref082","doi-asserted-by":"crossref","first-page":"42259","DOI":"10.1074\/jbc.M112.382937","article-title":"Network reconstruction and systems analysis of cardiac myocyte hypertrophy signaling","volume":"287","author":"KA Ryall","year":"2012","journal-title":"Journal of Biological Chemistry"},{"issue":"11","key":"pcbi.1008161.ref083","doi-asserted-by":"crossref","first-page":"e1005854","DOI":"10.1371\/journal.pcbi.1005854","article-title":"Predictive model identifies key network regulators of cardiomyocyte mechano-signaling","volume":"13","author":"PM Tan","year":"2017","journal-title":"PLoS Computational Biology"},{"issue":"1","key":"pcbi.1008161.ref084","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1186\/1752-0509-4-157","article-title":"Modeling cardiac \u03b2-adrenergic signaling with normalized-Hill differential equations: comparison with a biochemical model","volume":"4","author":"MJ Kraeutler","year":"2010","journal-title":"BMC Systems Biology"},{"issue":"1","key":"pcbi.1008161.ref085","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12918-015-0187-6","article-title":"Regulation of ERK-MAPK signaling in human epidermis","volume":"9","author":"J Cursons","year":"2015","journal-title":"BMC Systems Biology"},{"issue":"12","key":"pcbi.1008161.ref086","doi-asserted-by":"crossref","first-page":"3637","DOI":"10.1172\/JCI38308","article-title":"An adventitial IL-6\/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice","volume":"119","author":"BC Tieu","year":"2009","journal-title":"The Journal of Clinical Investigation"},{"issue":"2","key":"pcbi.1008161.ref087","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1161\/HYPERTENSIONAHA.115.06123","article-title":"Origin of matrix-producing cells that contribute to aortic fibrosis in hypertension","volume":"67","author":"J Wu","year":"2016","journal-title":"Hypertension"},{"issue":"1","key":"pcbi.1008161.ref088","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1752-0509-3-98","article-title":"Transforming Boolean models to continuous models: methodology and application to T-cell receptor signaling","volume":"3","author":"DM Wittmann","year":"2009","journal-title":"BMC Systems Biology"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1008161","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T00:00:00Z","timestamp":1599091200000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1008161","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T17:57:34Z","timestamp":1599155854000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1008161"}},"subtitle":[],"editor":[{"given":"Jeffrey J.","family":"Saucerman","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2020,8,24]]},"references-count":88,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1008161","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1008161","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,24]]}}}