{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T18:30:55Z","timestamp":1772303455557,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1008805","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T00:00:00Z","timestamp":1616976000000}}],"reference-count":124,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL151392"],"award-info":[{"award-number":["HL151392"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000038","name":"U.S. Food and Drug Administration","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000038","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CBER Coronavirus (COVID-19) Supplemental Funding"}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Thrombosis is a recognized complication of Coronavirus disease of 2019 (COVID-19) and is often associated with poor prognosis. There is a well-recognized link between coagulation and inflammation, however, the extent of thrombotic events associated with COVID-19 warrants further investigation. Poly(A) Binding Protein Cytoplasmic 4 (PABPC4), Serine\/Cysteine Proteinase Inhibitor Clade G Member 1 (SERPING1) and Vitamin K epOxide Reductase Complex subunit 1 (VKORC1), which are all proteins linked to coagulation, have been shown to interact with SARS proteins. We computationally examined the interaction of these with SARS-CoV-2 proteins and, in the case of VKORC1, we describe its binding to ORF7a in detail. We examined the occurrence of variants of each of these proteins across populations and interrogated their potential contribution to COVID-19 severity. Potential mechanisms, by which some of these variants may contribute to disease, are proposed. Some of these variants are prevalent in minority groups that are disproportionally affected by severe COVID-19. Therefore, we are proposing that further investigation around these variants may lead to better understanding of disease pathogenesis in minority groups and more informed therapeutic approaches.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1008805","type":"journal-article","created":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T17:55:19Z","timestamp":1616003719000},"page":"e1008805","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Gene variants of coagulation related proteins that interact with SARS-CoV-2"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4712-7952","authenticated-orcid":true,"given":"David","family":"Holcomb","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2511-8569","authenticated-orcid":true,"given":"Aikaterini","family":"Alexaki","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8307-4704","authenticated-orcid":true,"given":"Nancy","family":"Hernandez","sequence":"additional","affiliation":[]},{"given":"Ryan","family":"Hunt","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5596-6692","authenticated-orcid":true,"given":"Kyle","family":"Laurie","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1614-6915","authenticated-orcid":true,"given":"Jacob","family":"Kames","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4954-9435","authenticated-orcid":true,"given":"Nobuko","family":"Hamasaki-Katagiri","sequence":"additional","affiliation":[]},{"given":"Anton A.","family":"Komar","sequence":"additional","affiliation":[]},{"given":"Michael","family":"DiCuccio","sequence":"additional","affiliation":[]},{"given":"Chava","family":"Kimchi-Sarfaty","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"issue":"6","key":"pcbi.1008805.ref001","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/bjh.16749","article-title":"COVID-19 Coagulopathy in Caucasian patients","volume":"189","author":"H Fogarty","year":"2020","journal-title":"British Journal of Haematoloy"},{"issue":"7","key":"pcbi.1008805.ref002","doi-asserted-by":"crossref","first-page":"E437","DOI":"10.1016\/S2665-9913(20)30121-1","article-title":"Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia","volume":"2","author":"D McGonagle","year":"2020","journal-title":"The Lancet Rheumatology."},{"key":"pcbi.1008805.ref003","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1056\/NEJMoa2015432","article-title":"Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19.","volume":"383","author":"M Ackermann","year":"2020","journal-title":"New England Journal of Medicine."},{"issue":"5","key":"pcbi.1008805.ref004","article-title":"Venous Thrombosis Among Critically Ill Patients With Coronavirus Disease 2019 (COVID-19).","volume":"3","author":"J Nahum","year":"2020","journal-title":"Critical Care Medicine"},{"key":"pcbi.1008805.ref005","author":"UK Katneni","year":"2020","journal-title":"Coagulopathy and Thrombosis as a Result of Severe COVID-19 Infection: A Microvascular Focus"},{"issue":"23","key":"pcbi.1008805.ref006","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood.2020006000","article-title":"COVID-19 and its implications for thrombosis and anticoagulation","volume":"135","author":"J Connors","year":"2020","journal-title":"Blood"},{"issue":"6","key":"pcbi.1008805.ref007","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1111\/jth.14830","article-title":"Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia","volume":"18","author":"S Cui","year":"2020","journal-title":"Journal of Thrombosis and Haemostatis"},{"issue":"2","key":"pcbi.1008805.ref008","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.jvs.2020.04.488","article-title":"Choong AMTL. 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