{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:39:52Z","timestamp":1767181192539,"version":"build-2238731810"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1009088","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T00:00:00Z","timestamp":1626912000000}}],"reference-count":74,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Max Planck Society"},{"name":"Max Planck Society"},{"name":"Center of Advanced European Studies and Research"},{"name":"Center of Advanced European Studies and Research"},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["SFB~1089"],"award-info":[{"award-number":["SFB~1089"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    During sleep, the brain undergoes dynamic and structural changes. In\n                    <jats:italic>Drosophila<\/jats:italic>\n                    , such changes have been observed in the central complex, a brain area important for sleep control and navigation. The connectivity of the central complex raises the question about how navigation, and specifically the head direction system, can operate in the face of sleep related plasticity. To address this question, we develop a model that integrates sleep homeostasis and head direction. We show that by introducing plasticity, the head direction system can function in a stable way by balancing plasticity in connected circuits that encode sleep pressure. With increasing sleep pressure, the head direction system nevertheless becomes unstable and a sleep phase with a different plasticity mechanism is introduced to reset network connectivity. The proposed integration of sleep homeostasis and head direction circuits captures features of their neural dynamics observed in flies and mice.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1009088","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T13:43:41Z","timestamp":1626097421000},"page":"e1009088","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Integration of sleep homeostasis and navigation in Drosophila"],"prefix":"10.1371","volume":"17","author":[{"given":"Andres","family":"Flores-Valle","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6987-4836","authenticated-orcid":true,"given":"Pedro J.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9048-2784","authenticated-orcid":true,"given":"Johannes D.","family":"Seelig","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"pcbi.1009088.ref001","first-page":"105","volume-title":"Progress in brain research","author":"WD Killgore","year":"2010"},{"issue":"7","key":"pcbi.1009088.ref002","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/nrn.2017.55","article-title":"The sleep-deprived human brain","volume":"18","author":"AJ Krause","year":"2017","journal-title":"Nature Reviews Neuroscience"},{"key":"pcbi.1009088.ref003","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.neubiorev.2016.07.004","article-title":"Sleep, sleep deprivation, autonomic nervous system and cardiovascular diseases","volume":"74","author":"E Tobaldini","year":"2017","journal-title":"Neuroscience & Biobehavioral Reviews"},{"key":"pcbi.1009088.ref004","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.nlm.2018.10.003","article-title":"Computational models of memory consolidation and long-term synaptic plasticity during sleep","volume":"160","author":"C Renn\u00f3-Costa","year":"2019","journal-title":"Neurobiology of learning and memory"},{"issue":"5922","key":"pcbi.1009088.ref005","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/304111a0","article-title":"The function of dream sleep","volume":"304","author":"F Crick","year":"1983","journal-title":"Nature"},{"issue":"5922","key":"pcbi.1009088.ref006","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/304158a0","article-title":"\u2018Unlearning\u2019has a stabilizing effect in collective memories","volume":"304","author":"JJ Hopfield","year":"1983","journal-title":"Nature"},{"key":"pcbi.1009088.ref007","unstructured":"Thiele J, Diehl P, Cook M. 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