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Various early electrographic seizure patterns differing in frequency, amplitude, and waveform of the oscillations are observed. The pattern most common in the areas of seizure propagation is the so-called theta-alpha activity (TAA), whose defining features are oscillations in the\n                    <jats:italic>\u03b8<\/jats:italic>\n                    \u2212\n                    <jats:italic>\u03b1<\/jats:italic>\n                    range and gradually increasing amplitude. A deeper understanding of the mechanism underlying the generation of the TAA pattern is however lacking. In this work we evaluate the hypothesis that the TAA patterns are caused by seizures spreading across the cortex. To do so, we perform simulations of seizure dynamics on detailed patient-derived cortical surfaces using the spreading seizure model as well as reference models with one or two homogeneous sources. We then detect the occurrences of the TAA patterns both in the simulated stereo-electroencephalographic signals and in the signals of recorded epileptic seizures from a cohort of fifty patients, and we compare the features of the groups of detected TAA patterns to assess the plausibility of the different models. Our results show that spreading seizure hypothesis is qualitatively consistent with the evidence available in the seizure recordings, and it can explain the features of the detected TAA groups best among the examined models.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1008731","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T13:46:24Z","timestamp":1614347184000},"page":"e1008731","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Evidence for spreading seizure as a cause of theta-alpha activity electrographic pattern in stereo-EEG seizure recordings"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5006-9765","authenticated-orcid":true,"given":"Viktor","family":"Sip","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7962-2942","authenticated-orcid":true,"given":"Julia","family":"Scholly","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4435-2257","authenticated-orcid":true,"given":"Maxime","family":"Guye","sequence":"additional","affiliation":[]},{"given":"Fabrice","family":"Bartolomei","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8251-8860","authenticated-orcid":true,"given":"Viktor","family":"Jirsa","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"issue":"7","key":"pcbi.1008731.ref001","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1111\/epi.13791","article-title":"Defining epileptogenic networks: Contribution of SEEG and signal analysis","volume":"58","author":"F Bartolomei","year":"2017","journal-title":"Epilepsia"},{"issue":"4","key":"pcbi.1008731.ref002","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/s41593-018-0108-2","article-title":"Promises and limitations of human intracranial electroencephalography","volume":"21","author":"J Parvizi","year":"2018","journal-title":"Nature Neuroscience"},{"issue":"5","key":"pcbi.1008731.ref003","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/0013-4694(94)00286-T","article-title":"Power spectrum and intracranial EEG patterns at seizure onset in partial epilepsy","volume":"94","author":"G Alarcon","year":"1995","journal-title":"Electroencephalography and Clinical Neurophysiology"},{"issue":"4","key":"pcbi.1008731.ref004","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1111\/j.1528-1157.1998.tb01390.x","article-title":"Characterization and Comparison of Local Onset and Remote Propagated Electrographic Seizures Recorded with Intracranial Electrodes","volume":"39","author":"Y Schiller","year":"1998","journal-title":"Epilepsia"},{"issue":"6","key":"pcbi.1008731.ref005","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.clinph.2012.12.046","article-title":"Intracranial EEG seizure onset patterns in unilateral temporal lobe epilepsy and their relationship to other variables","volume":"124","author":"I Dole\u017ealov\u00e1","year":"2013","journal-title":"Clinical Neurophysiology"},{"issue":"1","key":"pcbi.1008731.ref006","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1093\/brain\/awt299","article-title":"Intracranial electroencephalographic seizure-onset patterns: effect of underlying pathology","volume":"137","author":"P Perucca","year":"2014","journal-title":"Brain"},{"issue":"10","key":"pcbi.1008731.ref007","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1111\/epi.13120","article-title":"Ictal onset on intracranial EEG: Do we know it when we see it? 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