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Phenotypic plasticity between two morphological phenotypes, yeast and hyphae, is a key mechanism by which\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>albicans<\/jats:italic>\n                    can thrive in many microenvironments and cause disease in the host. Understanding the decision points and key driver genes controlling this important transition and how these genes respond to different environmental signals is critical to understanding how\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>albicans<\/jats:italic>\n                    causes infections in the host. Here we build and analyze a Boolean dynamical model of the\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>albicans<\/jats:italic>\n                    yeast to hyphal transition, integrating multiple environmental factors and regulatory mechanisms. We validate the model by a systematic comparison to prior experiments, which led to agreement in 17 out of 22 cases. The discrepancies motivate alternative hypotheses that are testable by follow-up experiments. Analysis of this model revealed two time-constrained windows of opportunity that must be met for the complete transition from the yeast to hyphal phenotype, as well as control strategies that can robustly prevent this transition. We experimentally validate two of these control predictions in\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>albicans<\/jats:italic>\n                    strains lacking the transcription factor\n                    <jats:italic>UME6<\/jats:italic>\n                    and the histone deacetylase\n                    <jats:italic>HDA1<\/jats:italic>\n                    , respectively. This model will serve as a strong base from which to develop a systems biology understanding of\n                    <jats:italic>C<\/jats:italic>\n                    .\n                    <jats:italic>albicans<\/jats:italic>\n                    morphogenesis.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1008690","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T13:43:19Z","timestamp":1617025399000},"page":"e1008690","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Mathematical modeling of the Candida albicans yeast to hyphal transition reveals novel control strategies"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0067-123X","authenticated-orcid":true,"given":"David J.","family":"Wooten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1092-0068","authenticated-orcid":true,"given":"Jorge G\u00f3mez Tejeda","family":"Za\u00f1udo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9710-5025","authenticated-orcid":true,"given":"David","family":"Murrugarra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0847-787X","authenticated-orcid":true,"given":"Austin M.","family":"Perry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7615-1417","authenticated-orcid":true,"given":"Anna","family":"Dongari-Bagtzoglou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9143-9451","authenticated-orcid":true,"given":"Reinhard","family":"Laubenbacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0799-6499","authenticated-orcid":true,"given":"Clarissa J.","family":"Nobile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9485-0828","authenticated-orcid":true,"given":"R\u00e9ka","family":"Albert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2021,3,29]]},"reference":[{"key":"pcbi.1008690.ref001","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1517\/14656566.3.8.1059","article-title":"Treatment of vaginal Candida infections","author":"JD Sobel","year":"2002","journal-title":"Expert Opinion on Pharmacotherapy"},{"key":"pcbi.1008690.ref002","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1128\/CMR.17.2.255-267.2004","article-title":"Candida infections of medical devices","volume":"17","author":"EM Kojic","year":"2004","journal-title":"Clin Microbiol 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