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The increase of the power of the slow-wave events, obtained by auditory sensory stimulation, positively correlates with memory consolidation performance. However, little is known about the experimental protocol maximizing this effect, which could be induced by the power of slow-oscillation, the number of sleep spindles, or the timing of both events\u2019 co-occurrence. Using a mean-field model of thalamocortical activity, we studied the effect of several stimulation protocols, varying the pulse shape, duration, amplitude, and frequency, as well as a target-phase using a closed-loop approach. We evaluated the effect of these parameters on slow-oscillations (SO) and sleep-spindles (SP), considering: (i) the power at the frequency bands of interest, (ii) the number of SO and SP, (iii) co-occurrences between SO and SP, and (iv) synchronization of SP with the up-peak of the SO. The first three targets are maximized using a decreasing ramp pulse with a pulse duration of 50 ms. Also, we observed a reduction in the number of SO when increasing the stimulus energy by rising its amplitude. To assess the target-phase parameter, we applied closed-loop stimulation at 0\u00b0, 45\u00b0, and 90\u00b0 of the phase of the narrow-band filtered ongoing activity, at 0.85 Hz as central frequency. The 0\u00b0 stimulation produces better results in the power and number of SO and SP than the rhythmic or random stimulation. On the other hand, stimulating at 45\u00b0 or 90\u00b0 change the timing distribution of spindles centers but with fewer co-occurrences than rhythmic and 0\u00b0 phase. Finally, we propose the application of closed-loop stimulation at the rising zero-cross point using pulses with a decreasing ramp shape and 50 ms of duration for future experimental work.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1008758","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T14:27:06Z","timestamp":1627655226000},"page":"e1008758","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Selection of stimulus parameters for enhancing slow wave sleep events with a neural-field theory thalamocortical model"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6818-5254","authenticated-orcid":true,"given":"Felipe 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