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Small animal models have been used for studying OA progression mechanisms. However, numerical models to study cartilage responses under dynamic loading in preclinical animal models have not been developed. Here we present a musculoskeletal finite element model of a rat knee joint to evaluate cartilage biomechanical responses during a gait cycle. The rat knee joint geometries were obtained from a 3-D MRI dataset and the boundary conditions regarding loading in the joint were extracted from a musculoskeletal model of the rat hindlimb. The fibril-reinforced poroelastic (FRPE) properties of the rat cartilage were derived from data of mechanical indentation tests. Our numerical results showed the relevance of simulating anatomical and locomotion characteristics in the rat knee joint for estimating tissue responses such as contact pressures, stresses, strains, and fluid pressures. We found that the contact pressure and maximum principal strain were virtually constant in the medial compartment whereas they showed the highest values at the beginning of the gait cycle in the lateral compartment. Furthermore, we found that the maximum principal stress increased during the stance phase of gait, with the greatest values at midstance. We anticipate that our approach serves as a first step towards investigating the effects of gait abnormalities on the adaptation and degeneration of rat knee joint tissues and could be used to evaluate biomechanically-driven mechanisms of the progression of OA as a consequence of joint injury or obesity.<\/jats:p>","DOI":"10.1371\/journal.pcbi.1009398","type":"journal-article","created":{"date-parts":[[2022,6,3]],"date-time":"2022-06-03T13:59:36Z","timestamp":1654264776000},"page":"e1009398","update-policy":"https:\/\/doi.org\/10.1371\/journal.pcbi.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["A musculoskeletal finite element model of rat knee joint for evaluating cartilage biomechanics during gait"],"prefix":"10.1371","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1054-7937","authenticated-orcid":true,"given":"Gustavo 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Kuan","family":"Moo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7705-9188","authenticated-orcid":true,"given":"Lauri","family":"Stenroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9684-6902","authenticated-orcid":true,"given":"Petri","family":"Tanska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3679-2869","authenticated-orcid":true,"given":"Jaqueline Lourdes","family":"Rios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8115-9296","authenticated-orcid":true,"given":"Teemu 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Vaienti","year":"2017","journal-title":"Acta Biomed."},{"key":"pcbi.1009398.ref072","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1249\/01.mss.0000180404.86078.ff","article-title":"Muscle, ligament, and joint-contact forces at the knee during walking","volume":"37","author":"KB Shelburne","year":"2005","journal-title":"Med Sci Sports Exerc"},{"key":"pcbi.1009398.ref073","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1055\/s-0036-1571803","article-title":"Influence of Posterior Cruciate Ligament Tension on Knee Kinematics and Kinetics.","volume":"29","author":"MS Abubakar","year":"2016","journal-title":"The Journal of Knee Surgery"},{"key":"pcbi.1009398.ref074","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1302\/2046-3758.61.BJR-2016-0184.R1","article-title":"The effects of posterior cruciate ligament deficiency on posterolateral corner structures under gait- and squat-loading conditions","volume":"6","author":"K-T 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Allen","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"pcbi.1009398.ref081","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1002\/jez.589","article-title":"X-ray reconstruction of moving morphology (XROMM): precision, accuracy and applications in comparative biomechanics research.","volume":"313A","author":"EL Brainerd","year":"2010","journal-title":"Journal of Experimental Zoology Part A: Ecological Genetics and Physiology"},{"key":"pcbi.1009398.ref082","doi-asserted-by":"crossref","first-page":"862903","DOI":"10.1155\/2013\/862903","article-title":"Altered knee joint mechanics in simple compression associated with early cartilage degeneration.","volume":"2013","author":"Y Dabiri","year":"2013","journal-title":"Comput Math Methods Med"},{"key":"pcbi.1009398.ref083","doi-asserted-by":"crossref","first-page":"20200737","DOI":"10.1098\/rsif.2020.0737","article-title":"Structure, composition and fibril-reinforced poroviscoelastic properties of bovine knee ligaments 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