{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T08:18:36Z","timestamp":1775117916017,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1008322","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000}}],"reference-count":68,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009193","name":"Marsden Fund","doi-asserted-by":"crossref","award":["18-UOA-096"],"award-info":[{"award-number":["18-UOA-096"]}],"id":[{"id":"10.13039\/501100009193","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100009193","name":"Marsden Fund","doi-asserted-by":"crossref","award":["18-UOA-096"],"award-info":[{"award-number":["18-UOA-096"]}],"id":[{"id":"10.13039\/501100009193","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Relaxed clock models enable estimation of molecular substitution rates across lineages and are widely used in phylogenetics for dating evolutionary divergence times. Under the (uncorrelated) relaxed clock model, tree branches are associated with molecular substitution rates which are independently and identically distributed. In this article we delved into the internal complexities of the relaxed clock model in order to develop efficient MCMC operators for Bayesian phylogenetic inference. We compared three substitution rate parameterisations, introduced an adaptive operator which learns the weights of other operators during MCMC, and we explored how relaxed clock model estimation can benefit from two cutting-edge proposal kernels: the AVMVN and Bactrian kernels. This work has produced an operator scheme that is up to 65 times more efficient at exploring continuous relaxed clock parameters compared with previous setups, depending on the dataset. Finally, we explored variants of the standard narrow exchange operator which are specifically designed for the relaxed clock model. In the most extreme case, this new operator traversed tree space 40% more efficiently than narrow exchange. The methodologies introduced are adaptive and highly effective on short as well as long alignments. The results are available via the open source optimised relaxed clock (ORC) package for BEAST 2 under a GNU licence (\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/github.com\/jordandouglas\/ORC\" xlink:type=\"simple\">https:\/\/github.com\/jordandouglas\/ORC<\/jats:ext-link>\n                    ).\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1008322","type":"journal-article","created":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T15:53:39Z","timestamp":1612281219000},"page":"e1008322","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":183,"title":["Adaptive dating and fast proposals: Revisiting the phylogenetic relaxed clock model"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0371-9961","authenticated-orcid":true,"given":"Jordan","family":"Douglas","sequence":"first","affiliation":[]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6765-3813","authenticated-orcid":true,"given":"Remco","family":"Bouckaert","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"pcbi.1008322.ref001","first-page":"189","article-title":"Molecular disease, evolution, and genetic heterogeneity","author":"E Zuckerkandl","year":"1962","journal-title":"Horizons in biochemistry"},{"issue":"1","key":"pcbi.1008322.ref002","doi-asserted-by":"crossref","first-page":"S201","DOI":"10.1007\/s00239-003-0028-x","article-title":"Local molecular clocks in three nuclear genes: divergence times for rodents and other mammals and incompatibility among fossil 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Green","year":"1995","journal-title":"Biometrika"},{"key":"pcbi.1008322.ref035"},{"issue":"466","key":"pcbi.1008322.ref036","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1198\/016214504000000458","article-title":"Parameterization and Bayesian modeling","volume":"99","author":"A Gelman","year":"2004","journal-title":"Journal of the American Statistical Association"},{"issue":"1","key":"pcbi.1008322.ref037","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1214\/aoap\/1034625254","article-title":"Weak convergence and optimal scaling of random walk Metropolis algorithms","volume":"7","author":"GO Roberts","year":"1997","journal-title":"The annals of applied probability"},{"key":"pcbi.1008322.ref038","volume-title":"Handbook of Markov Chain Monte Carlo","author":"JS Rosenthal","year":"2011"},{"issue":"1-2","key":"pcbi.1008322.ref039","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0025-5564(81)90043-2","article-title":"Comparison of phylogenetic 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MATLAB guide. SIAM; 2016."},{"issue":"402-410","key":"pcbi.1008322.ref045","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1098\/rstb.1925.0002","article-title":"II.\u2014A mathematical theory of evolution, based on the conclusions of Dr. JC Willis, FR S","volume":"213","author":"GU Yule","year":"1925","journal-title":"Philosophical transactions of the Royal Society of London Series B, containing papers of a biological character"},{"issue":"2","key":"pcbi.1008322.ref046","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/BF02101694","article-title":"Dating of the human-ape splitting by a molecular clock of mitochondrial DNA","volume":"22","author":"M Hasegawa","year":"1985","journal-title":"Journal of molecular evolution"},{"issue":"1","key":"pcbi.1008322.ref047","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/sysbio\/syr100","article-title":"BEAGLE: an application programming interface and high-performance computing library for statistical phylogenetics","volume":"61","author":"DL Ayres","year":"2012","journal-title":"Systematic biology"},{"issue":"4","key":"pcbi.1008322.ref048","first-page":"406","article-title":"The neighbor-joining method: a new method for reconstructing phylogenetic trees","volume":"4","author":"N Saitou","year":"1987","journal-title":"Molecular biology and evolution"},{"issue":"1881","key":"pcbi.1008322.ref049","doi-asserted-by":"crossref","first-page":"20181012","DOI":"10.1098\/rspb.2018.1012","article-title":"Phylogenomics resolves the deep phylogeny of seed plants and indicates partial convergent or homoplastic evolution between Gnetales and angiosperms","volume":"285","author":"JH Ran","year":"2018","journal-title":"Proceedings of the Royal Society B: Biological Sciences"},{"issue":"2","key":"pcbi.1008322.ref050","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.ympev.2012.07.020","article-title":"Molecular phylogenetics of squirrelfishes and soldierfishes (Teleostei: Beryciformes: Holocentridae): Reconciling more than 100 years of taxonomic confusion","volume":"65","author":"A Dornburg","year":"2012","journal-title":"Molecular Phylogenetics and Evolution"},{"issue":"6","key":"pcbi.1008322.ref051","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1080\/106351501753462803","article-title":"Exploring Data Interaction and Nucleotide Alignment in a Multiple Gene Analysis of Ips (Coleoptera: Scolytinae)","volume":"50","author":"AI Cognato","year":"2001","journal-title":"Systematic Biology"},{"issue":"2","key":"pcbi.1008322.ref052","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1093\/sysbio\/syr116","article-title":"Testing the Impact of Calibration on Molecular Divergence Times Using a Fossil-Rich Group: The Case of Nothofagus (Fagales)","volume":"61","author":"H Sauquet","year":"2011","journal-title":"Systematic Biology"},{"key":"pcbi.1008322.ref053","article-title":"Multi-locus phylogenetic analysis reveals the pattern and tempo of bony fish evolution","author":"RE Broughton","year":"2013","journal-title":"PLoS Currents"},{"issue":"8","key":"pcbi.1008322.ref054","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1111\/jeb.12176","article-title":"Convergent evolution of morphology and habitat use in the explosive Hawaiian fancy case caterpillar radiation","volume":"26","author":"AY Kawahara","year":"2013","journal-title":"Journal of Evolutionary Biology"},{"issue":"3","key":"pcbi.1008322.ref055","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1111\/syen.12013","article-title":"Phylogeny and systematics of the bee genus Osmia (Hymenoptera: Megachilidae) with emphasis on North American Melanosmia: subgenera, synonymies and nesting biology revisited","volume":"38","author":"MG Rightmyer","year":"2013","journal-title":"Systematic Entomology"},{"issue":"1","key":"pcbi.1008322.ref056","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms12709","article-title":"Tectonic collision and uplift of Wallacea triggered the global songbird radiation","volume":"7","author":"RG Moyle","year":"2016","journal-title":"Nature Communications"},{"key":"pcbi.1008322.ref057","unstructured":"Lanfear R. BenchmarkAlignments https:\/\/github.com\/roblanf\/BenchmarkAlignments. GitHub. 2019."},{"issue":"3","key":"pcbi.1008322.ref058","first-page":"772","article-title":"PartitionFinder 2: new methods for selecting partitioned models of evolution for molecular and morphological phylogenetic analyses","volume":"34","author":"R Lanfear","year":"2016","journal-title":"Molecular biology and evolution"},{"key":"pcbi.1008322.ref059","article-title":"UglyTrees: a browser-based multispecies coalescent tree visualiser","author":"J Douglas","year":"2020","journal-title":"Bioinformatics"},{"issue":"2","key":"pcbi.1008322.ref060","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2307\/3318737","article-title":"An adaptive Metropolis algorithm","volume":"7","author":"H Haario","year":"2001","journal-title":"Bernoulli"},{"issue":"5","key":"pcbi.1008322.ref061","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s11222-011-9269-5","article-title":"Robust adaptive Metropolis algorithm with coerced acceptance rate","volume":"22","author":"M Vihola","year":"2012","journal-title":"Statistics and Computing"},{"issue":"2","key":"pcbi.1008322.ref062","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1214\/18-EJS1418","article-title":"Adaptive MCMC for multiple changepoint analysis with applications to large datasets","volume":"12","author":"A Benson","year":"2018","journal-title":"Electronic Journal of Statistics"},{"issue":"2","key":"pcbi.1008322.ref063","doi-asserted-by":"crossref","first-page":"E67","DOI":"10.1190\/geo2019-0095.1","article-title":"Blocking borehole conductivity logs at the resolution of above-ground electromagnetic systems","volume":"85","author":"A Davis","year":"2020","journal-title":"Geophysics"},{"issue":"2","key":"pcbi.1008322.ref064","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1239\/jap\/1183667414","article-title":"Coupling and ergodicity of adaptive Markov chain Monte Carlo algorithms","volume":"44","author":"GO Roberts","year":"2007","journal-title":"Journal of applied probability"},{"key":"pcbi.1008322.ref065","doi-asserted-by":"crossref","unstructured":"Hohna S, Defoin-Platel M, Drummond AJ. Clock-constrained tree proposal operators in Bayesian phylogenetic inference. In: 2008 8th IEEE International Conference on BioInformatics and BioEngineering. IEEE; 2008. p. 1\u20137.","DOI":"10.1109\/BIBE.2008.4696663"},{"key":"pcbi.1008322.ref066","unstructured":"Simon D, Larget B. Bayesian analysis in molecular biology and evolution (BAMBE) http:\/\/www.mathcs.duq.edu\/larget\/bambe.html. Pittsburgh, Pennsylvania. 1998."},{"issue":"9","key":"pcbi.1008322.ref067","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1093\/oxfordjournals.molbev.a004221","article-title":"Bayesian phylogenetics using an RNA substitution model applied to early mammalian evolution","volume":"19","author":"H Jow","year":"2002","journal-title":"Molecular Biology and Evolution"},{"issue":"1","key":"pcbi.1008322.ref068","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1080\/10635150801886156","article-title":"Efficiency of Markov chain Monte Carlo tree proposals in Bayesian phylogenetics","volume":"57","author":"C Lakner","year":"2008","journal-title":"Systematic biology"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1008322","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1008322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T08:44:16Z","timestamp":1724402656000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1008322"}},"subtitle":[],"editor":[{"given":"Roger Dimitri","family":"Kouyos","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2021,2,2]]},"references-count":68,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2,2]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1008322","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.09.09.289124","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,2]]}}}