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Neuroimaging studies have shown that the brain transits between different functionally segregated and integrated states, and neuromodulatory systems have been proposed as key to facilitate these transitions. Although whole-brain computational models have reproduced this neuromodulatory effect, the role of local inhibitory circuits and their cholinergic modulation has not been studied. In this article, we consider a Jansen &amp; Rit whole-brain model in a network interconnected using a human connectome, and study the influence of the cholinergic and noradrenergic neuromodulatory systems on the segregation\/integration balance. In our model, we introduce a local inhibitory feedback as a plausible biophysical mechanism that enables the integration of whole-brain activity, and that interacts with the other neuromodulatory influences to facilitate the transition between different functional segregation\/integration regimes in the brain.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1008737","type":"journal-article","created":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T15:44:10Z","timestamp":1613663050000},"page":"e1008737","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":31,"title":["Cholinergic neuromodulation of inhibitory interneurons facilitates functional integration in whole-brain 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