{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:12:24Z","timestamp":1772172744799,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1008503","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,1,5]],"date-time":"2021-01-05T00:00:00Z","timestamp":1609804800000}}],"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T00:00:00Z","timestamp":1608508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    In this work, we introduce new phenomenological neuronal models (\n                    <jats:italic>e<\/jats:italic>\n                    LIF and mAdExp) that account for energy supply and demand in the cell as well as the inactivation of spike generation how these interact with subthreshold and spiking dynamics. Including these constraints, the new models reproduce a broad range of biologically-relevant behaviors that are identified to be crucial in many neurological disorders, but were not captured by commonly used phenomenological models. Because of their low dimensionality\n                    <jats:italic>e<\/jats:italic>\n                    LIF and mAdExp open the possibility of future large-scale simulations for more realistic studies of brain circuits involved in neuronal disorders. The new models enable both more accurate modeling and the possibility to study energy-associated disorders over the whole time-course of disease progression instead of only comparing the initially healthy status with the final diseased state. These models, therefore, provide new theoretical and computational methods to assess the opportunities of early diagnostics and the potential of energy-centered approaches to improve therapies.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1008503","type":"journal-article","created":{"date-parts":[[2020,12,21]],"date-time":"2020-12-21T14:40:02Z","timestamp":1608561602000},"page":"e1008503","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Simple models including energy and spike constraints reproduce complex activity patterns and metabolic disruptions"],"prefix":"10.1371","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8753-7246","authenticated-orcid":true,"given":"Tanguy","family":"Fardet","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1355-6617","authenticated-orcid":true,"given":"Anna","family":"Levina","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2020,12,21]]},"reference":[{"issue":"1","key":"pcbi.1008503.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.physiol.64.081501.130716","article-title":"A Hundred Years of Sodium Pumping","volume":"64","author":"IM Glynn","year":"2002","journal-title":"Annual Review of Physiology"},{"issue":"7","key":"pcbi.1008503.ref002","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/jcbfm.2012.35","article-title":"Updated Energy Budgets for Neural Computation in the Neocortex and Cerebellum","volume":"32","author":"C Howarth","year":"2012","journal-title":"Journal of Cerebral Blood Flow & Metabolism"},{"issue":"2","key":"pcbi.1008503.ref003","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/0014-5793(90)81278-V","article-title":"The energy coupled exchange of Na+ for K+ across the cell membrane: The Na+, K+ -pump","volume":"268","author":"JC Skou","year":"1990","journal-title":"FEBS Letters"},{"key":"pcbi.1008503.ref004","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2014.00472","article-title":"The Sodium-Potassium Pump Is an Information Processing Element in Brain Computation","volume":"5","author":"MD Forrest","year":"2014","journal-title":"Frontiers in Physiology"},{"issue":"2","key":"pcbi.1008503.ref005","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/ejn.12042","article-title":"Sodium and Calcium Mechanisms of Rhythmic Bursting in Excitatory Neural Networks of the Pre-B\u00f6tzinger Complex: A Computational Modelling Study","volume":"37","author":"PE Jasinski","year":"2013","journal-title":"European Journal of Neuroscience"},{"issue":"9","key":"pcbi.1008503.ref006","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1152\/jn.00460.2014","article-title":"Electrogenic Properties of the Na+ \/K+ ATPase Control Transitions between Normal and Pathological Brain States","volume":"113","author":"GP Krishnan","year":"2015","journal-title":"Journal of Neurophysiology"},{"key":"pcbi.1008503.ref007","first-page":"24","article-title":"Analyzing and Modeling the Dysfunction of Inhibitory Neurons in Alzheimer\u2019s Disease","author":"C Perez","year":"2016","journal-title":"PLOS ONE"},{"key":"pcbi.1008503.ref008","doi-asserted-by":"crossref","DOI":"10.3389\/fncom.2013.00013","article-title":"The Energy Cost of Action Potential Propagation in Dopamine Neurons: Clues to Susceptibility in Parkinson\u2019s Disease","volume":"7","author":"EK Pissadaki","year":"2013","journal-title":"Frontiers in Computational Neuroscience"},{"issue":"35","key":"pcbi.1008503.ref009","doi-asserted-by":"crossref","first-page":"11733","DOI":"10.1523\/JNEUROSCI.0516-14.2014","article-title":"Unification of Neuronal Spikes, Seizures, and Spreading Depression","volume":"34","author":"Y Wei","year":"2014","journal-title":"Journal of Neuroscience"},{"issue":"5930","key":"pcbi.1008503.ref010","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/305147a0","article-title":"ATP-regulated K+ channels in cardiac muscle","volume":"305","author":"A Noma","year":"1983","journal-title":"Nature"},{"issue":"6","key":"pcbi.1008503.ref011","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1161\/01.RES.74.6.1071","article-title":"A dynamic model of the cardiac ventricular action potential. 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