{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:51:53Z","timestamp":1792788713053,"version":"4.5.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1008532","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000}}],"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T00:00:00Z","timestamp":1611878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1177824"],"award-info":[{"award-number":["OPP1177824"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1177824"],"award-info":[{"award-number":["OPP1177824"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1177824"],"award-info":[{"award-number":["OPP1177824"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1177824"],"award-info":[{"award-number":["OPP1177824"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1177824"],"award-info":[{"award-number":["OPP1177824"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NTD Modelling Consortium","award":["OPP1156227"],"award-info":[{"award-number":["OPP1156227"]}]},{"name":"NTD Modelling Consortium","award":["OPP1156227"],"award-info":[{"award-number":["OPP1156227"]}]},{"name":"NTD Modelling Consortium","award":["OPP1156227"],"award-info":[{"award-number":["OPP1156227"]}]},{"name":"NTD Modelling Consortium","award":["OPP1156227"],"award-info":[{"award-number":["OPP1156227"]}]},{"name":"NTD Modelling Consortium","award":["OPP1186851"],"award-info":[{"award-number":["OPP1186851"]}]},{"name":"NTD Modelling Consortium","award":["OPP1186851"],"award-info":[{"award-number":["OPP1186851"]}]},{"name":"NTD Modelling Consortium","award":["OPP1186851"],"award-info":[{"award-number":["OPP1186851"]}]},{"name":"NTD Modelling Consortium","award":["OPP1186851"],"award-info":[{"award-number":["OPP1186851"]}]},{"name":"NTD Modelling Consortium","award":["OPP1184344"],"award-info":[{"award-number":["OPP1184344"]}]},{"name":"NTD Modelling Consortium","award":["OPP1184344"],"award-info":[{"award-number":["OPP1184344"]}]},{"name":"NTD Modelling Consortium","award":["OPP1184344"],"award-info":[{"award-number":["OPP1184344"]}]},{"name":"NTD Modelling Consortium","award":["OPP1184344"],"award-info":[{"award-number":["OPP1184344"]}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    <jats:italic>Gambiense<\/jats:italic>\n                    human African trypanosomiasis (gHAT) is a virulent disease declining in burden but still endemic in West and Central Africa. Although it is targeted for elimination of transmission by 2030, there remain numerous questions about the drivers of infection and how these vary geographically.\n                  <\/jats:p>\n                  <jats:p>In this study we focus on the Democratic Republic of Congo (DRC), which accounted for 84% of the global case burden in 2016, to explore changes in transmission across the country and elucidate factors which may have contributed to the persistence of disease or success of interventions in different regions. We present a Bayesian fitting methodology, applied to 168 endemic health zones (\u223c100,000 population size), which allows for calibration of a mechanistic gHAT model to case data (from the World Health Organization HAT Atlas) in an adaptive and automated framework.<\/jats:p>\n                  <jats:p>It was found that the model needed to capture improvements in passive detection to match observed trends in the data within former Bandundu and Bas Congo provinces indicating these regions have substantially reduced time to detection. Health zones in these provinces generally had longer burn-in periods during fitting due to additional model parameters.<\/jats:p>\n                  <jats:p>\n                    Posterior probability distributions were found for a range of fitted parameters in each health zone; these included the basic reproduction number estimates for pre-1998 (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sub>0<\/jats:sub>\n                    ) which was inferred to be between 1 and 1.14, in line with previous gHAT estimates, with higher median values typically in health zones with more case reporting in the 2000s.\n                  <\/jats:p>\n                  <jats:p>Previously, it was not clear whether a fall in active case finding in the period contributed to the declining case numbers. The modelling here accounts for variable screening and suggests that underlying transmission has also reduced greatly\u2014on average 96% in former Equateur, 93% in former Bas Congo and 89% in former Bandundu\u2014Equateur and Bandundu having had the highest case burdens in 2000. This analysis also sets out a framework to enable future predictions for the country.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1008532","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T13:45:38Z","timestamp":1611927938000},"page":"e1008532","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Quantifying epidemiological drivers of gambiense human African Trypanosomiasis across the Democratic Republic of Congo"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9884-4900","authenticated-orcid":true,"given":"Ronald E.","family":"Crump","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-I","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1135-9652","authenticated-orcid":true,"given":"Edward S.","family":"Knock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8375-5542","authenticated-orcid":true,"given":"Simon E. F.","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8764-4583","authenticated-orcid":true,"given":"Paul E.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erick","family":"Mwamba Miaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chansy","family":"Shampa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4639-4765","authenticated-orcid":true,"given":"Matt J.","family":"Keeling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8414-7648","authenticated-orcid":true,"given":"Kat S.","family":"Rock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2021,1,29]]},"reference":[{"issue":"12","key":"pcbi.1008532.ref001","doi-asserted-by":"crossref","first-page":"e0006890","DOI":"10.1371\/journal.pntd.0006890","article-title":"Monitoring the elimination of human African trypanosomiasis: Update to 2016","volume":"12","author":"JR Franco","year":"2018","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"pcbi.1008532.ref002","unstructured":"World Health Organization. WHO interim guidelines for the treatment of gambiense human African trypanosomiasis; 2019."},{"issue":"1","key":"pcbi.1008532.ref003","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1476-072X-13-4","article-title":"Mapping the capacities of fixed health facilities to cover people at risk of gambiense human African trypanosomiasis","volume":"13","author":"PP Simarro","year":"2014","journal-title":"International Journal of Health Geographics"},{"issue":"5","key":"pcbi.1008532.ref004","doi-asserted-by":"crossref","first-page":"e0008261","DOI":"10.1371\/journal.pntd.0008261","article-title":"Monitoring the elimination of human African trypanosomiasis at continental and country level: Update to 2018","volume":"14","author":"JR Franco","year":"2020","journal-title":"PLOS Neglected Tropical Diseases"},{"issue":"10","key":"pcbi.1008532.ref005","doi-asserted-by":"crossref","first-page":"e0007838","DOI":"10.1371\/journal.pntd.0007838","article-title":"Village-scale persistence and elimination of gambiense human African trypanosomiasis","volume":"13","author":"CN Davis","year":"2019","journal-title":"PLOS Neglected Tropical Diseases"},{"issue":"1","key":"pcbi.1008532.ref006","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/s13071-015-1131-8","article-title":"Quantitative evaluation of the strategy to eliminate human African trypanosomiasis in the Democratic Republic of Congo","volume":"8","author":"KS Rock","year":"2015","journal-title":"Parasites & Vectors"},{"issue":"7","key":"pcbi.1008532.ref007","doi-asserted-by":"crossref","first-page":"e0005792","DOI":"10.1371\/journal.pntd.0005792","article-title":"Adding tsetse control to medical activities contributes to decreasing transmission of sleeping sickness in the Mandoul focus (Chad)","volume":"11","author":"MH Mahamat","year":"2017","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"pcbi.1008532.ref008","doi-asserted-by":"crossref","unstructured":"Huang CI, Crump RE, Brown P, Spencer SEF, Mwamba Miaka E, Shampa C, et al. Shrinking the gHAT map: identifying target regions for enhanced control of gambiense human African trypanosomiasis in the Democratic Republic of Congo. medRxiv [Preprint]. 2020;","DOI":"10.1101\/2020.07.03.20145847"},{"key":"pcbi.1008532.ref009","doi-asserted-by":"crossref","unstructured":"Antillon M, Huang CI, Crump RE, Brown PE, Snijders R, Miaka EM, et al. Economic evaluation of gambiense human African trypanosomiasis elimination campaigns in five distinct transmission settings in the Democratic Republic of Congo. medRxiv [Preprint]. 2020;","DOI":"10.2139\/ssrn.3684430"},{"key":"pcbi.1008532.ref010","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1476-072X-9-57","article-title":"The Atlas of human African trypanosomiasis: a contribution to global mapping of neglected tropical diseases","volume":"9","author":"PP Simarro","year":"2010","journal-title":"International Journal of Health Geographics"},{"issue":"6","key":"pcbi.1008532.ref011","doi-asserted-by":"crossref","first-page":"e0003785","DOI":"10.1371\/journal.pntd.0003785","article-title":"Monitoring the progress towards the elimination of gambiense human African trypanosomiasis","volume":"9","author":"PP Simarro","year":"2015","journal-title":"PLoS Neglected Tropical Diseases"},{"issue":"7","key":"pcbi.1008532.ref012","doi-asserted-by":"crossref","first-page":"e1233","DOI":"10.1371\/journal.pntd.0001233","article-title":"Accuracy of Five Algorithms to Diagnose Gambiense Human African Trypanosomiasis","volume":"5","author":"F Checchi","year":"2011","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"pcbi.1008532.ref013","doi-asserted-by":"crossref","first-page":"e0005162","DOI":"10.1371\/journal.pntd.0005162","article-title":"Predicting the impact of intervention strategies for sleeping sickness in two high-endemicity health zones of the Democratic Republic of Congo","volume":"11","author":"KS Rock","year":"2017","journal-title":"PLoS Neglected Tropical Diseases"},{"key":"pcbi.1008532.ref014","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.epidem.2017.01.006","article-title":"Data-driven models to predict the elimination of sleeping sickness in former Equateur province of DRC","volume":"18","author":"KS Rock","year":"2017","journal-title":"Epidemics"},{"issue":"suppl. 4","key":"pcbi.1008532.ref015","doi-asserted-by":"crossref","first-page":"S286","DOI":"10.1093\/cid\/ciy018","article-title":"Assessing Strategies Against Gambiense Sleeping Sickness Through Mathematical Modeling","volume":"66","author":"KS Rock","year":"2018","journal-title":"Clinical Infectious Diseases"},{"issue":"1","key":"pcbi.1008532.ref016","doi-asserted-by":"crossref","first-page":"e0007976","DOI":"10.1371\/journal.pntd.0007976","article-title":"Assessing the impact of aggregating disease stage data in model predictions of human African trypanosomiasis transmission and control activities in Bandundu province (DRC)","volume":"14","author":"MS Casta\u00f1o","year":"2020","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"pcbi.1008532.ref017","unstructured":"United Nations Office for the Coordination of Humanitarian Affairs. Journees Nationales de Vaccination (JNV) activities de vaccination supplementaire, RDC; Accessed May 2016. Available from: https:\/\/data.humdata.org\/dataset\/rdc-statistiques-des-populations."},{"key":"pcbi.1008532.ref018","unstructured":"The World Bank. Data:Democratic Republic of Congo; Accessed 2015. Available from: https:\/\/data.worldbank.org\/country\/congo-dem-rep?view=chart."},{"key":"pcbi.1008532.ref019","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1017\/S0031182000066853","article-title":"A general model for the African trypanosomiases","volume":"97","author":"DJ Rogers","year":"1988","journal-title":"Parasitology"},{"issue":"12","key":"pcbi.1008532.ref020","doi-asserted-by":"crossref","first-page":"e303","DOI":"10.1371\/journal.pntd.0000303","article-title":"The natural progression of Gambiense sleeping sickness: What is the evidence?","volume":"2","author":"F Checchi","year":"2008","journal-title":"PLoS Neglected Tropical Diseases"},{"issue":"1","key":"pcbi.1008532.ref021","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s13104-015-1244-3","article-title":"Updated estimate of the duration of the meningo-encephalitic stage in gambiense human African trypanosomiasis","volume":"8","author":"F Checchi","year":"2015","journal-title":"BMC Research Notes"},{"issue":"1","key":"pcbi.1008532.ref022","doi-asserted-by":"crossref","first-page":"e1467","DOI":"10.1371\/journal.pntd.0001467","article-title":"Should I Get Screened for Sleeping Sickness? A Qualitative Study in Kasai Province, Democratic Republic of Congo","volume":"6","author":"A Mpanya","year":"2012","journal-title":"PLoS Neglected Tropical Diseases"},{"issue":"04","key":"pcbi.1008532.ref023","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1017\/S0031182010001496","article-title":"A global sensitivity analysis for African sleeping sickness","volume":"138","author":"S Davis","year":"2010","journal-title":"Parasitology"},{"issue":"2","key":"pcbi.1008532.ref024","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0001-706X(03)00191-8","article-title":"Monitoring the developmental status of Trypanosoma brucei gambiense in the tsetse fly by means of PCR analysis of anal and saliva drops","volume":"88","author":"S Ravel","year":"2003","journal-title":"Acta Tropica"},{"key":"pcbi.1008532.ref025","unstructured":"WHO. Control and surveillance of human African trypanosomiasis; 2013. 984."},{"issue":"2","key":"pcbi.1008532.ref026","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1046\/j.1365-2915.1998.00097.x","article-title":"Host preferences of tsetse (Diptera: Glossinidae) based on bloodmeal identifications","volume":"12","author":"PH Clausen","year":"1998","journal-title":"Medical and Veterinary Entomology"},{"key":"pcbi.1008532.ref027","doi-asserted-by":"crossref","unstructured":"Tirados I, Stanton MC, Selby R, Mpembele F, Miaka EM, Boelaert M, et al. Impact of Tiny Targets on Glossina fuscipes quanzensis, the primary vector of Human African Trypanosomiasis in the Democratic Republic of the Congo. bioRxiv [Preprint]. 2020;","DOI":"10.1101\/2020.04.07.029587"},{"issue":"1","key":"pcbi.1008532.ref028","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s12942-015-0013-9","article-title":"Human African trypanosomiasis in the Democratic Republic of the Congo: disease distribution and risk","volume":"14","author":"C Lumbala","year":"2015","journal-title":"International journal of health geographics"},{"key":"pcbi.1008532.ref029","unstructured":"FIND. Project Update: Kongo Central Driving elimination of human African trypanosomiasis in a challenging transboundary region; 2016. 984. Available from: https:\/\/www.finddx.org\/wp-content\/uploads\/2016\/03\/HAT-KongoCentral-Eng-Jan2016.pdf."},{"issue":"8","key":"pcbi.1008532.ref030","doi-asserted-by":"crossref","first-page":"e0003822","DOI":"10.1371\/journal.pntd.0003822","article-title":"Tsetse Control and Gambian Sleeping Sickness; Implications for Control Strategy","volume":"9","author":"I Tirados","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"pcbi.1008532.ref031","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2307\/3318737","article-title":"An adaptive Metropolis algorithm","volume":"7","author":"H Haario","year":"2001","journal-title":"Bernoulli"},{"issue":"599-608","key":"pcbi.1008532.ref032","first-page":"42","article-title":"Efficient Metropolis jumping rules","volume":"5","author":"A Gelman","year":"1996","journal-title":"Bayesian Statistics"},{"issue":"4","key":"pcbi.1008532.ref033","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1214\/ss\/1177011136","article-title":"Inference from iterative simulation using multiple sequences","volume":"7","author":"A Gelman","year":"1992","journal-title":"Statistical Science"},{"issue":"1","key":"pcbi.1008532.ref034","first-page":"7","article-title":"CODA: Convergence Diagnosis and Output Analysis for MCMC","volume":"6","author":"M Plummer","year":"2006","journal-title":"R News"},{"issue":"8","key":"pcbi.1008532.ref035","doi-asserted-by":"crossref","first-page":"e0003727","DOI":"10.1371\/journal.pntd.0003727","article-title":"Reducing Human-Tsetse Contact Significantly Enhances the Efficacy of Sleeping Sickness Active Screening Campaigns: A Promising Result in the Context of Elimination","volume":"9","author":"F Courtin","year":"2015","journal-title":"PLOS Neglected Tropical Diseases"},{"issue":"9394","key":"pcbi.1008532.ref036","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1016\/S0140-6736(03)14694-6","article-title":"The trypanosomiases","volume":"362","author":"MP Barrett","year":"2003","journal-title":"The Lancet"},{"issue":"3","key":"pcbi.1008532.ref037","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.pt.2017.11.008","article-title":"Do Cryptic Reservoirs Threaten Gambiense-Sleeping Sickness Elimination?","volume":"34","author":"P B\u00fcscher","year":"2018","journal-title":"Trends in Parasitology"},{"issue":"1553","key":"pcbi.1008532.ref038","article-title":"Insights from quantitative and mathematical modelling on the proposed 2030 goal for gambiense human African trypanosomiasis (gHAT) [version 2; peer review: 2 approved]","volume":"3","author":"NTD Modelling Consortium Discussion Group on Gambiense Human African Trypanosomiasis","year":"2020","journal-title":"Gates Open Res"},{"key":"pcbi.1008532.ref039","volume-title":"Environmental change and the autonomous control of tsetse and trypanosomosis in sub-Saharan Africa: Case histories from Ethiopia, The Gambia, Kenya, Nigeria and Zimbabwe","author":"D Bourn","year":"2001"},{"issue":"3","key":"pcbi.1008532.ref040","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.pt.2015.11.008","article-title":"Beyond tsetse\u2014implications for research and control of human African trypanosomiasis epidemics","volume":"32","author":"SC Welburn","year":"2016","journal-title":"Trends in Parasitology"},{"issue":"11","key":"pcbi.1008532.ref041","doi-asserted-by":"crossref","first-page":"e0006060","DOI":"10.1371\/journal.pntd.0006060","article-title":"Impact of the Ebola outbreak on Trypanosoma brucei gambiense infection medical activities in coastal Guinea, 2014-2015: A retrospective analysis from the Guinean national Human African Trypanosomiasis control program","volume":"11","author":"M Camara","year":"2017","journal-title":"PLOS Neglected Tropical Diseases"},{"key":"pcbi.1008532.ref042","doi-asserted-by":"crossref","unstructured":"Kagabadouno M, Camara O, Camara M, Ilboudo H, Camara M, Rayaisse JB, et al. Ebola outbreak brings to light an unforeseen impact of tsetse control on sleeping sickness transmission in Guinea. bioRxiv [Preprint]. 2018;","DOI":"10.1101\/202762"},{"issue":"4","key":"pcbi.1008532.ref043","doi-asserted-by":"crossref","first-page":"0008033","DOI":"10.1371\/journal.pntd.0008033","article-title":"Modelling for policy: The five principles of the Neglected Tropical Diseases Modelling Consortium","volume":"14","author":"M Behrend","year":"2020","journal-title":"PLOS Neglected Tropical Diseases"},{"issue":"1","key":"pcbi.1008532.ref044","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1016\/S2214-109X(16)30237-6","article-title":"Seeing beyond 2020: an economic evaluation of contemporary and emerging strategies for elimination of Trypanosoma brucei gambiense","volume":"5","author":"CS Sutherland","year":"2017","journal-title":"The Lancet Global Health"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1008532","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T00:00:00Z","timestamp":1613952000000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1008532","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,2,22]],"date-time":"2021-02-22T13:42:13Z","timestamp":1614001333000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1008532"}},"subtitle":[],"editor":[{"given":"Alex","family":"Perkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2021,1,29]]},"references-count":44,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1008532","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.06.23.20138065","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,29]]}}}