{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T21:10:33Z","timestamp":1777065033701,"version":"3.51.4"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1008198","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000}}],"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Taiwan National Health Research Institute","award":["NHRI-ex-105-10509NC"],"award-info":[{"award-number":["NHRI-ex-105-10509NC"]}]},{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"crossref","award":["SCGB 542969SPI"],"award-info":[{"award-number":["SCGB 542969SPI"]}],"id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"crossref","award":["SCGB 542969SPI"],"award-info":[{"award-number":["SCGB 542969SPI"]}],"id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"crossref","award":["SCGB 542969SPI"],"award-info":[{"award-number":["SCGB 542969SPI"]}],"id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000893","name":"Simons Foundation","doi-asserted-by":"crossref","award":["SCGB 542943SPI"],"award-info":[{"award-number":["SCGB 542943SPI"]}],"id":[{"id":"10.13039\/100000893","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS104781"],"award-info":[{"award-number":["NS104781"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1008198","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T14:45:06Z","timestamp":1600181106000},"page":"e1008198","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":162,"title":["A comparison of neuronal population dynamics measured with calcium imaging and electrophysiology"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8694-1260","authenticated-orcid":true,"given":"Ziqiang","family":"Wei","sequence":"first","affiliation":[]},{"given":"Bei-Jung","family":"Lin","sequence":"additional","affiliation":[]},{"given":"Tsai-Wen","family":"Chen","sequence":"additional","affiliation":[]},{"given":"Kayvon","family":"Daie","sequence":"additional","affiliation":[]},{"given":"Karel","family":"Svoboda","sequence":"additional","affiliation":[]},{"given":"Shaul","family":"Druckmann","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2020,9,15]]},"reference":[{"issue":"5","key":"pcbi.1008198.ref001","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nn1233","article-title":"Large-scale recording of neuronal ensembles","volume":"7","author":"G Buzsaki","year":"2004","journal-title":"Nat Neurosci"},{"key":"pcbi.1008198.ref002","doi-asserted-by":"crossref","first-page":"e27702","DOI":"10.7554\/eLife.27702","article-title":"Automated long-term recording and analysis of neural activity in behaving animals.","volume":"6","author":"AK Dhawale","year":"2017","journal-title":"eLife"},{"issue":"7","key":"pcbi.1008198.ref003","doi-asserted-by":"crossref","first-page":"e1000153","DOI":"10.1371\/journal.pbio.1000153","article-title":"Emergence of a stable cortical map for neuroprosthetic control","volume":"7","author":"K Ganguly","year":"2009","journal-title":"PLoS biology"},{"issue":"6","key":"pcbi.1008198.ref004","doi-asserted-by":"crossref","first-page":"3780","DOI":"10.1152\/jn.00260.2007","article-title":"Recording chronically from the same neurons in awake, behaving primates","volume":"98","author":"AS Tolias","year":"2007","journal-title":"J Neurophysiol"},{"issue":"3","key":"pcbi.1008198.ref005","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.neuron.2015.03.027","article-title":"A Cellular Resolution Map of Barrel Cortex Activity during Tactile Behavior","volume":"86","author":"SP Peron","year":"2015","journal-title":"Neuron"},{"issue":"7395","key":"pcbi.1008198.ref006","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nature11039","article-title":"Multiple dynamic representations in the motor cortex during sensorimotor learning","volume":"484","author":"D Huber","year":"2012","journal-title":"Nature"},{"key":"pcbi.1008198.ref007","first-page":"5","article-title":"A large field of view two-photon mesoscope with subcellular resolution for in vivo imaging","author":"NJ Sofroniew","year":"2016","journal-title":"Elife"},{"issue":"7765","key":"pcbi.1008198.ref008","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41586-019-1346-5","article-title":"High-dimensional geometry of population responses in visual cortex","volume":"571","author":"C Stringer","year":"2019","journal-title":"Nature"},{"issue":"6","key":"pcbi.1008198.ref009","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1016\/j.cell.2014.01.050","article-title":"A cortical circuit for gain control by behavioral state","volume":"156","author":"Y Fu","year":"2014","journal-title":"Cell"},{"key":"pcbi.1008198.ref010","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.conb.2015.03.016","article-title":"Comprehensive imaging of cortical networks","volume":"32","author":"S Peron","year":"2015","journal-title":"Curr Opin Neurobiol"},{"key":"pcbi.1008198.ref011","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nature13235","article-title":"Emergence of reproducible spatiotemporal activity during motor learning","volume":"510","author":"AJ Peters","year":"2014","journal-title":"Nature"},{"issue":"12","key":"pcbi.1008198.ref012","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nmeth.1398","article-title":"Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators.","volume":"6","author":"L Tian","year":"2009","journal-title":"Nat Methods"},{"issue":"7458","key":"pcbi.1008198.ref013","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nature12354","article-title":"Ultrasensitive fluorescent proteins for imaging neuronal activity","volume":"499","author":"TW Chen","year":"2013","journal-title":"Nature"},{"issue":"40","key":"pcbi.1008198.ref014","first-page":"13819","article-title":"Optimization of a GCaMP Calcium Indicator for Neural Activity Imaging. The Journal of neuroscience: the official journal of the","volume":"32","author":"J Akerboom","year":"2012","journal-title":"Society for Neuroscience"},{"issue":"12","key":"pcbi.1008198.ref015","doi-asserted-by":"crossref","first-page":"e51286","DOI":"10.1371\/journal.pone.0051286","article-title":"Genetically Encoded Green Fluorescent Ca2+ Indicators with Improved Detectability for Neuronal Ca2+ Signals.","volume":"7","author":"M Ohkura","year":"2012","journal-title":"PLoS ONE."},{"issue":"1","key":"pcbi.1008198.ref016","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nmeth.3185","article-title":"Rational design of a high-affinity, fast, red calcium indicator R-CaMP2","volume":"12","author":"M Inoue","year":"2015","journal-title":"Nature methods"},{"key":"pcbi.1008198.ref017","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.12727","article-title":"Sensitive red protein calcium indicators for imaging neural activity.","volume":"5","author":"H Dana","year":"2016","journal-title":"Elife"},{"key":"pcbi.1008198.ref018","first-page":"434589","article-title":"High-performance GFP-based calcium indicators for imaging activity in neuronal populations and microcompartments.","author":"H Dana","year":"2018","journal-title":"bioRxiv"},{"issue":"1","key":"pcbi.1008198.ref019","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.neuron.2015.03.055","article-title":"Cellular level brain imaging in behaving mammals: an engineering approach","volume":"86","author":"EJ Hamel","year":"2015","journal-title":"Neuron"},{"issue":"5","key":"pcbi.1008198.ref020","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.neuron.2012.02.011","article-title":"Imaging calcium in neurons","volume":"73","author":"C Grienberger","year":"2012","journal-title":"Neuron"},{"issue":"31","key":"pcbi.1008198.ref021","doi-asserted-by":"crossref","first-page":"8183","DOI":"10.1523\/JNEUROSCI.1962-06.2006","article-title":"Nonlinear [Ca2+] signaling in dendrites and spines caused by activity-dependent depression of Ca2+ extrusion","volume":"26","author":"V Scheuss","year":"2006","journal-title":"J Neurosci"},{"issue":"43","key":"pcbi.1008198.ref022","doi-asserted-by":"crossref","first-page":"9572","DOI":"10.1523\/JNEUROSCI.2854-04.2004","article-title":"Monitoring neural activity and [Ca2+] with genetically encoded Ca2+ indicators","volume":"24","author":"TA Pologruto","year":"2004","journal-title":"J Neurosci"},{"issue":"6","key":"pcbi.1008198.ref023","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.neuron.2010.08.026","article-title":"Neural activity in barrel cortex underlying vibrissa-based object localization in mice","volume":"67","author":"DH O'Connor","year":"2010","journal-title":"Neuron"},{"issue":"1","key":"pcbi.1008198.ref024","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1371\/journal.pbio.0060016","article-title":"Sparse representation of sounds in the unanesthetized auditory cortex","volume":"6","author":"T Hromadka","year":"2008","journal-title":"PLoS Biol"},{"issue":"7541","key":"pcbi.1008198.ref025","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature14178","article-title":"A motor cortex circuit for motor planning and movement","volume":"519","author":"N Li","year":"2015","journal-title":"Nature"},{"issue":"2","key":"pcbi.1008198.ref026","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0959-4388(03)00050-3","article-title":"Basic mechanisms for graded persistent activity: discrete attractors, continuous attractors, and dynamic representations","volume":"13","author":"CD Brody","year":"2003","journal-title":"Curr Opin Neurobiol"},{"key":"pcbi.1008198.ref027","article-title":"Robust neuronal dynamics in premotor cortex during motor planning","author":"N Li","year":"2016","journal-title":"Nature"},{"key":"pcbi.1008198.ref028","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1016\/S0006-3495(00)76809-3","article-title":"Estimating intracellular calcium concentrations and buffering without wavelength ratioing","volume":"78","author":"M Maravall","year":"2000","journal-title":"Biophys J"},{"key":"pcbi.1008198.ref029","first-page":"479055","article-title":"Accurate action potential inference from a calcium sensor protein through biophysical modeling.","author":"DS Greenberg","year":"2018","journal-title":"bioRxiv"},{"key":"pcbi.1008198.ref030","article-title":"Dimensionality reduction for large-scale neural recordings","author":"JP Cunningham","year":"2014","journal-title":"Nature neuroscience"},{"issue":"9","key":"pcbi.1008198.ref031","doi-asserted-by":"crossref","first-page":"e108697","DOI":"10.1371\/journal.pone.0108697","article-title":"Thy1-GCaMP6 Transgenic Mice for Neuronal Population Imaging In Vivo.","volume":"9","author":"H Dana","year":"2014","journal-title":"PloS ONE"},{"issue":"3","key":"pcbi.1008198.ref032","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.neuron.2016.04.014","article-title":"Benchmarking Spike Rate Inference in Population Calcium Imaging","volume":"90","author":"L Theis","year":"2016","journal-title":"Neuron"},{"issue":"1","key":"pcbi.1008198.ref033","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/s41467-018-08141-6","article-title":"An orderly single-trial organization of population dynamics in premotor cortex predicts behavioral variability","volume":"10","author":"Z Wei","year":"2019","journal-title":"Nature Communications"},{"issue":"1","key":"pcbi.1008198.ref034","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuron.2013.10.020","article-title":"Flow of cortical activity underlying a tactile decision in mice","volume":"81","author":"ZV Guo","year":"2014","journal-title":"Neuron"},{"issue":"2","key":"pcbi.1008198.ref035","doi-asserted-by":"crossref","first-page":"e88678","DOI":"10.1371\/journal.pone.0088678","article-title":"Procedures for behavioral experiments in head-fixed mice.","volume":"9","author":"ZV Guo","year":"2014","journal-title":"PloS one."},{"issue":"4","key":"pcbi.1008198.ref036","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.neuron.2017.05.005","article-title":"A Map of Anticipatory Activity in Mouse Motor Cortex","volume":"94","author":"T-W Chen","year":"2017","journal-title":"Neuron"},{"key":"pcbi.1008198.ref037","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nature22324","article-title":"Maintenance of persistent activity in a frontal thalamocortical loop","volume":"545","author":"ZV Guo","year":"2017","journal-title":"Nature"},{"issue":"6","key":"pcbi.1008198.ref038","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1152\/jn.01073.2009","article-title":"Fast nonnegative deconvolution for spike train inference from population calcium imaging","volume":"104","author":"JT Vogelstein","year":"2010","journal-title":"Journal of neurophysiology"},{"issue":"2","key":"pcbi.1008198.ref039","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.bpj.2008.08.005","article-title":"Spike inference from calcium imaging using sequential Monte Carlo methods","volume":"97","author":"JT Vogelstein","year":"2009","journal-title":"Biophysical journal"},{"key":"pcbi.1008198.ref040","doi-asserted-by":"crossref","unstructured":"Pnevmatikakis EA, Merel J, Pakman A, Paninski L, editors. Bayesian spike inference from calcium imaging data. Signals, Systems and Computers, 2013 Asilomar Conference on; 2013: IEEE.","DOI":"10.1109\/ACSSC.2013.6810293"},{"issue":"2","key":"pcbi.1008198.ref041","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neuron.2015.11.037","article-title":"Simultaneous Denoising, Deconvolution, and Demixing of Calcium Imaging Data","volume":"89","author":"EA Pnevmatikakis","year":"2016","journal-title":"Neuron"},{"key":"pcbi.1008198.ref042","doi-asserted-by":"crossref","first-page":"12190","DOI":"10.1038\/ncomms12190","article-title":"Accurate spike estimation from noisy calcium signals for ultrafast three-dimensional imaging of large neuronal populations in vivo","volume":"7","author":"T Deneux","year":"2016","journal-title":"Nature Communications"},{"issue":"5","key":"pcbi.1008198.ref043","doi-asserted-by":"crossref","first-page":"e1006157","DOI":"10.1371\/journal.pcbi.1006157","article-title":"Community-based benchmarking improves spike rate inference from two-photon calcium imaging data","volume":"14","author":"P Berens","year":"2018","journal-title":"PLOS Computational Biology"},{"issue":"37","key":"pcbi.1008198.ref044","doi-asserted-by":"crossref","first-page":"7976","DOI":"10.1523\/JNEUROSCI.3339-17.2018","article-title":"Robustness of Spike Deconvolution for Neuronal Calcium Imaging","volume":"38","author":"M Pachitariu","year":"2018","journal-title":"The Journal of Neuroscience"},{"issue":"17","key":"pcbi.1008198.ref045","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1523\/JNEUROSCI.3152-17.2018","article-title":"Low-Dimensional and Monotonic Preparatory Activity in Mouse Anterior Lateral Motor Cortex","volume":"38","author":"HK Inagaki","year":"2018","journal-title":"The Journal of Neuroscience"},{"issue":"219","key":"pcbi.1008198.ref046","doi-asserted-by":"crossref","first-page":"pl5","DOI":"10.1126\/stke.2192004pl5","article-title":"Imaging calcium concentration dynamics in small neuronal compartments","volume":"2004","author":"R Yasuda","year":"2004","journal-title":"Sci STKE"},{"key":"pcbi.1008198.ref047","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3389\/fncir.2013.00201","article-title":"Inference of neuronal network spike dynamics and topology from calcium imaging data.","volume":"7","author":"H L\u00fctcke","year":"2013","journal-title":"Frontiers in Neural Circuits"},{"issue":"2","key":"pcbi.1008198.ref048","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0006-3495(96)79653-4","article-title":"Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons","volume":"70","author":"F Helmchen","year":"1996","journal-title":"Biophys J"},{"issue":"9","key":"pcbi.1008198.ref049","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1523\/JNEUROSCI.4469-11.2012","article-title":"A Cre-Dependent GCaMP3 Reporter Mouse for Neuronal Imaging <em>In Vivo<\/em&gt.","volume":"32","author":"HA Zariwala","year":"2012","journal-title":"The Journal of Neuroscience."},{"issue":"6437","key":"pcbi.1008198.ref050","doi-asserted-by":"crossref","first-page":"eaav7893","DOI":"10.1126\/science.aav7893","article-title":"Spontaneous behaviors drive multidimensional, brainwide activity","volume":"364","author":"C Stringer","year":"2019","journal-title":"Science"},{"issue":"7392","key":"pcbi.1008198.ref051","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nature10918","article-title":"Choice-specific sequences in parietal cortex during a virtual-navigation decision task","volume":"484","author":"CD Harvey","year":"2012","journal-title":"Nature"},{"issue":"6241","key":"pcbi.1008198.ref052","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1126\/science.aab0551","article-title":"Cortical information flow during flexible sensorimotor decisions","volume":"348","author":"M Siegel","year":"2015","journal-title":"Science"},{"issue":"2","key":"pcbi.1008198.ref053","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.neuron.2017.06.013","article-title":"Fronto-parietal Cortical Circuits Encode Accumulated Evidence with a Diversity of Timescales","volume":"95","author":"BB Scott","year":"2017","journal-title":"Neuron"},{"key":"pcbi.1008198.ref054","first-page":"803437","article-title":"A unified framework for dopamine signals across timescales.","author":"HR Kim","year":"2019","journal-title":"bioRxiv"},{"issue":"5","key":"pcbi.1008198.ref055","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.neuron.2010.08.002","article-title":"Broadly tuned response properties of diverse inhibitory neuron subtypes in mouse visual cortex","volume":"67","author":"AM Kerlin","year":"2010","journal-title":"Neuron"},{"issue":"7026","key":"pcbi.1008198.ref056","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nature03274","article-title":"Functional imaging with cellular resolution reveals precise micro-architecture in visual cortex","volume":"433","author":"K Ohki","year":"2005","journal-title":"Nature"},{"issue":"6","key":"pcbi.1008198.ref057","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.cell.2017.10.021","article-title":"Ancestral Circuits for the Coordinated Modulation of Brain State","volume":"171","author":"M Lovett-Barron","year":"2017","journal-title":"Cell"},{"issue":"7337","key":"pcbi.1008198.ref058","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nature09818","article-title":"Wiring specificity in the direction-selectivity circuit of the retina","volume":"471","author":"KL Briggman","year":"2011","journal-title":"Nature"},{"issue":"7337","key":"pcbi.1008198.ref059","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature09802","article-title":"Network anatomy and in vivo physiology of visual cortical neurons","volume":"471","author":"DD Bock","year":"2011","journal-title":"Nature"},{"issue":"7292","key":"pcbi.1008198.ref060","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1038\/nature08897","article-title":"Learning-related fine-scale specificity imaged in motor cortex circuits of behaving mice","volume":"464","author":"T Komiyama","year":"2010","journal-title":"Nature"},{"key":"pcbi.1008198.ref061","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1038\/nature08947","article-title":"Dendritic organization of sensory input to cortical neurons in vivo","volume":"464","author":"H Jia","year":"2010","journal-title":"Nature"},{"issue":"7415","key":"pcbi.1008198.ref062","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nature11321","article-title":"Activity in motor-sensory projections reveals distributed coding in somatosensation","volume":"489","author":"L Petreanu","year":"2012","journal-title":"Nature"},{"issue":"7428","key":"pcbi.1008198.ref063","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature11601","article-title":"Nonlinear dendritic integration of sensory and motor input during an active sensing task","volume":"492","author":"NL Xu","year":"2012","journal-title":"Nature"},{"key":"pcbi.1008198.ref064","first-page":"788802","article-title":"Relationship between spiking activity and simultaneously recorded fluorescence signals in transgenic mice expressing GCaMP6.","author":"L Huang","year":"2019","journal-title":"bioRxiv"},{"issue":"5","key":"pcbi.1008198.ref065","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.cell.2019.04.007","article-title":"Rational Engineering of XCaMPs, a Multicolor GECI Suite for In Vivo Imaging of Complex Brain Circuit Dynamics","volume":"177","author":"M Inoue","year":"2019","journal-title":"Cell"},{"key":"pcbi.1008198.ref066","first-page":"eaav6416","article-title":"Bright and photostable chemigenetic indicators for extended in vivo voltage imaging","author":"AS Abdelfattah","year":"2019","journal-title":"Science"},{"issue":"7756","key":"pcbi.1008198.ref067","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41586-019-1166-7","article-title":"Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics","volume":"569","author":"Y Adam","year":"2019","journal-title":"Nature"},{"key":"pcbi.1008198.ref068","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature24636","article-title":"Fully integrated silicon probes for high-density recording of neural activity","volume":"551","author":"JJ Jun","year":"2017","journal-title":"Nature"},{"key":"pcbi.1008198.ref069","article-title":"Simultaneous calcium imaging using GCaMP sensors and electrophysiology in L2\/3 pyramidal neurons of the visual cortex in thy1 transgenic mice.","author":"B-J Lin","year":"2016"},{"key":"pcbi.1008198.ref070","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev.ne.12.030189.001303","article-title":"Fluorescent probes of cell signaling","volume":"12","author":"RY Tsien","year":"1989","journal-title":"Annu Rev Neurosci"},{"issue":"1","key":"pcbi.1008198.ref071","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1093\/biostatistics\/kxj035","article-title":"Regularized linear discriminant analysis and its application in microarrays.","volume":"8","author":"Y Guo","year":"2007","journal-title":"Biostatistics"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1008198","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T00:00:00Z","timestamp":1600992000000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1008198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T08:26:08Z","timestamp":1668759968000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1008198"}},"subtitle":[],"editor":[{"given":"Boris S.","family":"Gutkin","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2020,9,15]]},"references-count":71,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1008198","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/840686","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,15]]}}}