{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T21:57:50Z","timestamp":1773439070289,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1008785","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000}}],"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"crossref","award":["TheraCoV ANR-20-COVI-0018"],"award-info":[{"award-number":["TheraCoV ANR-20-COVI-0018"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"crossref","award":["INV- 017335"],"award-info":[{"award-number":["INV- 017335"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Non-human primates infected with SARS-CoV-2 exhibit mild clinical signs. Here we used a mathematical model to characterize in detail the viral dynamics in 31 cynomolgus macaques for which nasopharyngeal and tracheal viral load were frequently assessed. We identified that infected cells had a large burst size (&gt;10<jats:sup>4<\/jats:sup> virus) and a within-host reproductive basic number of approximately 6 and 4 in nasopharyngeal and tracheal compartment, respectively. After peak viral load, infected cells were rapidly lost with a half-life of 9 hours, with no significant association between cytokine elevation and clearance, leading to a median time to viral clearance of 10 days, consistent with observations in mild human infections. Given these parameter estimates, we predict that a prophylactic treatment blocking 90% of viral production or viral infection could prevent viral growth. In conclusion, our results provide estimates of SARS-CoV-2 viral kinetic parameters in an experimental model of mild infection and they provide means to assess the efficacy of future antiviral treatments.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1008785","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T17:55:45Z","timestamp":1616003745000},"page":"e1008785","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":58,"title":["SARS-CoV-2 viral dynamics in non-human primates"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8759-2429","authenticated-orcid":true,"given":"Antonio","family":"Gon\u00e7alves","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0555-207X","authenticated-orcid":true,"given":"Pauline","family":"Maisonnasse","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2862-9751","authenticated-orcid":true,"given":"Flora","family":"Donati","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3826-8729","authenticated-orcid":true,"given":"M\u00e9lanie","family":"Albert","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1520-5020","authenticated-orcid":true,"given":"Sylvie","family":"Behillil","sequence":"additional","affiliation":[]},{"given":"Vanessa","family":"Contreras","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6261-6412","authenticated-orcid":true,"given":"Thibaut","family":"Naninck","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8932-0171","authenticated-orcid":true,"given":"Romain","family":"Marlin","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0943-9648","authenticated-orcid":true,"given":"Caroline","family":"Solas","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0918-6804","authenticated-orcid":true,"given":"Andres","family":"Pizzorno","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6239-0110","authenticated-orcid":true,"given":"Julien","family":"Lemaitre","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4784-0819","authenticated-orcid":true,"given":"Nidhal","family":"Kahlaoui","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9393-7684","authenticated-orcid":true,"given":"Olivier","family":"Terrier","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2322-3392","authenticated-orcid":true,"given":"Raphael","family":"Ho Tsong Fang","sequence":"additional","affiliation":[]},{"given":"Vincent","family":"Enouf","sequence":"additional","affiliation":[]},{"given":"Nathalie","family":"Dereuddre-Bosquet","sequence":"additional","affiliation":[]},{"given":"Angela","family":"Brisebarre","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4734-2249","authenticated-orcid":true,"given":"Franck","family":"Touret","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3210-8468","authenticated-orcid":true,"given":"Catherine","family":"Chapon","sequence":"additional","affiliation":[]},{"given":"Bruno","family":"Hoen","sequence":"additional","affiliation":[]},{"given":"Bruno","family":"Lina","sequence":"additional","affiliation":[]},{"given":"Manuel","family":"Rosa Calatrava","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7895-2720","authenticated-orcid":true,"given":"Xavier","family":"de Lamballerie","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-1275","authenticated-orcid":true,"given":"France","family":"Mentr\u00e9","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4928-4484","authenticated-orcid":true,"given":"Roger","family":"Le Grand","sequence":"additional","affiliation":[]},{"given":"Sylvie","family":"van der Werf","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-5482","authenticated-orcid":true,"given":"J\u00e9r\u00e9mie","family":"Guedj","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"pcbi.1008785.ref001","unstructured":"Weekly epidemiological update\u201422 December 2020. 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