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Genetic regulatory and neural networks can be modelled by analogous formalism raising the important question of productive analogies in principles, processes and performance. We investigate the formation and persistence of various developmental memories of past phenotypes asking how the number of remembered past phenotypes scales with network size, to what extent memories stored form by Hebbian-like rules, and how robust these developmental \u201cdevo-engrams\u201d are against networks perturbations (graceful degradation). The analogy between neural and genetic regulatory networks is not superficial in that it allows knowledge transfer between fields that used to be developed separately from each other. Known examples of spectacular phenotypic radiations could partly be accounted for in such terms.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1008425","type":"journal-article","created":{"date-parts":[[2020,11,30]],"date-time":"2020-11-30T13:27:01Z","timestamp":1606742821000},"page":"e1008425","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Phenotypes to remember: Evolutionary developmental memory capacity and robustness"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6894-4652","authenticated-orcid":true,"given":"Andr\u00e1s","family":"Szil\u00e1gyi","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0521-3094","authenticated-orcid":true,"given":"P\u00e9ter","family":"Szab\u00f3","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6478-6570","authenticated-orcid":true,"given":"Mauro","family":"Santos","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5227-2997","authenticated-orcid":true,"given":"E\u00f6rs","family":"Szathm\u00e1ry","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2020,11,30]]},"reference":[{"key":"pcbi.1008425.ref001","first-page":"37","article-title":"The chemical basis of morphogenesis","volume":"237","author":"AM Turing","year":"1952","journal-title":"Philos Trans R Soc B"},{"issue":"3","key":"pcbi.1008425.ref002","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/0022-5193(69)90015-0","article-title":"Metabolic stability and epigenesis in randomly constructed genetic nets","volume":"22","author":"SA Kauffman","year":"1969","journal-title":"J Theor Biol"},{"issue":"1","key":"pcbi.1008425.ref003","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/0022-5193(73)90208-7","article-title":"The logical analysis of continuous, non-linear biochemical control networks","volume":"39","author":"L Glass","year":"1973","journal-title":"J Theor Biol"},{"key":"pcbi.1008425.ref004","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1046\/j.1525-142x.2001.003002084.x","article-title":"Phenotypic and dynamical transitions in model genetic networks I. 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