{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T23:31:19Z","timestamp":1786491079683,"version":"3.56.0"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1009173","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000}}],"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T00:00:00Z","timestamp":1625529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008982","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CBET 1603627"],"award-info":[{"award-number":["CBET 1603627"]}],"id":[{"id":"10.13039\/501100008982","id-type":"DOI","asserted-by":"publisher"}]},{"name":"South Plains Foundation"},{"name":"texas tech university health sciences center department of cell biology and biochemistry"},{"DOI":"10.13039\/501100004087","name":"Shizuoka University","doi-asserted-by":"publisher","award":["Startup Fund"],"award-info":[{"award-number":["Startup Fund"]}],"id":[{"id":"10.13039\/501100004087","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007131","name":"Texas Tech University","doi-asserted-by":"publisher","award":["Doctoral Dissertation Completion Fellowship"],"award-info":[{"award-number":["Doctoral Dissertation Completion Fellowship"]}],"id":[{"id":"10.13039\/100007131","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Angelo State University","award":["Startup Fund"],"award-info":[{"award-number":["Startup Fund"]}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    Formation of the ventral furrow in the\n                    <jats:italic>Drosophila<\/jats:italic>\n                    embryo relies on the apical constriction of cells in the ventral region to produce bending forces that drive tissue invagination. In our recent paper we observed that apical constrictions during the initial phase of ventral furrow formation produce elongated patterns of cellular constriction chains prior to invagination and argued that these are indicative of tensile stress feedback. Here, we quantitatively analyze the constriction patterns preceding ventral furrow formation and find that they are consistent with the predictions of our active-granular-fluid model of a monolayer of mechanically coupled stress-sensitive constricting particles. Our model shows that tensile feedback causes constriction chains to develop along underlying precursor tensile stress chains that gradually strengthen with subsequent cellular constrictions. As seen in both our model and available optogenetic experiments, this mechanism allows constriction chains to penetrate or circumvent zones of reduced cell contractility, thus increasing the robustness of ventral furrow formation to spatial variation of cell contractility by rescuing cellular constrictions in the disrupted regions.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1009173","type":"journal-article","created":{"date-parts":[[2021,7,6]],"date-time":"2021-07-06T13:39:06Z","timestamp":1625578746000},"page":"e1009173","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Mechanical feedback and robustness of apical constrictions in Drosophila embryo ventral furrow formation"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8384-0368","authenticated-orcid":true,"given":"Michael 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