{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:13:19Z","timestamp":1772172799255,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1008575","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000}}],"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T00:00:00Z","timestamp":1625011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["NIH DC015137"],"award-info":[{"award-number":["NIH DC015137"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000147","name":"Division of Civil, Mechanical and Manufacturing Innovation","doi-asserted-by":"publisher","award":["NSF-CMMI-1435358"],"award-info":[{"award-number":["NSF-CMMI-1435358"]}],"id":[{"id":"10.13039\/100000147","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    The synchronization of different\n                    <jats:italic>\u03b3<\/jats:italic>\n                    -rhythms arising in different brain areas has been implicated in various cognitive functions. Here, we focus on the effect of the ubiquitous neuronal heterogeneity on the synchronization of ING (interneuronal network gamma) and PING (pyramidal-interneuronal network gamma) rhythms. The synchronization properties of rhythms depends on the response of their collective phase to external input. We therefore determine the macroscopic phase-response curve for finite-amplitude perturbations (fmPRC) of ING- and PING-rhythms in all-to-all coupled networks comprised of linear (IF) or quadratic (QIF) integrate-and-fire neurons. For the QIF networks we complement the direct simulations with the adjoint method to determine the infinitesimal macroscopic PRC (imPRC) within the exact mean-field theory. We show that the intrinsic neuronal heterogeneity can qualitatively modify the fmPRC and the imPRC. Both PRCs can be biphasic and change sign (type II), even though the phase-response curve for the individual neurons is strictly non-negative (type I). Thus, for ING rhythms, say, external inhibition to the inhibitory cells can, in fact, advance the collective oscillation of the network, even though the same inhibition would lead to a delay when applied to uncoupled neurons. This paradoxical advance arises when the external inhibition modifies the internal dynamics of the network by reducing the number of spikes of inhibitory neurons; the advance resulting from this disinhibition outweighs the immediate delay caused by the external inhibition. These results explain how intrinsic heterogeneity allows ING- and PING-rhythms to become synchronized with a periodic forcing or another rhythm for a wider range in the mismatch of their frequencies. Our results identify a potential function of neuronal heterogeneity in the synchronization of coupled\n                    <jats:italic>\u03b3<\/jats:italic>\n                    -rhythms, which may play a role in neural information transfer via communication through coherence.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1008575","type":"journal-article","created":{"date-parts":[[2021,6,30]],"date-time":"2021-06-30T13:52:15Z","timestamp":1625061135000},"page":"e1008575","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Paradoxical phase response of gamma rhythms facilitates their entrainment in heterogeneous networks"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6992-8323","authenticated-orcid":true,"given":"Xize","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6070-4742","authenticated-orcid":true,"given":"Hermann","family":"Riecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,6,30]]},"reference":[{"issue":"11","key":"pcbi.1008575.ref001","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1364\/OL.30.001339","article-title":"Self-organized coherence in fiber laser arrays","volume":"30","author":"H Bruesselbach","year":"2005","journal-title":"Optics Letters"},{"issue":"3","key":"pcbi.1008575.ref002","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1103\/PhysRevLett.76.404","article-title":"Synchronization Transitions in a Disordered Josephson Series Array","volume":"76","author":"K Wiesenfeld","year":"1996","journal-title":"Phys Rev Lett"},{"issue":"6","key":"pcbi.1008575.ref003","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0092-8674(00)80473-0","article-title":"Cellular Construction of a Circadian Clock: Period Determination in the Suprachiasmatic Nuclei","volume":"91","author":"C Liu","year":"1997","journal-title":"Cell"},{"issue":"1","key":"pcbi.1008575.ref004","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.ydbio.2019.06.024","article-title":"What are you synching about? 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