{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T20:49:18Z","timestamp":1771102158097,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1008235","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000}}],"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"DOI":"10.1371\/journal.pcbi.1008235","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T18:09:40Z","timestamp":1602180580000},"page":"e1008235","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Use of Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers During the COVID-19 Pandemic: A Modeling Analysis"],"prefix":"10.1371","volume":"16","author":[{"given":"Mehrshad","family":"Sadria","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1753-4063","authenticated-orcid":true,"given":"Anita T.","family":"Layton","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2020,10,8]]},"reference":[{"issue":"10229","key":"pcbi.1008235.ref001","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study","volume":"395","author":"F Zhou","year":"2020","journal-title":"Lancet"},{"issue":"6","key":"pcbi.1008235.ref002","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41581-020-0279-4","article-title":"Controversies of renin-angiotensin system inhibition during the COVID-19 pandemic","volume":"16","author":"AM South","year":"2020","journal-title":"Nat Rev Nephrol."},{"key":"pcbi.1008235.ref003","doi-asserted-by":"crossref","first-page":"307315","DOI":"10.1155\/2012\/307315","article-title":"Angiotensin-converting enzyme 2: the first decade","volume":"2012","author":"NE Clarke","year":"2012","journal-title":"Int J Hypertens"},{"issue":"3","key":"pcbi.1008235.ref004","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1002\/cphy.c130040","article-title":"Classical Renin-Angiotensin system in kidney physiology","volume":"4","author":"MA Sparks","year":"2014","journal-title":"Compr Physiol"},{"issue":"4","key":"pcbi.1008235.ref005","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1002\/cphy.c120002","article-title":"Nonclassical renin-angiotensin system and renal function","volume":"2","author":"MC Chappell","year":"2012","journal-title":"Compr Physiol"},{"key":"pcbi.1008235.ref006","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3389\/fendo.2013.00201","article-title":"Update on the Angiotensin converting enzyme 2-Angiotensin (1-7)-MAS receptor axis: fetal programing, sex differences, and intracellular pathways","volume":"4","author":"MC Chappell","year":"2014","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"20","key":"pcbi.1008235.ref007","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1161\/CIRCULATIONAHA.104.510461","article-title":"Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2","volume":"111","author":"CM Ferrario","year":"2005","journal-title":"Circulation"},{"issue":"2","key":"pcbi.1008235.ref008","first-page":"152","article-title":"Inflammation in hypertension","volume":"15","author":"C Savoia","year":"2006","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"2","key":"pcbi.1008235.ref009","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor","volume":"181","author":"M Hoffmann","year":"2020","journal-title":"Cell"},{"key":"pcbi.1008235.ref010","first-page":"253","article-title":"Modeling Sex Differences in the Renin Angiotensin System and the Efficacy of Antihypertensive Therapies. Computers &","volume":"112","author":"J Leete","year":"2018","journal-title":"Chemical Engineering"},{"issue":"1","key":"pcbi.1008235.ref011","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1161\/HYPERTENSIONAHA.109.138420","article-title":"Targeting the Degradation of Angiotensin II With Recombinant Angiotensin-Converting Enzyme 2: Prevention of Angiotensin II\u2013Dependent Hypertension","volume":"55","author":"J. Wysocki","year":"2010","journal-title":"Hypertension"},{"issue":"5","key":"pcbi.1008235.ref012","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.coi.2005.07.013","article-title":"The aging innate immune system","volume":"17","author":"C.R. Gomez","year":"2005","journal-title":"Curr Opin Immunol"},{"key":"pcbi.1008235.ref013","article-title":"Neutrophil extracellular traps (NETs) as markers of disease severity in COVID-19","author":"Y Zuo","year":"2020","journal-title":"medRxiv"},{"key":"pcbi.1008235.ref014","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1056\/NEJMoa2008975","article-title":"Renin-Angiotensin-Aldosterone System Inhibitors and Risk of Covid-19","volume":"382","author":"HR Reynolds","year":"2020","journal-title":"N Engl J Med"},{"key":"pcbi.1008235.ref015","article-title":"Modeling Within-host SARS-CoV-2 Infection Dynamics and Potential Treatments","author":"M Sadria","year":"2020","journal-title":"Scientific reports"},{"key":"pcbi.1008235.ref016","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.compbiomed.2018.11.002","article-title":"Sex-specific long-term blood pressure regulation: Modeling and analysis","volume":"104","author":"J Leete","year":"2019","journal-title":"Comput Biol Med"},{"issue":"2","key":"pcbi.1008235.ref017","doi-asserted-by":"crossref","first-page":"F174","DOI":"10.1152\/ajprenal.00482.2016","article-title":"Sex-specific computational models of the spontaneously hypertensive rat kidneys: factors affecting nitric oxide bioavailability","volume":"313","author":"Y Chen","year":"2017","journal-title":"Am J Physiol Renal Physiol"},{"key":"pcbi.1008235.ref018","article-title":"Sex-specific computational models for blood pressure regulation in the rat","author":"S Ahmed","year":"2019","journal-title":"Am J Physiol Renal Physiol"},{"issue":"6","key":"pcbi.1008235.ref019","doi-asserted-by":"crossref","first-page":"F1462","DOI":"10.1152\/ajprenal.00352.2019","article-title":"Functional implications of the sex differences in transporter abundance along the rat nephron: modeling and analysis","volume":"317","author":"R Hu","year":"2019","journal-title":"Am J Physiol Renal Physiol"},{"key":"pcbi.1008235.ref020","article-title":"Sex-Differences in Solute Transport Along the Nephrons: Effects of Na+ Transport Inhibition","author":"R Hu","year":"2020","journal-title":"American Journal of Physiology-Renal Physiology"},{"issue":"5","key":"pcbi.1008235.ref021","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1161\/01.HYP.1.5.468","article-title":"Pathophysiology of hypertension in blacks and whites. A review of the basis of racial blood pressure differences","volume":"1","author":"RF Gillum","year":"1979","journal-title":"Hypertension"},{"issue":"5","key":"pcbi.1008235.ref022","doi-asserted-by":"crossref","first-page":"F969","DOI":"10.1152\/ajprenal.00551.2017","article-title":"SGLT2 Inhibition in a Kidney with Reduced Nephron Number: Modeling and Analysis of Solute Transport and Metabolism","volume":"314","author":"AT Layton","year":"2018","journal-title":"Am J Physiol Renal Physiol"},{"issue":"4","key":"pcbi.1008235.ref023","doi-asserted-by":"crossref","first-page":"e13050","DOI":"10.1111\/apha.13050","article-title":"Cardiovascular benefits of SGLT2 inhibition in diabetes and chronic kidney diseases","volume":"222","author":"AT Layton","year":"2018","journal-title":"Acta Physiol (Oxf)"},{"issue":"47","key":"pcbi.1008235.ref024","doi-asserted-by":"crossref","first-page":"39353","DOI":"10.1074\/jbc.M508914200","article-title":"Angiotensin-converting enzyme 2 (ACE2), but not ACE, is preferentially localized to the apical surface of polarized kidney cells","volume":"280","author":"FJ Warner","year":"2005","journal-title":"J Biol Chem"},{"key":"pcbi.1008235.ref025","doi-asserted-by":"crossref","first-page":"0113","DOI":"10.1074\/jbc.M505111200","article-title":"Tumor Necrosis Factor- Convertase (ADAM17) Mediates Regulated Ectodomain Shedding of the Severe-acute Respiratory Syndrome-Coronavirus (SARS-CoV) Receptor, Angiotensin-converting Enzyme-2 (ACE2)","volume":"280","author":"W Lambert","year":"2005","journal-title":"Journal of Biological Chemistry"},{"issue":"1","key":"pcbi.1008235.ref026","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jtbi.2006.02.016","article-title":"A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation","volume":"242","author":"A Reynolds","year":"2006","journal-title":"J Theor Biol"},{"issue":"4","key":"pcbi.1008235.ref027","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(20)30113-4","article-title":"Viral load of SARS-CoV-2 in clinical samples","volume":"20","author":"Y Pan","year":"2020","journal-title":"Lancet Infect Dis"},{"issue":"1","key":"pcbi.1008235.ref028","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1159\/000329451","article-title":"Activation of the renin-angiotensin system in hyperoxia-induced lung fibrosis in neonatal rats","volume":"101","author":"JS Jiang","year":"2012","journal-title":"Neonatology"},{"issue":"11","key":"pcbi.1008235.ref029","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1164\/rccm.200811-1678OC","article-title":"Evidence for Angiotensin-converting Enzyme 2 as a Therapeutic Target for the Prevention of Pulmonary Hypertension","volume":"179","author":"AJ Ferreira","year":"2009","journal-title":"Am J Res Crit Care Med"},{"issue":"8","key":"pcbi.1008235.ref030","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1164\/rccm.200912-1840OC","article-title":"The angiotensin-converting enzyme 2\/angiogenesis-(1\u20137)\/Mas axis confers cardiopulmonary protection against lung fibrosis and pulmonary hypertension","volume":"182","author":"V. Shenoy","year":"2010","journal-title":"Am J Res Crit Care Med"},{"issue":"5","key":"pcbi.1008235.ref031","doi-asserted-by":"crossref","first-page":"L341","DOI":"10.1152\/ajplung.00360.2012","article-title":"Agonists of MAS oncogene and angiotensin II type 2 receptors attenuate cardiopulmonary disease in rats with neonatal hyperoxia-induced lung injury","volume":"305","author":"GT Wagenaar","year":"2013","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"5425","key":"pcbi.1008235.ref032","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.285.5425.248","article-title":"HMG-1 as a late mediator of endotoxin lethality in mice","volume":"285","author":"H Wang","year":"1999","journal-title":"Science"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1008235","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1008235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T17:44:08Z","timestamp":1669139048000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1008235"}},"subtitle":[],"editor":[{"given":"Daniel A.","family":"Beard","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2020,10,8]]},"references-count":32,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2020,10,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1008235","relation":{"new_version":[{"id-type":"doi","id":"10.1371\/journal.pcbi.1008235","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,8]]}}}