{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:16:17Z","timestamp":1772172977195,"version":"3.50.1"},"update-to":[{"DOI":"10.1371\/journal.pcbi.1009385","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000}}],"reference-count":54,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T00:00:00Z","timestamp":1635984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Australian National Health and Medical Research Council","award":["APP1145642"],"award-info":[{"award-number":["APP1145642"]}]},{"name":"SPHERE","award":["SPHERE III seed grant 2018"],"award-info":[{"award-number":["SPHERE III seed grant 2018"]}]}],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"short-container-title":["PLoS Comput Biol"],"abstract":"<jats:p>\n                    The ability to treat gonorrhoea with current first-line drugs is threatened by the global spread of extensively drug resistant (XDR)\n                    <jats:italic>Neisseria gonorrhoeae<\/jats:italic>\n                    (NG) strains. In Australia, urban transmission is high among men who have sex with men (MSM) and importation of an XDR NG strain in this population could result in an epidemic that would be difficult and costly to control. An individual-based, anatomical site-specific mathematical model of NG transmission among Australian MSM was developed and used to evaluate the potential for elimination of an imported NG strain under a range of case-based and population-based test-and-treat strategies. When initiated upon detection of the imported strain, these strategies enhance the probability of elimination and reduce the outbreak size compared with current practice (current testing levels and no contact tracing). The most effective strategies combine testing targeted at regular and casual partners with increased rates of population testing. However, even with the most effective strategies, outbreaks can persist for up to 2 years post-detection. Our simulations suggest that local elimination of imported NG strains can be achieved with high probability using combined case-based and population-based test-and-treat strategies. These strategies may be an effective means of preserving current treatments in the event of wider XDR NG emergence.\n                  <\/jats:p>","DOI":"10.1371\/journal.pcbi.1009385","type":"journal-article","created":{"date-parts":[[2021,11,4]],"date-time":"2021-11-04T13:48:27Z","timestamp":1636033707000},"page":"e1009385","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Modelling response strategies for controlling gonorrhoea outbreaks in men who have sex with men in Australia"],"prefix":"10.1371","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0764-1380","authenticated-orcid":true,"given":"Qibin","family":"Duan","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7234-381X","authenticated-orcid":true,"given":"Chris","family":"Carmody","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8851-4126","authenticated-orcid":true,"given":"Basil","family":"Donovan","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2929-4634","authenticated-orcid":true,"given":"Rebecca J.","family":"Guy","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6567-5821","authenticated-orcid":true,"given":"Ben B.","family":"Hui","sequence":"additional","affiliation":[]},{"given":"John M.","family":"Kaldor","sequence":"additional","affiliation":[]},{"given":"Monica M.","family":"Lahra","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3540-8837","authenticated-orcid":true,"given":"Matthew G.","family":"Law","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5534-8392","authenticated-orcid":true,"given":"David A.","family":"Lewis","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-0677","authenticated-orcid":true,"given":"Michael","family":"Maley","sequence":"additional","affiliation":[]},{"given":"Skye","family":"McGregor","sequence":"additional","affiliation":[]},{"given":"Anna","family":"McNulty","sequence":"additional","affiliation":[]},{"given":"Christine","family":"Selvey","sequence":"additional","affiliation":[]},{"given":"David J.","family":"Templeton","sequence":"additional","affiliation":[]},{"given":"David M.","family":"Whiley","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2893-0969","authenticated-orcid":true,"given":"David G.","family":"Regan","sequence":"additional","affiliation":[]},{"given":"James G.","family":"Wood","sequence":"additional","affiliation":[]}],"member":"340","published-online":{"date-parts":[[2021,11,4]]},"reference":[{"issue":"3","key":"pcbi.1009385.ref001","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1128\/CMR.00010-14","article-title":"Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future","volume":"27","author":"M Unemo","year":"2014","journal-title":"Clinical Microbiology Reviews."},{"key":"pcbi.1009385.ref002","unstructured":"Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the United States 2013. Available from: https:\/\/www.cdc.gov\/drugresistance\/threat-report-2013\/index.html."},{"key":"pcbi.1009385.ref003","unstructured":"World Health Organization. Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrhoeae 2013. Available from: http:\/\/www.who.int\/reproductivehealth\/publications\/rtis\/9789241503501\/en\/."},{"issue":"4","key":"pcbi.1009385.ref004","doi-asserted-by":"crossref","first-page":"735","DOI":"10.3201\/eid2404.171873","article-title":"Cooperative recognition of internationally disseminated ceftriaxone-resistant Neisseria gonorrhoeae strain","volume":"24","author":"MM Lahra","year":"2018","journal-title":"Emerging Infectious Diseases"},{"issue":"7","key":"pcbi.1009385.ref005","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S1473-3099(18)30340-2","article-title":"Genetic characterisation of Neiserria gonorrhoeae resistant to both ceftriaxone and azithromycin, Australia 2018","volume":"18","author":"DM Whiley","year":"2018","journal-title":"Lancet Infectious Diseases"},{"issue":"8","key":"pcbi.1009385.ref006","doi-asserted-by":"crossref","first-page":"1900118","DOI":"10.2807\/1560-7917.ES.2019.24.8.1900118","article-title":"Genetic relatedness of ceftriaxone-resistant and high-level azithromycin resistant Neisseria gonorrhoeae cases, United Kingdom and Australia, February to April 2018","volume":"24","author":"AV Jennison","year":"2019","journal-title":"Eurosurveillance"},{"issue":"10","key":"pcbi.1009385.ref007","article-title":"Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018","volume":"24","author":"DW Eyre","year":"2019","journal-title":"Euro Surveill."},{"issue":"21","key":"pcbi.1009385.ref008","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2018.23.21.1800264","article-title":"Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017","volume":"23","author":"T Poncin","year":"2018","journal-title":"Euro Surveill"},{"issue":"2","key":"pcbi.1009385.ref009","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.cmi.2019.08.004","article-title":"Gentamicin 240 mg plus azithromycin 2 g vs. ceftriaxone 500 mg plus azithromycin 2 g for treatment of rectal and pharyngeal gonorrhoea: a randomized controlled trial","volume":"26","author":"F Rob","year":"2020","journal-title":"Clin Microbiol Infect"},{"issue":"5","key":"pcbi.1009385.ref010","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1071\/SH19034","article-title":"New treatment options for Neisseria gonorrhoeae in the era of emerging antimicrobial resistance","volume":"16","author":"DA Lewis","year":"2019","journal-title":"Sexual Health"},{"issue":"5","key":"pcbi.1009385.ref011","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/OLQ.0000000000000971","article-title":"Efficacy and Safety of Single-Dose Oral Delafloxacin Compared With Intramuscular Ceftriaxone for Uncomplicated Gonorrhea Treatment: An Open-Label, Noninferiority, Phase 3, Multicenter, Randomized Study","volume":"46","author":"EW Hook","year":"2019","journal-title":"Sex Transm Dis"},{"issue":"2","key":"pcbi.1009385.ref012","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1473-3099(17)30007-5","article-title":"Treatment guidelines after an outbreak of azithromycin-resistant Neisseria gonorrhoeae in South Australia","volume":"17","author":"MM Lahra","year":"2017","journal-title":"Lancet Infectious Diseases"},{"issue":"8","key":"pcbi.1009385.ref013","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1093\/jac\/dkz182","article-title":"Emergence and spread of ciprofloxacin-resistant Neisseria gonorrhoeae in New South Wales, Australia: lessons from history","volume":"74","author":"JK Hanrahan","year":"2019","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"9492","key":"pcbi.1009385.ref014","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0140-6736(05)67470-3","article-title":"Ciprofloxacin-resistant gonorrhoea in South Africa","volume":"366","author":"P Moodley","year":"2005","journal-title":"Lancet (London, England)."},{"issue":"1","key":"pcbi.1009385.ref015","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/jac\/dkm434","article-title":"Analysis of trends in antimicrobial resistance in Neisseria gonorrhoeae isolated in Australia, 1997\u20132006","volume":"61","author":"JW Tapsall","year":"2008","journal-title":"Journal of Antimicrobial Chemotherapy"},{"issue":"Suppl 1","key":"pcbi.1009385.ref016","first-page":"A295","article-title":"P675 Two recent cases of extensively drug-resistant (XDR) gonorrhoea in the united kingdom linked to a european party destination","volume":"95","author":"P Horner","year":"2019","journal-title":"Sex Transm Infect"},{"issue":"5","key":"pcbi.1009385.ref017","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1136\/sextrans-2014-051760","article-title":"Oral and anal sex are key to sustaining gonorrhoea at endemic levels in MSM populations: a mathematical model","volume":"91","author":"B Hui","year":"2015","journal-title":"Sex Transm Infect."},{"issue":"10","key":"pcbi.1009385.ref018","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1097\/OLQ.0000000000000661","article-title":"Neisseria gonorrhoeae transmission among men who have sex with men: an anatomical site-specific mathematical model evaluating the potential preventive impact of mouthwash","volume":"44","author":"L Zhang","year":"2017","journal-title":"Sex Transm Dis"},{"issue":"11","key":"pcbi.1009385.ref019","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/S1473-3099(18)30610-8","article-title":"Treatment for pharyngeal gonorrhoea under threat","volume":"18","author":"DG Regan","year":"2018","journal-title":"Lancet Infectious Diseases"},{"key":"pcbi.1009385.ref020","article-title":"Identifying factors that lead to the persistence of imported gonorrhoeae strains: a modelling study","author":"BB Hui","year":"2016","journal-title":"Sex Transm Infect:"},{"issue":"5","key":"pcbi.1009385.ref021","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/OLQ.0000000000000953","article-title":"Assessing Uncertainty in an Anatomical Site-Specific Gonorrhea Transmission Model of Men Who Have Sex With Men.","volume":"46","author":"IH Spicknall","year":"2019","journal-title":"Sex Transm Dis"},{"key":"pcbi.1009385.ref022","article-title":"Modeling the Cost-Effectiveness of Express Multi-Site Gonorrhea Screening among Men Who Have Sex with Men in the United States","author":"R Earnest","year":"2021","journal-title":"Sex Transm Dis"},{"key":"pcbi.1009385.ref023","volume-title":"Gay Community Periodic Survey: Sydney 2018","author":"T Broady","year":"2018"},{"key":"pcbi.1009385.ref024","volume-title":"The Health in Men and Positive Health cohorts: a comparison of trends in the health and sexual behaviour of HIV-negative and HIV-positive gay men, 2002\u20132005","author":"A Fogarty","year":"2006"},{"issue":"5","key":"pcbi.1009385.ref025","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1071\/SH18097","article-title":"Gonorrhoea gone wild: rising incidence of gonorrhoea and associated risk factors among gay and bisexual men attending Australian sexual health clinics","volume":"16","author":"D Callander","year":"2019","journal-title":"Sex Health"},{"key":"pcbi.1009385.ref026","volume-title":"The Australian Collaboration for Coordinated Enhanced Sentinel Surveillance of Sexually Transmissible Infections and Blood Borne Viruses: NSW STI report 2007\u20132014","author":"D Callander","year":"2015"},{"key":"pcbi.1009385.ref027","unstructured":"Australasian Sexual Health Alliance. Australian STI Management Guidelines 2018. Available from: http:\/\/www.sti.guidelines.org.au\/."},{"key":"pcbi.1009385.ref028","unstructured":"STIGMA. Australian STI & HIV Testing Guidelines 2019 for Asymptomatic MSM 2019. Available from: https:\/\/stipu.nsw.gov.au\/wp-content\/uploads\/STIGMA_Guidelines2019_Final-1.pdf."},{"key":"pcbi.1009385.ref029","unstructured":"Australian Contact Tracing Guidelines. Available from: http:\/\/www.contacttracing.ashm.org.au\/."},{"issue":"23","key":"pcbi.1009385.ref030","first-page":"1800287","volume":"23","author":"C Smolarchuk","year":"2018","journal-title":"Persistence of an outbreak of gonorrhoea with high-level resistance to azithromycin in England, November 2014\u2013May 2018"},{"key":"pcbi.1009385.ref031","unstructured":"World Health Organization (WHO). Guidelines: Prevention and Treatment of HIV and Other Sexually Transmitted Infections Among Men Who Have Sex with Men and Transgender People: Recommendations for a Public Health Approach 2011. 2011. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK304456\/."},{"key":"pcbi.1009385.ref032","unstructured":"The Australasian Society of HIV, Viral Hepatitis and Sexual Health Medicine, (ASHM). PrEP Guidelines Update. Prevent HIV by Prescribing PrEP. Sydney, 2019. Sydney. Available from: https:\/\/ashm.org.au\/resources\/hiv-resources-list\/prep-guidelines-2019\/."},{"issue":"2","key":"pcbi.1009385.ref033","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/OLQ.0000000000000232","article-title":"Substantial increases in chlamydia and gonorrhea positivity unexplained by changes in individual-level sexual behaviors among men who have sex with men in an Australian sexual health service from 2007 to 2013.","volume":"42","author":"EPF Chow","year":"2015","journal-title":"Sexually Transmitted Diseases"},{"issue":"2","key":"pcbi.1009385.ref034","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/jac\/dkw406","article-title":"Mixed gonococcal infections in a high-risk population, Sydney, Australia 2015: implications for antimicrobial resistance surveillance?","volume":"72","author":"N Goire","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"pcbi.1009385.ref035","unstructured":"Communicable Diseases Network Australia (CDNA). The Series of National Guidelines (SoNG): Gonococcal Infection (Appendix G) 2019. Available from: https:\/\/www1.health.gov.au\/internet\/main\/publishing.nsf\/Content\/cdnasongs.htm."},{"key":"pcbi.1009385.ref036","unstructured":"Department of Health, Australian Government,. Pharmaceutical Benefits Scheme (PBS). Available from: http:\/\/www.pbs.gov.au\/pbs\/home."},{"key":"pcbi.1009385.ref037","first-page":"52","article-title":"New Concepts in Immunity to Neisseria Gonorrhoeae: Innate Responses and Suppression of Adaptive Immunity Favor the Pathogen, Not the Host","volume":"2","author":"Y Liu","year":"2011","journal-title":"Front Microbiol"},{"issue":"6","key":"pcbi.1009385.ref038","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1258\/095646206777323337","article-title":"Re-infection of Neisseria gonorrhoeae and Chlamydia trachomatis infections among men who have sex with men","volume":"17","author":"NA Lister","year":"2006","journal-title":"Int J STD AIDS"},{"key":"pcbi.1009385.ref039","volume-title":"Phase A of the National Gay Men\u2019s Syphilis Action Plan: modelling evidence and research on acceptability of interventions for controlling syphilis in Australia","author":"DP Wilson","year":"2009"},{"issue":"3","key":"pcbi.1009385.ref040","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1136\/sti.2007.028787","article-title":"More than just anal sex: the potential for sexually transmitted infection transmission among men visiting sex-on-premises venues","volume":"84","author":"CW Phang","year":"2008","journal-title":"Sex Transm Infect."},{"issue":"11","key":"pcbi.1009385.ref041","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1111\/j.1743-6109.2011.02438.x","article-title":"Sexual behaviors and situational characteristics of most recent male-partnered sexual event among gay and bisexually identified men in the United States","volume":"8","author":"JG Rosenberger","year":"2011","journal-title":"J Sex Med"},{"issue":"7","key":"pcbi.1009385.ref042","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1136\/sextrans-2018-053896","article-title":"Kissing may be an important and neglected risk factor for oropharyngeal gonorrhoea: a cross-sectional study in men who have sex with men","volume":"95","author":"EP Chow","year":"2019","journal-title":"Sexually transmitted infections"},{"issue":"10","key":"pcbi.1009385.ref043","doi-asserted-by":"crossref","first-page":"e360","DOI":"10.1016\/S1473-3099(19)30304-4","article-title":"Models of gonorrhoea transmission from the mouth and saliva","volume":"19","author":"CK Fairley","year":"2019","journal-title":"The Lancet Infectious Diseases"},{"key":"pcbi.1009385.ref044","volume-title":"Sexually Transmitted Diseases","author":"III Hook EW","year":"2008"},{"issue":"1","key":"pcbi.1009385.ref045","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1071\/SH09100","article-title":"Is screening asymptomatic men who have sex with men for urethral gonorrhoea worthwhile?","volume":"7","author":"N Ryder","year":"2010","journal-title":"Sexual Health"},{"issue":"9","key":"pcbi.1009385.ref046","doi-asserted-by":"crossref","first-page":"e0138315","DOI":"10.1371\/journal.pone.0138315","article-title":"A Cross Sectional Analysis of Gonococcal and Chlamydial Infections among Men-Who-Have-Sex-with-Men in Cape Town, South Africa","volume":"10","author":"K Rebe","year":"2015","journal-title":"PLoS One."},{"issue":"1","key":"pcbi.1009385.ref047","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1136\/sextrans-2012-050929","article-title":"Prevalence of pharyngeal and rectal Chlamydia trachomatis and Neisseria gonorrhoeae infections among men who have sex with men in Germany","volume":"90","author":"S Dudareva-Vizule","year":"2014","journal-title":"Sexually Transmitted Infections"},{"issue":"1","key":"pcbi.1009385.ref048","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1071\/SH10134","article-title":"Is it time to move to nucleic acid amplification tests screening for pharyngeal and rectal gonorrhoea in men who have sex with men to improve gonorrhoea control?","volume":"8","author":"CK Fairley","year":"2011","journal-title":"Sexual Health"},{"issue":"3","key":"pcbi.1009385.ref049","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1071\/SH15175","article-title":"Duration of gonorrhoea and chlamydia infection at the pharynx and rectum among men who have sex with men: a systematic review.","volume":"13","author":"EP Chow","year":"2016","journal-title":"Sex Health."},{"issue":"3","key":"pcbi.1009385.ref050","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1071\/SH15036","article-title":"Early presentation of symptomatic individuals is critical in controlling sexually transmissible infections.","volume":"12","author":"CK Fairley","year":"2015","journal-title":"Sexual Health"},{"issue":"19","key":"pcbi.1009385.ref051","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1056\/NEJM197905103001903","article-title":"A trial of minocycline given after exposure to prevent gonorrhea","volume":"300","author":"WO Harrison","year":"1979","journal-title":"N Engl J Med"},{"issue":"2","key":"pcbi.1009385.ref052","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1136\/sti.79.2.124","article-title":"Gonorrhoea reinfection in heterosexual STD clinic attendees: longitudinal analysis of risks for first reinfection","volume":"79","author":"SD Mehta","year":"2003","journal-title":"Sexually Transmitted Infections"},{"issue":"8","key":"pcbi.1009385.ref053","doi-asserted-by":"crossref","first-page":"3937","DOI":"10.1128\/IAI.67.8.3937-3946.1999","article-title":"Limited local and systemic antibody responses to Neisseria gonorrhoeae during uncomplicated genital infections","volume":"67","author":"SR Hedges","year":"1999","journal-title":"Infection and immunity"},{"issue":"2","key":"pcbi.1009385.ref054","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/OLQ.0000000000000553","article-title":"Increased detection of pharyngeal and rectal gonorrhea in men who have sex with men after transition from culture to nucleic acid amplification testing","volume":"44","author":"VJ Cornelisse","year":"2017","journal-title":"Sex Transm Dis"}],"updated-by":[{"DOI":"10.1371\/journal.pcbi.1009385","type":"new_version","label":"New version","source":"publisher","updated":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000}}],"container-title":["PLOS Computational Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1009385","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T13:40:09Z","timestamp":1637070009000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pcbi.1009385"}},"subtitle":[],"editor":[{"given":"Roger Dimitri","family":"Kouyos","sequence":"first","affiliation":[]}],"short-title":[],"issued":{"date-parts":[[2021,11,4]]},"references-count":54,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pcbi.1009385","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.04.30.21256375","asserted-by":"object"}]},"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,4]]}}}