{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T09:48:28Z","timestamp":1776246508862,"version":"3.50.1"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T00:00:00Z","timestamp":1617148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"TiFN","award":["TiFN 16NH04"],"award-info":[{"award-number":["TiFN 16NH04"]}]},{"name":"TiFN","award":["TiFN 16NH04"],"award-info":[{"award-number":["TiFN 16NH04"]}]},{"name":"NWO","award":["ALWTF.2016.021"],"award-info":[{"award-number":["ALWTF.2016.021"]}]},{"name":"NWO","award":["ALWTF.2016.021"],"award-info":[{"award-number":["ALWTF.2016.021"]}]},{"name":"TiFN","award":["TiFN 16NH04"],"award-info":[{"award-number":["TiFN 16NH04"]}]},{"name":"TiFN","award":["TiFN 16NH04"],"award-info":[{"award-number":["TiFN 16NH04"]}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>Plasma glucose and insulin responses following an oral glucose challenge are representative of glucose tolerance and insulin resistance, key indicators of type 2 diabetes mellitus pathophysiology. A large heterogeneity in individuals\u2019 challenge test responses has been shown to underlie the effectiveness of lifestyle intervention. Currently, this heterogeneity is overlooked due to a lack of methods to quantify the interconnected dynamics in the glucose and insulin time-courses. Here, a physiology-based mathematical model of the human glucose-insulin system is personalized to elucidate the heterogeneity in individuals\u2019 responses using a large population of overweight\/obese individuals (n = 738) from the DIOGenes study. The personalized models are derived from population level models through a systematic parameter selection pipeline that may be generalized to other biological systems. The resulting personalized models showed a 4-5 fold decrease in discrepancy between measurements and model simulation compared to population level. The estimated model parameters capture relevant features of individuals\u2019 metabolic health such as gastric emptying, endogenous insulin secretion and insulin dependent glucose disposal into tissues, with the latter also showing a significant association with the Insulinogenic index and the Matsuda insulin sensitivity index, respectively.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1008852","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T17:28:46Z","timestamp":1617211726000},"page":"e1008852","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Personalized computational model quantifies heterogeneity in postprandial responses to oral glucose challenge"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8643-4915","authenticated-orcid":true,"given":"Bal\u00e1zs","family":"Erd\u0151s","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2827-9889","authenticated-orcid":true,"given":"Bart","family":"van Sloun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4472-7119","authenticated-orcid":true,"given":"Michiel E.","family":"Adriaens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2253-4903","authenticated-orcid":true,"given":"Shauna D.","family":"O\u2019Donovan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Langin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8968-8996","authenticated-orcid":true,"given":"Arne","family":"Astrup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2496-3464","authenticated-orcid":true,"given":"Ellen E.","family":"Blaak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6462-6692","authenticated-orcid":true,"given":"Ilja C. 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