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Long-term potentiation (LTP) is a key mechanism of neuroplasticity and has been studied extensively, and invasively in non-human animals. Translation to human application largely relies on the validation of non-invasive measures of LTP. The current study presents a generative thalamocortical computational model of visual cortex for investigating and replicating interlaminar connectivity changes using non-invasive EEG recording of humans. The model is combined with a commonly used visual sensory LTP paradigm and fit to the empirical EEG data using dynamic causal modelling. The thalamocortical model demonstrated remarkable accuracy recapitulating post-tetanus changes seen in invasive research, including increased excitatory connectivity from thalamus to layer IV and from layer IV to II\/III, established major sites of LTP in visual cortex. These findings provide justification for the implementation of the presented thalamocortical model for ERP research, including to provide increased detail on the nature of changes that underlie LTP induced in visual cortex. Future applications include translating rodent findings to non-invasive research in humans concerning deficits to LTP that may underlie neurological and psychiatric disease.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1008414","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T13:27:42Z","timestamp":1611235662000},"page":"e1008414","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Modelling thalamocortical circuitry shows that visually induced LTP changes laminar connectivity in human visual cortex"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2652-4617","authenticated-orcid":true,"given":"Rachael L.","family":"Sumner","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7800-1586","authenticated-orcid":true,"given":"Meg J.","family":"Spriggs","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5741-7526","authenticated-orcid":true,"given":"Alexander D.","family":"Shaw","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2021,1,21]]},"reference":[{"issue":"2","key":"pcbi.1008414.ref001","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1113\/jphysiol.1973.sp010273","article-title":"Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path","volume":"232","author":"TVP Bliss","year":"1973","journal-title":"The Journal of Physiology"},{"issue":"6407","key":"pcbi.1008414.ref002","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","article-title":"A synaptic model of memory: long-term potentiation in the hippocampus","volume":"361","author":"TV Bliss","year":"1993","journal-title":"Nature"},{"issue":"48","key":"pcbi.1008414.ref003","doi-asserted-by":"crossref","first-page":"16304","DOI":"10.1523\/JNEUROSCI.4333-10.2010","article-title":"Visual experience induces long-term potentiation in the primary visual cortex","volume":"30","author":"SF Cooke","year":"2010","journal-title":"The Journal of Neuroscience"},{"key":"pcbi.1008414.ref004","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.neubiorev.2020.03.013","article-title":"The role of Hebbian learning in human perception: a methodological and theoretical review of the human Visual Long-Term Potentiation paradigm","volume":"115","author":"RL Sumner","year":"2020","journal-title":"Neuroscience and biobehavioral reviews"},{"issue":"24","key":"pcbi.1008414.ref005","doi-asserted-by":"crossref","first-page":"9801","DOI":"10.1523\/JNEUROSCI.21-24-09801.2001","article-title":"Long-term potentiation of thalamocortical transmission in the adult visual cortex in vivo","volume":"21","author":"AJ Heynen","year":"2001","journal-title":"The Journal of Neuroscience"},{"issue":"3","key":"pcbi.1008414.ref006","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1523\/JNEUROSCI.14-03-01634.1994","article-title":"Hebbian synapses in visual cortex","volume":"14","author":"A Kirkwood","year":"1994","journal-title":"Journal of Neuroscience"},{"issue":"22","key":"pcbi.1008414.ref007","doi-asserted-by":"crossref","first-page":"7575","DOI":"10.1523\/JNEUROSCI.0983-14.2014","article-title":"Associative Hebbian Synaptic Plasticity in Primate Visual Cortex","volume":"34","author":"S Huang","year":"2014","journal-title":"The Journal of Neuroscience"},{"issue":"7","key":"pcbi.1008414.ref008","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1111\/j.1460-9568.2005.04007.x","article-title":"Long-term potentiation of human visual evoked responses","volume":"21","author":"TJ Teyler","year":"2005","journal-title":"European Journal of Neuroscience"},{"issue":"6","key":"pcbi.1008414.ref009","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.biopsych.2011.08.021","article-title":"Translating long-term potentiation from animals to humans: a novel method for noninvasive assessment of cortical plasticity","volume":"71","author":"WC Clapp","year":"2012","journal-title":"Biological psychiatry"},{"issue":"5","key":"pcbi.1008414.ref010","first-page":"766","article-title":"Long-term potentiation (LTP) of human sensory-evoked potentials. 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