{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:14:50Z","timestamp":1772172890324,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1008467","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000}}],"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T00:00:00Z","timestamp":1609113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62003230"],"award-info":[{"award-number":["62003230"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010822","name":"Chengdu Science and Technology Bureau","doi-asserted-by":"publisher","award":["2020-YF05-00073-SN"],"award-info":[{"award-number":["2020-YF05-00073-SN"]}],"id":[{"id":"10.13039\/501100010822","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["1082204112289"],"award-info":[{"award-number":["1082204112289"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2020YFS0009"],"award-info":[{"award-number":["2020YFS0009"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Funds for Prevention and Control of COVID-19 of Sichuan University","award":["0082604151026"],"award-info":[{"award-number":["0082604151026"]}]},{"DOI":"10.13039\/501100014219","name":"National Science Fund for Distinguished Young Scholars","doi-asserted-by":"crossref","award":["81525023"],"award-info":[{"award-number":["81525023"]}],"id":[{"id":"10.13039\/501100014219","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Science and Technology Major Project of China (","award":["2018ZX10713001-007,2017ZX10103009-005,2018ZX10201001-010"],"award-info":[{"award-number":["2018ZX10713001-007,2017ZX10103009-005,2018ZX10201001-010"]}]},{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2020YFS0007"],"award-info":[{"award-number":["2020YFS0007"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11975071, 61673085"],"award-info":[{"award-number":["11975071, 61673085"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    In January 2020, a COVID-19 outbreak was detected in Sichuan Province of China. Six weeks later, the outbreak was successfully contained. The aim of this work is to characterize the epidemiology of the Sichuan outbreak and estimate the impact of interventions in limiting SARS-CoV-2 transmission. We analyzed patient records for all laboratory-confirmed cases reported in the province for the period of January 21 to March 16, 2020. To estimate the basic and daily reproduction numbers, we used a Bayesian framework. In addition, we estimated the number of cases averted by the implemented control strategies. The outbreak resulted in 539 confirmed cases, lasted less than two months, and no further local transmission was detected after February 27. The median age of local cases was 8 years older than that of imported cases. We estimated R\n                    <jats:sub>0<\/jats:sub>\n                    at 2.4 (95% CI: 1.6\u20133.7). The epidemic was self-sustained for about 3 weeks before going below the epidemic threshold 3 days after the declaration of a public health emergency by Sichuan authorities. Our findings indicate that, were the control measures be adopted four weeks later, the epidemic could have lasted 49 days longer (95% CI: 31\u201368 days), causing 9,216 more cases (95% CI: 1,317\u201325,545).\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1008467","type":"journal-article","created":{"date-parts":[[2020,12,28]],"date-time":"2020-12-28T15:37:31Z","timestamp":1609169851000},"page":"e1008467","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["The COVID-19 outbreak in Sichuan, China: Epidemiology and impact of interventions"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6642-6854","authenticated-orcid":true,"given":"Quan-Hui","family":"Liu","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7728-007X","authenticated-orcid":true,"given":"Ana I.","family":"Bento","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1136-6801","authenticated-orcid":true,"given":"Kexin","family":"Yang","sequence":"additional","affiliation":[]},{"given":"Hang","family":"Zhang","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5965-1743","authenticated-orcid":true,"given":"Xiaohan","family":"Yang","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5117-0611","authenticated-orcid":true,"given":"Stefano","family":"Merler","sequence":"additional","affiliation":[]},{"given":"Alessandro","family":"Vespignani","sequence":"additional","affiliation":[]},{"given":"Jiancheng","family":"Lv","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6335-5648","authenticated-orcid":true,"given":"Hongjie","family":"Yu","sequence":"additional","affiliation":[]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0561-2316","authenticated-orcid":true,"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1753-4749","authenticated-orcid":true,"given":"Marco","family":"Ajelli","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2020,12,28]]},"reference":[{"issue":"6491","key":"pcbi.1008467.ref001","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1126\/science.abb6105","article-title":"An investigation of transmission control measures during the first 50 days of the COVID-19 epidemic in China","volume":"368","author":"H Tian","year":"2020","journal-title":"Science"},{"key":"pcbi.1008467.ref002","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41586-020-2405-7","article-title":"Estimating the effects of non-pharmaceutical interventions on COVID-19 in Europe","volume":"584","author":"S Flaxman","year":"2020","journal-title":"Nature"},{"issue":"6","key":"pcbi.1008467.ref003","first-page":"83","article-title":"Epidemic Update and Risk Assessment of 2019 Novel Coronavirus-China","volume":"2","author":"W Tu","year":"2020","journal-title":"China CDC Weekly"},{"key":"pcbi.1008467.ref004","author":"Health Commission of Sichuan Province","year":"2020","journal-title":"Notice of the first imported novel coronavirus case confirmed by the national health and Health Commission in January 21st"},{"key":"pcbi.1008467.ref005","author":"Health Commission of Sichuan Province","year":"2020","journal-title":"Update on novel coronavirus pneumonia in Sichuan province (released in June 2nd)"},{"issue":"9","key":"pcbi.1008467.ref006","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1093\/aje\/kwt133","article-title":"A new framework and software to estimate time-varying reproduction numbers during epidemics","volume":"178","author":"A Cori","year":"2013","journal-title":"Am. 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